UniProtKB - P0C6U6 (R1A_CVHNL)
Protein
Replicase polyprotein 1a
Gene
1a
Organism
Human coronavirus NL63 (HCoV-NL63)
Status
Functioni
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.1 Publication
Responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).PROSITE-ProRule annotation
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1062 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1212 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1678 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1836 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 2980 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3083 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1134 – 1165 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 1757 – 1788 | C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 3982 – 3998 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4024 – 4037 | By similarityAdd BLAST | 14 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
- RNA binding Source: UniProtKB-KW
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- transferase activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- induction by virus of host autophagy Source: UniProtKB-KW
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host IRF3 activity Source: UniProtKB-KW
- viral genome replication Source: InterPro
- viral protein processing Source: InterPro
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1aShort name: pp1a Alternative name(s): ORF1a polyprotein Cleaved into the following 11 chains: Alternative name(s): p9 Alternative name(s): p87 Alternative name(s): PL1-PRO/PL2-PRO PLP1/PLP2 Papain-like proteinases 1/2 p195 Alternative name(s): Peptide HD2 Alternative name(s): M-PRO nsp5 p34 Alternative name(s): p5 Alternative name(s): p23 Alternative name(s): p12 Alternative name(s): Growth factor-like peptide Short name: GFL p14 |
Gene namesi | ORF Names:1a |
Organismi | Human coronavirus NL63 (HCoV-NL63) |
Taxonomic identifieri | 277944 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Alphacoronavirus › Setracovirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1903 – 1923 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1968 – 1988 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2050 – 2070 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2073 – 2093 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2111 – 2131 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2468 – 2488 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2727 – 2747 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2752 – 2769 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 2772 – 2792 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2800 – 2820 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3254 – 3274 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3279 – 3299 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3303 – 3323 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3342 – 3362 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3376 – 3396 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3397 – 3417 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3442 – 3462 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cytoplasm, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000338230 | 1 – 4060 | Replicase polyprotein 1aAdd BLAST | 4060 | |
ChainiPRO_0000338231 | 1 – 110 | Non-structural protein 1By similarityAdd BLAST | 110 | |
ChainiPRO_0000338232 | 111 – 898 | Non-structural protein 2By similarityAdd BLAST | 788 | |
ChainiPRO_0000338233 | 899 – 2462 | Non-structural protein 3By similarityAdd BLAST | 1564 | |
ChainiPRO_0000338234 | 2463 – 2939 | Non-structural protein 4By similarityAdd BLAST | 477 | |
ChainiPRO_0000338235 | 2940 – 3242 | 3C-like proteinaseBy similarityAdd BLAST | 303 | |
ChainiPRO_0000338236 | 3243 – 3521 | Non-structural protein 6By similarityAdd BLAST | 279 | |
ChainiPRO_0000338237 | 3522 – 3604 | Non-structural protein 7By similarityAdd BLAST | 83 | |
ChainiPRO_0000338238 | 3605 – 3799 | Non-structural protein 8By similarityAdd BLAST | 195 | |
ChainiPRO_0000338239 | 3800 – 3908 | Non-structural protein 9By similarityAdd BLAST | 109 | |
ChainiPRO_0000338240 | 3909 – 4043 | Non-structural protein 10By similarityAdd BLAST | 135 | |
ChainiPRO_0000338241 | 4044 – 4060 | Non-structural protein 11Sequence analysisAdd BLAST | 17 |
Post-translational modificationi
Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 110 – 111 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 898 – 899 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 2462 – 2463 | Cleavage; by PL2-PROBy similarity | 2 | |
Sitei | 2939 – 2940 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3242 – 3243 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3521 – 3522 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3604 – 3605 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3799 – 3800 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3908 – 3909 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4043 – 4044 | Cleavage; by 3CL-PROBy similarity | 2 |
Proteomic databases
PRIDEi | P0C6U6 |
Interactioni
Subunit structurei
3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).
By similarityChemistry databases
BindingDBi | P0C6U6 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0C6U6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0C6U6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1021 – 1262 | Peptidase C16 1PROSITE-ProRule annotationAdd BLAST | 242 | |
Domaini | 1263 – 1421 | MacroPROSITE-ProRule annotationAdd BLAST | 159 | |
Domaini | 1640 – 1886 | Peptidase C16 2PROSITE-ProRule annotationAdd BLAST | 247 | |
Domaini | 2940 – 3242 | Peptidase C30PROSITE-ProRule annotationAdd BLAST | 303 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1903 – 2131 | HD1By similarityAdd BLAST | 229 | |
Regioni | 2468 – 2820 | HD2By similarityAdd BLAST | 353 | |
Regioni | 3254 – 3462 | HD3By similarityAdd BLAST | 209 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 625 – 628 | Poly-Leu | 4 | |
Compositional biasi | 1975 – 1978 | Poly-Leu | 4 |
Domaini
The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.
