rep

Functionⁱ

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.By similarity

Host translation inhibitor nsp1:

Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.By similarity

Non-structural protein 2:

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.By similarity

Papain-like proteinase:

Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.By similarity

Non-structural protein 4:

Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.By similarity

3C-like proteinase:

Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).PROSITE-ProRule annotationBy similarity

Non-structural protein 6:

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.By similarity

Non-structural protein 7:

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.By similarity

Non-structural protein 8:

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.By similarity

Non-structural protein 9:

May participate in viral replication by acting as a ssRNA-binding protein.By similarity

Non-structural protein 10:

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.By similarity

RNA-directed RNA polymerase:

Responsible for replication and transcription of the viral RNA genome.By similarity

Helicase:

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.By similarity

Guanine-N7 methyltransferase:

Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.By similarity

Uridylate-specific endoribonuclease:

Mn²⁺-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity

2'-O-methyltransferase:

Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.By similarity

Miscellaneous

Bat coronavirus 279/2005 is highly similar to SARS-CoV (SARS-like).

Catalytic activityⁱ

TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	1657	For PL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	1818	For PL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	3287	For 3CL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	3391	For 3CL-PRO activityPROSITE-ProRule annotation	1
Metal bindingⁱ	5312	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5315	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5323	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5326	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5333	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	5336	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5340	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5346	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	5357	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5362	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5379	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5382	Zinc 3PROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1735 – 1772	C4-typePROSITE-ProRule annotationAdd BLAST	38
Zinc fingerⁱ	4310 – 4326	By similarityAdd BLAST	17
Zinc fingerⁱ	4353 – 4366	By similarityAdd BLAST	14
Nucleotide bindingⁱ	5589 – 5596	ATPBy similarity	8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cysteine-type endopeptidase activity Source: InterPro
DNA helicase activity Source: UniProtKB-EC
endonuclease activity Source: UniProtKB-KW
exonuclease activity Source: UniProtKB-KW
methyltransferase activity Source: UniProtKB-KW
RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
RNA helicase activity Source: UniProtKB-EC
single-stranded RNA binding Source: InterPro
thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

induction by virus of catabolism of host mRNA Source: UniProtKB-KW
induction by virus of host autophagy Source: UniProtKB-KW
methylation Source: UniProtKB-KW
modulation by virus of host protein ubiquitination Source: UniProtKB-KW
suppression by virus of host ISG15 activity Source: UniProtKB-KW
suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
transcription, DNA-templated Source: InterPro
viral protein processing Source: InterPro
viral RNA genome replication Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Endonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological process	Activation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C16.009

MEROPSⁱ

C16.009

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Replicase polyprotein 1ab Short name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 15 chains: Host translation inhibitor nsp1 Short name: nsp1 Alternative name(s): Leader protein Non-structural protein 2 Short name: nsp2 Alternative name(s): p65 homolog Papain-like proteinase (EC:3.4.19.12, EC:3.4.22.69) Short name: PL-PRO Alternative name(s): Non-structural protein 3 Short name: nsp3 Non-structural protein 4 Short name: nsp4 3C-like proteinase (EC:3.4.22.-) Short name: 3CL-PRO Short name: 3CLp Alternative name(s): nsp5 Non-structural protein 6 Short name: nsp6 Non-structural protein 7 Short name: nsp7 Non-structural protein 8 Short name: nsp8 Non-structural protein 9 Short name: nsp9 Non-structural protein 10 Short name: nsp10 Alternative name(s): Growth factor-like peptide Short name: GFL RNA-directed RNA polymerase (EC:2.7.7.48) Short name: Pol Short name: RdRp Alternative name(s): nsp12 Helicase (EC:3.6.4.12, EC:3.6.4.13) Short name: Hel Alternative name(s): nsp13 Guanine-N7 methyltransferase (EC:2.1.1.-, EC:3.1.13.-) Short name: ExoN Alternative name(s): nsp14 Uridylate-specific endoribonuclease (EC:3.1.-.-) Alternative name(s): NendoU nsp15 2'-O-methyltransferase (EC:2.1.1.-) Alternative name(s): nsp16
Gene namesⁱ	Name:rep ORF Names:1a-1b
Organismⁱ	Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
Taxonomic identifierⁱ	389167 [NCBI]
Taxonomic lineageⁱ	Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus › Bat SARS CoV Rm1/2004
Virus hostⁱ	Rhinolophus macrotis (Big-eared horseshoe bat) [TaxID: 196889]
Proteomesⁱ	UP000006573 Componentⁱ: Genome

Subcellular locationⁱ

Papain-like proteinase:

Non-structural protein 4:

Host membrane ; Multi-pass membrane protein
Host cytoplasm

Note:

Localizes in virally-induced cytoplasmic double-membrane vesicles.By similarity

Non-structural protein 6:

Host membrane Curated; Multi-pass membrane protein Curated

Non-structural protein 7:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 8:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 9:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 10:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Helicase:

Host endoplasmic reticulum-Golgi intermediate compartment Curated

Note:

The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity

Uridylate-specific endoribonuclease:

host perinuclear region By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	2209 – 2229	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2310 – 2330	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2357 – 2377	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2761 – 2781	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2998 – 3018	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3028 – 3048	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3060 – 3080	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3083 – 3103	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3111 – 3131	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3148 – 3168	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3570 – 3590	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3592 – 3612	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3618 – 3638	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3665 – 3684	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	3691 – 3710	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	3734 – 3754	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3762 – 3782	HelicalSequence analysisAdd BLAST	21

GO - Cellular componentⁱ

host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
host cell membrane Source: UniProtKB-SubCell
host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cytoplasm, Host membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000289896	1 – 179	Host translation inhibitor nsp1By similarityAdd BLAST	179
ChainⁱPRO_0000289897	180 – 818	Non-structural protein 2By similarityAdd BLAST	639
ChainⁱPRO_0000289898	819 – 2746	Papain-like proteinaseBy similarityAdd BLAST	1928
ChainⁱPRO_0000289899	2747 – 3246	Non-structural protein 4By similarityAdd BLAST	500
ChainⁱPRO_0000289900	3247 – 3552	3C-like proteinaseBy similarityAdd BLAST	306
ChainⁱPRO_0000289901	3553 – 3842	Non-structural protein 6By similarityAdd BLAST	290
ChainⁱPRO_0000289902	3843 – 3925	Non-structural protein 7By similarityAdd BLAST	83
ChainⁱPRO_0000289903	3926 – 4123	Non-structural protein 8By similarityAdd BLAST	198
ChainⁱPRO_0000289904	4124 – 4236	Non-structural protein 9By similarityAdd BLAST	113
ChainⁱPRO_0000289905	4237 – 4375	Non-structural protein 10By similarityAdd BLAST	139
ChainⁱPRO_0000289906	4376 – 5307	RNA-directed RNA polymeraseBy similarityAdd BLAST	932
ChainⁱPRO_0000289907	5308 – 5908	HelicaseBy similarityAdd BLAST	601
ChainⁱPRO_0000289908	5909 – 6435	Guanine-N7 methyltransferaseBy similarityAdd BLAST	527
ChainⁱPRO_0000289909	6436 – 6781	Uridylate-specific endoribonucleaseBy similarityAdd BLAST	346
ChainⁱPRO_0000289910	6782 – 7079	2'-O-methyltransferaseBy similarityAdd BLAST	298

Post-translational modificationⁱ

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	179 – 180	CleavageBy similarity	2
Siteⁱ	818 – 819	Cleavage; by PL-PROBy similarity	2
Siteⁱ	3246 – 3247	Cleavage; by PL-PROBy similarity	2
Siteⁱ	3552 – 3553	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	3842 – 3843	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	3925 – 3926	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	4123 – 4124	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	4236 – 4237	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	4375 – 4376	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	5307 – 5308	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	5908 – 5909	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	6435 – 6436	Cleavage; by 3CL-PROBy similarity	2
Siteⁱ	6781 – 6782	Cleavage; by 3CL-PROBy similarity	2

Interactionⁱ

Subunit structureⁱ

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

By similarity

Structureⁱ

3D structure databases

BMRBⁱ	P0C6V9
SMRⁱ	P0C6V9
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1001 – 1167	MacroPROSITE-ProRule annotationAdd BLAST	167
Domainⁱ	1617 – 1881	Peptidase C16PROSITE-ProRule annotationAdd BLAST	265
Domainⁱ	3247 – 3552	Peptidase C30PROSITE-ProRule annotationAdd BLAST	306
Domainⁱ	4987 – 5149	RdRp catalyticPROSITE-ProRule annotationAdd BLAST	163
Domainⁱ	5308 – 5391	CV ZBDPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	5564 – 5745	(+)RNA virus helicase ATP-bindingAdd BLAST	182
Domainⁱ	5746 – 5915	(+)RNA virus helicase C-terminalAdd BLAST	170

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2098 – 2377	HD1By similarityAdd BLAST	280
Regionⁱ	2761 – 3168	HD2By similarityAdd BLAST	408
Regionⁱ	3570 – 3782	HD3By similarityAdd BLAST	213
Regionⁱ	4918 – 5220	RNA-directed RNA polymeraseBy similarityAdd BLAST	303

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	930 – 999	Glu-richAdd BLAST	70
Compositional biasⁱ	2216 – 2219	Poly-Leu	4
Compositional biasⁱ	3772 – 3775	Poly-Cys	4
Compositional biasⁱ	5312 – 5337	Cys-richAdd BLAST	26

