Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 80 (02 Jun 2021)
Sequence version 1 (10 Jun 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Breda virus 1 (BRV-1)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 3C-like serine proteinase is responsible for the majority of cleavages.

By similarity

The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity.

By similarity

The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.

By similarity

NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3184Charge relay system; for 3C-like serine proteinase activitySequence analysis1
Active sitei3222Charge relay system; for 3C-like serine proteinase activitySequence analysis1
Active sitei3291Charge relay system; for 3C-like serine proteinase activitySequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5293Zinc 1PROSITE-ProRule annotation1
Metal bindingi5296Zinc 1PROSITE-ProRule annotation1
Metal bindingi5304Zinc 2PROSITE-ProRule annotation1
Metal bindingi5307Zinc 1PROSITE-ProRule annotation1
Metal bindingi5314Zinc 1PROSITE-ProRule annotation1
Metal bindingi5317Zinc 2PROSITE-ProRule annotation1
Metal bindingi5321Zinc 2PROSITE-ProRule annotation1
Metal bindingi5327Zinc 2PROSITE-ProRule annotation1
Metal bindingi5336Zinc 3PROSITE-ProRule annotation1
Metal bindingi5338Zinc 3PROSITE-ProRule annotation1
Metal bindingi5355Zinc 3PROSITE-ProRule annotation1
Metal bindingi5359Zinc 3PROSITE-ProRule annotation1
Active sitei5860PROSITE-ProRule annotation1
Active sitei5862PROSITE-ProRule annotation1
Active sitei5961PROSITE-ProRule annotation1
Metal bindingi6025Zinc 4PROSITE-ProRule annotation1
Metal bindingi6029Zinc 4PROSITE-ProRule annotation1
Metal bindingi6033Zinc 4PROSITE-ProRule annotation1
Active sitei6037PROSITE-ProRule annotation1
Active sitei6042PROSITE-ProRule annotation1
Metal bindingi6048Zinc 4PROSITE-ProRule annotation1
Active sitei6363PROSITE-ProRule annotation1
Active sitei6380PROSITE-ProRule annotation1
Active sitei6412PROSITE-ProRule annotation1
Active sitei6509PROSITE-ProRule annotation1
Active sitei6585PROSITE-ProRule annotation1
Active sitei6613PROSITE-ProRule annotation1
Active sitei6647PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S65.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 14 chains:
Non-structural protein 1 (EC:3.4.22.-)
Short name:
nsp1
Alternative name(s):
Papain-like proteinase
Short name:
PL-PRO
Non-structural protein 2
Short name:
nsp2
3C-like serine proteinase (EC:3.4.21.-)
Short name:
3CLSP
Alternative name(s):
M-PRO
nsp3
p27
Non-structural protein 4
Short name:
nsp4
Non-structural protein 5
Short name:
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp10
p100
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp11
p67
Exoribonuclease (EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp12
Non-structural protein 13
Short name:
nsp13
Uridylate-specific endoribonuclease (EC:3.1.-.-)
Alternative name(s):
NendoU
nsp14
Putative 2'-O-methyl transferase (EC:2.1.1.-)
Alternative name(s):
nsp15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rep
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBreda virus 1 (BRV-1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri360393 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesTornidovirineaeTobaniviridaeTorovirinaeTorovirusRenitovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBos taurus (Bovine) [TaxID: 9913]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000355 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2191 – 2211HelicalSequence analysisAdd BLAST21
Transmembranei2219 – 2239HelicalSequence analysisAdd BLAST21
Transmembranei2266 – 2286HelicalSequence analysisAdd BLAST21
Transmembranei2411 – 2431HelicalSequence analysisAdd BLAST21
Transmembranei2521 – 2541HelicalSequence analysisAdd BLAST21
Transmembranei2546 – 2566HelicalSequence analysisAdd BLAST21
Transmembranei2769 – 2789HelicalSequence analysisAdd BLAST21
Transmembranei2937 – 2957HelicalSequence analysisAdd BLAST21
Transmembranei2986 – 3006HelicalSequence analysisAdd BLAST21
Transmembranei3022 – 3042HelicalSequence analysisAdd BLAST21
Transmembranei3422 – 3442HelicalSequence analysisAdd BLAST21
Transmembranei3456 – 3478HelicalSequence analysisAdd BLAST23
Transmembranei3486 – 3506HelicalSequence analysisAdd BLAST21
Transmembranei3514 – 3534HelicalSequence analysisAdd BLAST21
Transmembranei3538 – 3558HelicalSequence analysisAdd BLAST21
Transmembranei3573 – 3593HelicalSequence analysisAdd BLAST21
Transmembranei3598 – 3613HelicalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002838591 – 2753Non-structural protein 1Sequence analysisAdd BLAST2753
ChainiPRO_00002838602754 – 3131Non-structural protein 2Sequence analysisAdd BLAST378
ChainiPRO_00002838623132 – 34183C-like serine proteinaseBy similarityAdd BLAST287
ChainiPRO_00002838633419 – 3677Non-structural protein 4Sequence analysisAdd BLAST259
ChainiPRO_00002838643678 – 3854Non-structural protein 5Sequence analysisAdd BLAST177
ChainiPRO_00002838653855 – 4036Non-structural protein 6Sequence analysisAdd BLAST182
ChainiPRO_00002838664037 – 4121Non-structural protein 7Sequence analysisAdd BLAST85
ChainiPRO_00002838674122 – 4274Non-structural protein 8Sequence analysisAdd BLAST153
ChainiPRO_00002838684275 – 5286RNA-directed RNA polymeraseSequence analysisAdd BLAST1012
ChainiPRO_00002838695287 – 5844HelicaseSequence analysisAdd BLAST558
ChainiPRO_00002838705845 – 6174ExoribonucleaseSequence analysisAdd BLAST330
ChainiPRO_00002838716175 – 6318Non-structural protein 13Sequence analysisAdd BLAST144
ChainiPRO_00002838726319 – 6468Uridylate-specific endoribonucleaseSequence analysisAdd BLAST150
ChainiPRO_00002838736469 – 6733Putative 2'-O-methyl transferaseSequence analysisAdd BLAST265

