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UniProtKB - P0C6W2 (R1AB_BCHK3)

Entry version 95 (25 May 2022)
Sequence version 1 (10 Jun 2008)
Previous versions | rss
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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.

By similarity

Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

By similarity

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.

By similarity

Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.

By similarity

Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.

By similarity

Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).

PROSITE-ProRule annotationBy similarity

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.

By similarity

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

By similarity

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

By similarity

May participate in viral replication by acting as a ssRNA-binding protein.

By similarity

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.

By similarity

Responsible for replication and transcription of the viral RNA genome.

By similarity

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.

By similarity

Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.

By similarity

Plays a role in viral transcription/replication and prevents the simultaneous activation of host cell dsRNA sensors, such as MDA5/IFIH1, OAS, and PKR (By similarity).

Acts by degrading the 5'-polyuridines generated during replication of the poly(A) region of viral genomic and subgenomic RNAs. Catalyzes a two-step reaction in which a 2'3'-cyclic phosphate (2'3'-cP) is first generated by 2'-O transesterification, which is then hydrolyzed to a 3'-phosphate (3'-P) (By similarity).

If not degraded, poly(U) RNA would hybridize with poly(A) RNA tails and activate host dsRNA sensors (By similarity).

By similarity

Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.

By similarity

Miscellaneous

Bat coronavirus HKU3 is highly similar to SARS-CoV (SARS-like).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Uridylate-specific endoribonuclease:
Mn2+By similarityNote: Likely affects Nsp15 binding to RNA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi200Zinc 1PROSITE-ProRule annotation1
Metal bindingi231Zinc 1PROSITE-ProRule annotation1
Metal bindingi234Zinc 1PROSITE-ProRule annotation1
Metal bindingi236Zinc 1PROSITE-ProRule annotation1
Metal bindingi323Zinc 2PROSITE-ProRule annotation1
Metal bindingi326Zinc 2PROSITE-ProRule annotation1
Metal bindingi341Zinc 2PROSITE-ProRule annotation1
Metal bindingi344Zinc 2PROSITE-ProRule annotation1
Metal bindingi370Zinc 3PROSITE-ProRule annotation1
Metal bindingi373Zinc 3PROSITE-ProRule annotation1
Metal bindingi382Zinc 3PROSITE-ProRule annotation1
Metal bindingi416Zinc 3PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1645For PL-PRO activityPROSITE-ProRule annotation1
Active sitei1806For PL-PRO activityPROSITE-ProRule annotation1
Active sitei3275For 3CL-PRO activityPROSITE-ProRule annotation1
Active sitei3379For 3CL-PRO activityPROSITE-ProRule annotation1
Metal bindingi4298Zinc 1PROSITE-ProRule annotation1
Metal bindingi4301Zinc 1PROSITE-ProRule annotation1
Metal bindingi4307Zinc 1PROSITE-ProRule annotation1
Metal bindingi4314Zinc 1PROSITE-ProRule annotation1
Metal bindingi4341Zinc 2PROSITE-ProRule annotation1
Metal bindingi4344Zinc 2PROSITE-ProRule annotation1
Metal bindingi4352Zinc 2PROSITE-ProRule annotation1
Metal bindingi4354Zinc 2PROSITE-ProRule annotation1
Active sitei5122PROSITE-ProRule annotation1
Active sitei5123PROSITE-ProRule annotation1
Active sitei5124PROSITE-ProRule annotation1
Metal bindingi5300Zinc 3PROSITE-ProRule annotation1
Metal bindingi5303Zinc 3PROSITE-ProRule annotation1
Metal bindingi5311Zinc 4PROSITE-ProRule annotation1
Metal bindingi5314Zinc 3PROSITE-ProRule annotation1
Metal bindingi5321Zinc 3PROSITE-ProRule annotation1
Metal bindingi5324Zinc 4PROSITE-ProRule annotation1
Metal bindingi5328Zinc 4PROSITE-ProRule annotation1
Metal bindingi5334Zinc 4PROSITE-ProRule annotation1
Metal bindingi5345Zinc 5PROSITE-ProRule annotation1
Metal bindingi5350Zinc 5PROSITE-ProRule annotation1
Metal bindingi5367Zinc 5PROSITE-ProRule annotation1
Metal bindingi5370Zinc 5PROSITE-ProRule annotation1
Active sitei5986PROSITE-ProRule annotation1
Active sitei5988PROSITE-ProRule annotation1
Active sitei6087PROSITE-ProRule annotation1
Metal bindingi6103Zinc 6PROSITE-ProRule annotation1
Metal bindingi6106Zinc 6PROSITE-ProRule annotation1