Sequence similaritiesi
Belongs to the coronaviruses polyprotein 1ab family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1134 – 1165 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 1757 – 1788 | C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 3982 – 3998 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4024 – 4037 | By similarityAdd BLAST | 14 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerFamily and domain databases
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.370, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.40.220.10, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR011050, Pectin_lyase_fold/virulence IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043503, PLpro_palm_finger_dom_CoV IPR018995, RNA_synth_NSP10_CoV |
Pfami | View protein in Pfam PF09401, CoV_NSP10, 1 hit PF19212, CoV_NSP2_C, 2 hits PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 2 hits PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF50494, SSF50494, 1 hit SSF51126, SSF51126, 1 hit SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketIsoform Replicase polyprotein 1a (identifier: P0C6U6-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFYNQVTLAV ASDSEISGFG FAIPSVAVRT YSEAAAQGFQ ACRFVAFGLQ
60 70 80 90 100
DCVTGINDDD YVIALTGTNQ LCAKILPFSD RPLNLRGWLI FSNSNYVLQD
110 120 130 140 150
FDVVFGHGAG SVVFVDKYMC GFDGKPVLPK NMWEFRDYFN NNTDSIVIGG
160 170 180 190 200
VTYQLAWDVI RKDLSYEQQN VLAIESIHYL GTTGHTLKSG CKLTNAKPPK
210 220 230 240 250
YSSKVVLSGE WNAVYRAFGS PFITNGMSLL DIIVKPVFFN AFVKCNCGSE
260 270 280 290 300
SWSVGAWDGY LSSCCGTPAK KLCVVPGNVV PGDVIITSTS AGCGVKYYAG
310 320 330 340 350
LVVKHITNIT GVSLWRVTAV HSDGMFVASS SYDALLHRNS LDPFCFDVNT
360 370 380 390 400
LLSNQLRLAF LGASVTEDVK FAASTGVIDI SAGMFGLYDD ILTNNKPWFV
410 420 430 440 450
RKASGLFDAI WDAFVAAIKL VPTTTGVLVR FVKSIASTVL TVSNGVIIMC
460 470 480 490 500
ADVPDAFQSV YRTFTQAICA AFDFSLDVFK IGDVKFKRLG DYVLTENALV
510 520 530 540 550
RLTTEVVRGV RDARIKKAMF TKVVVGPTTE VKFSVIELAT VNLRLVDCAP
560 570 580 590 600
VVCPKGKIVV IAGQAFFYSG GFYRFMVDPT TVLNDPVFTG DLFYTIKFSG
610 620 630 640 650
FKLDGFNHQF VTASSATDAI IAVELLLLDF KTAVFVYTCV VDGCSVIVRR
660 670 680 690 700
DATFATHVCF KDCYNVWEQF CIDNCGEPWF LTDYNAILQS NNPQCAIVQA
710 720 730 740 750
SESKVLLERF LPKCPEILLS IDDGHLWNLF VEKFNFVTDW LKTLKLTLTS
760 770 780 790 800
NGLLGNCAKR FRRVLVKLLD VYNGFLETVC SVAYTAGVCI KYYAVNVPYV
810 820 830 840 850
VISGFVSRVI RRERCDMTFP CVSCVTFFYE FLDTCFGVSK PNAIDVEHLE
860 870 880 890 900
LKETVFVEPK DGGQFFVSGD YLWYVVDDIY YPASCNGVLP VAFTKLAGGK
910 920 930 940 950
ISFSDDVIVH DVEPTHKVKL IFEFEDDVVT SLCKKSFGKS IIYTGDWEGL