Domainⁱ

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Sequence similaritiesⁱ

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1735 – 1772	C4-typePROSITE-ProRule annotationAdd BLAST	38
Zinc fingerⁱ	4310 – 4326	By similarityAdd BLAST	17
Zinc fingerⁱ	4353 – 4366	By similarityAdd BLAST	14

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd18808, SF1_C_Upf1, 1 hit
Gene3Dⁱ	1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.30.30.590, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.220.20, 1 hit 3.40.220.30, 1 hit 3.40.50.11020, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 1 hit
InterProⁱ	View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR022733, DPUP_SUD_C_bCoV IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR042570, NAR_sf IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR021590, NSP1_bCoV IPR038030, NSP1_sf_bCoV IPR024375, NSP3_bCoV IPR024358, NSP3_N_bCoV IPR032592, NSP3_NAR_bCoV IPR038166, NSP3_PL2pro_sf_CoV IPR038400, NSP3_SUD-M_sf_bCoV IPR043478, NSP3_SUD-N_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16251, bCoV_NAR, 1 hit PF11501, bCoV_NSP1, 1 hit PF12379, bCoV_NSP3_N, 1 hit PF12124, bCoV_SUD_C, 1 hit PF11633, bCoV_SUD_M, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit PF01443, Viral_helicase1, 1 hit
SMARTⁱ	View protein in SMART SM00506, A1pp, 1 hit
SUPFAMⁱ	SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF160099, SSF160099, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit
PROSITEⁱ	View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by ribosomal frameshifting. Align Add to basket

Isoform Replicase polyprotein 1ab (identifier: P0C6V9-1) [UniParc]FASTA Add to basket