Metal bindingi6122Zinc 6PROSITE-ProRule annotation1
Metal bindingi6125Zinc 6PROSITE-ProRule annotation1
Metal bindingi6153Zinc 7PROSITE-ProRule annotation1
Metal bindingi6157Zinc 7PROSITE-ProRule annotation1
Metal bindingi6160Zinc 7PROSITE-ProRule annotation1
Active sitei6164PROSITE-ProRule annotation1
Active sitei6169PROSITE-ProRule annotation1
Metal bindingi6175Zinc 7PROSITE-ProRule annotation1
Metal bindingi6348Zinc 8PROSITE-ProRule annotation1
Metal bindingi6369Zinc 8PROSITE-ProRule annotation1
Metal bindingi6380Zinc 8PROSITE-ProRule annotation1
Metal bindingi6383Zinc 8PROSITE-ProRule annotation1
Active sitei6657PROSITE-ProRule annotation1
Active sitei6672PROSITE-ProRule annotation1
Active sitei6712PROSITE-ProRule annotation1
Active sitei6815PROSITE-ProRule annotation1
Active sitei6899PROSITE-ProRule annotation1
Active sitei6939PROSITE-ProRule annotation1
Active sitei6972PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1723 – 1760C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4298 – 4314By similarityAdd BLAST17
Zinc fingeri4341 – 4354By similarityAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi5577 – 5584ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Helicase, Hydrolase, Lyase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processActivation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...MEROPSi		C30.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 15 chains:
Host translation inhibitor nsp1
Short name:
nsp1
Alternative name(s):
Leader protein
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p65 homolog
Papain-like proteinase (EC:3.4.19.12, EC:3.4.22.-)
Short name:
PL-PRO
Alternative name(s):
Non-structural protein 3
Short name:
nsp3
Non-structural protein 4
Short name:
nsp4
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
Guanine-N7 methyltransferase (EC:2.1.1.-, EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
Uridylate-specific endoribonuclease (EC:4.6.1.-)
Alternative name(s):
NendoU
nsp15
2'-O-methyltransferase (EC:2.1.1.57)
Alternative name(s):
nsp16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rep
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri442736 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiRhinolophus sinicus (Chinese rufous horseshoe bat) [TaxID: 89399]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2197 – 2217HelicalSequence analysisAdd BLAST21
Transmembranei2298 – 2318HelicalSequence analysisAdd BLAST21
Transmembranei2345 – 2365HelicalSequence analysisAdd BLAST21
Transmembranei2744 – 2764HelicalSequence analysisAdd BLAST21
Transmembranei2986 – 3006HelicalSequence analysisAdd BLAST21
Transmembranei3016 – 3036HelicalSequence analysisAdd BLAST21
Transmembranei3048 – 3068HelicalSequence analysisAdd BLAST21
Transmembranei3071 – 3091HelicalSequence analysisAdd BLAST21
Transmembranei3099 – 3119HelicalSequence analysisAdd BLAST21
Transmembranei3136 – 3156HelicalSequence analysisAdd BLAST21
Transmembranei3558 – 3578HelicalSequence analysisAdd BLAST21
Transmembranei3580 – 3600HelicalSequence analysisAdd BLAST21
Transmembranei3606 – 3626HelicalSequence analysisAdd BLAST21
Transmembranei3652 – 3672HelicalSequence analysisAdd BLAST21
Transmembranei3679 – 3698HelicalSequence analysisAdd BLAST20
Transmembranei3722 – 3742HelicalSequence analysisAdd BLAST21
Transmembranei3750 – 3770HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002913351 – 179Host translation inhibitor nsp1By similarityAdd BLAST179
ChainiPRO_0000291336180 – 818Non-structural protein 2By similarityAdd BLAST639
ChainiPRO_0000291337819 – 2734Papain-like proteinaseBy similarityAdd BLAST1916
ChainiPRO_00002913382735 – 3234Non-structural protein 4By similarityAdd BLAST500
ChainiPRO_00002913393235 – 35403C-like proteinaseBy similarityAdd BLAST306
ChainiPRO_00002913403541 – 3830Non-structural protein 6By similarityAdd BLAST290
ChainiPRO_00002913413831 – 3913Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_00002913423914 – 4111Non-structural protein 8By similarityAdd BLAST198
ChainiPRO_00002913434112 – 4224Non-structural protein 9By similarityAdd BLAST113
ChainiPRO_00002913444225 – 4363Non-structural protein 10By similarityAdd BLAST139
ChainiPRO_00002913454364 – 5295RNA-directed RNA polymeraseBy similarityAdd BLAST932
ChainiPRO_00002913465296 – 5896HelicaseBy similarityAdd BLAST601
ChainiPRO_00002913475897 – 6423Guanine-N7 methyltransferaseBy similarityAdd BLAST527
ChainiPRO_00002913486424 – 6769Uridylate-specific endoribonucleaseBy similarityAdd BLAST346
ChainiPRO_00002913496770 – 70672'-O-methyltransferaseBy similarityAdd BLAST298