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own protease yield mature proteins. 3CL-PRO is autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2753 – 2754Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei3131 – 3132Cleavage; by 3C-like serine proteinaseBy similarity2
Sitei3418 – 3419Cleavage; by 3C-like serine proteinaseBy similarity2
Sitei3677 – 3678Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei3854 – 3855Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4036 – 4037Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4121 – 4122Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4274 – 4275Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei5286 – 5287Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei5844 – 5845Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei6174 – 6175Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei6468 – 6469Cleavage; by 3C-like serine proteinaseSequence analysis2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0C6V8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1633 – 1814MacroPROSITE-ProRule annotationAdd BLAST182
Domaini1821 – 1969Peptidase C28Add BLAST149
Domaini4442 – 4673NiRANPROSITE-ProRule annotationAdd BLAST232
Domaini4981 – 5132RdRp catalyticPROSITE-ProRule annotationAdd BLAST152
Domaini5287 – 5368CV ZBDPROSITE-ProRule annotationAdd BLAST82
Domaini5509 – 5688(+)RNA virus helicase ATP-bindingAdd BLAST180
Domaini5689 – 5848(+)RNA virus helicase C-terminalAdd BLAST160
Domaini5846 – 6059ExoNPROSITE-ProRule annotationAdd BLAST214
Domaini6327 – 6467NendoUPROSITE-ProRule annotationAdd BLAST141
Domaini6469 – 6733Nidovirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST265

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2183 – 2565HD1By similarityAdd BLAST383
Regioni2769 – 3042HD2By similarityAdd BLAST274
Regioni3430 – 3613HD3By similarityAdd BLAST184

