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UniProtKB - P0C6U8 (R1A_CVHSA)

Entry version 99 (22 Apr 2020)
Sequence version 1 (10 Jun 2008)
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Protein

Replicase polyprotein 1a

Gene

1a

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein.
Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371).2 Publications
May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.1 Publication
Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Prevents also host NF-kappa-B signaling.1 Publication3 Publications
Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV.1 Publication1 Publication
Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH.PROSITE-ProRule annotation2 Publications
Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833).1 Publication1 Publication
Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.1 Publication
Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.1 Publication
May participate in viral replication by acting as a ssRNA-binding protein.1 Publication
Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.1 Publication

Caution

Isolates SZ3 and SZ16 have been isolated from Paguma larvata and are described as SARS-like in literature.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
  • TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1651For PL-PRO activityPROSITE-ProRule annotation1
Active sitei1812For PL-PRO activityPROSITE-ProRule annotation1
Active sitei3281For 3CL-PRO activityPROSITE-ProRule annotation1
Active sitei3385For 3CL-PRO activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4304Zinc1
Metal bindingi4307Zinc1
Metal bindingi4313Zinc1
Metal bindingi4320Zinc1
Metal bindingi4347Zinc1
Metal bindingi4350Zinc1
Metal bindingi4358Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4304 – 4320Add BLAST17
Zinc fingeri4347 – 4360Add BLAST14

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, Protease, RNA-binding, Thiol protease
Biological processActivation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF3 by virus, Inhibition of host ISG15 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.22.69 7599

Protein family/group databases

MEROPS protease database

More...MEROPSi		C16.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1a
Short name:
pp1a
Alternative name(s):
ORF1a polyprotein
Cleaved into the following 11 chains:
Non-structural protein 1
Short name:
nsp1
Alternative name(s):
Leader protein
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p65 homolog
Non-structural protein 3 (EC:3.4.19.12, EC:3.4.22.-)
Short name:
nsp3
Alternative name(s):
PL2-PRO
Papain-like proteinase
Short name:
PL-PRO
SARS coronavirus main proteinase
Non-structural protein 4
Short name:
nsp4
3C-like proteinase (EC:3.4.22.69)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
Non-structural protein 11
Short name:
nsp11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri694009 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2202CytoplasmicCuratedAdd BLAST2202
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2203 – 2223HelicalSequence analysisAdd BLAST21
Topological domaini2224 – 2303LumenalCuratedAdd BLAST80
Transmembranei2304 – 2324HelicalSequence analysisAdd BLAST21
Topological domaini2325 – 2350CytoplasmicCuratedAdd BLAST26
Transmembranei2351 – 2371HelicalSequence analysisAdd BLAST21
Topological domaini2372 – 2754LumenalCuratedAdd BLAST383
Transmembranei2755 – 2775HelicalSequence analysisAdd BLAST21
Topological domaini2776 – 2991CytoplasmicCuratedAdd BLAST216
Transmembranei2992 – 3012HelicalSequence analysisAdd BLAST21
Topological domaini3013 – 3021LumenalCurated9
Transmembranei3022 – 3042HelicalSequence analysisAdd BLAST21
Topological domaini3043 – 3053CytoplasmicCuratedAdd BLAST11
Transmembranei3054 – 3074HelicalSequence analysisAdd BLAST21
Topological domaini3075 – 3076LumenalCurated2
Transmembranei3077 – 3097HelicalSequence analysisAdd BLAST21
Topological domaini3098 – 3104CytoplasmicCurated7
Transmembranei3105 – 3125HelicalSequence analysisAdd BLAST21
Topological domaini3126 – 3141LumenalCuratedAdd BLAST16
Transmembranei3142 – 3162HelicalSequence analysisAdd BLAST21
Topological domaini3163 – 3563CytoplasmicCuratedAdd BLAST401
Transmembranei3564 – 3584HelicalSequence analysisAdd BLAST21
Topological domaini3585LumenalCurated1
Transmembranei3586 – 3606HelicalSequence analysisAdd BLAST21
Topological domaini3607 – 3611CytoplasmicCurated5
Transmembranei3612 – 3632HelicalSequence analysisAdd BLAST21
Topological domaini3633 – 3657LumenalCuratedAdd BLAST25
Transmembranei3658 – 3678HelicalSequence analysisAdd BLAST21
Topological domaini3679 – 3684CytoplasmicCurated6
Transmembranei3685 – 3704HelicalSequence analysisAdd BLAST20
Topological domaini3705 – 3727LumenalCuratedAdd BLAST23
Transmembranei3728 – 3748HelicalSequence analysisAdd BLAST21
Topological domaini3749 – 3755CytoplasmicCurated7
Transmembranei3756 – 3776HelicalSequence analysisAdd BLAST21
Topological domaini3777 – 4382LumenalCuratedAdd BLAST606