Also known as: pp1ab

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MESLALGVSE KTHVQLSLPV LQVRDVLVRG FGDSVEEALA EAREHLKNGT 
        60         70         80         90        100
CGLVELEKGV LPQLEQPYVF IKRSDAQGTN HGYKVVELVA ELDGIQYGRS 
       110        120        130        140        150
GTTLGVLVPH VGETPVAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGVELG 
       160        170        180        190        200
TDPIEDYEQN WNTKHGGGVL RELIRELNGG AFTRYVDNNF CGPDGYPLEC 
       210        220        230        240        250
IKDLLARAGK SMCTLSEQLD YIESKRGVYC CREHEHEIVW FTERSEKSYE 
       260        270        280        290        300
RQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI 
       310        320        330        340        350
RSVYPVATPQ ECNDMHLSTL MKCNHCDEVS WQTCDFLKAT CEQCGTENLV 
       360        370        380        390        400
CEGPTTCGYL PANAVVKMPC PACQDPEVGP EHSVADYHNH SNIETRLRKG 
       410        420        430        440        450
GRTKCFGGCV FAYVGCYNKR AYWVPRASAN IGASHTGITG DNVETLNEDL 
       460        470        480        490        500
MEILNRDRVN INIVGDFHLN EEVAIILASF SASTCAFVDT VKGLDYKTFK 
       510        520        530        540        550
DIVESCGNFK VTRGRAKKGA WNIGQEKSIL TPLYGFPSQA AGVIRSIFTR 
       560        570        580        590        600
ALDTANHSIP DLQRAAITIL DGISEQSLRL IDAMVYTSDL LTNSVIVMAY 
       610        620        630        640        650
VTGGLVQQIT QWLSNMLGTT VDKLKPVFTW VEAKLSAGIE FLRDAWEILK 
       660        670        680        690        700
FLVTGVFDIV KGQIQVASDN LKECVKAFLD VLNKALEMCI DQVIIAGAKL 
       710        720        730        740        750
RTLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLRAPKEVT FFEGDSHDTV 
       760        770        780        790        800
FTSEEVVLKN GELEALETPV DSFTNGAVIG TPVCVNGLML LELKDKEQYC 
       810        820        830        840        850
ALSPGLLATN NVFSLKGGAP VKGVTFGEDT VLEVQGYKNV KITFELDERV 
       860        870        880        890        900
DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE 
       910        920        930        940        950
WSVATFYLFD DAGEEKLSSR MYCSFYPPDE EEDCEEYEDE EEIPEETCEH 
       960        970        980        990       1000
EYGTEDDYKG LPLEFGASTE IQQVDEEEEE DWLEEAIAAK PEPEPLPEEP 
      1010       1020       1030       1040       1050
VNQFTGYLKL TDNVAIKCVD IVKEAQHAKP TVIVNAANVH LKHGGGVAGA 
      1060       1070       1080       1090       1100
LNKATNGAMQ QESDDYIKKN GPLTVGGSCL LSGHNLAKKC MHVVGPNLNA 
      1110       1120       1130       1140       1150
GEDVQLLKAA YANFNSQDVL LAPLLSAGIF GAKPLQSLKM CVETVRTQVY 
      1160       1170       1180       1190       1200
FAVNDQDLYD HVVLGYLDSL KPKVETPTQE NLELKEQPAV ETLTQENLEL 
      1210       1220       1230       1240       1250
EELPVIEKPV DVKFKARIEE VNTSLEETKF LTSRLLLFAD INGKLYQDSQ 
      1260       1270       1280       1290       1300
NMLRGEDMFF LEKDAPYIVG DVISSGDITC VIIPAKKAGG TTEMLAKALK 
      1310       1320       1330       1340       1350
KVPVSEYITT YPGQGCAGYT LEEAKTALRK CKSVFYVLPS KTPNDKEEIL 
      1360       1370       1380       1390       1400
GTVSWNLREM LAHAEETRKL MLICMDVKAL MSTIHRRYKG IKVQEGIVDY 
      1410       1420       1430       1440       1450
GVRFFFYTSK EPVASIITKL NLLNEPLVTM PIGYVTHGLN LEEAARCMRS 
      1460       1470       1480       1490       1500
LKAPAVVSVS SPDAVTTYNG YLTSSSKTSE EHFIETVSLA GMYRDWSYSG 
      1510       1520       1530       1540       1550
QRTELGVEFL KRGDKVVYHT VGSPIQFHLD GEVLLLDKLK SLLSLREVRT 
      1560       1570       1580       1590       1600
IKVFTTVDNT NLHTQIVDMS MTYGQQFGPT YLDGADVTKI KPHAKHEGKT 
      1610       1620       1630       1640       1650
FFVLPSDDTL RSEAFEYYHT LDESFLGRYM SALNHTKKWK FPQIGGLTSI 
      1660       1670       1680       1690       1700
KWADNNCYLS SVLLALQQIE VKFNAPALQE AYYRARAGDA ANFCALILAY 
      1710       1720       1730       1740       1750
SNRTVGELGD VRETMTHLLQ HANLESAKRV LNVVCKTCGQ KSTTLTGVEA 
