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UniProtKB - P0C6U8 (R1A_SARS)

Entry version 106 (02 Jun 2021)
Sequence version 1 (10 Jun 2008)
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Protein

Replicase polyprotein 1a

Gene

1a

Organism
Severe acute respiratory syndrome coronavirus (SARS-CoV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein.

Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226).

May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371).

2 Publications

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.

1 Publication

Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280).

Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069).

Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840).

Prevents also host NF-kappa-B signaling.

1 Publication4 Publications

Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV.

1 Publication1 Publication

Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH.

PROSITE-ProRule annotation1 Publication

Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069).

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833).

1 Publication1 Publication

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

1 Publication

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

1 Publication

May participate in viral replication by acting as a ssRNA-binding protein.

1 Publication

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.

1 Publication

Caution

Isolates SZ3 and SZ16 have been isolated from Paguma larvata and are described as SARS-like in literature.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
  • TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.1 Publication EC:3.4.22.69

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The kinetic parameters are studied for the 3C-like proteinase domain.
  1. KM=1.15 mM for peptide TSAVLQSGFRK-NH21 Publication
  2. KM=0.58 mM for peptide SGVTFQGKFKK1 Publication
  3. KM=1.44 mM for peptide ATVRLQAGNAT1 Publication

    pH dependencei

    Optimum pH is 7.0 for 3C-like proteinase activity.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1651For PL-PRO activityPROSITE-ProRule annotation1
    Active sitei1812For PL-PRO activityPROSITE-ProRule annotation1
    Active sitei3281For 3CL-PRO activityPROSITE-ProRule annotation1
    Active sitei3385For 3CL-PRO activityPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4304Zinc1
    Metal bindingi4304Zinc 1PROSITE-ProRule annotation1
    Metal bindingi4307Zinc1
    Metal bindingi4307Zinc 1PROSITE-ProRule annotation1
    Metal bindingi4313Zinc1
    Metal bindingi4313Zinc 1PROSITE-ProRule annotation1
    Metal bindingi4320Zinc1
    Metal bindingi4320Zinc 1PROSITE-ProRule annotation1
    Metal bindingi4347Zinc1
    Metal bindingi4347Zinc 2PROSITE-ProRule annotation1
    Metal bindingi4350Zinc1
    Metal bindingi4350Zinc 2PROSITE-ProRule annotation1
    Metal bindingi4358Zinc1
    Metal bindingi4358Zinc 2PROSITE-ProRule annotation1
    Metal bindingi4360Zinc 2PROSITE-ProRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
    Zinc fingeri4304 – 4320Add BLAST17
    Zinc fingeri4347 – 4360Add BLAST14

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionEndonuclease, Hydrolase, Nuclease, Protease, RNA-binding, Thiol protease
    Biological processActivation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF3 by virus, Inhibition of host ISG15 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-9679504, Translation of Replicase and Assembly of the Replication Transcription Complex
    R-HSA-9682706, Replication of the SARS-CoV-1 genome
    R-HSA-9682708, Transcription of SARS-CoV-1 sgRNAs
    R-HSA-9683439, Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
    R-HSA-9684325, Maturation of replicase proteins

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P0C6U8

    Protein family/group databases

    MEROPS protease database

    More...    MEROPSi    		C30.005

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Replicase polyprotein 1a
    Short name:
    pp1a
    Alternative name(s):
    ORF1a polyprotein
    Cleaved into the following 11 chains:
    Non-structural protein 1
    Short name:
    nsp1
    Alternative name(s):
    Leader protein
    Non-structural protein 2
    Short name:
    nsp2
    Alternative name(s):
    p65 homolog
    Non-structural protein 3 (EC:3.4.19.12, EC:3.4.22.-)
    Short name:
    nsp3
    Alternative name(s):
    PL2-PRO
    Papain-like proteinase
    Short name:
    PL-PRO
    Non-structural protein 4
    Short name:
    nsp4
    3C-like proteinase (EC:3.4.22.69)
    Short name:
    3CL-PRO
    Short name:
    3CLp
    Alternative name(s):
    Main protease
    Short name:
    Mpro
    Non-structural protein 5
    Short name:
    nsp5
    SARS coronavirus main proteinase
    Non-structural protein 6
    Short name:
    nsp6
    Non-structural protein 7
    Short name:
    nsp7
    Non-structural protein 8
    Short name:
    nsp8
    Non-structural protein 9
    Short name:
    nsp9
    Non-structural protein 10
    Short name:
    nsp10
    Alternative name(s):
    Growth factor-like peptide
    Short name:
    GFL
    Non-structural protein 11
    Short name:
    nsp11
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    ORF Names:1a
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSevere acute respiratory syndrome coronavirus (SARS-CoV)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri694009 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Paguma larvata (Masked palm civet) [TaxID: 9675]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    • host perinuclear region By similarity
      • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
    • host perinuclear region By similarity
      • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
    • host perinuclear region By similarity
      • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
    • host perinuclear region By similarity
      • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2202CytoplasmicCuratedAdd BLAST2202
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2203 – 2223HelicalSequence analysisAdd BLAST21
    Topological domaini2224 – 2303LumenalCuratedAdd BLAST80
    Transmembranei2304 – 2324HelicalSequence analysisAdd BLAST21
    Topological domaini2325 – 2350CytoplasmicCuratedAdd BLAST26
    Transmembranei2351 – 2371HelicalSequence analysisAdd BLAST21
    Topological domaini2372 – 2754LumenalCuratedAdd BLAST383
    Transmembranei2755 – 2775HelicalSequence analysisAdd BLAST21
    Topological domaini2776 – 2991CytoplasmicCuratedAdd BLAST216
    Transmembranei2992 – 3012HelicalSequence analysisAdd BLAST21
    Topological domaini3013 – 3021LumenalCurated9
    Transmembranei3022 – 3042HelicalSequence analysisAdd BLAST21
    Topological domaini3043 – 3053CytoplasmicCuratedAdd BLAST11
    Transmembranei3054 – 3074HelicalSequence analysisAdd BLAST21
    Topological domaini3075 – 3076LumenalCurated2
    Transmembranei3077 – 3097HelicalSequence analysisAdd BLAST21
    Topological domaini3098 – 3104CytoplasmicCurated7
    Transmembranei3105 – 3125HelicalSequence analysisAdd BLAST21
    Topological domaini3126 – 3141LumenalCuratedAdd BLAST16
    Transmembranei3142 – 3162HelicalSequence analysisAdd BLAST21
    Topological domaini3163 – 3563CytoplasmicCuratedAdd BLAST401
    Transmembranei3564 – 3584HelicalSequence analysisAdd BLAST21
    Topological domaini3585LumenalCurated1
    Transmembranei3586 – 3606HelicalSequence analysisAdd BLAST21
    Topological domaini3607 – 3611CytoplasmicCurated5
    Transmembranei3612 – 3632HelicalSequence analysisAdd BLAST21
    Topological domaini3633 – 3657LumenalCuratedAdd BLAST25
    Transmembranei3658 – 3678HelicalSequence analysisAdd BLAST21
    Topological domaini3679 – 3684CytoplasmicCurated6
    Transmembranei3685 – 3704HelicalSequence analysisAdd BLAST20
    Topological domaini3705 – 3727LumenalCuratedAdd BLAST23
    Transmembranei3728 – 3748HelicalSequence analysisAdd BLAST21
    Topological domaini3749 – 3755CytoplasmicCurated7
    Transmembranei3756 – 3776HelicalSequence analysisAdd BLAST21
    Topological domaini3777 – 4382LumenalCuratedAdd BLAST606