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3927

Drug and drug target database

More...DrugBanki		DB07620 2-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]-1,3-DINITRO-5-(TRIFLUOROMETHYL)BENZENE
DB08732 NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE
DB07743 S-[5-(TRIFLUOROMETHYL)-4H-1,2,4-TRIAZOL-3-YL] 5-(PHENYLETHYNYL)FURAN-2-CARBOTHIOATE

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003382541 – 4382Replicase polyprotein 1aAdd BLAST4382
ChainiPRO_00003382551 – 180Non-structural protein 1By similarityAdd BLAST180
ChainiPRO_0000338256181 – 818Non-structural protein 2By similarityAdd BLAST638
ChainiPRO_0000338257819 – 2740Non-structural protein 3By similarityAdd BLAST1922
ChainiPRO_00003382582741 – 3240Non-structural protein 4Sequence analysisAdd BLAST500
ChainiPRO_00003382593241 – 35463C-like proteinaseBy similarityAdd BLAST306
ChainiPRO_00003382603547 – 3836Non-structural protein 6By similarityAdd BLAST290
ChainiPRO_00003382613837 – 3919Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_00003382623920 – 4117Non-structural protein 8By similarityAdd BLAST198
ChainiPRO_00003382634118 – 4230Non-structural protein 9By similarityAdd BLAST113
ChainiPRO_00003382644231 – 4369Non-structural protein 10By similarityAdd BLAST139
ChainiPRO_00003382654370 – 4382Non-structural protein 11Sequence analysisAdd BLAST13

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei180 – 181CleavageBy similarity2
Sitei818 – 819Cleavage; by PL-PROBy similarity2
Sitei2740 – 2741Cleavage; by PL-PROBy similarity2
Sitei3240 – 3241Cleavage; by 3CL-PROBy similarity2
Sitei3546 – 3547Cleavage; by 3CL-PROBy similarity2
Sitei3836 – 3837Cleavage; by 3CL-PROBy similarity2
Sitei3919 – 3920Cleavage; by 3CL-PROBy similarity2
Sitei4117 – 4118Cleavage; by 3CL-PROBy similarity2
Sitei4230 – 4231Cleavage; by 3CL-PROBy similarity2
Sitei4369 – 4370Cleavage; by 3CL-PROBy similarity2

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P0C6U8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-48580N

Protein interaction database and analysis system

More...IntActi		P0C6U8, 3 interactors

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P0C6U8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C6U8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P0C6U8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1003 – 1169MacroPROSITE-ProRule annotationAdd BLAST167
Domaini1611 – 1875Peptidase C16PROSITE-ProRule annotationAdd BLAST265
Domaini3241 – 3546Peptidase C30PROSITE-ProRule annotationAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2092 – 2371HD1Add BLAST280
Regioni2755 – 3162HD2Add BLAST408
Regioni3564 – 3776HD3Add BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi930 – 1001Glu-richAdd BLAST72
Compositional biasi2210 – 2213Poly-Leu4
Compositional biasi3766 – 3769Poly-Cys4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4304 – 4320Add BLAST17
Zinc fingeri4347 – 4360Add BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.40.220.20, 1 hit
3.40.50.11020, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032505 Corona_NSP4_C
IPR002589 Macro_dom
IPR032592 NAR_dom
IPR042570 NAR_sf
IPR021590 NSP1
IPR036333 NSP10_sf
IPR038030 NSP1_sf
IPR024375 Nsp3_coronavir
IPR038400 Nsp3_coronavir_sf
IPR022733 Nsp3_PL2pro
IPR038166 Nsp3_PL2pro_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR038083 R1a/1ab
IPR018995 RNA_synth_NSP10_coronavirus
IPR024358 SARS-CoV_Nsp3_N
IPR014827 Viral_protease