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei179 – 180Cleavage; by PL-PROBy similarity2
Sitei818 – 819Cleavage; by PL-PROBy similarity2
Sitei3234 – 3235Cleavage; by 3CL-PROBy similarity2
Sitei3540 – 3541Cleavage; by 3CL-PROBy similarity2
Sitei3830 – 3831Cleavage; by 3CL-PROBy similarity2
Sitei3913 – 3914Cleavage; by 3CL-PROBy similarity2
Sitei4111 – 4112Cleavage; by 3CL-PROBy similarity2
Sitei4224 – 4225Cleavage; by 3CL-PROBy similarity2
Sitei4363 – 4364Cleavage; by 3CL-PROBy similarity2
Sitei5295 – 5296Cleavage; by 3CL-PROBy similarity2
Sitei5896 – 5897Cleavage; by 3CL-PROBy similarity2
Sitei6423 – 6424Cleavage; by 3CL-PROBy similarity2
Sitei6769 – 6770Cleavage; by 3CL-PROBy similarity2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P0C6W2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C6W2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 127CoV Nsp1 globularPROSITE-ProRule annotationAdd BLAST116
Domaini148 – 179BetaCoV Nsp1 C-terminalPROSITE-ProRule annotationAdd BLAST32
Domaini183 – 456CoV Nsp2 N-terminalPROSITE-ProRule annotationAdd BLAST274
Domaini458 – 688CoV Nsp2 middlePROSITE-ProRule annotationAdd BLAST231
Domaini690 – 818CoV Nsp2 C-terminalPROSITE-ProRule annotationAdd BLAST129
Domaini822 – 930Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST109
Domaini998 – 1164Macro 1PROSITE-ProRule annotationAdd BLAST167
Domaini1201 – 1329Macro 2PROSITE-ProRule annotationAdd BLAST129
Domaini1337 – 1464Macro 3PROSITE-ProRule annotationAdd BLAST128
Domaini1466 – 1532DPUPPROSITE-ProRule annotationAdd BLAST67
Domaini1536 – 1591Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini1605 – 1869Peptidase C16PROSITE-ProRule annotationAdd BLAST265
Domaini1882 – 1992Nucleic acid-bindingPROSITE-ProRule annotationAdd BLAST111
Domaini2017 – 2126G2MPROSITE-ProRule annotationAdd BLAST110
Domaini2631 – 2734CoV Nsp3 Y3PROSITE-ProRule annotationAdd BLAST104
Domaini3136 – 3234Nsp4CPROSITE-ProRule annotationAdd BLAST99
Domaini3235 – 3540Peptidase C30PROSITE-ProRule annotationAdd BLAST306
Domaini3831 – 3913RdRp Nsp7 cofactorPROSITE-ProRule annotationAdd BLAST83
Domaini3914 – 4111RdRp Nsp8 cofactorPROSITE-ProRule annotationAdd BLAST198
Domaini4112 – 4224Nsp9 ssRNA-bindingPROSITE-ProRule annotationAdd BLAST113
Domaini4225 – 4363ExoN/MTase coactivatorPROSITE-ProRule annotationAdd BLAST139
Domaini4370 – 4624NiRANPROSITE-ProRule annotationAdd BLAST255
Domaini4728 – 5295Nsp12 RNA-dependent RNA polymerasePROSITE-ProRule annotationAdd BLAST568
Domaini4975 – 5137RdRp catalyticPROSITE-ProRule annotationAdd BLAST163
Domaini5296 – 5379CV ZBDPROSITE-ProRule annotationAdd BLAST84
Domaini5552 – 5733(+)RNA virus helicase ATP-bindingAdd BLAST182
Domaini5734 – 5903(+)RNA virus helicase C-terminalAdd BLAST170
Domaini5968 – 6183ExoNPROSITE-ProRule annotationAdd BLAST216
Domaini6192 – 6423N7-MTasePROSITE-ProRule annotationAdd BLAST232
Domaini6424 – 6484Nsp15 N-terminal oligomerizationPROSITE-ProRule annotationAdd BLAST61
Domaini6485 – 6610AV-Nsp11N/CoV-Nsp15MPROSITE-ProRule annotationAdd BLAST126
Domaini6627 – 6766NendoUPROSITE-ProRule annotationAdd BLAST140
Domaini6771 – 7065Nidovirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST295

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni200 – 236C2H2PROSITE-ProRule annotationAdd BLAST37
Regioni323 – 344C4PROSITE-ProRule annotationAdd BLAST22
Regioni370 – 416C2HCPROSITE-ProRule annotationAdd BLAST47
Regioni2086 – 2365HD1By similarityAdd BLAST280
Regioni2749 – 3156HD2By similarityAdd BLAST408
Regioni3558 – 3770HD3By similarityAdd BLAST213
Regioni6227 – 6233SAM-bindingPROSITE-ProRule annotation7
Regioni6310 – 6324GpppA-bindingPROSITE-ProRule annotationAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1723 – 1760C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4298 – 4314By similarityAdd BLAST17
Zinc fingeri4341 – 4354By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Conserved Domains Database

