rep

Functionⁱ

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.By similarity

Host translation inhibitor nsp1:

Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.By similarity1 Publication

Non-structural protein 2:

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.By similarity

Papain-like proteinase:

Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.By similarity

Non-structural protein 4:

Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.By similarity

Proteinase 3CL-PRO: Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).PROSITE-ProRule annotationBy similarity

Non-structural protein 6:

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.By similarity

Non-structural protein 7:

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.By similarity

Non-structural protein 8:

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.By similarity

Non-structural protein 9:

May participate in viral replication by acting as a ssRNA-binding protein.By similarity

Non-structural protein 10:

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.By similarity

RNA-directed RNA polymerase:

Responsible for replication and transcription of the viral RNA genome.By similarity

Helicase:

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.By similarity

Guanine-N7 methyltransferase:

Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.By similarity

Uridylate-specific endoribonuclease:

Mn²⁺-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity

2'-O-methyltransferase:

Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.By similarity

Catalytic activityⁱ

TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	1641	For PL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	1807	For PL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	3339	For 3CL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	3446	For 3CL-PRO activityPROSITE-ProRule annotation	1
Metal bindingⁱ	5366	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5369	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5377	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5380	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5387	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5390	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5394	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5400	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5411	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5416	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5433	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5436	Zinc 3PROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1721 – 1758	C4-typePROSITE-ProRule annotationAdd BLAST	38
Zinc fingerⁱ	4362 – 4378	By similarityAdd BLAST	17
Zinc fingerⁱ	4404 – 4417	By similarityAdd BLAST	14
Nucleotide bindingⁱ	5643 – 5650	ATPSequence analysis	8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cysteine-type endopeptidase activity Source: InterPro
DNA helicase activity Source: UniProtKB-EC
endonuclease activity Source: UniProtKB-KW
exoribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
methyltransferase activity Source: UniProtKB-KW
omega peptidase activity Source: InterPro
RNA binding Source: UniProtKB-KW
RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
RNA helicase activity Source: UniProtKB-EC
thiol-dependent ubiquitinyl hydrolase activity Source: UniProtKB-EC
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

induction by virus of catabolism of host mRNA Source: UniProtKB-KW
induction by virus of host autophagy Source: UniProtKB-KW
methylation Source: UniProtKB-KW
modulation by virus of host protein ubiquitination Source: UniProtKB-KW
suppression by virus of host ISG15 activity Source: UniProtKB-KW
suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
transcription, DNA-templated Source: InterPro
viral protein processing Source: InterPro
viral RNA genome replication Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Endonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological process	Activation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Replicase polyprotein 1ab Short name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 15 chains: Host translation inhibitor nsp1 Short name: nsp1 Alternative name(s): Leader protein Non-structural protein 2 Short name: nsp2 Alternative name(s): p65 homolog Papain-like proteinase (EC:3.4.19.12, EC:3.4.22.69) Short name: PL-PRO Alternative name(s): Non-structural protein 3 Short name: nsp3 Non-structural protein 4 Short name: nsp4 3C-like proteinase (EC:3.4.22.-) Short name: 3CL-PRO Short name: 3CLp Alternative name(s): nsp5 Non-structural protein 6 Short name: nsp6 Non-structural protein 7 Short name: nsp7 Non-structural protein 8 Short name: nsp8 Non-structural protein 9 Short name: nsp9 Non-structural protein 10 Short name: nsp10 Alternative name(s): Growth factor-like peptide Short name: GFL RNA-directed RNA polymerase (EC:2.7.7.48) Short name: Pol Short name: RdRp Alternative name(s): nsp12 Helicase (EC:3.6.4.12, EC:3.6.4.13) Short name: Hel Alternative name(s): nsp13 Guanine-N7 methyltransferase (EC:2.1.1.-, EC:3.1.13.-) Short name: ExoN Alternative name(s): nsp14 Uridylate-specific endoribonuclease (EC:3.1.-.-) Alternative name(s): NendoU nsp15 2'-O-methyltransferase (EC:2.1.1.-) Alternative name(s): nsp16
Gene namesⁱ	Name:rep ORF Names:1a-1b
Organismⁱ	Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
Taxonomic identifierⁱ	389230 [NCBI]
Taxonomic lineageⁱ	Viruses › Riboviria › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus › Bat coronavirus HKU4
Virus hostⁱ	Tylonycteris pachypus (Lesser bamboo bat) [TaxID: 258959]
Proteomesⁱ	UP000007449 Componentⁱ: Genome

Subcellular locationⁱ

Papain-like proteinase:

Non-structural protein 4:

Host membrane ; Multi-pass membrane protein
Host cytoplasm

Note:

Localizes in virally-induced cytoplasmic double-membrane vesicles.By similarity

Non-structural protein 6:

Host membrane Curated; Multi-pass membrane protein Curated

Non-structural protein 7:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 8:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 9:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 10:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Helicase:

Host endoplasmic reticulum-Golgi intermediate compartment Curated

Note:

The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity

Uridylate-specific endoribonuclease:

host perinuclear region By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	2119 – 2139	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2152 – 2172	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2229 – 2249	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2333 – 2353	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2357 – 2377	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2382 – 2402	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2807 – 2827	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3079 – 3099	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3112 – 3132	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3156 – 3176	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3610 – 3630	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3644 – 3664	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3669 – 3689	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3714 – 3734	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3742 – 3762	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3791 – 3811	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3815 – 3835	HelicalSequence analysisAdd BLAST	21

GO - Cellular componentⁱ

host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
host cell membrane Source: UniProtKB-SubCell
host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cytoplasm, Host membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000290273	1 – 195	Host translation inhibitor nsp1By similarityAdd BLAST	195
ChainⁱPRO_0000290274	196 – 847	Non-structural protein 2By similarityAdd BLAST	652
ChainⁱPRO_0000290275	848 – 2791	Papain-like proteinaseBy similarityAdd BLAST	1944
ChainⁱPRO_0000290276	2792 – 3298	Non-structural protein 4By similarityAdd BLAST	507
ChainⁱPRO_0000290277	3299 – 3604	3C-like proteinaseBy similarityAdd BLAST	306
ChainⁱPRO_0000290278	3605 – 3896	Non-structural protein 6By similarityAdd BLAST	292
ChainⁱPRO_0000290279	3897 – 3979	Non-structural protein 7By similarityAdd BLAST	83
ChainⁱPRO_0000290280	3980 – 4178	Non-structural protein 8By similarityAdd BLAST	199
ChainⁱPRO_0000290281	4179 – 4288	Non-structural protein 9By similarityAdd BLAST	110
ChainⁱPRO_0000290282	4289 – 4427	Non-structural protein 10By similarityAdd BLAST	139
ChainⁱPRO_0000290283	4428 – 5361	RNA-directed RNA polymeraseBy similarityAdd BLAST	934
ChainⁱPRO_0000290284	5362 – 5959	HelicaseBy similarityAdd BLAST	598
ChainⁱPRO_0000290285	5960 – 6482	Guanine-N7 methyltransferaseBy similarityAdd BLAST	523
ChainⁱPRO_0000290286	6483 – 6824	Uridylate-specific endoribonucleaseBy similarityAdd BLAST	342
ChainⁱPRO_0000290287	6825 – 7126	2'-O-methyltransferaseBy similarityAdd BLAST	302

Post-translational modificationⁱ

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	195 – 196	CleavageSequence analysis	2
Siteⁱ	847 – 848	Cleavage; by PL-PROSequence analysis	2
Siteⁱ	2791 – 2792	Cleavage; by PL-PROSequence analysis	2
Siteⁱ	3298 – 3299	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	3604 – 3605	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	3896 – 3897	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	3979 – 3980	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	4178 – 4179	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	4288 – 4289	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	4427 – 4428	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	5361 – 5362	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	5959 – 5960	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	6482 – 6483	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	6824 – 6825	Cleavage; by 3CL-PROSequence analysis	2

Proteomic databases

PRIDEⁱ	P0C6W1

PRIDEⁱ

P0C6W1

Interactionⁱ

Subunit structureⁱ

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

By similarity

Structureⁱ

3D structure databases

SMRⁱ	P0C6W1
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1159 – 1328	MacroPROSITE-ProRule annotationAdd BLAST	170
Domainⁱ	1600 – 1871	Peptidase C16PROSITE-ProRule annotationAdd BLAST	272
Domainⁱ	3299 – 3604	Peptidase C30PROSITE-ProRule annotationAdd BLAST	306
Domainⁱ	5041 – 5203	RdRp catalyticPROSITE-ProRule annotationAdd BLAST	163
Domainⁱ	5362 – 5445	CV ZBDPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	5618 – 5799	(+)RNA virus helicase ATP-bindingAdd BLAST	182
Domainⁱ	5800 – 5974	(+)RNA virus helicase C-terminalAdd BLAST	175

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2119 – 2402	HD1By similarityAdd BLAST	284
Regionⁱ	2807 – 3176	HD2By similarityAdd BLAST	370
Regionⁱ	3610 – 3835	HD3By similarityAdd BLAST	226

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	960 – 1059	Glu-richAdd BLAST		100
Compositional biasⁱ	5366 – 5391	Cys-richAdd BLAST		26

Domainⁱ

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Sequence similaritiesⁱ

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1721 – 1758	C4-typePROSITE-ProRule annotationAdd BLAST	38
Zinc fingerⁱ	4362 – 4378	By similarityAdd BLAST	17
Zinc fingerⁱ	4404 – 4417	By similarityAdd BLAST	14