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16348 Corona_NSP4_C, 1 hit
PF12379 DUF3655, 1 hit
PF01661 Macro, 1 hit
PF16251 NAR, 1 hit
PF11501 Nsp1, 1 hit
PF09401 NSP10, 1 hit
PF12124 Nsp3_PL2pro, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF11633 SUD-M, 1 hit
PF08715 Viral_protease, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506 A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 1 hit
SSF159936 SSF159936, 1 hit
SSF160099 SSF160099, 1 hit
SSF50494 SSF50494, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1a (identifier: P0C6U8-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT 
        60         70         80         90        100
CGLVELEKGV LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS 
       110        120        130        140        150
GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGDELG 
       160        170        180        190        200
TDPIEDYEQN WNTKHGSGAL RELTRELNGG AVTRYVDNNF CGPDGYPLDC 
       210        220        230        240        250
IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW FTERSDKSYE 
       260        270        280        290        300
HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI 
       310        320        330        340        350
RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV 
       360        370        380        390        400
IEGPTTCGYL PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG 
       410        420        430        440        450
GRTRCFGGCV FAYVGCYNKR AYWVPRASAD IGSGHTGITG DNVETLNEDL 
       460        470        480        490        500
LEILSRERVN INIVGDFHLN EEVAIILASF SASTSAFIDT IKSLDYKSFK 
       510        520        530        540        550
TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA AGVIRSIFAR 
       560        570        580        590        600
TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY 
       610        620        630        640        650
VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK 
       660        670        680        690        700
FLITGVFDIV KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL 
       710        720        730        740        750
RSLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV 
       760        770        780        790        800
LTSEEVVLKN GELEALETPV DSFTNGAIVG TPVCVNGLML LEIKDKEQYC 
       810        820        830        840        850
ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV RITFELDERV 
       860        870        880        890        900
DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE 
       910        920        930        940        950
WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE 
       960        970        980        990       1000
YGTEDDYQGL PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE 
      1010       1020       1030       1040       1050
EPVNQFTGYL KLTDNVAIKC VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA 
      1060       1070       1080       1090       1100
GALNKATNGA MQKESDDYIK LNGPLTVGGS CLLSGHNLAK KCLHVVGPNL 
      1110       1120       1130       1140       1150
NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL QVCVQTVRTQ 
      1160       1170       1180       1190       1200
VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK 
      1210       1220       1230       1240       1250
PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE 
      1260       1270       1280       1290       1300
DMSFLEKDAP YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE 
      1310       1320       1330       1340       1350
YITTYPGQGC AGYTLEEAKT ALKKCKSAFY VLPSEAPNAK EEILGTVSWN 
      1360       1370       1380       1390       1400
LREMLAHAEE TRKLMPICMD VRAIMATIQR KYKGIKIQEG IVDYGVRFFF 
      1410       1420       1430       1440       1450
YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR CMRSLKAPAV 
      1460       1470       1480       1490       1500
VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG 
      1510       1520       1530       1540       1550
VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT 
      1560       1570       1580       1590       1600
VDNTNLHTQL VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS 
      1610       1620       1630       1640       1650
DDTLRSEAFE YYHTLDESFL GRYMSALNHT KKWKFPQVGG LTSIKWADNN 
      1660       1670       1680       1690       1700
CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR AGDAANFCAL ILAYSNKTVG 
      1710       1720       1730       1740       1750
ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT GVEAVMYMGT 
      1760       1770       1780       1790       1800
LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC 
      1810       1820       1830       1840       1850
ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY 
      1860       1870       1880       1890       1900
TTTIKPVSYK LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA 
      1910       1920       1930       1940       1950
SFDNFKLTCS NTKFADDLNQ MTGFTKPASR ELSVTFFPDL NGDVVAIDYR 
      1960       1970       1980       1990       2000
HYSASFKKGA KLLHKPIVWH INQATTKTTF KPNTWCLRCL WSTKPVDTSN 
      2010       2020       2030       2040       2050
SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE CDVKTTEVVG 
      2060       2070       2080       2090       2100
NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA 
      2110       2120       2130       2140       2150
THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF 
      2160       2170       2180       2190       2200