More...CDDi		cd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21516, cv_beta_Nsp2_SARS-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit
cd21562, Macro_cv_SUD-N_Nsp3-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21591, SARS-CoV-like_RdRp, 1 hit
cd21525, SUD_C_SARS-CoV_Nsp3, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.60.120.1680, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.30.160.820, 1 hit
3.30.70.3540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.30.150, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.40.50.150, 1 hit
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR022733, DPUP_SUD_C_bCoV
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR044863, NIRAN
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044322, NSP15_M_alpha_beta_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR043615, NSP2_N_CoV
IPR044389, NSP2_SARS-CoV-like
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAB_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR044864, NSP3_SUD-N_bCoV
IPR044374, NSP3_SUD-N_SARS-CoV
IPR043478, NSP3_SUD-N_sf_bCoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044351, RdRp_SARS-CoV-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_CoV
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF06471, CoV_ExoN, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51961, AV_NSP11N_COV_NSP15M, 1 hit
PS51963, BCOV_NSP1_C, 1 hit
PS51942, BCOV_NSP3C_C, 1 hit
PS51941, BCOV_NSP3C_M, 1 hit
PS51994, BCOV_NSP3E_G2M, 1 hit
PS51945, BCOV_NSP3E_NAB, 1 hit
PS51952, COV_EXON_MTASE_COACT, 1 hit
PS51954, COV_N7_MTASE, 1 hit
PS51962, COV_NSP1, 1 hit
PS51948, COV_NSP12_RDRP, 1 hit
PS51960, COV_NSP15_NTD, 1 hit
PS51991, COV_NSP2_C, 1 hit
PS51990, COV_NSP2_M, 1 hit
PS51989, COV_NSP2_N, 1 hit
PS51992, COV_NSP3_Y3, 1 hit
PS51943, COV_NSP3A_UBL, 1 hit
PS51944, COV_NSP3D_UBL, 1 hit
PS51946, COV_NSP4C, 1 hit
PS51949, COV_NSP7, 1 hit
PS51950, COV_NSP8, 1 hit
PS51951, COV_NSP9_SSRNA_BD, 1 hit
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51955, NIV_2_O_MTASE, 1 hit
PS51953, NIV_EXON, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51940, SARS_NSP3C_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1ab (identifier: P0C6W2-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT 
        60         70         80         90        100
CGLVELEKGV LPQLEQPYVF IKRSDALSTN HGHKVVELVA ELDGIQFGRS 
       110        120        130        140        150
GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSFGIDL KSYDLGDELG 
       160        170        180        190        200
TDPIEDYEQN WNTKHGSGAL RELTRELNGG VVTRYVDNNF CGPDGYPLEC 
       210        220        230        240        250
IKDFLARAGK SMCTLSEQLD YIESKRGVYC CREHEHEIVW FTERSEKSYE 
       260        270        280        290        300
HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI 
       310        320        330        340        350
RSVYPVATPQ ECNDMHLSTL MKCNHCDEVS WQTCDFLKAT CEQCGTENLV 
       360        370        380        390        400
CEGPTTCGYL PTNAVVKMPC PACQDPEVGP EHSVADYHNH SNIETRLRKG 
       410        420        430        440        450
GRTKCFGGCV FSYVGCYNKR AYWVPRASAN IGANHTGITG ENVETLNEDL 
       460        470        480        490        500
LEILNRERVN INIVGDFRFN EEVAIILASF SASPSAFIET VKGLDYKSFK 
       510        520        530        540        550
VIVESCGNYK VTNGKPVTGA WNIGQQRSIL TPLCGFPSQA AGVIRSIFSR 
       560        570        580        590        600
TLDAANHSIL DLQRAAVTTL DGISEQSLRL VDAMVYTSDL LTNSVVVMAY 
       610        620        630        640        650
VTGGLVQQTM QWLSNMLGTA VDKLKPVFTW VEAKLSAGVE FLRDAWEILK 
       660        670        680        690        700
FLITGVFDVI KGQIQVATDN IKECVKIFLG VVNKALEMCL DQVTIAGTKL 
       710        720        730        740        750
RALNLGEVFI AQSRGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDAHDTV 
       760        770        780        790        800
LTSEEVVLKS GELEALETPI DSFTSGAVVG TPVCINGLML LELENKEQYC 
       810        820        830        840        850
ALSPGLLATN NVFRLKGGAP VKGVTFGEDT VLEVQGYKNV KITFELDVRV 
       860        870        880        890        900
DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTPMGIDLDE 
       910        920        930        940        950
WSVATFYLFD DAGEEKLSSR MYCSFYPPDE EEDCEECEDE EETCEHEYGT 
       960        970        980        990       1000
EDDYKGLPLE FGASTETPHV EEEEEEEDWL DDAIEAEPEP EPLPEEPVNQ 
      1010       1020       1030       1040       1050
FVGYLKLTDN VAIKCIDIVK EAQSAKPTVI VNAANTHLKH GGGVAGALNK 
      1060       1070       1080       1090       1100