    Keywords - Cellular componenti

    Host cytoplasm, Host membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3927

    Drug and drug target database

    More...    DrugBanki    		DB07620, 2-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]-1,3-DINITRO-5-(TRIFLUOROMETHYL)BENZENE
    DB08732, NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE
    DB07743, S-[5-(TRIFLUOROMETHYL)-4H-1,2,4-TRIAZOL-3-YL] 5-(PHENYLETHYNYL)FURAN-2-CARBOTHIOATE

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003382541 – 4382Replicase polyprotein 1aAdd BLAST4382
    ChainiPRO_00003382551 – 180Non-structural protein 1By similarityAdd BLAST180
    ChainiPRO_0000338256181 – 818Non-structural protein 2By similarityAdd BLAST638
    ChainiPRO_0000338257819 – 2740Non-structural protein 3By similarityAdd BLAST1922
    ChainiPRO_00003382582741 – 3240Non-structural protein 4Sequence analysisAdd BLAST500
    ChainiPRO_00003382593241 – 35463C-like proteinaseBy similarityAdd BLAST306
    ChainiPRO_00003382603547 – 3836Non-structural protein 6By similarityAdd BLAST290
    ChainiPRO_00003382613837 – 3919Non-structural protein 7By similarityAdd BLAST83
    ChainiPRO_00003382623920 – 4117Non-structural protein 8By similarityAdd BLAST198
    ChainiPRO_00003382634118 – 4230Non-structural protein 9By similarityAdd BLAST113
    ChainiPRO_00003382644231 – 4369Non-structural protein 10By similarityAdd BLAST139
    ChainiPRO_00003382654370 – 4382Non-structural protein 11Sequence analysisAdd BLAST13

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei180 – 181CleavageBy similarity2
    Sitei818 – 819Cleavage; by PL-PROBy similarity2
    Sitei2740 – 2741Cleavage; by PL-PROBy similarity2
    Sitei3240 – 3241Cleavage; by 3CL-PROBy similarity2
    Sitei3546 – 3547Cleavage; by 3CL-PROBy similarity2
    Sitei3836 – 3837Cleavage; by 3CL-PROBy similarity2
    Sitei3919 – 3920Cleavage; by 3CL-PROBy similarity2
    Sitei4117 – 4118Cleavage; by 3CL-PROBy similarity2
    Sitei4230 – 4231Cleavage; by 3CL-PROBy similarity2
    Sitei4369 – 4370Cleavage; by 3CL-PROBy similarity2

    Proteomic databases

    PRoteomics IDEntifications database

    More...    PRIDEi    		P0C6U8

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with host PHB and PHB2.

    1 Publication

    Interacts with PL-PRO and nsp6.

    1 Publication

    Exists as monomer and homodimer. Only the homodimer shows catalytic activity.

    2 Publications

    Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure.

    1 Publication

    Interacts with ORF6 protein.

    1 Publication

    Homodimerizes.

    1 Publication

    Forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities.

    3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		4383937, 4 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-48580N

    Protein interaction database and analysis system

    More...    IntActi    		P0C6U8, 13 interactors

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P0C6U8

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    14382
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Biological Magnetic Resonance Data Bank

    More...    BMRBi    		P0C6U8

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P0C6U8

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P0C6U8

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 133CoV Nsp1 globularPROSITE-ProRule annotationAdd BLAST122
    Domaini148 – 179BetaCoV Nsp1 C-terminalPROSITE-ProRule annotationAdd BLAST32
    Domaini821 – 930Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST110
    Domaini1003 – 1169Macro 1PROSITE-ProRule annotationAdd BLAST167
    Domaini1207 – 1335Macro 2PROSITE-ProRule annotationAdd BLAST129
    Domaini1343 – 1470Macro 3PROSITE-ProRule annotationAdd BLAST128
    Domaini1472 – 1538DPUPPROSITE-ProRule annotationAdd BLAST67
    Domaini1542 – 1597Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST56
    Domaini1611 – 1875Peptidase C16PROSITE-ProRule annotationAdd BLAST265
    Domaini1888 – 1998Nucleic acid-bindingPROSITE-ProRule annotationAdd BLAST111
    Domaini3142 – 3240Nsp4CPROSITE-ProRule annotationAdd BLAST99
    Domaini3241 – 3546Peptidase C30PROSITE-ProRule annotationAdd BLAST306
    Domaini3837 – 3919RdRp Nsp7 cofactorPROSITE-ProRule annotationAdd BLAST83
    Domaini3920 – 4117RdRp Nsp8 cofactorPROSITE-ProRule annotationAdd BLAST198
    Domaini4118 – 4230Nsp9 ssRNA-bindingPROSITE-ProRule annotationAdd BLAST113
    Domaini4231 – 4369ExoN/MTase coactivatorPROSITE-ProRule annotationAdd BLAST139