TLLFQLCTFT KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF 
      2210       2220       2230       2240       2250
SKLFTIAMWL LLLSICLGSL ICVTAAFGVL LSNFGAPSYC NGVRELYLNS 
      2260       2270       2280       2290       2300
SNVTTMDFCE GSFPCSICLS GLDSLDSYPA LETIQVTISS YKLDLTILGL 
      2310       2320       2330       2340       2350
AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW LMWFIISIVQ 
      2360       2370       2380       2390       2400
MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC 
      2410       2420       2430       2440       2450
TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL 
      2460       2470       2480       2490       2500
SLQFKRPINP TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN 
      2510       2520       2530       2540       2550
LDNLRANNTK GSLPINVIVF DGKSKCDESA SKSASVYYSQ LMCQPILLLD 
      2560       2570       2580       2590       2600
QALVSDVGDS TEVSVKMFDA YVDTFSATFS VPMEKLKALV ATAHSELAKG 
      2610       2620       2630       2640       2650
VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL EVTGDSCNNF 
      2660       2670       2680       2690       2700
MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE 
      2710       2720       2730       2740       2750
QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM 
      2760       2770       2780       2790       2800
LKATLLCVLA ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST 
      2810       2820       2830       2840       2850
DDCFANKHAG FDAWFSQRGG SYKNDKSCPV VAAIITREIG FIVPGLPGTV 
      2860       2870       2880       2890       2900
LRAINGDFLH FLPRVFSAVG NICYTPSKLI EYSDFATSAC VLAAECTIFK 
      2910       2920       2930       2940       2950
DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ FPNTYLEGSV 
      2960       2970       2980       2990       3000
RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA 
      3010       3020       3030       3040       3050
MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE 
      3060       3070       3080       3090       3100
YNHVVAANAL LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL 
      3110       3120       3130       3140       3150
AHLQWFAMFS PIVPFWITAI YVFCISLKHC HWFFNNYLRK RVMFNGVTFS 
      3160       3170       3180       3190       3200
TFEEAALCTF LLNKEMYLKL RSETLLPLTQ YNRYLALYNK YKYFSGALDT 
      3210       3220       3230       3240       3250
TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ SGFRKMAFPS 
      3260       3270       3280       3290       3300
GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR 
      3310       3320       3330       3340       3350
KSNHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ 
      3360       3370       3380       3390       3400
TFSVLACYNG SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC 
      3410       3420       3430       3440       3450
YMHHMELPTG VHAGTDLEGK FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA 
      3460       3470       3480       3490       3500
AVINGDRWFL NRFTTTLNDF NLVAMKYNYE PLTQDHVDIL GPLSAQTGIA 
      3510       3520       3530       3540       3550
VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC SGVTFQGKFK 
      3560       3570       3580       3590       3600
KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA 
      3610       3620       3630       3640       3650
CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS 
      3660       3670       3680       3690       3700
LSGYRLKDCV MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY 
      3710       3720       3730       3740       3750
GNALDQAISM WALVISVTSN YSGVVTTIMF LARAIVFVCV EYYPLLFITG 
      3760       3770       3780       3790       3800
NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY FRLTLGVYDY LVSTQEFRYM 
      3810       3820       3830       3840       3850
NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS DVKCTSVVLL 
      3860       3870       3880       3890       3900
SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG 
      3910       3920       3930       3940       3950
AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS 
      3960       3970       3980       3990       4000
EVVLKKLKKS LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA 
      4010       4020       4030       4040       4050
KVTSAMQTML FTMLRKLDND ALNNIINNAR DGCVPLNIIP LTTAAKLMVV 
      4060       4070       4080       4090       4100
VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD ADSKIVQLSE INMDNSPNLA 
      4110       4120       4130       4140       4150
WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC TDDNALAYYN 
      4160       4170       4180       4190       4200
NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP 
      4210       4220       4230       4240       4250
KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA 
      4260       4270       4280       4290       4300
VDPAKAYKDY LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG 
      4310       4320       4330       4340       4350
ASCCLYCRCH IDHPNPKGFC DLKGKYVQIP TTCANDPVGF TLRNTVCTVC 
      4360       4370       4380 
GMWKGYGCSC DQLREPLMQS ADASTFLNGF AV
Note: Produced by conventional translation.
Length:4,382
Mass (Da):486,373
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1F65D5FD5DFF828
GO
Isoform Replicase polyprotein 1ab (identifier: P0C6X7-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
The sequence of this isoform can be found in the external entry P0C6X7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:7,073
Mass (Da):790,248
GO