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Conserved Domains Database

More...
CDDi
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21162, NendoU_tv_PToV-like, 1 hit
cd21413, unc_tv_SF1_Hel-like, 1 hit
cd21403, ZBD_tv_SF1_Hel-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR009097, Cyclic_Pdiesterase
IPR043502, DNA/RNA_pol_sf
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR043609, NendoU_nidovirus
IPR044397, NendoU_PToV-like
IPR039573, NS2A-like
IPR027352, NSP13_ZBD_CoV-like
IPR009461, NSP16_CoV-like
IPR027417, P-loop_NTPase
IPR038765, Papain-like_cys_pep_sf
IPR009003, Peptidase_S1_PA
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR044355, SF1_Hel_unc_tv
IPR044336, SF1_Hel_ZBD_tv

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05213, Corona_NS2A, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF01661, Macro, 1 hit
PF00680, RdRP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF142877, SSF142877, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF54001, SSF54001, 1 hit
SSF55144, SSF55144, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51154, MACRO, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51955, NIV_2_O_MTASE, 1 hit
PS51953, NIV_EXON, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1ab (identifier: P0C6V8-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTSRELTN ETELHLCSST LDLISKSQLL AQCLGTPQNL VSLSKMVPSI
60 70 80 90 100
LESPTLEPRY TSTHSSSLQS LQLLALNTSS TLYKWTTGSI SKLRGHLERE
110 120 130 140 150
LCRGLVPLND FIPKGNYVEL SLMIPSVLTG QGTSTTTTLQ EMCSDMVQSC
160 170 180 190 200
IKSMETDLLK GVLALKDQTS CQEYFLSANY QSLIPPQPLV NAMRMSSVVD
210 220 230 240 250
LSPLILENTR LLLKLSPFHG GTSVSYTSMI REFVDCSRRD EKCLKRRLTK
260 270 280 290 300
KQKRQEEGSF DANKVITLGG KMYRYRVVIL KCSDEVDDLI GFDGKVGEFD
310 320 330 340 350
YNFENVPHCW RDLVKRRCLI RAKATWNLAG GVDENLDHVY IDESQXDFRC
360 370 380 390 400
ADGSSDSPSA CVEDPHLEER IFSRVWLKQT SRFFGTKIQQ VSELFKSIGL
410 420 430 440 450
PELETTYCGV NPVKVGNKWL SFRDQGRSRV FFVYTDSNVY LATTRQKVCC
460 470 480 490 500
DYILTKFKSV KWIGNKPDQC RVVKVLAWLI SVNKVKNCTR VITPMLTVQG
510 520 530 540 550
KISHRRVDYL DISVLDSYVS DTAGLNCVQK VKKFLSMYYN CGADLGLLDN
560 570 580 590 600
FLTPIECGTK QLVFERCNCP NHQFYVAQFD NHVVLGLGRP TGVVYPEEIP
610 620 630 640 650
SCANIYAVGF ATQKRVVEVH YYSEMDRHQL PQDYYYFAYD QEFQHVGGDD
660 670 680 690 700
YVNHHLDDVE DQPFPPVLFD DVYDSGDSLD DGGSDLDCFD VGYDFFWPEA
710 720 730 740 750
PIPVPSPYGY YQGQRLRDLC VAGGDFGCDC PRCDGTFIYH PFRPRHYHSF
760 770 780 790 800
DEVGPFIQMC EFTLTYSGQN YNLFYGLEPK VCLQDLVEAS DKLLQLLVRG