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni972 – 1003DisorderedSequence analysisAdd BLAST32
    Regioni1175 – 1198DisorderedSequence analysisAdd BLAST24
    Regioni2092 – 2371HD1Add BLAST280
    Regioni2755 – 3162HD2Add BLAST408
    Regioni3564 – 3776HD3Add BLAST213

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi972 – 997Acidic residuesSequence analysisAdd BLAST26

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the coronaviruses polyprotein 1ab family.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri1729 – 1766C4-typePROSITE-ProRule annotationAdd BLAST38
    Zinc fingeri4304 – 4320Add BLAST17
    Zinc fingeri4347 – 4360Add BLAST14

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix, Zinc-finger

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd21560, betaCoV-Nsp6, 1 hit
    cd21666, betaCoV_Nsp5_Mpro, 1 hit
    cd21516, cv_beta_Nsp2_SARS-like, 1 hit
    cd21473, cv_Nsp4_TM, 1 hit
    cd21562, Macro_cv_SUD-N_Nsp3-like, 1 hit
    cd21557, Macro_X_Nsp3-like, 1 hit
    cd21525, SUD_C_SARS-CoV_Nsp3, 1 hit
    cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
    cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.150.420, 1 hit
    1.10.1840.10, 1 hit
    1.10.8.1190, 1 hit
    1.10.8.370, 1 hit
    2.30.30.590, 1 hit
    2.40.10.10, 2 hits
    2.40.10.250, 1 hit
    2.40.10.290, 1 hit
    3.10.20.350, 1 hit
    3.10.20.540, 1 hit
    3.40.220.10, 1 hit
    3.40.220.20, 1 hit
    3.40.220.30, 1 hit
    3.40.50.11020, 1 hit
    3.90.70.90, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR043613, CoV_NSP2_C
    IPR043611, CoV_NSP3_C
    IPR043612, CoV_NSP4_N
    IPR022733, DPUP_SUD_C_bCoV
    IPR002589, Macro_dom
    IPR043472, Macro_dom-like
    IPR044371, Macro_X_NSP3-like
    IPR042570, NAR_sf
    IPR036333, NSP10_sf_CoV
    IPR021590, NSP1_bCoV
    IPR038030, NSP1_sf_bCoV
    IPR043615, NSP2_N_CoV
    IPR044389, NSP2_SARS-CoV-like
    IPR024375, NSP3_bCoV
    IPR024358, NSP3_N_bCoV
    IPR032592, NSP3_NAR_bCoV
    IPR038166, NSP3_PL2pro_sf_CoV
    IPR038400, NSP3_SUD-M_sf_bCoV
    IPR043478, NSP3_SUD-N_bCoV
    IPR044374, NSP3_SUD-N_SARS-CoV
    IPR044357, NSP3_Ubl1_dom_CoV
    IPR044353, Nsp3_Ubl2_dom_CoV
    IPR038083, NSP3A-like
    IPR032505, NSP4_C_CoV
    IPR038123, NSP4_C_sf_CoV
    IPR044367, NSP6_betaCoV
    IPR043610, NSP6_CoV
    IPR014828, NSP7_CoV
    IPR037204, NSP7_sf_CoV
    IPR014829, NSP8_CoV-like
    IPR037230, NSP8_sf_CoV
    IPR014822, NSP9_CoV
    IPR036499, NSP9_sf_CoV
    IPR013016, Peptidase_C16_CoV
    IPR008740, Peptidase_C30_CoV
    IPR043477, Peptidase_C30_dom3_CoV
    IPR009003, Peptidase_S1_PA
    IPR043504, Peptidase_S1_PA_chymotrypsin
    IPR043177, PLpro_N_sf_CoV
    IPR043503, PLpro_palm_finger_dom_CoV
    IPR043178, PLpro_thumb_sf_CoV
    IPR018995, RNA_synth_NSP10_CoV

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF16251, bCoV_NAR, 1 hit
    PF11501, bCoV_NSP1, 1 hit
    PF12379, bCoV_NSP3_N, 1 hit
    PF12124, bCoV_SUD_C, 1 hit
    PF11633, bCoV_SUD_M, 1 hit
    PF09401, CoV_NSP10, 1 hit
    PF19212, CoV_NSP2_C, 1 hit
    PF19211, CoV_NSP2_N, 1 hit
    PF19218, CoV_NSP3_C, 1 hit
    PF16348, CoV_NSP4_C, 1 hit
    PF19217, CoV_NSP4_N, 1 hit
    PF19213, CoV_NSP6, 1 hit
    PF08716, CoV_NSP7, 1 hit
    PF08717, CoV_NSP8, 1 hit
    PF08710, CoV_NSP9, 1 hit
    PF08715, CoV_peptidase, 1 hit
    PF01661, Macro, 1 hit
    PF05409, Peptidase_C30, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00506, A1pp, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF101816, SSF101816, 1 hit
    SSF140367, SSF140367, 1 hit
    SSF143076, SSF143076, 1 hit
    SSF144246, SSF144246, 1 hit
    SSF159936, SSF159936, 1 hit
    SSF160099, SSF160099, 1 hit
    SSF50494, SSF50494, 1 hit
    SSF52949, SSF52949, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS51963, BCOV_NSP1_C, 1 hit
    PS51942, BCOV_NSP3C_C, 1 hit
    PS51941, BCOV_NSP3C_M, 1 hit
    PS51945, BCOV_NSP3E_NAB, 1 hit
    PS51952, COV_EXON_MTASE_COACT, 1 hit
    PS51962, COV_NSP1, 1 hit
    PS51943, COV_NSP3A_UBL, 1 hit
    PS51944, COV_NSP3D_UBL, 1 hit
    PS51946, COV_NSP4C, 1 hit
    PS51949, COV_NSP7, 1 hit
    PS51950, COV_NSP8, 1 hit
    PS51951, COV_NSP9_SSRNA_BD, 1 hit
    PS51442, M_PRO, 1 hit
    PS51154, MACRO, 1 hit
    PS51124, PEPTIDASE_C16, 1 hit
    PS51940, SARS_NSP3C_N, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
    Isoform Replicase polyprotein 1a (identifier: P0C6U8-1) [UniParc]FASTAAdd to basket
    Also known as: pp1a, ORF1a polyprotein