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3Dⁱ	1.10.150.420, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.40.220.20, 1 hit 3.40.50.11020, 1 hit
InterProⁱ	View protein in InterPro IPR027351 (+)RNA_virus_helicase_core_dom IPR032505 Corona_NSP4_C IPR009461 Coronavirus_NSP16 IPR027352 CV_ZBD IPR041679 DNA2/NAM7-like_AAA IPR037227 EndoU-like IPR002589 Macro_dom IPR032592 NAR_dom IPR042570 NAR_sf IPR036333 NSP10_sf IPR009466 NSP11 IPR042515 Nsp15_N IPR024375 Nsp3_coronavir IPR038400 Nsp3_coronavir_sf IPR038123 NSP4_C_sf IPR014828 NSP7 IPR037204 NSP7_sf IPR014829 NSP8 IPR037230 NSP8_sf IPR014822 NSP9 IPR036499 NSP9_sf IPR027417 P-loop_NTPase IPR008740 Peptidase_C30 IPR013016 Peptidase_C30/C16 IPR009003 Peptidase_S1_PA IPR038083 R1a/1ab IPR001205 RNA-dir_pol_C IPR007094 RNA-dir_pol_PSvirus IPR009469 RNA_pol_N_coronovir IPR018995 RNA_synth_NSP10_coronavirus IPR029063 SAM-dependent_MTases IPR014827 Viral_protease
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13087 AAA_12, 1 hit PF16348 Corona_NSP4_C, 1 hit PF06478 Corona_RPol_N, 1 hit PF01661 Macro, 1 hit PF16251 NAR, 1 hit PF09401 NSP10, 1 hit PF06471 NSP11, 1 hit PF06460 NSP16, 1 hit PF08716 nsp7, 1 hit PF08717 nsp8, 1 hit PF08710 nsp9, 1 hit PF05409 Peptidase_C30, 1 hit PF00680 RdRP_1, 1 hit PF11633 SUD-M, 1 hit PF08715 Viral_protease, 1 hit
SMARTⁱ	View protein in SMART SM00506 A1pp, 1 hit
SUPFAMⁱ	SSF101816 SSF101816, 1 hit SSF140367 SSF140367, 1 hit SSF142877 SSF142877, 1 hit SSF143076 SSF143076, 1 hit SSF144246 SSF144246, 1 hit SSF159936 SSF159936, 1 hit SSF50494 SSF50494, 1 hit SSF52540 SSF52540, 1 hit SSF53335 SSF53335, 1 hit
PROSITEⁱ	View protein in PROSITE PS51653 CV_ZBD, 1 hit PS51442 M_PRO, 1 hit PS51154 MACRO, 1 hit PS51124 PEPTIDASE_C16, 1 hit PS51657 PSRV_HELICASE, 1 hit PS50507 RDRP_SSRNA_POS, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by ribosomal frameshifting. Align Add to basket

Isoform Replicase polyprotein 1ab (identifier: P0C6W1-1) [UniParc]FASTA Add to basket