810 820 830 840 850
QLENISLPND ILACLSSLKL GANIHPFLWP APFFNANGEW VDIFGGGDFT
860 870 880 890 900
VFGEDFCLKA KSMVESVYFL VENFFSVDCP IGNLYCNLHL DGDVKKMLWS
910 920 930 940 950
TIHMKYIYLA LIHSEKVFNI ILNSRQLSHQ ELVKLVIIGT FDVSIVAPCA
960 970 980 990 1000
CSGDCNHGKV YNWTNLLSSV YRFVTLDQLV GLSYCEKRSL VLRKVQQYLE
1010 1020 1030 1040 1050
VEEGYQRPVQ LLMAPFYGFN DNAEPDEQPL TGVFHQQVMQ MFDTCVMLDV
1060 1070 1080 1090 1100
ICGLKRPRAS VYNLFGVLAD YFRRPFTFRY YQVAEFSGSE STQVFTDVTS
1110 1120 1130 1140 1150
ALTSKDPCSN RPYIYHDYAV CRVVEPRTAA VTTRGAIYPP EVIEMIRSYL
1160 1170 1180 1190 1200
PIEFDVGVMN YVDGNCDFKY CNLEFCLSGR GLVKLDTGEL LDYKTNLFVV
1210 1220 1230 1240 1250
RYKTLPLLYV TSNPIYLSDF SLDNAVCLTG DFKLSFDVEP GSTLFGLYFT
1260 1270 1280 1290 1300
NGRCYRDVWE TLPRFGLGTL SPPKCHSKCE PFENLAEVFF FKRRVQLVPL
1310 1320 1330 1340 1350
VNNYTPVFRH RPDIPKVLTV ELMPYYSSIG YQGFVAPKCV LPGCVATQYC
1360 1370 1380 1390 1400
KLRHQLDRCV QVTKLAVAYA FYFKPLNIGS LYHLDPMRGT SYGKPAVVQF
1410 1420 1430 1440 1450
EPVGLIKEVN ILVYQFGKHV AIHYFPECPT YVAYGHYPSH SVGVWLGYLP
1460 1470 1480 1490 1500
SVEECVIAQR NYRVYVPTCF RLSRTGCYHI QQDEDFERTH ITVSYHYARD
1510 1520 1530 1540 1550
FDTKSLTPMF QMFSKIFGKS KQDLICALNS LSEESQSVLT LFCEEFDSAY
1560 1570 1580 1590 1600
TLQTISDEVS FETSTSPELV ACVLAYAIGY ELCLTVKTDG ECESLDVGSS
1610 1620 1630 1640 1650
LEQVYVDYDV SKNVWDLSTH LQDDSSDDLE LPFNQYYEFK VGRASVVLVQ
1660 1670 1680 1690 1700
DDFKSVYDFL KSEQGVDYVV NPANNQLKHG GGIAKVISCM CGPKLTSWSN
1710 1720 1730 1740 1750
NYIKQYKKLG VTCAIRSPGF QLGKGVQIIH VVGPKSADSD VVNKLEASWR
1760 1770 1780 1790 1800
SVFQNVKPDT TVLTSMLSTG IFGCSVTDSA TTLLSNLVDL DKDVVVFVVT
1810 1820 1830 1840 1850
NVSDQYIEAL GVVESFQSAH GLPNFGNTCW FNALYQLLKS FAVKEQIVQD
1860 1870 1880 1890 1900
LVNCFDDFYE CPTRQCVEWV CDQLGVVFGE QYDAVEMLVK IFDVFKCNVR
1910 1920 1930 1940 1950
VGYDCLARLQ QVALGSCREV PADAVLMFFG QDKSGHWVAA RKVCGVWYTF
1960 1970 1980 1990 2000
DDKVVVKKDP DWSKVVLVLR ERGLFKATDF ETPRPRRRRV AYRVPRDTIS
2010 2020 2030 2040 2050
QDAIMFLEER QFSSGTMLAH SCVESVESFH VEGVQPSPLQ SVDGLDDVAD
2060 2070 2080 2090 2100
LSCDNHVCDN SDLQEPQVVV SQPSEVLTTS MSIECPVLEN SECSVETDLN
2110 2120 2130 2140 2150
PVCEENEQVG ESGIKEQDGV TTSDSQQVFS KSLDPIIKQH EVESVEPQDL
2160 2170 2180 2190 2200
PVFSQQPQVM LSMTWRDVLF QQYLGFKSDL LSLTHVNKFK IVVYLMVLWF
2210 2220 2230 2240 2250
VLLYCFSDFS LLSRFCLYVF LLWLSHVVLV VKKLDLGLVN SGGESYVLRI
2260 2270 2280 2290 2300
LSSVKVPNCI AFNCDGVHWL ILKLLFYSFH FYDFFVKTLV VVFQMPQLRC
2310 2320 2330 2340 2350
FTWPLLKLGF ADTFLSHHIL AFPTKQVSQS CLPVFGDERK YIYVPYWCKE
2360 2370 2380 2390 2400