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT 
            60         70         80         90        100
    CGLVELEKGV LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS 
           110        120        130        140        150
    GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGDELG 
           160        170        180        190        200
    TDPIEDYEQN WNTKHGSGAL RELTRELNGG AVTRYVDNNF CGPDGYPLDC 
           210        220        230        240        250
    IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW FTERSDKSYE 
           260        270        280        290        300
    HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI 
           310        320        330        340        350
    RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV 
           360        370        380        390        400
    IEGPTTCGYL PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG 
           410        420        430        440        450
    GRTRCFGGCV FAYVGCYNKR AYWVPRASAD IGSGHTGITG DNVETLNEDL 
           460        470        480        490        500
    LEILSRERVN INIVGDFHLN EEVAIILASF SASTSAFIDT IKSLDYKSFK 
           510        520        530        540        550
    TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA AGVIRSIFAR 
           560        570        580        590        600
    TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY 
           610        620        630        640        650
    VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK 
           660        670        680        690        700
    FLITGVFDIV KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL 
           710        720        730        740        750
    RSLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV 
           760        770        780        790        800
    LTSEEVVLKN GELEALETPV DSFTNGAIVG TPVCVNGLML LEIKDKEQYC 
           810        820        830        840        850
    ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV RITFELDERV 
           860        870        880        890        900
    DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE 
           910        920        930        940        950
    WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE 
           960        970        980        990       1000
    YGTEDDYQGL PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE 
          1010       1020       1030       1040       1050
    EPVNQFTGYL KLTDNVAIKC VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA 
          1060       1070       1080       1090       1100
    GALNKATNGA MQKESDDYIK LNGPLTVGGS CLLSGHNLAK KCLHVVGPNL 
          1110       1120       1130       1140       1150
    NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL QVCVQTVRTQ 
          1160       1170       1180       1190       1200
    VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK 
          1210       1220       1230       1240       1250
    PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE 
          1260       1270       1280       1290       1300
    DMSFLEKDAP YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE 
          1310       1320       1330       1340       1350
    YITTYPGQGC AGYTLEEAKT ALKKCKSAFY VLPSEAPNAK EEILGTVSWN 
          1360       1370       1380       1390       1400
    LREMLAHAEE TRKLMPICMD VRAIMATIQR KYKGIKIQEG IVDYGVRFFF 
          1410       1420       1430       1440       1450
    YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR CMRSLKAPAV 
          1460       1470       1480       1490       1500
    VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG 
          1510       1520       1530       1540       1550
    VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT 
          1560       1570       1580       1590       1600
    VDNTNLHTQL VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS 
          1610       1620       1630       1640       1650
    DDTLRSEAFE YYHTLDESFL GRYMSALNHT KKWKFPQVGG LTSIKWADNN 
          1660       1670       1680       1690       1700
    CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR AGDAANFCAL ILAYSNKTVG 
          1710       1720       1730       1740       1750
    ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT GVEAVMYMGT 
          1760       1770       1780       1790       1800
    LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC 
          1810       1820       1830       1840       1850
    ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY 
          1860       1870       1880       1890       1900
    TTTIKPVSYK LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA 
          1910       1920       1930       1940       1950
    SFDNFKLTCS NTKFADDLNQ MTGFTKPASR ELSVTFFPDL NGDVVAIDYR 
          1960       1970       1980       1990       2000
    HYSASFKKGA KLLHKPIVWH INQATTKTTF KPNTWCLRCL WSTKPVDTSN 
          2010       2020       2030       2040       2050
    SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE CDVKTTEVVG 
          2060       2070       2080       2090       2100
    NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA 
          2110       2120       2130       2140       2150
    THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF 
          2160       2170       2180       2190       2200
    TLLFQLCTFT KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF 
          2210       2220       2230       2240       2250
    SKLFTIAMWL LLLSICLGSL ICVTAAFGVL LSNFGAPSYC NGVRELYLNS 
          2260       2270       2280       2290       2300
    SNVTTMDFCE GSFPCSICLS GLDSLDSYPA LETIQVTISS YKLDLTILGL 
          2310       2320       2330       2340       2350
    AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW LMWFIISIVQ 
          2360       2370       2380       2390       2400
    MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC 
          2410       2420       2430       2440       2450
    TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL 
          2460       2470       2480       2490       2500
    SLQFKRPINP TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN 
          2510       2520       2530       2540       2550
    LDNLRANNTK GSLPINVIVF DGKSKCDESA SKSASVYYSQ LMCQPILLLD 
          2560       2570       2580       2590       2600
    QALVSDVGDS TEVSVKMFDA YVDTFSATFS VPMEKLKALV ATAHSELAKG 
          2610       2620       2630       2640       2650
    VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL EVTGDSCNNF 
          2660       2670       2680       2690       2700
    MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE 
          2710       2720       2730       2740       2750
    QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM 
          2760       2770       2780       2790       2800
    LKATLLCVLA ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST 
          2810       2820       2830       2840       2850
    DDCFANKHAG FDAWFSQRGG SYKNDKSCPV VAAIITREIG FIVPGLPGTV 
          2860       2870       2880       2890       2900
    LRAINGDFLH FLPRVFSAVG NICYTPSKLI EYSDFATSAC VLAAECTIFK 
          2910       2920       2930       2940       2950
    DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ FPNTYLEGSV 
          2960       2970       2980       2990       3000
    RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA 
          3010       3020       3030       3040       3050
    MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE 
          3060       3070       3080       3090       3100
    YNHVVAANAL LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL 
          3110       3120       3130       3140       3150
    AHLQWFAMFS PIVPFWITAI YVFCISLKHC HWFFNNYLRK RVMFNGVTFS 
          3160       3170       3180       3190       3200
    TFEEAALCTF LLNKEMYLKL RSETLLPLTQ YNRYLALYNK YKYFSGALDT 
          3210       3220       3230       3240       3250
    TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ SGFRKMAFPS 
          3260       3270       3280       3290       3300
    GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR 
          3310       3320       3330       3340       3350
    KSNHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ 
          3360       3370       3380       3390       3400
    TFSVLACYNG SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC 
          3410       3420       3430       3440       3450
    YMHHMELPTG VHAGTDLEGK FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA 
          3460       3470       3480       3490       3500
    AVINGDRWFL NRFTTTLNDF NLVAMKYNYE PLTQDHVDIL GPLSAQTGIA 
          3510       3520       3530       3540       3550
    VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC SGVTFQGKFK 
          3560       3570       3580       3590       3600
    KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA 
          3610       3620       3630       3640       3650
    CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS 
          3660       3670       3680       3690       3700
    LSGYRLKDCV MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY 
          3710       3720       3730       3740       3750
    GNALDQAISM WALVISVTSN YSGVVTTIMF LARAIVFVCV EYYPLLFITG 
          3760       3770       3780       3790       3800
    NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY FRLTLGVYDY LVSTQEFRYM 
          3810       3820       3830       3840       3850
    NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS DVKCTSVVLL 
          3860       3870       3880       3890       3900
    SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG 
          3910       3920       3930       3940       3950
    AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS 
          3960       3970       3980       3990       4000
    EVVLKKLKKS LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA 
          4010       4020       4030       4040       4050
    KVTSAMQTML FTMLRKLDND ALNNIINNAR DGCVPLNIIP LTTAAKLMVV 
          4060       4070       4080       4090       4100
    VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD ADSKIVQLSE INMDNSPNLA 
          4110       4120       4130       4140       4150
    WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC TDDNALAYYN 
          4160       4170       4180       4190       4200
    NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP 
          4210       4220       4230       4240       4250
    KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA 
          4260       4270       4280       4290       4300
    VDPAKAYKDY LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG 
          4310       4320       4330       4340       4350
    ASCCLYCRCH IDHPNPKGFC DLKGKYVQIP TTCANDPVGF TLRNTVCTVC 
          4360       4370       4380 
    GMWKGYGCSC DQLREPLMQS ADASTFLNGF AV
    Note: Produced by conventional translation.
    Length:4,382
    Mass (Da):486,373
    Last modified:June 10, 2008 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1F65D5FD5DFF828
    GO
    Isoform Replicase polyprotein 1ab (identifier: P0C6X7-1) [UniParc]FASTAAdd to basket
    Also known as: pp1ab
    The sequence of this isoform can be found in the external entry P0C6X7.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:7,073
    Mass (Da):790,248
    GO