ATNGAMQNES DEYIRQNGPL TVGGSCLLSG HNLAEKCLHV VGPNLNAGED 
      1110       1120       1130       1140       1150
VQLLKRAYEN FNSQDVLLAP LLSAGIFGAK PLQSLKMCVE IVRTQVYLAV 
      1160       1170       1180       1190       1200
NDKSLYDQIV LDYLDSLKPK VESPNKEEEP KLEEPKAVQP VAEKPVDVKP 
      1210       1220       1230       1240       1250
KIKACIDEVT TTLEETKFLT NKLLLFADIN GKLYQDSQNM LRGEDMSFLE 
      1260       1270       1280       1290       1300
KDAPYIVGDV ITSGDITCVI IPAKKSGGTT EMLARALKEV PVAEYITTYP 
      1310       1320       1330       1340       1350
GQGCAGYTLE EAKTALKKCK SAFYVLPSET PNEKEEVLGT VSWNLREMLA 
      1360       1370       1380       1390       1400
HAEETRKLMP ICLDVRAIMA TIQRKYKGIK VQEGIVDYGV RFFFYTSKEP 
      1410       1420       1430       1440       1450
VASIITKLNS LNEPLVTMPI GYVTHGLNLE EAARCMRSLK APAVVSVSSP 
      1460       1470       1480       1490       1500
DAVTAYNGYL TSSSKTPEEY FVETTSLAGS YRDWSYSGQR TELGVEFLKR 
      1510       1520       1530       1540       1550
GDKIVYHTTG SPIEFHLDGE VLPLDKLKSL LSLREVKTIK VFTTVDNTNL 
      1560       1570       1580       1590       1600
HTHIVDMSMT YGQQFGPTYL DGADVTKIKP HVNHEGKTFF VLPSDDTLRS 
      1610       1620       1630       1640       1650
EAFEYYHTID ESFLGRYMSA LNHTKKWKFP QVGGLTSIKW ADNNCYLSSV 
      1660       1670       1680       1690       1700
LLALQQVEVK FNAPALQEAY YRARAGDAAN FCALILAYSN KTVGELGDVR 
      1710       1720       1730       1740       1750
ETMTHLLQHA NLESAKRVLN VVCKHCGQKT TTLKGVEAVM YMGTLSYDEL 
      1760       1770       1780       1790       1800
KTGVSIPCVC GRNATQYLVQ QESSFVMMSA PPAEYKLQQG AFLCANEYTG 
      1810       1820       1830       1840       1850
NYQCGHYTHI TAKETLYRVD GAHLTKMSEY KGPVTDVFYK ETSYTTAIKP 
      1860       1870       1880       1890       1900
VSYKLDGVTY TEIEPKLDGY YKKGNAYYTE QPIDLVPTQP MPNASFDNFK 
      1910       1920       1930       1940       1950
LTCSNTKFAD DLNQMTGFKK PASRELTVTF FPDLNGDVVA IDYRHYSTSF 
      1960       1970       1980       1990       2000
KKGAKLVHKP ILWHINQTTN KTTYKPNIWC LRCLWSTKPV DTSNSFEVLV 
      2010       2020       2030       2040       2050
VEDTQGMDNL ACESQTTTSE EVVENPTVQK EIIECDVKTT EVVGNVILKP 
      2060       2070       2080       2090       2100
SEEGVKVTQE LGHEDLMAAY VEETSITIKK PNELSLALGL KTLATHGAAA 
      2110       2120       2130       2140       2150
INSVPWSKIL AYVKPFLGQT AVITSNCIKK CVQRVFSNYM PYVITLLFQL 
      2160       2170       2180       2190       2200
CTFTKSTNSR IKASLPTTIA KNSVKSVAKL CLDVCINYVK SPKFSKLFTI 
      2210       2220       2230       2240       2250
VMWLLLLSIC LGSLTYVTAV LGVCLSSLGV PSYCDGVREL YINSSNVTTM 
      2260       2270       2280       2290       2300
DFCQGYFPCS VCLSGLDSLD SYPALETIQV TISSYKLDLT FLGLAAEWLL 
      2310       2320       2330       2340       2350
AYMLFTKFFY LLGLSAIMQA FFGYFASHFI SNSWLMWFII SIVQMAPVSA 
      2360       2370       2380       2390       2400
MVRMYIFFAS FYYVWKSYVH IMDGCTSSTC MMCYKRNRAT RVECTTIVNG 
      2410       2420       2430       2440       2450
VKRSFYVYAN GGRGFCKAHN WNCLNCDTFC AGSTFISDEV ARDLSLQFKR 
      2460       2470       2480       2490       2500
PINPTDQSAY VVDSVTVKNG ALHLYFDKAG QKTYERHPLS HFVNLDNLRA 
      2510       2520       2530       2540       2550
NNTKGSLPIN VIVFDGKSKC EESAAKSASV YYSQLMCQPI LLLDQALVSD 
      2560       2570       2580       2590       2600
VGDSTEVSVK MFDAYVDTFS ATFSVPMEKL KALVATAHSE LAKGVALDGV 
      2610       2620       2630       2640       2650
LSTFVSAARQ GVVDTDVDTK DVIECLKLSH HSDIEVTGDS CNNFMLTYNK 
      2660       2670       2680       2690       2700
VENMTPRDLG ACIDCNARHI NAQVAKSHNV SLVWNVKDYM SLSEQLRKQI 
      2710       2720       2730       2740       2750
RSAAKKNNIP FRLTCATTRQ VVNVITTKIS LKGGKVVSTW FKLLLKVTLL 
      2760       2770       2780       2790       2800
CVLAALFCYV IMPVHSLSVH DGYTNEIIGY KAIQDGVTRD IVSTDDCFAN 
      2810       2820       2830       2840       2850
KHAGFDSWFS QRGGSYRNDK NCPVVAAIIT REIGFIVPGL PGTVLRALNG 
      2860       2870       2880       2890       2900
DFLHFLPRVF SAVGNICYTP SKLIEYSDFA TSACVLAAEC TIFKDAMGKP 
      2910       2920       2930       2940       2950
VPYCYDTNLL EGSISYSELR PDTRYVLMDG SIIQFPNTYL EGSVRVVTTF 
      2960       2970       2980       2990       3000
DAEYCRHGTC ERSEVGVCLS TSGRWVLNNE HYRALPGVFC GVDAMNLIAN 
      3010       3020       3030       3040       3050
IFTPLVQPVG ALDVSASVVA GGIIAILVTC AAYYFMKFRR AFGEYNHVVA 
      3060       3070       3080       3090       3100
ANALLFLMSF TILCLAPAYS FLPGVYSIFY LYLTFYFTND VSFLAHLQWF 
      3110       3120       3130       3140       3150
AMFSPIVPFW ITAIYVFCIS LKHFHWFFSN YLKKRVMFNG VTFSTFEEAA 