SFRTLVARAK QLTATGRTKT LDNWHYQCCS KTVKPSSCFN VRDFVFDDAC
2410 2420 2430 2440 2450
NNHKHYGFFS ALWFYVVFYS GFVSFWLPLM FCYCALFMCT FKNLPVNITR
2460 2470 2480 2490 2500
PIRWTVLQQV VDDLLSIITK PLFGRPACPP LSAYLTATTA DEAVRASRSL
2510 2520 2530 2540 2550
LGRFCTPVGF QQPIMNVENG VAVSSLGFIN PLMWPLFIVV LLDNRFVWFF
2560 2570 2580 2590 2600
NVLSYIMLPV FVIILFYFYL RKICGCVNVK GVVKNCTRHF QNFSKPLVAA
2610 2620 2630 2640 2650
GVHGNRTNFT YQPMQENWCD RHSWYCPKEE HYMTPEMAMF IKNYYNLATS
2660 2670 2680 2690 2700
PMADTIWCDY VKSVPNMTWA NFKFSLFKSN ETVMCGPSSH ADSMLLSWYA
2710 2720 2730 2740 2750
FLHGIRFAVN PSVIDIPSQT QPIYVSSDSD DSLDKGCDVS LRPTKNKGKF
2760 2770 2780 2790 2800
KKQSVAYFSA GPVDLWYYVM LIIALGAIFV FMYSCFMVGQ YVVMPRDKFF
2810 2820 2830 2840 2850
GVNPTGYSYV NAQPYLHASP PVLRNSDGMV LATPLKVPSI SYSVYRLLSG
2860 2870 2880 2890 2900
HLYFTKLIVA ENECTPPFGA XRLSHEFTCN DFTYILPAHL RIFGRYIMLI
2910 2920 2930 2940 2950
HPDQLHMLPF EVEHSTHTRL CYVTGTNIVE CLPTFEIISP YVFVVLVAIF
2960 2970 2980 2990 3000
TIVFLFLLRM YIVMYSYFKV FTYVVFKLLF VNTVMVLFVV CLPPLVPGVV
3010 3020 3030 3040 3050
FVLALWLCDS VVFLLYLAVL SLFILPWFYV MLFVLIVGGF VFWWMMKSSD
3060 3070 3080 3090 3100
VVHLTPDGLT FNGTFEQVSK CVFPLNPLIV NRLLLDCRMS HSDLVEKSKL
3110 3120 3130 3140 3150
KTTEGKLATE MMKVFMTGET AYYQPSNFSF QSVFSKVVSP FTLHARPPMP
3160 3170 3180 3190 3200
MFRLYVYFNG QCVGTTCTGT GFAIDDSTIV TAKHLFECDD LKPTHLSVEL
3210 3220 3230 3240 3250
SCRSYWCTWK EPNVLSWKFE GENAYISVEN LRDFYGIDFK YLPFQQIECE
3260 3270 3280 3290 3300
FYKRMEAVTI YSIKYGSEFA TQAWQTVNGH FVCCNTEGGD SGAPLVWRDS
3310 3320 3330 3340 3350
VIGVHQGLCD SFKTTLASDS KGVMMTEVKG YHVDPPVYYK PIIMSAAYNK
3360 3370 3380 3390 3400
FVADSDVSVG ECTNYHNFVN EDFFSMHDEL EKVSFGDKMF RYCQSLPRYL
3410 3420 3430 3440 3450
EPLHYFHVPS FWQPFKKQSV SSNVSWVVEN LHFIFSVYFL VCDFVAYWWL
3460 3470 3480 3490 3500
DDPFSVVLPL FFVVQLLSTV VLKNVLFWNT SYLVTLAVTF YVHSEVAESM
3510 3520 3530 3540 3550
YLLGLFSDQI VNRVGLILVV SVMCLFVVVR VVVNVKRAIF VVVVSVLLIV
3560 3570 3580 3590 3600
VNVVLGVVQF NSLVAVCMFD IYAVFAALLT PQPVVAIMML ILFDTKCLMS
3610 3620 3630 3640 3650
FAFVVIVLSF RVFKNYKFVR VLHNLCNFDF VLTQLSLFRY RHHNQGNNPS
3660 3670 3680 3690 3700
HYEALWLFLK ELYYGVQDVK YEVFSPQAGT YNVRFLTDMT EQDQLEAVEQ
3710 3720 3730 3740 3750
VQRRLQRFSI VQDKNSQRLV LYSKNVDFLR SQIQHQRVLG ANPFIITTLT
3760 3770 3780 3790 3800
PKDIAIDNVE VHNPSQFKPE DLQAHMWFYS KSPIFVGQVP IPTNVQTAAV
3810 3820 3830 3840 3850
LDTTYNCQDL TADEKNNVAA NLQIQNAALT LSLFEECNRF LESELGDVPT
3860 3870 3880 3890 3900
LMWQSEDVVD VKQLEVQIEK LRVVLDGMQL GTSEYKATRK QINILQSQLD
3910 3920 3930 3940 3950
KALAFERKLA KFLEKVDQQQ AITNETAKQL SAFKNLVKQV YESYMSSLKV