    <p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 21871 Da. Determined by ESI. 1 Publication
    Molecular mass is 12403 Da. Determined by ESI. 1 Publication
    Molecular mass is 14974 Da. Determined by ESI. 1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti82G → C in strain: Isolate GD01. 1
    Natural varianti130G → R in strain: Isolate GD01. 1
    Natural varianti138I → T in strain: Isolate SZ16. 1
    Natural varianti181A → V in strain: Isolate Shanghai LY. 1
    Natural varianti225K → Q in strain: Isolate GD01. 1
    Natural varianti249Y → C in strain: Isolate Shanghai LY. 1
    Natural varianti306V → F in strain: Isolate BJ04. 1
    Natural varianti549A → S in strain: Isolate SZ3. 1
    Natural varianti765A → T in strain: Isolate FRA and Isolate Frankfurt-1. 1
    Natural varianti852K → R in strain: Isolate SZ16. 1
    Natural varianti1004N → H in strain: Isolate BJ03. 1
    Natural varianti1021V → A in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1023I → T in strain: Isolate Shanghai QXC1. 1
    Natural varianti1121I → T in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1136P → L in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1257K → E in strain: Isolate Shanghai QXC1. 1
    Natural varianti1319K → R in strain: Isolate GD01. 1
    Natural varianti1329F → S in strain: Isolate GD01. 1
    Natural varianti1361T → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti1385I → V in strain: Isolate Shanghai QXC1. 1
    Natural varianti1538S → T in strain: Isolate GD01. 1
    Natural varianti1563M → K in strain: Isolate BJ02. 1
    Natural varianti1663L → I in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti1762I → L in strain: Isolate BJ03. 1
    Natural varianti1776 – 1777QQ → PP in strain: Isolate BJ03. 2
    Natural varianti1790E → G in strain: Isolate Shanghai QXC1. 1
    Natural varianti1806G → V in strain: Isolate BJ02. 1
    Natural varianti1962L → I in strain: Isolate BJ04. 1
    Natural varianti2116L → F in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2222C → Y in strain: Isolate GD01, Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2269L → S in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2326V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti2392 – 2394RNR → CNH in strain: Isolate Shanghai QXC1. 3
    Natural varianti2480L → P in strain: Isolate Shanghai QXC1. 1
    Natural varianti2552A → V in strain: Isolate Urbani and Isolate Taiwan TC2. 1
    Natural varianti2556D → N in strain: Isolate HKU-39849. 1
    Natural varianti2564S → P in strain: Isolate GD01. 1
    Natural varianti2648N → Y in strain: Isolate Shanghai QXC1. 1
    Natural varianti2708S → T in strain: Isolate HKU-39849. 1
    Natural varianti2718R → T in strain: Isolate HKU-39849. 1
    Natural varianti2746C → W in strain: Isolate SZ3 and Isolate SZ16. 1
    Natural varianti2770V → L in strain: Isolate BJ01 and Isolate BJ02. 1
    Natural varianti2944T → I in strain: Isolate SIN2500, Isolate GD01 and Isolate GZ50. 1
    Natural varianti2971V → A in strain: Isolate GD01 and Isolate SZ16. 1
    Natural varianti3020V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti3047V → A in strain: Isolate CUHK-W1, Isolate GD01, Isolate SZ3, Isolate SZ16, Isolate BJ01, Isolate BJ02, Isolate BJ03 and Isolate Shanghai QXC1. 1
    Natural varianti3072V → A in strain: Isolate CUHK-W1, Isolate SZ3, Isolate SZ16 and Isolate GD01. 1
    Natural varianti3197A → V in strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate Shanghai QXC1. 1
    Natural varianti3429Q → P in strain: Isolate BJ02. 1
    Natural varianti3488D → E in strain: Isolate BJ04. 1
    Natural varianti3717V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti3818N → T in strain: Isolate BJ04. 1
    Natural varianti3903D → N in strain: Isolate BJ03. 1
    Natural varianti3904I → F in strain: Isolate BJ02. 1
    Natural varianti3911M → V in strain: Isolate Shanghai QXC1. 1
    Natural varianti4001K → Q in strain: Isolate Shanghai LY. 1
    Natural varianti4003T → A in strain: Isolate Shanghai LY. 1
    Natural varianti4085I → H in strain: Isolate ZJ01. 1
    Natural varianti4114V → A in strain: Isolate Shanghai QXC1. 1
    Natural varianti4202V → M in strain: Isolate Shanghai QXC1. 1
    Natural varianti4240N → H in strain: Isolate ZJ01. 1
    Natural varianti4296E → G in strain: Isolate Shanghai QXC1. 1
    Natural varianti4377 – 4378LN → FK in strain: Isolate Shanghai QXC1. 2