Also known as: pp1ab

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MLSKAGVTTQ GARGKYRAEL YNEKRSDHVA CTVPLCDTED MASKLTPWFE 
        60         70         80         90        100
DGETAFNQVS SILKEKGKIL FVPMHMQRAM KFLPGPRVYL VERLTGGMLS 
       110        120        130        140        150
KHFLVNQLAY KDHVGAAMMR TTLNVKPLGM FFPYDSSLET GEHTFLLRKN 
       160        170        180        190        200
GLGGQLFRER PWDRKETPYV EILDDLEADP TGKYSQNLLK KLIGGDCIPV 
       210        220        230        240        250
DQYMCGKNGK PIADYAKIVA KEGLTTLADI EVDVKSRMDS DRFIVLNKKL 
       260        270        280        290        300
YRVVWNVTRR NVPYSKQTAF TVVSVIQCDD KESVPEHTFT IGSQILMVSP 
       310        320        330        340        350
LKATNNKNFN LKQRLLHTFY GKEAVQQPGY IYHSAYVDCN ACGRGTWCTG 
       360        370        380        390        400
NAIQGFACDC GANYSANDVD LQSSGLVPKN ALFLANCPCA NNGACSHNAA 
       410        420        430        440        450
QVYSILDGKA CVEVGGKSFT LTFGGVVYAY MGCCDGTMYF VPRAKSCVSR 
       460        470        480        490        500
IGDAIFTGCT GTWDKVVETA NLFLEKAQHS LNFCQQFALT EVVLAILSGT 
       510        520        530        540        550
TSTFEELRDL CHNASYEKVR DHLVNHGFVV TIGDYIRDAI NIGANGVCNA 
       560        570        580        590        600
TINAPFIAFT GLGESFKKVA AIPWKICSNL KSALDYYCSN IMFRVFPYDI 
       610        620        630        640        650
PCDVNDFVEL LLDCGKLTVA TSYFVLRYLD EKFDTVLGTV SNACQTALSS 
       660        670        680        690        700
FLNACVAASR ATAGFISDMF KLFKVLMHKL YVYTSCGYVA VAEHSSKIVQ 
       710        720        730        740        750
QVLDIMSKAM KLLHTNVSWA GTKLSAIIYE GREALLFNSG TYFCLSTKAK 
       760        770        780        790        800
TLQDQMNLVL PGDYNKKTLG ILDPVPNADT IDVTANSTVV DVVHGQLEPT 
       810        820        830        840        850
NEHGPSMIVG NYVLVSDKLF VRTDDEEFYP LCINGKVVST LFRLKGGMPS 
       860        870        880        890        900
KKVTFGDVNT VEVTAYRSVS ITYDIHPVLD ALLSSSKLAT FTVEKDLLVE 
       910        920        930        940        950
DFVDVIKDEV LTLLTPLLRG YDIDGFDVED FIDVPCYVYN QDGDCAWSSN 
       960        970        980        990       1000
MTFSINPVED VEEVEEFIED DYLSDELPIA DDEEAWTRAV EEVMPLDDIL 
      1010       1020       1030       1040       1050
VAEIELEEDL PLETALESVE AEVGESISDE LCVVETAKAQ EPSVESTDST 
      1060       1070       1080       1090       1100
PSTSTVVSEN DLSVKPMSRV AETGDVLEVE TAVVGGPVSD VTASVVTNDI 
      1110       1120       1130       1140       1150
VSVEQAQQCG VSSLPIQDEA SENQVHQVPD LQCTSETKVE IVQPRQDLRP 
      1160       1170       1180       1190       1200
RRLRKSKVDL SKYKHTVINN SVTLVLGDAI QIASLLPKCV LVNAANRHLK 
      1210       1220       1230       1240       1250
HGGGIAGAIN KASGGDVQEE SDEYISNSGP LHVGDSVLLK GYGLADAILR 
      1260       1270       1280       1290       1300
VVGPDARNNE DAALLKRCYK TFNKHTIVVT PLISSGIFSV DPKVSFEYLL 
      1310       1320       1330       1340       1350
ANVTTTTYVV VNNEDIYNTL ATPSKPDGLV YSFEGWRGTV RTAKNYGFTC 
      1360       1370       1380       1390       1400
FICTEYSANV KFLRTKGVDT TKKIQTVDGV SYYLYSARDA LTDVIAAANG 
      1410       1420       1430       1440       1450
CPGICAMPFG YVTHGLDLAQ SGNYVRQVKV PYVCLLASKE QIPIMNSDVA 
      1460       1470       1480       1490       1500
IQTPETAFIN NVTSNGGYHS WHLVSGDLIV KDVCYKKLLH WSGQTICYAD 
      1510       1520       1530       1540       1550
NKFYVVKNDV ALPFSDLEAC RAYLTSRAAQ QVNIEVLVTI DGVNFRTVIL 
      1560       1570       1580       1590       1600
NDATTFRKQL GATFYKGVDI SDALPTVKMG GESLFVADNL SESEEVVLKE 
      1610       1620       1630       1640       1650
YYGTSDVTFL QRYYSLQPLV QQWKFVVHDG VKSLKLSNYN CYINATIMMI 
      1660       1670       1680       1690       1700
DMLHDIKFVV PALQNAYLRY KGGDPYDFLA LIMAYGDCTF DNPDDEAKLL 
      1710       1720       1730       1740       1750
HTLLAKAELT VSAKMVWREW CTVCGIRDIE YTGMRACVYA GVNSMEELQS 
      1760       1770       1780       1790       1800