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 21871 Da. Determined by ESI. 1 Publication
Molecular mass is 12403 Da. Determined by ESI. 1 Publication
Molecular mass is 14974 Da. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti82G → C in strain: Isolate GD01. 1
Natural varianti130G → R in strain: Isolate GD01. 1
Natural varianti138I → T in strain: Isolate SZ16. 1
Natural varianti181A → V in strain: Isolate Shanghai LY. 1
Natural varianti225K → Q in strain: Isolate GD01. 1
Natural varianti249Y → C in strain: Isolate Shanghai LY. 1
Natural varianti306V → F in strain: Isolate BJ04. 1
Natural varianti549A → S in strain: Isolate SZ3. 1
Natural varianti765A → T in strain: Isolate FRA and Isolate Frankfurt-1. 1
Natural varianti852K → R in strain: Isolate SZ16. 1
Natural varianti1004N → H in strain: Isolate BJ03. 1
Natural varianti1021V → A in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti1023I → T in strain: Isolate Shanghai QXC1. 1
Natural varianti1121I → T in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
Natural varianti1136P → L in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti1257K → E in strain: Isolate Shanghai QXC1. 1
Natural varianti1319K → R in strain: Isolate GD01. 1
Natural varianti1329F → S in strain: Isolate GD01. 1
Natural varianti1361T → A in strain: Isolate Shanghai QXC1. 1
Natural varianti1385I → V in strain: Isolate Shanghai QXC1. 1
Natural varianti1538S → T in strain: Isolate GD01. 1
Natural varianti1563M → K in strain: Isolate BJ02. 1
Natural varianti1663L → I in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti1762I → L in strain: Isolate BJ03. 1
Natural varianti1776 – 1777QQ → PP in strain: Isolate BJ03. 2
Natural varianti1790E → G in strain: Isolate Shanghai QXC1. 1
Natural varianti1806G → V in strain: Isolate BJ02. 1
Natural varianti1962L → I in strain: Isolate BJ04. 1
Natural varianti2116L → F in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
Natural varianti2222C → Y in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
Natural varianti2269L → S in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti2326V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti2392 – 2394RNR → CNH in strain: Isolate Shanghai QXC1. 3
Natural varianti2480L → P in strain: Isolate Shanghai QXC1. 1
Natural varianti2552A → V in strain: Isolate Urbani and Isolate Taiwan TC2. 1
Natural varianti2556D → N in strain: Isolate HKU-39849. 1
Natural varianti2564S → P in strain: Isolate GD01. 1
Natural varianti2648N → Y in strain: Isolate Shanghai QXC1. 1
Natural varianti2708S → T in strain: Isolate HKU-39849. 1
Natural varianti2718R → T in strain: Isolate HKU-39849. 1
Natural varianti2746C → W in strain: Isolate SZ3 and Isolate SZ16. 1
Natural varianti2770V → L in strain: Isolate BJ01 and Isolate BJ02. 1
Natural varianti2944T → I in strain: Isolate SIN2500, Isolate GD01 and Isolate GZ50. 1
Natural varianti2971V → A in strain: Isolate GD01 and Isolate SZ16. 1
Natural varianti3020V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti3047V → A in strain: Isolate CUHK-W1, Isolate GD01, Isolate SZ3, Isolate SZ16, Isolate BJ01, Isolate BJ02, Isolate BJ03 and Isolate Shanghai QXC1. 1
Natural varianti3072V → A in strain: Isolate CUHK-W1, Isolate SZ3, Isolate SZ16 and Isolate GD01. 1
Natural varianti3197A → V in strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate Shanghai QXC1. 1
Natural varianti3429Q → P in strain: Isolate BJ02. 1
Natural varianti3488D → E in strain: Isolate BJ04. 1
Natural varianti3717V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti3818N → T in strain: Isolate BJ04. 1
Natural varianti3903D → N in strain: Isolate BJ03. 1
Natural varianti3904I → F in strain: Isolate BJ02. 1