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AY278741 Genomic RNA Translation: AAP13439.1
    AY274119 Genomic RNA No translation available.
    AY278554 Genomic RNA Translation: AAP13575.1
    AY282752 Genomic RNA Translation: AAP30712.1
    AY304495 Genomic RNA No translation available.
    AY304486 Genomic RNA No translation available.
    AY304488 Genomic RNA No translation available.
    AY278491 Genomic RNA No translation available.
    AY283794 Genomic RNA No translation available.
    AY283795 Genomic RNA No translation available.
    AY283796 Genomic RNA No translation available.
    AY283797 Genomic RNA No translation available.
    AY283798 Genomic RNA No translation available.
    AY286320 Genomic RNA Translation: AAR16181.1
    AY278488 Genomic RNA Translation: AAP30029.1
    AY278490 Genomic RNA No translation available.
    AY279354 Genomic RNA No translation available.
    AY278489 Genomic RNA Translation: AAP51226.1
    AY291451 Genomic RNA Translation: AAP37016.1
    AY310120 Genomic RNA Translation: AAP50484.1
    AY291315 Genomic RNA Translation: AAP33695.1
    AY323977 Genomic RNA Translation: AAP72974.2
    AY321118 Genomic RNA No translation available.
    AY338174 Genomic RNA Translation: AAQ01595.1
    AY338175 Genomic RNA Translation: AAQ01607.1
    AY348314 Genomic RNA Translation: AAP97880.1
    AP006557 Genomic RNA Translation: BAC81347.1
    AP006558 Genomic RNA Translation: BAC81361.1
    AP006559 Genomic RNA Translation: BAC81375.1
    AP006560 Genomic RNA Translation: BAC81389.1
    AP006561 Genomic RNA Translation: BAC81403.1
    AY427439 Genomic RNA Translation: AAQ94059.1
    AY322205 Genomic RNA Translation: AAP82966.1
    AY322206 Genomic RNA Translation: AAP82976.1
    AY463059 Genomic RNA No translation available.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AY278741 Genomic RNA Translation: AAP13439.1
    AY274119 Genomic RNA No translation available.
    AY278554 Genomic RNA Translation: AAP13575.1
    AY282752 Genomic RNA Translation: AAP30712.1
    AY304495 Genomic RNA No translation available.
    AY304486 Genomic RNA No translation available.
    AY304488 Genomic RNA No translation available.
    AY278491 Genomic RNA No translation available.
    AY283794 Genomic RNA No translation available.
    AY283795 Genomic RNA No translation available.
    AY283796 Genomic RNA No translation available.
    AY283797 Genomic RNA No translation available.
    AY283798 Genomic RNA No translation available.
    AY286320 Genomic RNA Translation: AAR16181.1
    AY278488 Genomic RNA Translation: AAP30029.1
    AY278490 Genomic RNA No translation available.
    AY279354 Genomic RNA No translation available.
    AY278489 Genomic RNA Translation: AAP51226.1
    AY291451 Genomic RNA Translation: AAP37016.1
    AY310120 Genomic RNA Translation: AAP50484.1
    AY291315 Genomic RNA Translation: AAP33695.1
    AY323977 Genomic RNA Translation: AAP72974.2
    AY321118 Genomic RNA No translation available.
    AY338174 Genomic RNA Translation: AAQ01595.1
    AY338175 Genomic RNA Translation: AAQ01607.1
    AY348314 Genomic RNA Translation: AAP97880.1
    AP006557 Genomic RNA Translation: BAC81347.1
    AP006558 Genomic RNA Translation: BAC81361.1
    AP006559 Genomic RNA Translation: BAC81375.1
    AP006560 Genomic RNA Translation: BAC81389.1
    AP006561 Genomic RNA Translation: BAC81403.1
    AY427439 Genomic RNA Translation: AAQ94059.1
    AY322205 Genomic RNA Translation: AAP82966.1
    AY322206 Genomic RNA Translation: AAP82976.1
    AY463059 Genomic RNA No translation available.