      1760       1770       1780       1790       1800
VMYMGTLSYE ELKTGVTIPC ICGRDATQYL VQQESSFVMM SAPPSEYTLQ 
      1810       1820       1830       1840       1850
QGAFLCANEY TGSYQCGHYT HVTVKETLYR IDGAYLTKMS EYKGPVTDVF 
      1860       1870       1880       1890       1900
YKEISYTTTI KPVSYKLDGV IYTEIQPKLD EYYKKDNAYY TEQPIDLVPT 
      1910       1920       1930       1940       1950
QPLPNASFDN FKLTCSNTKF ADDLNQMTGF KKPASRELSV TFFPDLNGDV 
      1960       1970       1980       1990       2000
VAIDYRHYSA SFKKGAKLLH KPIIWHINQT TNKTTYKPNT WCLRCLWSTK 
      2010       2020       2030       2040       2050
PVETSNSFEV LEVEDTQGMD NLACESQTPT SEEVVENPTI QKEVIECDVK 
      2060       2070       2080       2090       2100
TIEVVGNVIL KPSEEGVKVT QELGHEDLMA AYVEETSITI KKPNELSLAL 
      2110       2120       2130       2140       2150
GLRTLATHGA AAINSVPWSK ILAYVKPFLG QAAVTTTNCI KRCVQRVFNN 
      2160       2170       2180       2190       2200
YMPYVITLLF QLCTFTRSTN SRIRASLPTT IAKNSVKSVA KLCLDVCINY 
      2210       2220       2230       2240       2250
VKSPKFSKLF TIAMWLLLLS ICLGSLIYVT AAFGVLLSNL GIPSYCDGVR 
      2260       2270       2280       2290       2300
ESYVNSSNVT TMDFCEGSFL CSVCLNGLDS LDSYPALETI QVTISSYKLD 
      2310       2320       2330       2340       2350
LTSLGLAAEW FLAYMLFTKF FYLLGLSAIM QVFFGYFASH FISNSWLMWF 
      2360       2370       2380       2390       2400
IISIVQMAPV SAMVRMYIFF AFCYYVWKSY VHIMDGCTSS TCMMCYKRNR 
      2410       2420       2430       2440       2450
ATRVECTTIV NGMKRSFYVY ANGGRGFCKA HNWNCLNCDT FCAGSTFISD 
      2460       2470       2480       2490       2500
EVARDLSLQF KRPINPTDQS SYVVDSVAVK NGALHLYFDK AGQKTYERHP 
      2510       2520       2530       2540       2550
LSHFVNLDNL RANNTKGSLP INVIVFDGKS KCDESAAKSA SVYYSQLMCQ 
      2560       2570       2580       2590       2600
PILLLDQALV SDVGDSTEVS VKMFDAYVDT FSATFSVPME KLKALVATAH 
      2610       2620       2630       2640       2650
SELAKGVALD GVLSTFVSAA RQGVVDTDVD TKDVIECLKL SHHSDLEVTG 
      2660       2670       2680       2690       2700
DSCNNFMLTY NKVENMTPRD LGACIDCNAR HINAQVAKSH NVSLIWNVKD 
      2710       2720       2730       2740       2750
YMSLSEQLRK QIRSAAKKNN IPFRLTCATT RQVVNAITTK ISLKGGKIVS 
      2760       2770       2780       2790       2800
TWFKLMLKAT LLCVLAALFC YIIMPVHSLS VHDGYTNEII GYKAIQDGVT 
      2810       2820       2830       2840       2850
RDIMATDDCF ANKHAGFDSW FSQRGGSYRN DKSCPVVAAI ITREIGFIVP 
      2860       2870       2880       2890       2900
GLPGTVLRAI NGDFLHFLPR VFSAVGNICY TPSKLIEYSD FATSACVLAA 
      2910       2920       2930       2940       2950
ECTIFKDAMG KPVPYCYDTN LLEGSISYSE LRPDTRYVLM DGSIIQFPNT 
      2960       2970       2980       2990       3000
YLEGSVRVVT TFDAEYCRHG TCERSEAGVC LSTSGRWVLN NEHYRALPGV 
      3010       3020       3030       3040       3050
FCGVDAMNLI ANIFTPLVQP VGALDVSASV VAGGIIAILV TCAAYYFMKF 
      3060       3070       3080       3090       3100
RRAFGEYNHV VAANALLFLM SFTILCLAPA YSFLPGVYSI FYLYLTFYFT 
      3110       3120       3130       3140       3150
NDVSFLAHLQ WFAMFSPIVP FWITAIYVFC ISLKHCHWFF NNYLRKRVMF 
      3160       3170       3180       3190       3200
NGVTFSTFEE AALCTFLLNK EMYLKLRSET LLPLTQYNRY LALYNKYKYF 
      3210       3220       3230       3240       3250
SGALDTTSYR EAACCHLAKA LNDFSNSGAD VLYQPPQTSI TSAVLQSGFR 
      3260       3270       3280       3290       3300
KMAFPSGKVE GCMVQVTCGT TTLNGLWLDD TVYCPRHVIC TAEDMLNPNY 
      3310       3320       3330       3340       3350
EDLLIRKSNH SFLVQAGNVQ LRVIGHSMQN CLLRLKVDTS NPKTPKYKFV 
      3360       3370       3380       3390       3400
RIQPGQTFSV LACYNGSPSG VYQCAMRPNY TIKGSFLNGS CGSVGFNIDY 
      3410       3420       3430       3440       3450
DCVSFCYMHH MELPTGVHAG TDLEGKFYGP FVDRQTAQAA GTDTTITLNV 
      3460       3470       3480       3490       3500
LAWLYAAVIN GDRWFLNRFT TTLNDFNLVA MKYNYEPLTQ DHVDILGPLS 
      3510       3520       3530       3540       3550