      3160       3170       3180       3190       3200
LCTFLLNKEM YLRLRSETLL PLTQYNRYLA LYNKYKYFSG ALDTTSYREA 
      3210       3220       3230       3240       3250
ACCHLAKALN DFSNSGADVL YQPPQTSITS AVLQSGFRKM AFPSGKVEGC 
      3260       3270       3280       3290       3300
MVQVTCGTTT LNGLWLDDTV YCPRHVVCTA EDMLNPNYDD LLIRKSNHSF 
      3310       3320       3330       3340       3350
LVQAGNVQLR VIGHSMQNCL LRLKVDTSNP KTPKYKFVRI QPGQTFSVLA 
      3360       3370       3380       3390       3400
CYNGSPSGVY QCAMRPNHTI KGSFLNGSCG SVGFNIDYDC VSFCYMHHME 
      3410       3420       3430       3440       3450
LPTGVHAGTD LEGKFYGPFV DRQTAQAAGT DTTITLNVLA WLYAAVINGD 
      3460       3470       3480       3490       3500
RWFLNRFTTT LNDFNLVAMK YNYEPLTQDH VDILGPLSAQ TGIAVLDMCA 
      3510       3520       3530       3540       3550
ALKELLQNGM NGRTILGSTI LEDEFTPFDV VRQCSGVTFQ GKFKKIVKGT 
      3560       3570       3580       3590       3600
HHWMLLTFLT SLLILVQSTQ WSLFFFVYEN AFLPFALGIM AVAACAMLLV 
      3610       3620       3630       3640       3650
KHKHAFLCLF LLPSLATVAY FNMVYMPASW VMRIMTWLEL ADTSLSGYRL 
      3660       3670       3680       3690       3700
KDCVMYASAL VLLILMTART VYDDAARRVW TLMNVITLVY KVYYGNSLDQ 
      3710       3720       3730       3740       3750
AISMWALVIS VTSNYSGVVT TIMFLARAIV FVCVEYYPLL FITGNTLQCI 
      3760       3770       3780       3790       3800
MLVYCFLGYC CCCYFGLFCL LNRYFRLTLG VYDYLVSTQE FRYMNSQGLL 
      3810       3820       3830       3840       3850
PPKSSIDAFK LNIKLLGIGG KPCIKVATVQ SKMSDVKCTS VVLLSVLQQL 
      3860       3870       3880       3890       3900
RVESSSKLWA QCVQLHNDIL LAKDTTEAFE KMVSLLSVLL SMQGAVDINK 
      3910       3920       3930       3940       3950
LCEEMLDNRA TLQAIASEFS SLPSYAAYAT AQEAYEQAVS NGDSEVVLKK 
      3960       3970       3980       3990       4000
LKKSLNVAKS EFDHDAAMQR KLEKMADQAM TQMYKQARSE DKRAKVTSAM 
      4010       4020       4030       4040       4050
QTMLFTMLRK LDNDALNNII NNARDGCVPL NIIPLTTAAK LMVVVPDYGT 
      4060       4070       4080       4090       4100
YKNTCDGNTF TYASALWEIQ QVVDADSKIV QLSEINMDNS PNLAWPLIVT 
      4110       4120       4130       4140       4150
ALRANSAVKL QNNELSPVAL RQMSCAAGTT QTACTDDNAL AYYNNAKGGR 
      4160       4170       4180       4190       4200
FVLALLSDHQ DLKWARFPKS DGTGTIYTEL EPPCRFVTDT PKGPKVKYLY 
      4210       4220       4230       4240       4250
FIKGLNNLNR GMVLGSLAAT VRLQAGNATE VPANSTVLSF CAFAVDPAKA 
      4260       4270       4280       4290       4300
YKDYLASGGQ PITNCVKMLC THTGTGQAIT VTPEANMDQE SFGGASCCLY 
      4310       4320       4330       4340       4350
CRCHIDHPNP KGFCDLKGKY VQIPTTCAND PVGFTLRNTV CTVCGMWKGY 
      4360       4370       4380       4390       4400
GCSCDQLREP MMQSADASTF LNRVCGVSAA RLTPCGTGTS TDVVYRAFDI 
      4410       4420       4430       4440       4450
YNEKVAGFAK FLKTNCCRFQ EKDEEGNLLD SYFVVKRHTM SNYQHEETIY 
      4460       4470       4480       4490       4500
NLIKECPAVA VHDFFKFRVD GDMVPHISRQ RLTKYTMADL VYALRHFDEG 
      4510       4520       4530       4540       4550
NCDTLKEILV TYNCCDDNYF NKKDWYDFVE NPDVLRVYAN LGERVRRALL 
      4560       4570       4580       4590       4600
KTVQFCDAMR DAGIVGVLTL DNQDLNGNWY DFGDFVQVAP GCGVPIVDSY 
      4610       4620       4630       4640       4650
YSLLMPILTL TKALAAESHM DADLAKPLVK WDLLKYDFTE ERLCLFDRYF 
      4660       4670       4680       4690       4700
KYWDQTYHPN CINCLDDRCI LHCANFNVLF STVFPPTSFG PLVRKIFVDG 
      4710       4720       4730       4740       4750
VPFVVSTGYH FRELGVVHNQ DVNLHSSRLS FKELLVYAAD PAMHAASGNL 
      4760       4770       4780       4790       4800
LLDKRTTCFS VAALTNNVAF QTVKPGNFNK DFYDFAVSKG FFKEGSSVEL 
      4810       4820       4830       4840       4850
KHFFFAQDGN AAISDYDYYR YNLPTMCDIR QLLFVVEVVD KYFDCYDGGC 
      4860       4870       4880       4890       4900
INANQVIVNN LDKSAGFPFN KWGKARLYYD SMSYEDQDAL FAYTKRNVIP 
      4910       4920       4930       4940       4950
TITQMNLKYA ISAKNRARTV AGVSICSTMT NRQFHQKLLK SIAATRGATV 
      4960       4970       4980       4990       5000
VIGTSKFYGG WHNMLKTVYS DVESPHLMGW DYPKCDRAMP NMLRIMASLI 
      5010       5020       5030       5040       5050
LARKHSTCCN LSHRFYRLAN ECAQVLSEMV MCGGSLYVKP GGTSSGDATT 
      5060       5070       5080       5090       5100
AYANSVFNIC QAVTANVNAL LSTDGNKIAD KYVRNLQHRL YECLYRNRDV 
      5110       5120       5130       5140       5150
DHEFVDEFYA YLRKHFSMMI LSDDAVVCYN SNYAAQGLVA SIKNFKAVLY 
      5160       5170       5180       5190       5200
YQNNVFMSEA KCWTETDLTR GPHEFCSQHT MLVKQGDDYV YLPYPDPSRI 
      5210       5220       5230       5240       5250