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1P76model-A3241-3541[»]
    B4225-4231[»]
    1P9Tmodel-A3241-3544[»]
    1PA5model-A3241-3546[»]
    1PUKmodel-A3241-3550[»]
    1Q1Xmodel-A3241-3542[»]
    1Q2WX-ray1.86A/B3241-3544[»]
    1QZ8X-ray2.70A/B4118-4230[»]
    1UJ1X-ray1.90A/B3241-3546[»]
    1UK2X-ray2.20A/B3241-3546[»]
    1UK3X-ray2.40A/B3241-3546[»]
    1UK4X-ray2.50A/B3241-3546[»]
    1UW7X-ray2.80A4118-4230[»]
    1WOFX-ray2.00A/B3241-3546[»]
    1YSYNMR-A3837-3919[»]
    1Z1IX-ray2.80A3241-3546[»]
    1Z1JX-ray2.80A/B3241-3546[»]
    2A5AX-ray2.08A3241-3546[»]
    2A5IX-ray1.88A3241-3546[»]
    2A5KX-ray2.30A/B3241-3546[»]
    2ACFX-ray1.40A/B/C/D1002-1176[»]
    2AHMX-ray2.40A/B/C/D3837-3919[»]
    E/F/G/H3920-4117[»]
    2AJ5model-A3241-3546[»]
    2ALVX-ray1.90A3241-3543[»]
    2AMDX-ray1.85A/B3241-3546[»]
    2AMQX-ray2.30A/B3241-3546[»]
    2BX3X-ray2.00A3241-3546[»]
    2BX4X-ray2.79A3241-3546[»]
    2C3SX-ray1.90A3241-3546[»]
    2D2DX-ray2.70A/B3241-3546[»]
    2DUCX-ray1.70A/B3241-3546[»]
    2FAVX-ray1.80A/B/C1000-1173[»]
    2FE8X-ray1.85A/B/C1541-1854[»]
    2FYGX-ray1.80A4240-4362[»]
    2G9TX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
    2GA6X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X4231-4382[»]
    2GDTNMR-A13-127[»]
    2GRINMR-A819-930[»]
    2GT7X-ray1.82A/B3241-3546[»]
    2GT8X-ray2.00A3241-3546[»]
    2GTBX-ray2.00A3241-3546[»]
    2GX4X-ray1.93A3241-3546[»]
    2GZ7X-ray1.86A3241-3546[»]
    2GZ8X-ray1.97A3241-3546[»]
    2GZ9X-ray2.17A3241-3546[»]
    2H2ZX-ray1.60A3241-3546[»]
    2HOBX-ray1.95A3241-3546[»]
    2HSXNMR-A13-127[»]
    2IDYNMR-A819-930[»]
    2KAFNMR-A1473-1538[»]
    2KQVNMR-A1345-1538[»]
    2KQWNMR-A1345-1538[»]
    2KYSNMR-A3837-3919[»]
    2LIZNMR-A3427-3546[»]
    2OP9X-ray1.80A/B3241-3541[»]
    2PWXX-ray2.50A3241-3546[»]
    2W2GX-ray2.22A/B1207-1470[»]
    2WCTX-ray2.79A/B/C/D1207-1470[»]
    2Z3CX-ray1.79A3241-3546[»]
    2Z3DX-ray2.10A3241-3546[»]
    2Z3EX-ray2.32A3241-3546[»]
    2ZU4X-ray1.93A3241-3546[»]
    2ZU5X-ray1.65A3241-3546[»]
    3ATWX-ray2.36A/B3241-3546[»]
    3AVZX-ray2.46A3241-3546[»]
    3AW0X-ray2.30A3241-3546[»]
    3AW1X-ray2.00A/B3241-3546[»]
    3E91X-ray2.55A/B3241-3546[»]
    3EA7X-ray2.65A/B3241-3546[»]
    3EA8X-ray2.25A3241-3546[»]
    3EA9X-ray2.40A3241-3546[»]
    3EAJX-ray2.70A/B3241-3546[»]
    3EE7X-ray2.60A/B/C/D4118-4230[»]
    3F9EX-ray2.50A3241-3546[»]
    3F9FX-ray2.30A/B3241-3546[»]
    3F9GX-ray2.60A/B3241-3541[»]
    3F9HX-ray2.90A/B3241-3546[»]
    3FZDX-ray2.35A3241-3541[»]
    3IWMX-ray3.20A/B/C/D3241-3546[»]
    3M3SX-ray2.30A/B3241-3546[»]
    3M3TX-ray2.90A3241-3546[»]
    3M3VX-ray2.70A/B3241-3546[»]
    3MJ5X-ray2.63A/B1541-1855[»]
    3R24X-ray2.00B4240-4382[»]
    3SN8X-ray1.99A3241-3546[»]
    3SNAX-ray3.05A3241-3541[»]
    3SNBX-ray2.40A3241-3546[»]
    3SNCX-ray2.58A3241-3546[»]
    3SNDX-ray1.89A/B3241-3546[»]
    3SNEX-ray2.60A3241-3546[»]
    3SZNX-ray1.69A3241-3546[»]
    3TITX-ray1.99A3241-3546[»]
    3TIUX-ray2.08A3241-3546[»]
    3TNSX-ray1.99A3241-3546[»]
    3TNTX-ray1.59A3241-3546[»]
    3V3MX-ray1.96A3241-3546[»]
    3VB3X-ray2.20A/B3241-3546[»]
    3VB4X-ray2.20A/B3241-3546[»]
    3VB5X-ray1.95A/B3241-3546[»]
    3VB6X-ray2.50A/B3241-3546[»]
    3VB7X-ray1.95A/B3241-3546[»]
    4HI3X-ray2.09A/B3241-3546[»]
    4M0WX-ray1.40A1541-1858[»]
    4MDSX-ray1.60A3241-3542[»]
    4MM3X-ray2.75B1541-1855[»]
    4OVZX-ray2.50A/B1541-1855[»]
    4OW0X-ray2.10A/B1541-1855[»]
    5F22X-ray2.15A3837-3919[»]
    5Y3EX-ray1.65A1541-1854[»]
    5Y3QX-ray1.65A1541-1854[»]
    6LNYX-ray2.25A3241-3546[»]
    6LO0X-ray1.94A3241-3546[»]
    6NURelectron microscopy3.10B/D3920-4117[»]
    6NUSelectron microscopy3.50B3920-4117[»]
    6W2AX-ray1.65A/B3241-3543[»]
    6XHLX-ray1.47A/B3241-3546[»]
    6XHNX-ray1.38A/B3241-3546[»]
    6XHOX-ray1.45A/B3241-3546[»]
    6Y7MX-ray1.90AAA3241-3546[»]
    BMRBiP0C6U8
    SMRiP0C6U8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi4383937, 4 interactors
    DIPiDIP-48580N
    IntActiP0C6U8, 13 interactors

    Chemistry databases

    BindingDBiP0C6U8
    ChEMBLiCHEMBL3927
    DrugBankiDB07620, 2-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]-1,3-DINITRO-5-(TRIFLUOROMETHYL)BENZENE
    DB08732, NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE
    DB07743, S-[5-(TRIFLUOROMETHYL)-4H-1,2,4-TRIAZOL-3-YL] 5-(PHENYLETHYNYL)FURAN-2-CARBOTHIOATE