VFNETCVCGS VKHRQLVEHS TPWLLVSGLN EVKVSTSTDP VYRAFNVFQG 
      1810       1820       1830       1840       1850
VETSVGHYVH VRVKDGLFYK YDSGSLTKTS DMKCKMTSVW YPKVRYTADC 
      1860       1870       1880       1890       1900
NVVVYDLDGV TKVEVNPDLS NYYMKDGKYY TSKPTIKYSP ATILPGSVYS 
      1910       1920       1930       1940       1950
NSCLVGVDGT PGSDTISKFF NDLLGFDETK PISKKLTYSL LPNEDGDVLL 
      1960       1970       1980       1990       2000
SEFNNYNPVY KKGVMLKGKP ILWVNNGVCD SALNKPNRAS LRQLYDVAPI 
      2010       2020       2030       2040       2050
VLDNKYTVLQ DNTSQLIEPN VPVVEDVSIT TRKLIEVKCK GLNKPFVKGN 
      2060       2070       2080       2090       2100
FSFVNDPNGV TVVDTLGLTE LRALYVDINT RYIVLRDNNW SSLFKLHTVE 
      2110       2120       2130       2140       2150
SGDLQIVANG GSVTRRARVL LGASSLFASF AKITVTATTA ACKTAGRSFC 
      2160       2170       2180       2190       2200
KFVVNYGVLQ NMFLFLKMLF FLPFNYLWPK KQPTVDVGVS GLRTAGVVTT 
      2210       2220       2230       2240       2250
NIVKQCGTAA YYMLLGKFKR VDWKATLRLF LLLCTTILLL SSIYHLVIFN 
      2260       2270       2280       2290       2300
QVLSSDVMLE DATGILAMYK EVRSYLGIRT LCDGLAVEYR NTSFDVVDFC 
      2310       2320       2330       2340       2350
SNRSVLCQWC LIGQDSLTRY SALQMLQTHI TSYVLNIDWI WFALEFFLAY 
      2360       2370       2380       2390       2400
VLYTSSFNVL LLVVTAQYFF AYTSAFVNWR AYNYIVSGLF FLVTHIPLHG 
      2410       2420       2430       2440       2450
LVRVYNFLAC LWFLRKFYSH VINGCKDTAC LLCYKRNRLT RVEASTIVCG 
      2460       2470       2480       2490       2500
TKRTFYIAAN GGTSYCCKHN WNCVECDTAG VGNTFICTEV ANDLTTTLRR 
      2510       2520       2530       2540       2550
LIKPTDQSHY YVDSVVVKDA VVELHYNRDG SSCYERYPLC YFTNLEKLKF 
      2560       2570       2580       2590       2600
KEVCKTPTGI PEHNFLIYDT NDRGQENLAR SACVYYSQVL CKPMLLVDVN 
      2610       2620       2630       2640       2650
LVTTVGDSRE IAIKMLDSFI NSFISLFSVS RDKLEKLINT ARDCVRRGDD 
      2660       2670       2680       2690       2700
FQTVLKTFTD AARGHAGVES DVETTMVVDA LQYAHKNDIQ LTTECYNNYV 
      2710       2720       2730       2740       2750
PGYIKPDSIN TLDLGCLIDL KAASVNQTSM RNANGACVWN SGDYMKLSDS 
      2760       2770       2780       2790       2800
FKRQIRIACR KCNIPFRLTT SKLRAADNIL SVKFSATKIV GGAPSWLLRV 
      2810       2820       2830       2840       2850
RDLTVKGYCI LTLFVFTVAV LSWFCLPSYS IATVNFNDDR ILTYKVIENG 
      2860       2870       2880       2890       2900
IVRDIAPNDA CFANKYGHFS KWFNENHGGV YRNSVDCPIT IAVIAGVAGA 
      2910       2920       2930       2940       2950
RVANVPATLA WVGRQIVLFV SRVFANTNVC FTPTNEIPYD TFSDSGCVLS 
      2960       2970       2980       2990       3000
SECTLFRDAE GNLNPFCYDP TVLPGASSYA DMKPHVRYDM YDSDMYIKFP 
      3010       3020       3030       3040       3050
EVIFESTLRI TKTLATQYCR FGSCEESAAG VCISTNGSWA LYNQNYSTRP 
      3060       3070       3080       3090       3100
GIYCGDDYFD IVRRLAVSLF QPVTYFQLST SLAMGLVLCV FLTAAFYYIN 
      3110       3120       3130       3140       3150
KVKRALADYT QCAVVAVVAA LLNSLCLCFI VANPLLVAPY TAMYYYATFY 
      3160       3170       3180       3190       3200
LTGEPAFIMH ISWYVMFGTV VPIWMLASYT VGVMLRHLFW VLAYFSKKHV 
      3210       3220       3230       3240       3250
DVFTDGKLNC SFQDAASNIF VIGKDTYVAL RNAITQDSFV RYLSLFNKYK 
      3260       3270       3280       3290       3300
YYSGAMDTAS YREACAAHLC KALQTYSETG SDILYQPPNC SVTSSVLQSG 
      3310       3320       3330       3340       3350
LVKMSAPSGA VENCIVQVTC GSMTLNGLWL DNTVWCPRHI MCPADQLTDP 
      3360       3370       3380       3390       3400
NYDALLISKT NHSFIVQKHI GAQANLRVVA HSMVGVLLKL TVDVANPSTP 
      3410       3420       3430       3440       3450
AYTFSTVKPG ASFSVLACYN GKPTGVFTVN LRHNSTIKGS FLCGSCGSVG 
      3460       3470       3480       3490       3500
YTENGGVLNF VYMHQMELSN GTHTGSSFDG VMYGAFEDKQ THQLQLTDKY 
      3510       3520       3530       3540       3550
CTINVVAWLY AAVLNGCKWF VKPTRVGIVT YNEWALSNQF TEFVGTQSID 