3960 3970 3980 3990 4000
RVVESNDASC LLTSTDLPRK LVLMRPITGL DNIKIVEKAN GCEITAFGDT
4010 4020 4030 4040 4050
FTTGLGSNLA GLAYSSTQPL SAYPFIFNLE GIFKQQANIG YKTVECNMSS
4060 4070 4080 4090 4100
DNGSVLYKGK IVAVPSEDNP DFVVCGKGYK LDCGINVLMI PSIVRYITLN
4110 4120 4130 4140 4150
LTDHLQRQSL KPRRRLQYKQ QGVRLGGVNL GEHQAFSNEL ISSVGYTTWV
4160 4170 4180 4190 4200
SSTVCTDKSH KHPWFVQIPS SEKDPEWFMH NTQVKNNQWV VDAKPTHWLV
4210 4220 4230 4240 4250
DADTNEQLFA LALTDEEYLK AESILAKWSP ITQDVECWFK DLRGYYTVSG
4260 4270 4280 4290 4300
LQPLWPVCPK KICSLKIVPI FQSQSVAYAD EPTHFLSLPV VNKNFLEAFY
4310 4320 4330 4340 4350
ELQEGFPGEK QVAPHISLTM LKLTEEDVAK VEDILDEMVL PNTYATITNP
4360 4370 4380 4390 4400
HMMGQYYVFE VEGLQALHDE VVSVLRQHGI ACDQTRMWKP HLTIGEIKDG
4410 4420 4430 4440 4450
SVFNKFKDFG ITCKLEDCDF VKLGAPKANA RYEFIATLPV GDFKLLRDVW
4460 4470 4480 4490 4500
CACRHLCFQN GAYQSSRSKH YIDLATEYNA GIVKVNKSNT HSVEYKGQRF
4510 4520 4530 4540 4550
MIKRVKDQHE FALARTAFLP SIIPHHMVHQ NGEWFLVRGP TTQWSLGDLV
4560 4570 4580 4590 4600
YAIWLGDQAY LDECGFVFNP SRDEFLDDAN QRSYLANLLE PAILSFCEIF
4610 4620 4630 4640 4650
HCVKGCQVPY KITLDNLDLK GQLYDFGDYP CPNKVDNQSA LFVLAEVWSM
4660 4670 4680 4690 4700
TRKPFPTKFA QVLAKEMNVP ADFQMYFQHT LLSGKYFDKA MCLNNVRPLL
4710 4720 4730 4740 4750
RDPANLTTTP FFSQHSGVWT HFYNPIYGLV ECDLEEFSNL PEVLQQLITV
4760 4770 4780 4790 4800
QGPITSAMTP AISIGEGVYA ANVPPVAAAK QKIPLYDVGL CQELTDAGVD
4810 4820 4830 4840 4850
CGEAFKYFYY LSNPAGALAD VCFYDYQGTG FYSPKLLAGV YDFMKRVTTC
4860 4870 4880 4890 4900
YKTDERFTYE QAKPRKSSMG INITGYQQDA VYRALGPENI TKLFEYAQKA
4910 4920 4930 4940 4950
PLPFCTKIIT KFALSAKARA RTVSSCSFIA STIFRFAHKP VTSKMVEVAQ
4960 4970 4980 4990 5000
NSQGFCLIGV SKYGLKFSKF LKDKYGAIEQ FDVFGSDYTK CDRTFPLSFR
5010 5020 5030 5040 5050
ALTAALLYEL GGWEEDSWLY LNEVNSYMLD TMLCDGMLLN KPGGTSSGDA
5060 5070 5080 5090 5100
TTAHSNTFYN YMVHYVVAFK TILSDLSDCN KVMRIAAHNA YTTGDYGVFN
5110 5120 5130 5140 5150
TLLEEQFQTN YFLNFLSDDS FIFSKPGALK IFTCENFSNK LQTILHTKVD
5160 5170 5180 5190 5200
LTKSWATTGH IEEFCSAHII KTDGEYHFLP SRGRLLASLL ILDKLSDVDI
5210 5220 5230 5240 5250
YYMRFVAILC ESAVYSRYQP EFFNGLFQVF LDKVQQFRKD YCCDPCPTQL
5260 5270 5280 5290 5300
LDRQFYENLV FTSNTEVGLV DCYLENFKLQ CEFKQQAGFD RVCFCCPNPA
5310 5320 5330 5340 5350
VSVCEECYVP LPLCAYCYYV HVVISSHCKI EDKFKCPCGQ DDIRELFIVL
5360 5370 5380 5390 5400
NNSICIYQCR SCVESDRLRI SLLSDVDQVV RLPGFKANSA SIAKNGVAQL
5410 5420 5430 5440 5450
LTPVDNVDVS LDWNHQETVQ QNVARIVYHS ANMTQMSIEV VYVNFSLVRN
5460 5470 5480 5490 5500
DGSSAILDIP NFKCPDTSYC LFYKPGKTGV LKFTGKGTLT SCYDSNNLTW