LGAGCFVDDI VKTDGTLMIE RFVSLAIDAY PLTKHPNQEY ADVFHLYLQY 
      5260       5270       5280       5290       5300
IRKLHDELTG HMLDMYSVML TNDNTSRYWE PEFYEAMYTP HTVLQAVGAC 
      5310       5320       5330       5340       5350
VLCNSQTSLR CGACIRRPFL CCKCCYDHVI STSHKLVLSV NPYVCNAPGC 
      5360       5370       5380       5390       5400
DVTDVTQLYL GGMSYYCKSH KPPISFPLCA NGQVFGLYKN TCVGSDNVTD 
      5410       5420       5430       5440       5450
FNAIATCDWT NAGDYILANT CTERLKLFAA ETLKATEETF KLSYGIATVR 
      5460       5470       5480       5490       5500
EVLSDRELYL SWEVGKPRPP LNRNYVFTGY RVTKNSKVQI GEYTFEKGDY 
      5510       5520       5530       5540       5550
GDAVVYRGTT TYKLNVGDYF VLTSHTVMPL SAPTLVPQEH YVRITGLYPT 
      5560       5570       5580       5590       5600
LNISNEFSSN VANYQKIGMQ KYSTLQGPPG TGKSHFAIGL ALYYPSARIV 
      5610       5620       5630       5640       5650
YTACSHAAVD ALCEKALKYL PIDKCSRIIP ARARVECFDK FKVNSTLEQY 
      5660       5670       5680       5690       5700
VFCTVNALPE TTADIVVFDE ISMATNYDLS VVNARLRAKH YVYIGDPAQL 
      5710       5720       5730       5740       5750
PAPRTLLTKG TLEPEYFNSV CRLMKTIGPD MFLGTCRRCP AEIVDTVSAL 
      5760       5770       5780       5790       5800
VYDNKLKAHK EKSAQCFKMY YKGVITHDVS SAINRPQIGV VREFLTRNPA 
      5810       5820       5830       5840       5850
WRKAVFISPY NSQNAVASKI LGLPTQTVDS SQGSEYDYVI FTQTTETAHS 
      5860       5870       5880       5890       5900
CNVNRFNVAI TRAKIGILCI MSDRDLYDKL QFTSLEVPRR NVATLQAENV 
      5910       5920       5930       5940       5950
TGLFKDCSKI ITGLHPTQAP THLSVDTKFK TEGLCVDIPG IPKDMTYRRL 
      5960       5970       5980       5990       6000
ISMMGFKMNY QVNGYPNMFI TREEAIRHVR AWIGFDVEGC HATRDAVGTN 
      6010       6020       6030       6040       6050
LPLQLGFSTG VNLVAVPTGY VDTENSTEFT RVNAKPPPGD QFKHLIPLMY 
      6060       6070       6080       6090       6100
KGLPWNVVRI KIVQMLSDTL KGLSDRVVFV LWAHGFELTS MKYFVKIGPE 
      6110       6120       6130       6140       6150
RTCCLCDKRA TCFSTSSDTY ACWNHSVGFD YVYNPFMIDV QQWGFTGNLQ 
      6160       6170       6180       6190       6200
SNHDQHCQVH GNAHVASCDA IMTRCLAVHE CFVKRVDWSV EYPIIGDELK 
      6210       6220       6230       6240       6250
INAACRKVQH MVVKSALLAD KFTVLHDIGN PKAIRCVPQA EVDWKFYDAQ 
      6260       6270       6280       6290       6300
PCSDKAYKIE ELFYSYATHH DKFTDGVCLF WNCNVDRYPA NAIVCRFDTR 
      6310       6320       6330       6340       6350
VLSNLNLPGC DGGSLYVNKH AFHTPAFDKS AFTHLKQLPF FYYSDSPCES 
      6360       6370       6380       6390       6400
HGKQVVSDID YVPLKSATCI TRCNLGGAVC RHHANEYRQY LDAYNMMISA 
      6410       6420       6430       6440       6450
GFSLWIYKQF DTYNLWNTFT KLQSLENVAY NVVNKGHFDG QSGEAPVSII 
      6460       6470       6480       6490       6500
NNAVYTKVDG IDVEIFENKT TLPVNVAFEL WAKRNIKPVP EIKILNNLGV 
      6510       6520       6530       6540       6550
DIAANNVIWD YKREAPAHVS TIGVCTMTDI AKKPTESACS SLIVLFDGRV 
      6560       6570       6580       6590       6600
EGQVDFFRNA RNGVLITEGS VKGLTPSKGP AQASVNGVTL IGESVKTQFN 
      6610       6620       6630       6640       6650
YFKKVDGIIQ QLPETYFTQS RDLEDFKPRS QMETDFLELA MDEFIQRYKL 
      6660       6670       6680       6690       6700
EGYAFEHIVY GDFSHGQLGG LHLMIGLAKR SQDSLLKLED FIPMDSTVKN 
      6710       6720       6730       6740       6750
YFITDAQTGS SKCVCSVIDL LLDDFVEIIK SQDLSVVSKV VKVTIDYAEI 
      6760       6770       6780       6790       6800
SFMLWCKDGH VETFYPKLQA SQAWQPGVAM PNLYKMQRML LEKCDLQNYG 
      6810       6820       6830       6840       6850
ENAVIPKGIM MNVAKYTQLC QYLNTLTLAV PYNMRVIHFG AGSDKGVAPG 
      6860       6870       6880       6890       6900
TAVLRQWLPT GTLLVDSDLN DFVSDADSTL IGDCATVHTA NKWDLIISDM 
      6910       6920       6930       6940       6950
YDPKTKHVLK DNDSKEGFFT YLCGFIKQKL ALGGSVAVKI TEHSWNADLY 
      6960       6970       6980       6990       7000
KLMGHFSWWT AFVTNVNASS SEAFLIGVNY LGKPKEQIDG YTMHANYIFW 
      7010       7020       7030       7040       7050
RNTNPIQLSS YSLFDMSKFP LKLRGTAVMS LKENQINDMI YSLLEKGRLI 
      7060 
IRENNRVVVS SDILVNN
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:7,067
Mass (Da):789,496
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EE66BBA1B5E6339
GO
Isoform Replicase polyprotein 1a (identifier: P0C6F8-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
The sequence of this isoform can be found in the external entry P0C6F8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:4,376
Mass (Da):485,585
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ022305 Genomic RNA Translation: AAY88865.2