      3560       3570       3580       3590       3600
MLAHRTGVSV EQMLAAIQSL HAGFQGKTIL GQSTLEDEFT PDDVNMQVMG 
      3610       3620       3630       3640       3650
VVMQSGVKRI SYGFMHWLMS TLVLAYVSVM QLTKFTMWTY LFETIPTQMT 
      3660       3670       3680       3690       3700
PLLFGFMACV MFTVKHKHTF LSLFLLPVAL CLTYANIVYE PQTLVSSTLI 
      3710       3720       3730       3740       3750
AVANWLTPTS VYMRTTHLDF GLYISLSFVL AIIVRRLYRP SMSNLALALC 
      3760       3770       3780       3790       3800
SGVMWFYTYV IGDHSSPITY LMFITTLTSD YTITVFATVN LAKFISGLVF 
      3810       3820       3830       3840       3850
LYAPHLGFIL PEVKLVLLIY LCLGYMCTMY FGVFSLLNLK LRVPLGVYDY 
      3860       3870       3880       3890       3900
SVSTQEFRFL TGNGLHAPRN SWEALILNFK LLGIGGTPCI KVATVQSKLT 
      3910       3920       3930       3940       3950
DLKCTSVVLL TVLQQLHLES NSKAWSYCVK LHNEILAAVD PTEAFERFVC 
      3960       3970       3980       3990       4000
LFATLMSFSA NVDLDALAND LFENSSVLQA TLTEFSHLAT YAELETAQSS 
      4010       4020       4030       4040       4050
YQKALNSGDA SPQVLKALQK AVNVAKNAYE KDKAVARKLE RMAEQAMTSM 
      4060       4070       4080       4090       4100
YKQARAEDKK AKIVSAMQTM LFGMIKKLDN DVLNGVIANA RNGCVPLSIV 
      4110       4120       4130       4140       4150
PLCASNKLRV VIPDISVWNK VVNWPSVSYA GSLWDVTVIN NVDNEVVKPT 
      4160       4170       4180       4190       4200
DVVETNESLT WPLVIECSRA SSSAVKLQNN EIHPKGLKTM VVTAGIDQVN 
      4210       4220       4230       4240       4250
CSSSAVAYYE PVQGHRMVMG LLSENAHLKW AKVEGKDGFI NIELQPPCKF 
      4260       4270       4280       4290       4300
LIAGPKGPEI RYLYFVKNLN NLHRGQLLGH IAATVRLQAG ANTEFASNST 
      4310       4320       4330       4340       4350
VLTLVAFAVD PAKAYLDYVG SGGTPLSNYV KMLAPKTGTG VAISVKPEAT 
      4360       4370       4380       4390       4400
ADQETYGGAS VCLYCRAHIE HPDVSGVCKY KTRFVQIPAH VRDPVGFLLK 
      4410       4420       4430       4440       4450
NVPCNVCQYW VGYGCNCDAL RNNTVPQSKD TNFLNRVRGS SVNARLEPCS 
      4460       4470       4480       4490       4500
SGLTTDVVYR AFDICNFKAR VAGIGKYYKT NTCRFVQVDD EGHKLDSYFI 
      4510       4520       4530       4540       4550
VKRHTMSNYE LEKRCYDLLK DCDAVAIHDF FIFDVDKTKT PHIVRQSLTE 
      4560       4570       4580       4590       4600
YTMMDLVYAL RHFDQNNCEV LKSILVKYGC CEQSYFDNKL WFDFVENPSV 
      4610       4620       4630       4640       4650
IGVYHKLGER IRQAMLNTVK MCDHMVKSGL VGVLTLDNQD LNGKWYDFGD 
      4660       4670       4680       4690       4700
FVITQPGAGV AIVDSYYSYL MPVLSMTNCL AAETHKDCDF NKPLIEWLLL 
      4710       4720       4730       4740       4750
EYDYTDYKIG LFNKYFKHWD QTYHPNCVNC GDDRCILHCA NFNVLFSMVL 
      4760       4770       4780       4790       4800
PNTSFGPIVR KIFVDGVPFI VSCGYHYKEL GLVMNMDVNI HRHRLALKEL 
      4810       4820       4830       4840       4850
MMYAADPAMH IASASALWDL RTPCFSVAAL TTGLTFQTVR PGNFNKDFYD 
      4860       4870       4880       4890       4900
FVVSRGFFKE GSSVTLKHFF FAQDGHAAIT DYSYYAYNLP TMVDIKQMLF 
      4910       4920       4930       4940       4950
CMEVVDKYFD IYDGGCLNAS EVIVNNLDKS AGHPFNKFGK ARVYYESMSY 
      4960       4970       4980       4990       5000
QEQDELFAVT KRNVLPTITQ MNLKYAISAK NRARTVAGVS ILSTMTNRQY 
      5010       5020       5030       5040       5050
HQKMLKSMAA TRGATCVIGT TKFYGGWDFM LKTLYKDVES PHLMGWDYPK 
      5060       5070       5080       5090       5100
CDRAMPNMCR ILASLILARK HSTCCTNSDR FYRLANECAQ VLSEYVLCGG 
      5110       5120       5130       5140       5150
GYYVKPGGTS SGDATTAYAN SVFNILQATT ANVSALMSAN GNTIIDREIK 
      5160       5170       5180       5190       5200
DMQFDLYINV YRKVVPDPKF VDKYYAFLNK HFSMMILSDD GVVCYNSDYA 
      5210       5220       5230       5240       5250
AKGYVASIQN FKETLYYQNN VFMSEAKCWV ETNLEKGPHE FCSQHTLYIK 
      5260       5270       5280       5290       5300
DGDDGYFLPY PDPSRILSAG CFVDDIVKTD GTVMMERYVS LAIDAYPLTK 
      5310       5320       5330       5340       5350
HDDTEYQNVF WVYLQYIEKL YKDLTGHMLD SYSVMLCGDD SAKFWEEGFY 