5510 5520 5530 5540 5550
FKVTCPDFNQ PWRLATCFVI QQHDAVYPPI KSTQYENVTF VMGPPGTGKT
5560 5570 5580 5590 5600
TFVYNTYLSK ASPSNRFVYC APTHRLVGDM DEKVDGAVVV SAYNDRTYRN
5610 5620 5630 5640 5650
PVWKKDDSYD VLLCTHNTLP FIKSAVLIVD EVSLIPPHVM IKILSMGFKK
5660 5670 5680 5690 5700
VVLLGDPFQL SPVYKNHKVH FKYDTFYLLQ LATQKRYLTA CYRCPPQILS
5710 5720 5730 5740 5750
AFSKPYCDVG VDLVSFNNKP GKFDIIVSKQ LANMQDFSVL SVLSKEYPGY
5760 5770 5780 5790 5800
VILVNYRAAV DYAMQNGLGD VTTIDSSQGT TAANHLLVLF GASNFSKTIN
5810 5820 5830 5840 5850
RVIVGCSRST THLVVVCCPE LYKHFQPILN WPEPVYRYFG MEKQSDFNII
5860 5870 5880 5890 5900
PEVASLVFCD IEFWHYKADP NSKTRTVYPG QIAVVTSQTL QLYLGVFDDA
5910 5920 5930 5940 5950
GYKSALRGLP KDVFVPPNWV WMRKHYPSFE QHAYNMQRLF KFIIDTTCGQ
5960 5970 5980 5990 6000
PWFILYSCSN DLKSLKFYVE FGTNYFCSCG ELAICLMRDG LYKCRNCYGN
6010 6020 6030 6040 6050
MSISKLVNCK YLDVQKERIK LQDAHDAICQ QFHGDSHEAL CDAVMTKCLY
6060 6070 6080 6090 6100
LASYDAAFKD TIHVKYKDLC LEIQYKITSP YVRYDGVNKR YLYRDHGAMH
6110 6120 6130 6140 6150
YFKTPKSPMQ NVYRYEVGAH TEYSINICNS YEGCQSFGKT CTKCIHIHCI
6160 6170 6180 6190 6200
VEQFMADDRY RDFILVSVVK SDFVEQALSP AAKALMLTVT RVEGKSFYTS
6210 6220 6230 6240 6250
NGQRYDLYDY DLSKSVMRVV GASVKPLPLY SVVVGLGINC TVGCVLPNVP
6260 6270 6280 6290 6300
MKLKDELLST DVPLSTLRLD LPTWYYVTWP TLSNRTSRWK LAGAQVYDCS
6310 6320 6330 6340 6350
VHIYVEATGE QPLYYLQLGN GESLRELPET LFSTGRLYNL EHDPSKNFNV
6360 6370 6380 6390 6400
QQLAIETIPK NHHVFAGDFT DVGTDIGGVH HVVALNGYKG SIIPNYVKPI
6410 6420 6430 6440 6450
ATGLINVGRS VKRTTLVDVC ANQLYEKVKQ QIAGVKVSKV IFVNIDFQEV
6460 6470 6480 6490 6500
QFMVFAKGED DIQTFYPQKE FIRSYYEWPT ILPELESHYD LKNYGQDPQF
6510 6520 6530 6540 6550
MPQPVNFAKY TQICTFIQEH VKVARNSLIW HVGAAGIDGC SPGDIVLSSF
6560 6570 6580 6590 6600
FKECLVYSWD VKDYDTLLEK HNYDCNFRPN LIVSDVYNVS SNVSEVLEDC
6610 6620 6630 6640 6650
VHRLALGGTI IFKTTESSRP DIQLSKVTKY FAAVHFFTAG VNTSSSEVFV
6660 6670 6680 6690 6700
VLKYKLHSEP IGEELCSPNI LRRIAAYRNK LCIVPNFKVF STSLSYRFSS
6710 6720 6730
VKFVQKCFYV SVPRQFCASG LIQEVPLLCQ MKH
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:6,733
Mass (Da):765,975
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7947CE8F5F1FA90D
GO
Isoform Replicase polyprotein 1a (identifier: P0C6F4-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
The sequence of this isoform can be found in the external entry P0C6F4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:4,445
Mass (Da):505,933
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY427798 Genomic RNA Translation: AAS17963.1
U50390 mRNA Translation: AAD11480.1