Natural varianti3911M → V in strain: Isolate Shanghai QXC1. 1
Natural varianti4001K → Q in strain: Isolate Shanghai LY. 1
Natural varianti4003T → A in strain: Isolate Shanghai LY. 1
Natural varianti4085I → H in strain: Isolate ZJ01. 1
Natural varianti4114V → A in strain: Isolate Shanghai QXC1. 1
Natural varianti4202V → M in strain: Isolate Shanghai QXC1. 1
Natural varianti4240N → H in strain: Isolate ZJ01. 1
Natural varianti4296E → G in strain: Isolate Shanghai QXC1. 1
Natural varianti4377 – 4378LN → FK in strain: Isolate Shanghai QXC1. 2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13439.1
AY274119 Genomic RNA No translation available.
AY278554 Genomic RNA Translation: AAP13575.1
AY282752 Genomic RNA Translation: AAP30712.1
AY304495 Genomic RNA No translation available.
AY304486 Genomic RNA No translation available.
AY304488 Genomic RNA No translation available.
AY278491 Genomic RNA No translation available.
AY283794 Genomic RNA No translation available.
AY283795 Genomic RNA No translation available.
AY283796 Genomic RNA No translation available.
AY283797 Genomic RNA No translation available.
AY283798 Genomic RNA No translation available.
AY286320 Genomic RNA Translation: AAR16181.1
AY278488 Genomic RNA Translation: AAP30029.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY278489 Genomic RNA Translation: AAP51226.1
AY291451 Genomic RNA Translation: AAP37016.1
AY310120 Genomic RNA Translation: AAP50484.1
AY291315 Genomic RNA Translation: AAP33695.1
AY323977 Genomic RNA Translation: AAP72974.2
AY321118 Genomic RNA No translation available.
AY338174 Genomic RNA Translation: AAQ01595.1
AY338175 Genomic RNA Translation: AAQ01607.1
AY348314 Genomic RNA Translation: AAP97880.1
AP006557 Genomic RNA Translation: BAC81347.1
AP006558 Genomic RNA Translation: BAC81361.1
AP006559 Genomic RNA Translation: BAC81375.1
AP006560 Genomic RNA Translation: BAC81389.1
AP006561 Genomic RNA Translation: BAC81403.1
AY427439 Genomic RNA Translation: AAQ94059.1
AY322205 Genomic RNA Translation: AAP82966.1
AY322206 Genomic RNA Translation: AAP82976.1
AY463059 Genomic RNA No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA Translation: AAP13439.1
AY274119 Genomic RNA No translation available.
AY278554 Genomic RNA Translation: AAP13575.1
AY282752 Genomic RNA Translation: AAP30712.1
AY304495 Genomic RNA No translation available.
AY304486 Genomic RNA No translation available.
AY304488 Genomic RNA No translation available.
AY278491 Genomic RNA No translation available.
AY283794 Genomic RNA No translation available.
AY283795 Genomic RNA No translation available.
AY283796 Genomic RNA No translation available.
AY283797 Genomic RNA No translation available.
AY283798 Genomic RNA No translation available.
AY286320 Genomic RNA Translation: AAR16181.1
AY278488 Genomic RNA Translation: AAP30029.1
AY278490 Genomic RNA No translation available.
AY279354 Genomic RNA No translation available.
AY278489 Genomic RNA Translation: AAP51226.1
AY291451 Genomic RNA Translation: AAP37016.1
AY310120 Genomic RNA Translation: AAP50484.1
AY291315 Genomic RNA Translation: AAP33695.1
AY323977 Genomic RNA Translation: AAP72974.2
AY321118 Genomic RNA No translation available.
AY338174 Genomic RNA Translation: AAQ01595.1
AY338175 Genomic RNA Translation: AAQ01607.1
AY348314 Genomic RNA Translation: AAP97880.1
AP006557 Genomic RNA Translation: BAC81347.1
AP006558 Genomic RNA Translation: BAC81361.1
AP006559 Genomic RNA Translation: BAC81375.1
AP006560 Genomic RNA Translation: BAC81389.1
AP006561 Genomic RNA Translation: BAC81403.1
AY427439 Genomic RNA Translation: AAQ94059.1
AY322205 Genomic RNA Translation: AAP82966.1
AY322206 Genomic RNA Translation: AAP82976.1
AY463059 Genomic RNA No translation available.