      5360       5370       5380       5390       5400
RDLYSSPTTL QAVGSCVVCH SQTSLRCGTC IRRPFLCCKC CYDHVIATTH 
      5410       5420       5430       5440       5450
KMVLSVSPYV CNAPGCDVSD VTKLYLGGMS YYCNDHRPVC SFPLCANGLV 
      5460       5470       5480       5490       5500
FGLYKNMCTG SSSIMEFNRL ATCDWSDSGD YTLANTTTEP LKLFAAETLR 
      5510       5520       5530       5540       5550
ATEEASKQSY AIATIKEIVG ERELILVWEV GKSKPPLNRN YVFTGYHLTK 
      5560       5570       5580       5590       5600
NSKVQLGEYV FERIDYSDAV SYKSSTTYKL AVGDIFVLTS HSVATLSAPT 
      5610       5620       5630       5640       5650
IVNQERYLKI TGIYPTITVP EEFANHVVNF QKAGFSKYVT VQGPPGTGKS 
      5660       5670       5680       5690       5700
HFAIGLAIYY PTARIVYTAC SHAAVDALCA KAFKYLNIAK CSRIIPAKAR 
      5710       5720       5730       5740       5750
VECYDRFKVN DTNAQYLFST VNALPEISVD ILVVDEVSMC TNYDLSIINS 
      5760       5770       5780       5790       5800
RVKAKHIVYV GDPAQLPAPR TLLTRGTLEP ENFNSVTRLM CNLGPDIFLS 
      5810       5820       5830       5840       5850
VCYRCPKEIV NTVSALVYNN KLSAKKDASG QCFKILFKGS VTHDASSAIN 
      5860       5870       5880       5890       5900
RPQLNFVKTF IAANPNWSKA VFISPYNSQN AVARSMLGLT TQTVDSSQGS 
      5910       5920       5930       5940       5950
EYPYVIFCQT ADTAHANNLN RFNVAVTRAQ KGILCVMTSQ VLFDSLEFAE 
      5960       5970       5980       5990       6000
LSLNNYKLQS QIVTGLFKDC SREDVGLPPA YAPTYLSVDA KYKTTDELCV 
      6010       6020       6030       6040       6050
NLNITPNVTY SRVISRMGFK LDATIPGYPK LFITRDEAIR QVRSWIGFDV 
      6060       6070       6080       6090       6100
EGAHASRNAC GTNVPLQLGF STGVNFVVQP VGVVDTEWGS MLTTISARPP 
      6110       6120       6130       6140       6150
PGEQFKHLVP LMNKGATWPI VRRRIVQMLS DTLDKLSDYC TFVCWAHGFE 
      6160       6170       6180       6190       6200
LTSASYFCKI GKEQRCCMCS RRASTFSSPL QSYACWSHSS GYDYVYNPFF 
      6210       6220       6230       6240       6250
VDVQQWGYVG NLATNHDRYC GIHAGAHVAS SDAIMTRCLA IYDCFIERVD 
      6260       6270       6280       6290       6300
WDVTYPYISH EQKLNSCCRT VERNVVRSAV LSGKFDKIYD IGNPKGIPII 
      6310       6320       6330       6340       6350
SEPVEWHFYD AQPLSNKVKK LFYTDDVAKQ FEDGLCLFWN CNVSKYPSNA 
      6360       6370       6380       6390       6400
VVCRFDTRVH SEFNLPGCNG GSLYVNKHAF HTPAYDINAF RDLKPLPFFY 
      6410       6420       6430       6440       6450
YSTTPCEVHG SGNMLEDIDY VPLKSAVCIT ACNLGGAVCR KHAAEYRDYM 
      6460       6470       6480       6490       6500
EAYNIVSAAG FRLWVYKTFD IYNLWSTFVK VQGLENIAFN VIKQGHFTGV 
      6510       6520       6530       6540       6550
DGELPVAVVN DKIFTKNGTD DVCIFKNETA LPTNVAFELY AKRAVRSHPD 
      6560       6570       6580       6590       6600
LNLLRNLEVD VCYNFVLWDY DRNNIYGTTT IGVCKYTDID VNPNLNMCFD 
      6610       6620       6630       6640       6650
IRDKGSLERF MSMPNGVLIS DRKIKNYPCI IGPKHAYFNG AILRNIDAKQ 
      6660       6670       6680       6690       6700
PITFYLYKKV NNEFVSFSDT FYTCGRTVND FTALTPMEED FLVLDSDVFI 
      6710       6720       6730       6740       6750
KKYSLEDYAF EHVVYGDFSH TTLGGLHLLI GLYKKMRDGH ILMEEMLKDR 
      6760       6770       6780       6790       6800
ATVHNYFITD SNTASYKAVC SVIDLRLDDF VNIIKEMDLD VVSKVVKVPI 
      6810       6820       6830       6840       6850
DLTMIEFMLW CKDGKVQTFY PRLQATNDWK PGLTMPSLFK VQQMNLEPCL 
      6860       6870       6880       6890       6900
LANYKQSIPM PNGVHMNVAK YMQLCQYLNT CTLAVPANMR VIHFGAGCEK 
      6910       6920       6930       6940       6950
GVAPGTSVLR QWLPLDAVLI DNDLNEFVSD ADITIFGDCV TVHVGQQVDL 
      6960       6970       6980       6990       7000
LISDMYDPCT KAVGEVNQTK ALFFVYLCNF IKNNLALGGS VAIKITEHSW 
      7010       7020       7030       7040       7050
SADLYKIMGR FAYWTVFCTN ANASSSEGFL IGINFLGELK EEIDGNVMHA 
      7060       7070       7080       7090       7100
NYIFWRNSTP MNLSTYSLFD LSRFPLKLKG TPVLQLKESQ INELVISLLS 
      7110       7120 
QGKLLIRDND TLNVSTDVLV NFRKRL

Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Length:7,126

Mass (Da):795,781

Last modified:June 10, 2008 - v1

Checksum:ⁱ23A0EB77D0CFD96F

GO

Isoform Replicase polyprotein 1a (identifier: P0C6F7-1) [UniParc]FASTA Add to basket

Also known as: pp1a, ORF1a polyprotein

The sequence of this isoform can be found in the external entry P0C6F7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:4,441

Mass (Da):492,464

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ648794 Genomic RNA Translation: ABG47051.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

DQ648794 Genomic RNA Translation: ABG47051.1

Keywords - Coding sequence diversityⁱ

Ribosomal frameshifting

Protein	Similar proteins		Species	Score	Length	Source
P0C6W1	Replicase polyprotein 1ab	)	BCHK4		7119	UniRef90_P0C6W1
p1ab protein		Bat coronavirus		7132
Orf1ab polyprotein		Bat coronavirus HKU4-4		7129
RNA-dependent RNA polymerase (Fragment)		Bat coronavirus (BtCoV/242/2005)		145
ORF1ab polyprotein		BtTp-BetaCoV/GX2012		7127
+31

Protein	Similar proteins		Species	Score	Length	Source
P0C6W1	Replicase polyprotein 1ab	)	CVEMC		7078	UniRef50_K9N7C7
Replicase polyprotein 1ab	)	BCHK4		7119
Replicase polyprotein 1ab		BCHK5		7182
ORF1ab (Fragment)		Middle East respiratory syndrome-related coronavirus		739
ORF1ab protein (Fragment)		Human betacoronavirus 2c EMC/2012		146
+677

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ648794 Genomic RNA Translation: ABG47051.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

DQ648794 Genomic RNA Translation: ABG47051.1

3D structure databases

SMRⁱ	P0C6W1
ModBaseⁱ	Search...

Proteomic databases

PRIDEⁱ	P0C6W1

PRIDEⁱ

P0C6W1

Family and domain databases

Gene3Dⁱ	1.10.150.420, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.40.220.20, 1 hit 3.40.50.11020, 1 hit
InterProⁱ	View protein in InterPro IPR027351 (+)RNA_virus_helicase_core_dom IPR032505 Corona_NSP4_C IPR009461 Coronavirus_NSP16 IPR027352 CV_ZBD IPR041679 DNA2/NAM7-like_AAA IPR037227 EndoU-like IPR002589 Macro_dom IPR032592 NAR_dom IPR042570 NAR_sf IPR036333 NSP10_sf IPR009466 NSP11 IPR042515 Nsp15_N IPR024375 Nsp3_coronavir IPR038400 Nsp3_coronavir_sf IPR038123 NSP4_C_sf IPR014828 NSP7 IPR037204 NSP7_sf IPR014829 NSP8 IPR037230 NSP8_sf IPR014822 NSP9 IPR036499 NSP9_sf IPR027417 P-loop_NTPase IPR008740 Peptidase_C30 IPR013016 Peptidase_C30/C16 IPR009003 Peptidase_S1_PA IPR038083 R1a/1ab IPR001205 RNA-dir_pol_C IPR007094 RNA-dir_pol_PSvirus IPR009469 RNA_pol_N_coronovir IPR018995 RNA_synth_NSP10_coronavirus IPR029063 SAM-dependent_MTases IPR014827 Viral_protease
Pfamⁱ	View protein in Pfam PF13087 AAA_12, 1 hit PF16348 Corona_NSP4_C, 1 hit PF06478 Corona_RPol_N, 1 hit PF01661 Macro, 1 hit PF16251 NAR, 1 hit PF09401 NSP10, 1 hit PF06471 NSP11, 1 hit PF06460 NSP16, 1 hit PF08716 nsp7, 1 hit PF08717 nsp8, 1 hit PF08710 nsp9, 1 hit PF05409 Peptidase_C30, 1 hit PF00680 RdRP_1, 1 hit PF11633 SUD-M, 1 hit PF08715 Viral_protease, 1 hit
SMARTⁱ	View protein in SMART SM00506 A1pp, 1 hit
SUPFAMⁱ	SSF101816 SSF101816, 1 hit SSF140367 SSF140367, 1 hit SSF142877 SSF142877, 1 hit SSF143076 SSF143076, 1 hit SSF144246 SSF144246, 1 hit SSF159936 SSF159936, 1 hit SSF50494 SSF50494, 1 hit SSF52540 SSF52540, 1 hit SSF53335 SSF53335, 1 hit
PROSITEⁱ	View protein in PROSITE PS51653 CV_ZBD, 1 hit PS51442 M_PRO, 1 hit PS51154 MACRO, 1 hit PS51124 PEPTIDASE_C16, 1 hit PS51657 PSRV_HELICASE, 1 hit PS50507 RDRP_SSRNA_POS, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	R1AB_BC133
Accessionⁱ	P0C6W1Primary (citable) accession number: P0C6W1 Secondary accession number(s): Q0Q4F3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	December 11, 2019
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P0C6W1 (R1AB_BC133)

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Replicase polyprotein 1ab

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Sites

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Family and domain databases

Sequence databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