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY427798 Genomic RNA Translation: AAS17963.1
U50390 mRNA Translation: AAD11480.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein family/group databases

MEROPSiS65.001

Proteomic databases

PRIDEiP0C6V8

Family and domain databases

CDDicd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21162, NendoU_tv_PToV-like, 1 hit
cd21413, unc_tv_SF1_Hel-like, 1 hit
cd21403, ZBD_tv_SF1_Hel-like, 1 hit
Gene3Di3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR009097, Cyclic_Pdiesterase
IPR043502, DNA/RNA_pol_sf
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR043609, NendoU_nidovirus
IPR044397, NendoU_PToV-like
IPR039573, NS2A-like
IPR027352, NSP13_ZBD_CoV-like
IPR009461, NSP16_CoV-like
IPR027417, P-loop_NTPase
IPR038765, Papain-like_cys_pep_sf
IPR009003, Peptidase_S1_PA
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR044355, SF1_Hel_unc_tv
IPR044336, SF1_Hel_ZBD_tv
PfamiView protein in Pfam
PF05213, Corona_NS2A, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF01661, Macro, 1 hit
PF00680, RdRP_1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF142877, SSF142877, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF54001, SSF54001, 1 hit
SSF55144, SSF55144, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51154, MACRO, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51955, NIV_2_O_MTASE, 1 hit
PS51953, NIV_EXON, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_BRV1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6V8
Secondary accession number(s): Q3T8J1, Q3T8J2, Q9YP98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 2, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again