AQTGIAVLDM CAALKELLQN GMNGRTILGS TILEDEFTPF DVVRQCSGVT 
      3560       3570       3580       3590       3600
FQGKFKKIVK GTHHWMLLTF LTSLLILVQS TQWSLFFFVY ENAFLPFTLG 
      3610       3620       3630       3640       3650
IMAIAACAML LVKHKHAFLC LFLLPSLATV AYFNMVYMPA SWVMRIMTWL 
      3660       3670       3680       3690       3700
ELADTSLSGY RLKDCVMYAS ALVLLVLMTA RTVYDDAARR VWTLMNVITL 
      3710       3720       3730       3740       3750
VYKVYYGNSL DQAISMWALV ISVTSNYSGV VTTIMFLARA IVFVCVEYYP 
      3760       3770       3780       3790       3800
LLFITGNTLQ CIMLVYCFLG YCCCCYFGLF CLLNRYFRLT LGVYDYLVST 
      3810       3820       3830       3840       3850
QEFRYMNSQG LLPPKSSIDA FKLNIKLLGI GGKPCIKVAT VQSKMSDVKC 
      3860       3870       3880       3890       3900
TSVVLLSVLQ QLRVESSSKL WAQCVQLHND ILLAKDTTEA FEKMVSLLSV 
      3910       3920       3930       3940       3950
LLSMQGAVDI NKLCEEMLDN RATLQAIASE FSSLPSYAAY ATAQEAYEQA 
      3960       3970       3980       3990       4000
VANGDSEVVL KKLKKSLNVA KSEFDRDAAM QRKLEKMADQ AMTQMYKQAR 
      4010       4020       4030       4040       4050
SEDKRAKVTS AMQTMLFTML RKLDNDALNN IINNARDGCV PLNIIPLTTA 
      4060       4070       4080       4090       4100
AKLMVVVPDY GTYKNTCDGN TFTYASALWE IQQVVDADSK IVQLSEINMD 
      4110       4120       4130       4140       4150
NSQNLAWPLI VTALRANSAV KLQNNELSPV ALRQMSCAAG TTQTACTDDN 
      4160       4170       4180       4190       4200
ALAYYNNSKG GRFVLALLSD HQDLKWARFP KSDGTGTIYT ELEPPCRFVT 
      4210       4220       4230       4240       4250
DTPRGPKVKY LYFIKGLNNL NRGMVLGSLA ATVRLQAGNA TEVPANSAVL 
      4260       4270       4280       4290       4300
SFCAFAVDPA KAYKDYLASG GQPITNCVKM LCTHTGTGQA ITVTPEANMD 
      4310       4320       4330       4340       4350
QESFGGASCC LYCRCHIDHP NPKGFCDLKG KYVQIPATCA NDPVGFTLKN 
      4360       4370       4380       4390       4400
TVCTVCGTWK GYGCSCDQLR EPMMQSADAS TFLNRVCGVS AARLTPCGTG 
      4410       4420       4430       4440       4450
TSTDVVYRAF DIYNERVAGF AKFLKTNCCR FQEKDEEGNL LDSYFVVKRH 
      4460       4470       4480       4490       4500
TMSNYQHEET IYNLVKECPA VAVHDFFKFR VDGDMVPHIS RQRLTKYTMA 
      4510       4520       4530       4540       4550
DLVYALRHFD EGNCDTLKEI LVTYNCCDDD YFNKKDWYDF VENPDILRVY 
      4560       4570       4580       4590       4600
ANLGERVRQA LLKTVQFCDA MRDAGIVGVL TLDNQDLNGN WYDFGDFVQV 
      4610       4620       4630       4640       4650
APGCGVPIVD SYYSLLMPIL TLTKALAAES HMDADLAKPL IKWDLLKYDF 
      4660       4670       4680       4690       4700
TEERLCLFDR YFKYWDQTYH PNCINCLDDR CILHCANFNV LFSTVFPPTS 
      4710       4720       4730       4740       4750
FGPLVRKIFV DGVPFVVSTG YHFRELGVVH NQDVNLHSSR LSFKELLVYA 
      4760       4770       4780       4790       4800
ADPAMHAASG NLLLDKRTTC FSVAALTNNV AFQTVKPGNF NKDFYDFAVS 
      4810       4820       4830       4840       4850
KGFFKEGSSV ELKHFFFAQD GNAAISDYDY YRYNLPTMCD IRQLLFVVEV 
      4860       4870       4880       4890       4900
VDKYFDCYDG GCINANQVIV NNLDKSAGFP FNKWGKARLY YDSMSYEDQD 
      4910       4920       4930       4940       4950
VLFAYTKRNV IPTITQMNLK YAISAKNRAR TVAGVSICST MTNRQFHQKL 
      4960       4970       4980       4990       5000
LKSIAATRGA TVVIGTSKFY GGWHNMLKTV YSDVETPHLM GWDYPKCDRA 
      5010       5020       5030       5040       5050
MPNMLRIMAS LVLARKHSTC CNLSHRFYRL ANECAQVLSE MVMCGGSLYV 
      5060       5070       5080       5090       5100
KPGGTSSGDA TTAYANSVFN ICQAVTANVN ALLSTDGNKI ADKYVRNLQH 
      5110       5120       5130       5140       5150
RLYECLYRNR DVDHEFVDEF YAYLRKHFSM MILSDDAVVC YNSNYAAQGL 
      5160       5170       5180       5190       5200
VASIKNFKAV HYYQNNVFMS EAKCWTETDL TKGPHEFCSQ HTMLVKQGDD 
      5210       5220       5230       5240       5250
YVYLPYPDPS RILGAGCFVD DIVKTDGTLM IERFVSLAID AYPLTKHPNQ 
      5260       5270       5280       5290       5300
EYADVFHLYL QYIRKLHDEL TGHMLDMYSV MLTNDNTSRY WEPEFYEAMY 