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ022305 Genomic RNA Translation: AAY88865.2

3D structure databases

BMRBiP0C6W2
SMRiP0C6W2
ModBaseiSearch...

Protein family/group databases

MEROPSiC30.005

Family and domain databases

CDDicd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21516, cv_beta_Nsp2_SARS-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit
cd21562, Macro_cv_SUD-N_Nsp3-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21591, SARS-CoV-like_RdRp, 1 hit
cd21525, SUD_C_SARS-CoV_Nsp3, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.60.120.1680, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.30.160.820, 1 hit
3.30.70.3540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.30.150, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.40.50.150, 1 hit
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR022733, DPUP_SUD_C_bCoV
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR044863, NIRAN
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044322, NSP15_M_alpha_beta_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR043615, NSP2_N_CoV
IPR044389, NSP2_SARS-CoV-like
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAB_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR044864, NSP3_SUD-N_bCoV
IPR044374, NSP3_SUD-N_SARS-CoV
IPR043478, NSP3_SUD-N_sf_bCoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044351, RdRp_SARS-CoV-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_CoV
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF06471, CoV_ExoN, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51961, AV_NSP11N_COV_NSP15M, 1 hit
PS51963, BCOV_NSP1_C, 1 hit
PS51942, BCOV_NSP3C_C, 1 hit
PS51941, BCOV_NSP3C_M, 1 hit
PS51994, BCOV_NSP3E_G2M, 1 hit
PS51945, BCOV_NSP3E_NAB, 1 hit
PS51952, COV_EXON_MTASE_COACT, 1 hit
PS51954, COV_N7_MTASE, 1 hit
PS51962, COV_NSP1, 1 hit
PS51948, COV_NSP12_RDRP, 1 hit
PS51960, COV_NSP15_NTD, 1 hit
PS51991, COV_NSP2_C, 1 hit
PS51990, COV_NSP2_M, 1 hit
PS51989, COV_NSP2_N, 1 hit
PS51992, COV_NSP3_Y3, 1 hit
PS51943, COV_NSP3A_UBL, 1 hit
PS51944, COV_NSP3D_UBL, 1 hit
PS51946, COV_NSP4C, 1 hit
PS51949, COV_NSP7, 1 hit
PS51950, COV_NSP8, 1 hit
PS51951, COV_NSP9_SSRNA_BD, 1 hit
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51955, NIV_2_O_MTASE, 1 hit
PS51953, NIV_EXON, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51940, SARS_NSP3C_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_BCHK3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6W2
Secondary accession number(s): Q3LZX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 25, 2022
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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