    Protein family/group databases

    MEROPSiC30.005

    Proteomic databases

    PRIDEiP0C6U8

    Enzyme and pathway databases

    ReactomeiR-HSA-9679504, Translation of Replicase and Assembly of the Replication Transcription Complex
    R-HSA-9682706, Replication of the SARS-CoV-1 genome
    R-HSA-9682708, Transcription of SARS-CoV-1 sgRNAs
    R-HSA-9683439, Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
    R-HSA-9684325, Maturation of replicase proteins
    SABIO-RKiP0C6U8

    Miscellaneous databases

    EvolutionaryTraceiP0C6U8

    Family and domain databases

    CDDicd21560, betaCoV-Nsp6, 1 hit
    cd21666, betaCoV_Nsp5_Mpro, 1 hit
    cd21516, cv_beta_Nsp2_SARS-like, 1 hit
    cd21473, cv_Nsp4_TM, 1 hit
    cd21562, Macro_cv_SUD-N_Nsp3-like, 1 hit
    cd21557, Macro_X_Nsp3-like, 1 hit
    cd21525, SUD_C_SARS-CoV_Nsp3, 1 hit
    cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
    cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
    Gene3Di1.10.150.420, 1 hit
    1.10.1840.10, 1 hit
    1.10.8.1190, 1 hit
    1.10.8.370, 1 hit
    2.30.30.590, 1 hit
    2.40.10.10, 2 hits
    2.40.10.250, 1 hit
    2.40.10.290, 1 hit
    3.10.20.350, 1 hit
    3.10.20.540, 1 hit
    3.40.220.10, 1 hit
    3.40.220.20, 1 hit
    3.40.220.30, 1 hit
    3.40.50.11020, 1 hit
    3.90.70.90, 1 hit
    InterProiView protein in InterPro
    IPR043613, CoV_NSP2_C
    IPR043611, CoV_NSP3_C
    IPR043612, CoV_NSP4_N
    IPR022733, DPUP_SUD_C_bCoV
    IPR002589, Macro_dom
    IPR043472, Macro_dom-like
    IPR044371, Macro_X_NSP3-like
    IPR042570, NAR_sf
    IPR036333, NSP10_sf_CoV
    IPR021590, NSP1_bCoV
    IPR038030, NSP1_sf_bCoV
    IPR043615, NSP2_N_CoV
    IPR044389, NSP2_SARS-CoV-like
    IPR024375, NSP3_bCoV
    IPR024358, NSP3_N_bCoV
    IPR032592, NSP3_NAR_bCoV
    IPR038166, NSP3_PL2pro_sf_CoV
    IPR038400, NSP3_SUD-M_sf_bCoV
    IPR043478, NSP3_SUD-N_bCoV
    IPR044374, NSP3_SUD-N_SARS-CoV
    IPR044357, NSP3_Ubl1_dom_CoV
    IPR044353, Nsp3_Ubl2_dom_CoV
    IPR038083, NSP3A-like
    IPR032505, NSP4_C_CoV
    IPR038123, NSP4_C_sf_CoV
    IPR044367, NSP6_betaCoV
    IPR043610, NSP6_CoV
    IPR014828, NSP7_CoV
    IPR037204, NSP7_sf_CoV
    IPR014829, NSP8_CoV-like
    IPR037230, NSP8_sf_CoV
    IPR014822, NSP9_CoV
    IPR036499, NSP9_sf_CoV
    IPR013016, Peptidase_C16_CoV
    IPR008740, Peptidase_C30_CoV
    IPR043477, Peptidase_C30_dom3_CoV
    IPR009003, Peptidase_S1_PA
    IPR043504, Peptidase_S1_PA_chymotrypsin
    IPR043177, PLpro_N_sf_CoV
    IPR043503, PLpro_palm_finger_dom_CoV
    IPR043178, PLpro_thumb_sf_CoV
    IPR018995, RNA_synth_NSP10_CoV
    PfamiView protein in Pfam
    PF16251, bCoV_NAR, 1 hit
    PF11501, bCoV_NSP1, 1 hit
    PF12379, bCoV_NSP3_N, 1 hit
    PF12124, bCoV_SUD_C, 1 hit
    PF11633, bCoV_SUD_M, 1 hit
    PF09401, CoV_NSP10, 1 hit
    PF19212, CoV_NSP2_C, 1 hit
    PF19211, CoV_NSP2_N, 1 hit
    PF19218, CoV_NSP3_C, 1 hit
    PF16348, CoV_NSP4_C, 1 hit
    PF19217, CoV_NSP4_N, 1 hit
    PF19213, CoV_NSP6, 1 hit
    PF08716, CoV_NSP7, 1 hit
    PF08717, CoV_NSP8, 1 hit
    PF08710, CoV_NSP9, 1 hit
    PF08715, CoV_peptidase, 1 hit
    PF01661, Macro, 1 hit
    PF05409, Peptidase_C30, 1 hit
    SMARTiView protein in SMART
    SM00506, A1pp, 1 hit
    SUPFAMiSSF101816, SSF101816, 1 hit
    SSF140367, SSF140367, 1 hit
    SSF143076, SSF143076, 1 hit
    SSF144246, SSF144246, 1 hit
    SSF159936, SSF159936, 1 hit
    SSF160099, SSF160099, 1 hit
    SSF50494, SSF50494, 1 hit
    SSF52949, SSF52949, 1 hit
    PROSITEiView protein in PROSITE
    PS51963, BCOV_NSP1_C, 1 hit
    PS51942, BCOV_NSP3C_C, 1 hit
    PS51941, BCOV_NSP3C_M, 1 hit
    PS51945, BCOV_NSP3E_NAB, 1 hit
    PS51952, COV_EXON_MTASE_COACT, 1 hit
    PS51962, COV_NSP1, 1 hit
    PS51943, COV_NSP3A_UBL, 1 hit
    PS51944, COV_NSP3D_UBL, 1 hit
    PS51946, COV_NSP4C, 1 hit
    PS51949, COV_NSP7, 1 hit
    PS51950, COV_NSP8, 1 hit
    PS51951, COV_NSP9_SSRNA_BD, 1 hit
    PS51442, M_PRO, 1 hit
    PS51154, MACRO, 1 hit
    PS51124, PEPTIDASE_C16, 1 hit
    PS51940, SARS_NSP3C_N, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1A_SARS
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6U8
    Secondary accession number(s): P59641
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: June 2, 2021
    This is version 106 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
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