      5310       5320       5330       5340       5350
TPHTVLQAVG ACVLCNSQTS LRCGACIRRP FLCCKCCYDH VISTSHKLVL 
      5360       5370       5380       5390       5400
SVNPYVCNAP GCDVTDVTQL YLGGMSYYCK LHKPPISFPL CANGQVFGLY 
      5410       5420       5430       5440       5450
KNTCVGSDNV TDFNAIATCD WTNAGDYILA NTCTERLKLF AAETLKATEE 
      5460       5470       5480       5490       5500
TFKLSYGIAT VREVLSDREL HLSWEVGKPR PPLNRNYVFT GYRVTKNSKV 
      5510       5520       5530       5540       5550
QIGEYTFEKG DYGDAVVYRG TTTYKLNVGD YFVLTSHTVM PLSAPTLVPQ 
      5560       5570       5580       5590       5600
EHYVRITGLY PTLNISDEFS SNVANYQKVG MQKYSTLQGP PGTGKSHFAI 
      5610       5620       5630       5640       5650
GLALYYPSAR IVYTACSHAA VDALCEKALK YLPIDKCSRI IPARARVECF 
      5660       5670       5680       5690       5700
DKFKVNSTLE QYVFCTVNAL PETTADIVVF DEISMATNYD LSVVNARLRA 
      5710       5720       5730       5740       5750
KHYVYIGDPA QLPAPRTLLT KGTLEPEYFN SVCRLMKTIG PDMFLGTCRR 
      5760       5770       5780       5790       5800
CPAEIVDTVS ALVYDNKLKA HKEKSAQCFK MFYKGVITHD VSSAINRPQI 
      5810       5820       5830       5840       5850
GVVREFLTRN PAWRKAVFIS PYNSQNAVAS KILGLPTQTV DSSQGSEYDY 
      5860       5870       5880       5890       5900
VIFTQTTETA HSCNVNRFNV AITRAKIGIL CIMSDRDLYD KLQFTSLEVP 
      5910       5920       5930       5940       5950
RRNVATLQAE NVTGLFKDCS KIITGLHPTQ APTHLSVDTK FKTEGLCVDI 
      5960       5970       5980       5990       6000
PGIPKDMTYR RLISMMGFKM NYQVNGYPNM FITREEAIRH VRAWIGFDVE 
      6010       6020       6030       6040       6050
GCHATRDAVG TNLPLQLGFS TGVNLVAVPT GYVDTENNTE FTRVNAKPPP 
      6060       6070       6080       6090       6100
GDQFKHLIPL MYKGLPWNVV RIKIVQMLSD TLKGLSDRVV FVLWAHGFEL 
      6110       6120       6130       6140       6150
TSMKYFVKIG PERTCCLCDR RATCFSTSSD TYACWNHSVG FDYVYNPFMI 
      6160       6170       6180       6190       6200
DVQQWGFTGN LQSNHDQHCQ VHGNAHVASC DAIMTRCLAV HECFVKRVDW 
      6210       6220       6230       6240       6250
SVEYPIIGDE LKINAACRKV QHMVVKSALL ADKFSVLHDI GNPKAIKCVP 
      6260       6270       6280       6290       6300
QAEVDWKFYD AQPCSDKAYK IEELFYSYAT HHDKFTDGVC LFWNCNVDRY 
      6310       6320       6330       6340       6350
PANAIVCRFD TRVLSNLNLP GCDGGSLYVN KHAFHTPAFD KSAFTYLKQL 
      6360       6370       6380       6390       6400
PFFYYSDSPC ESHGKQVVSD IDYVPLKSAT CITRCNLGGA VCRRHANEYR 
      6410       6420       6430       6440       6450
QYLDAYNMMI SAGFSLWIYK QFDTYNLWNT FTRLQSLENV AYNVVNKGHF 
      6460       6470       6480       6490       6500
DGQIGEAPVS IINNAVYTKV DGNDVEIFEN KTTLPVNVAF ELWAKRNIKP 
      6510       6520       6530       6540       6550
VPEIKILNNL GVDIAANTVI WDYKREAPAH VSTIGVCTMT DIAKKPTESA 
      6560       6570       6580       6590       6600
CSSLTVLFDG RVEGQVDLFR NARNGVLITE GSVKGLTPSK GPAQASVNGV 
      6610       6620       6630       6640       6650
TLIGESVKTQ FNYFKKVDGI IQQLPETYFT QSRDLEDFKP RSKMETDFLE 
      6660       6670       6680       6690       6700
LAMDEFIQRY KLEGYAFEHI VYGDFSHGQL GGLHLMIGLA KRSQDSPLKL 
      6710       6720       6730       6740       6750
EDFIPTDSTV KNYFITDAQT GSSKCVCSVI DLLLDDFVEI IKSQDLSVIS 
      6760       6770       6780       6790       6800
KVVKVTIDYA EISFMLWCKD GHVETFYPKL QASQAWQPGV AMPNLYKMQR 
      6810       6820       6830       6840       6850
MLLEKCDLQN YGENAVIPKG IMMNVAKYTQ LCQYLNTLTL AVPYNMRVIH 
      6860       6870       6880       6890       6900
FGAGSDKGVA PGTAVLRQWL PTGALLVDSD LNDFVSDADS TLIGDCATVH 
      6910       6920       6930       6940       6950
TANKWDLIIS DMYDPKTKHV TKENDSKEGF FTYLCGFIKQ KLALGGSVAV 
      6960       6970       6980       6990       7000
KITEHSWNAD LYKLMGHFSW WTAFVTNVNA SSSEAFLIGV NYLGKLREQI 
      7010       7020       7030       7040       7050
DGYTMHANYI FWRNTNPIQL SSYSLFDMSK FPLKLRGTAV MSLKENQIND 
      7060       7070 
MIYSLLENGR LIIRENNRVV VSSDILVNN

Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Length:7,079

Mass (Da):791,654

Last modified:June 10, 2008 - v1

Checksum:ⁱCE92AE7AE019B902

GO

Isoform Replicase polyprotein 1a (identifier: P0C6F5-1) [UniParc]FASTA Add to basket

Also known as: pp1a, ORF1a polyprotein

The sequence of this isoform can be found in the external entry P0C6F5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:4,388

Mass (Da):487,709

GO

Sequence cautionⁱ

The sequence ABG47068 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ648857 Genomic RNA Translation: ABG47068.1 Different initiation.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

DQ648857 Genomic RNA Translation: ABG47068.1 Different initiation.

Keywords - Coding sequence diversityⁱ

Ribosomal frameshifting

Protein	Similar proteins		Species	Score	Length	Source
P0C6V9	ORF1ab polyprotein (Fragment)		Bat SARS-like coronavirus		145	UniRef100_P0C6V9
ORF1ab polyprotein (Fragment)		Rhinolophus pusillus coronavirus		145
ORF1ab polyprotein (Fragment)		SARS-related betacoronavirus Rp3/2004		122
ORF1ab polyprotein (Fragment)		SARS-related bat coronavirus RsSHC014		129
ORF1ab polyprotein (Fragment)		BCHK3		129
+67

Protein	Similar proteins		Species	Score	Length	Source
P0C6V9	Replicase polyprotein 1ab	)	SARS		7073	UniRef90_P0C6X7
Replicase polyprotein 1ab		BCRP3		7071
Replicase polyprotein 1ab		BCHK3		7067
2'-O-methyltransferase		SARS coronavirus HKU-39849		7073
2'-O-methyltransferase		SARS coronavirus TW6		7073
+359

Protein	Similar proteins		Species	Score	Length	Source
P0C6V9	Replicase polyprotein 1ab	)	SARS		7073	UniRef50_P0C6X7
Replicase polyprotein 1ab		BCRP3		7071
Replicase polyprotein 1ab		BCHK3		7067
Replicase polyprotein 1ab	)	SARS2		7096
2'-O-methyltransferase		SARS coronavirus HKU-39849		7073
+6713

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ648857 Genomic RNA Translation: ABG47068.1 Different initiation.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

DQ648857 Genomic RNA Translation: ABG47068.1 Different initiation.

3D structure databases

BMRBⁱ	P0C6V9
SMRⁱ	P0C6V9
ModBaseⁱ	Search...

Protein family/group databases

MEROPSⁱ	C16.009

MEROPSⁱ

C16.009

Family and domain databases

CDDⁱ	cd18808, SF1_C_Upf1, 1 hit
Gene3Dⁱ	1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.30.30.590, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.220.20, 1 hit 3.40.220.30, 1 hit 3.40.50.11020, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 1 hit
InterProⁱ	View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR022733, DPUP_SUD_C_bCoV IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR042570, NAR_sf IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR021590, NSP1_bCoV IPR038030, NSP1_sf_bCoV IPR024375, NSP3_bCoV IPR024358, NSP3_N_bCoV IPR032592, NSP3_NAR_bCoV IPR038166, NSP3_PL2pro_sf_CoV IPR038400, NSP3_SUD-M_sf_bCoV IPR043478, NSP3_SUD-N_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases
Pfamⁱ	View protein in Pfam PF16251, bCoV_NAR, 1 hit PF11501, bCoV_NSP1, 1 hit PF12379, bCoV_NSP3_N, 1 hit PF12124, bCoV_SUD_C, 1 hit PF11633, bCoV_SUD_M, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit PF01443, Viral_helicase1, 1 hit
SMARTⁱ	View protein in SMART SM00506, A1pp, 1 hit
SUPFAMⁱ	SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF160099, SSF160099, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit
PROSITEⁱ	View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit
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Entry informationⁱ

Entry nameⁱ	R1AB_BC279
Accessionⁱ	P0C6V9Primary (citable) accession number: P0C6V9 Secondary accession number(s): Q0Q476
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	December 2, 2020
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

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UniProtKB - P0C6V9 (R1AB_BC279)

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Replicase polyprotein 1ab

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Functionⁱ

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GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

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Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