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P76model-A3241-3541[»]
B4225-4231[»]
1P9Tmodel-A3241-3544[»]
1PA5model-A3241-3546[»]
1PUKmodel-A3241-3550[»]
1Q1Xmodel-A3241-3542[»]
1Q2WX-ray1.86A/B3241-3544[»]
1QZ8X-ray2.70A/B4118-4230[»]
1UJ1X-ray1.90A/B3241-3546[»]
1UK2X-ray2.20A/B3241-3546[»]
1UK3X-ray2.40A/B3241-3546[»]
1UK4X-ray2.50A/B3241-3546[»]
1UW7X-ray2.80A4118-4230[»]
1WOFX-ray2.00A/B3241-3546[»]
1YSYNMR-A3837-3919[»]
1Z1IX-ray2.80A3241-3546[»]
1Z1JX-ray2.80A/B3241-3546[»]
2A5AX-ray2.08A3241-3546[»]
2A5IX-ray1.88A3241-3546[»]
2A5KX-ray2.30A/B3241-3546[»]
2ACFX-ray1.40A/B/C/D1002-1176[»]
2AHMX-ray2.40A/B/C/D3837-3919[»]
E/F/G/H3920-4117[»]
2AJ5model-A3241-3546[»]
2ALVX-ray1.90A3241-3543[»]
2AMDX-ray1.85A/B3241-3546[»]
2AMQX-ray2.30A/B3241-3546[»]
2BX3X-ray2.00A3241-3546[»]
2BX4X-ray2.79A3241-3546[»]
2C3SX-ray1.90A3241-3546[»]
2D2DX-ray2.70A/B3241-3546[»]
2DUCX-ray1.70A/B3241-3546[»]
2FAVX-ray1.80A/B/C1000-1173[»]
2FE8X-ray1.85A/B/C1541-1854[»]
2FYGX-ray1.80A4240-4362[»]
2G9TX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
2GA6X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
2GDTNMR-A13-127[»]
2GRINMR-A819-930[»]
2GT7X-ray1.82A/B3241-3546[»]
2GT8X-ray2.00A3241-3546[»]
2GTBX-ray2.00A3241-3546[»]
2GX4X-ray1.93A3241-3546[»]
2GZ7X-ray1.86A3241-3546[»]
2GZ8X-ray1.97A3241-3546[»]
2GZ9X-ray2.17A3241-3546[»]
2H2ZX-ray1.60A3241-3546[»]
2HOBX-ray1.95A3241-3546[»]
2HSXNMR-A13-127[»]
2IDYNMR-A819-930[»]
2KAFNMR-A1473-1538[»]
2KQVNMR-A1345-1538[»]
2KQWNMR-A1345-1538[»]
2KYSNMR-A3837-3919[»]
2LIZNMR-A3427-3546[»]
2OP9X-ray1.80A/B3241-3541[»]
2PWXX-ray2.50A3241-3546[»]
2W2GX-ray2.22A/B1207-1470[»]
2WCTX-ray2.79A/B/C/D1207-1470[»]
2Z3CX-ray1.79A3241-3546[»]
2Z3DX-ray2.10A3241-3546[»]
2Z3EX-ray2.32A3241-3546[»]
2ZU4X-ray1.93A3241-3546[»]
2ZU5X-ray1.65A3241-3546[»]
3ATWX-ray2.36A/B3241-3546[»]
3AVZX-ray2.46A3241-3546[»]
3AW0X-ray2.30A3241-3546[»]
3AW1X-ray2.00A/B3241-3546[»]
3E91X-ray2.55A/B3241-3546[»]
3EA7X-ray2.65A/B3241-3546[»]
3EA8X-ray2.25A3241-3546[»]
3EA9X-ray2.40A3241-3546[»]
3EAJX-ray2.70A/B3241-3546[»]
3EE7X-ray2.60A/B/C/D4118-4230[»]
3F9EX-ray2.50A3241-3546[»]
3F9FX-ray2.30A/B3241-3546[»]
3F9GX-ray2.60A/B3241-3541[»]
3F9HX-ray2.90A/B3241-3546[»]
3FZDX-ray2.35A3241-3541[»]
3IWMX-ray3.20A/B/C/D3241-3546[»]
3M3SX-ray2.30A/B3241-3546[»]
3M3TX-ray2.90A3241-3546[»]
3M3VX-ray2.70A/B3241-3546[»]
3MJ5X-ray2.63A/B1541-1855[»]
3R24X-ray2.00B4240-4382[»]
3SN8X-ray1.99A3241-3546[»]
3SNAX-ray3.05A3241-3541[»]
3SNBX-ray2.40A3241-3546[»]
3SNCX-ray2.58A3241-3546[»]
3SNDX-ray1.89A/B3241-3546[»]
3SNEX-ray2.60A3241-3546[»]
3SZNX-ray1.69A3241-3546[»]
3TITX-ray1.99A3241-3546[»]
3TIUX-ray2.08A3241-3546[»]
3TNSX-ray1.99A3241-3546[»]
3TNTX-ray1.59A3241-3546[»]
3V3MX-ray1.96A3241-3546[»]
3VB3X-ray2.20A/B3241-3546[»]
3VB4X-ray2.20A/B3241-3546[»]
3VB5X-ray1.95A/B3241-3546[»]
3VB6X-ray2.50A/B3241-3546[»]
3VB7X-ray1.95A/B3241-3546[»]
4HI3X-ray2.09A/B3241-3546[»]
4M0WX-ray1.40A1541-1858[»]
4MDSX-ray1.60A3241-3542[»]
4MM3X-ray2.75B1541-1855[»]
4OVZX-ray2.50A/B1541-1855[»]
4OW0X-ray2.10A/B1541-1855[»]
5F22X-ray2.15A3837-3919[»]
5Y3EX-ray1.65A1541-1854[»]
5Y3QX-ray1.65A1541-1854[»]
6NURelectron microscopy3.10B/D3920-4117[»]
6NUSelectron microscopy3.50B3920-4117[»]
6Y7MX-ray1.90AAA3241-3546[»]
SMRiP0C6U8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-48580N
IntActiP0C6U8, 3 interactors

Chemistry databases

BindingDBiP0C6U8
ChEMBLiCHEMBL3927
DrugBankiDB07620 2-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]-1,3-DINITRO-5-(TRIFLUOROMETHYL)BENZENE
DB08732 NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE
DB07743 S-[5-(TRIFLUOROMETHYL)-4H-1,2,4-TRIAZOL-3-YL] 5-(PHENYLETHYNYL)FURAN-2-CARBOTHIOATE

Protein family/group databases

MEROPSiC16.009

Proteomic databases

PRIDEiP0C6U8

Enzyme and pathway databases

BRENDAi3.4.22.69 7599

Miscellaneous databases

EvolutionaryTraceiP0C6U8

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.40.220.20, 1 hit
3.40.50.11020, 1 hit
InterProiView protein in InterPro
IPR032505 Corona_NSP4_C
IPR002589 Macro_dom
IPR032592 NAR_dom
IPR042570 NAR_sf
IPR021590 NSP1
IPR036333 NSP10_sf
IPR038030 NSP1_sf
IPR024375 Nsp3_coronavir
IPR038400 Nsp3_coronavir_sf
IPR022733 Nsp3_PL2pro
IPR038166 Nsp3_PL2pro_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR038083 R1a/1ab
IPR018995 RNA_synth_NSP10_coronavirus
IPR024358 SARS-CoV_Nsp3_N
IPR014827 Viral_protease
PfamiView protein in Pfam
PF16348 Corona_NSP4_C, 1 hit
PF12379 DUF3655, 1 hit
PF01661 Macro, 1 hit
PF16251 NAR, 1 hit
PF11501 Nsp1, 1 hit
PF09401 NSP10, 1 hit
PF12124 Nsp3_PL2pro, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF11633 SUD-M, 1 hit
PF08715 Viral_protease, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SUPFAMiSSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 1 hit
SSF159936 SSF159936, 1 hit
SSF160099 SSF160099, 1 hit
SSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1A_CVHSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6U8
Secondary accession number(s): P59641
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 22, 2020
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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