960 970 980 990 1000
HEVLTSAMNV IGQHIKLPQF YIYDEEGGYD VSKPVMISQW PISNDSNGCV
1010 1020 1030 1040 1050
VEASTDFHQL ECIVDDSVRE EVDIIEQPFE EVEHVLSIKQ PFSFSFRDEL
1060 1070 1080 1090 1100
GVRVLDQSDN NCWISTTLVQ LQLTKLLDDS IEMQLFKVGK VDSIVQKCYE
1110 1120 1130 1140 1150
LSHLISGSLG DSGKLLSELL KEKYTCSITF EMSCDCGKKF DDQVGCLFWI
1160 1170 1180 1190 1200
MPYTKLFQKG ECCICHKMQT YKLVSMKGTG VFVQDPAPID IDAFPVKPIC
1210 1220 1230 1240 1250
SSVYLGVKGS GHYQTNLYSF NKAIDGFGVF DIKNSSVNTV CFVDVDFHSV
1260 1270 1280 1290 1300
EIEAGEVKPF AVYKNVKFYL GDISHLVNCV SFDFVVNAAN ENLLHGGGVA
1310 1320 1330 1340 1350
RAIDILTEGQ LQSLSKDYIS SNGPLKVGAG VMLECEKFNV FNVVGPRTGK
1360 1370 1380 1390 1400
HEHSLLVEAY NSILFENGIP LMPLLSCGIF GVRIENSLKA LFSCDINKPL
1410 1420 1430 1440 1450
QVFVYSSNEE QAVLKFLDGL DLTPVIDDVD VVKPFRVEGN FSFFDCGVNA
1460 1470 1480 1490 1500
LDGDIYLLFT NSILMLDKQG QLLDTKLNGI LQQAALDYLA TVKTVPAGNL
1510 1520 1530 1540 1550
VKLFVESCTI YMCVVPSIND LSFDKNLGRC VRKLNRLKTC VIANVPAIDV
1560 1570 1580 1590 1600
LKKLLSSLTL TVKFVVESNV MDVNDCFKND NVVLKITEDG INVKDVVVES
1610 1620 1630 1640 1650
SKSLGKQLGV VSDGVDSFEG VLPINTDTVL SVAPEVDWVA FYGFEKAALF
1660 1670 1680 1690 1700
ASLDVKPYGY PNDFVGGFRV LGTTDNNCWV NATCIILQYL KPTFKSKGLN
1710 1720 1730 1740 1750
VLWNKFVTGD VGPFVSFIYF ITMSSKGQKG DAEEALSKLS EYLISDSIVT
1760 1770 1780 1790 1800
LEQYSTCDIC KSTVVEVKSA IVCASVLKDG CDVGFCPHRH KLRSRVKFVN
1810 1820 1830 1840 1850
GRVVITNVGE PIISQPSKLL NGIAYTTFSG SFDNGHYVVY DAANNAVYDG
1860 1870 1880 1890 1900
ARLFSSDLST LAVTAIVVVG GCVTSNVPTI VSEKISVMDK LDTGAQKFFQ
1910 1920 1930 1940 1950
FGDFVMNNIV LFLTWLLSMF SLLRTSIMKH DIKVIAKAPK RTGVILTRSF
1960 1970 1980 1990 2000
KYNIRSALFV IKQKWCVIVT LFKFLLLLYA IYALVFMIVQ FSPFNSLLCG
2010 2020 2030 2040 2050
DIVSGYEKST FNKDIYCGNS MVCKMCLFSY QEFNDLDHTS LVWKHIRDPI
2060 2070 2080 2090 2100
LISLQPFVIL VILLIFGNMY LRFGLLYFVA QFISTFGSFL GFHQKQWFLH
2110 2120 2130 2140 2150
FVPFDVLCNE FLATFIVCKI VLFVRHIIVG CNNADCVACS KSARLKRVPL
2160 2170 2180 2190 2200
QTIINGMHKS FYVNANGGTC FCNKHNFFCV NCDSFGPGNT FINGDIAREL
2210 2220 2230 2240 2250
GNVVKTAVQP TAPAYVIIDK VDFVNGFYRL YSGDTFWRYD FDITESKYSC
2260 2270 2280 2290 2300
KEVLKNCNVL ENFIVYNNSG SNITQIKNAC VYFSQLLCEP IKLVNSELLS
2310 2320 2330 2340 2350
TLSVDFNGVL HKAYVDVLCN SFFKELTANM SMAECKATLG LTVSDDDFVS
2360 2370 2380 2390 2400
AVANAHRYDV LLSDLSFNNF FISYAKPEDK LSVYDIACCM RAGSKVVNHN
2410 2420 2430 2440 2450
VLIKESIPIV WGVKDFNTLS QEGKKYLVKT TKAKGLTFLL TFNDNQAITQ
2460 2470 2480 2490 2500
VPATSIVAKQ GAGFKRTYNF LWYVCLFVVA LFIGVSFIDY TTTVTSFHGY
2510 2520 2530 2540 2550
DFKYIENGQL KVFEAPLHCV RNVFDNFNQW HEAKFGVVTT NSDKCPIVVG
2560 2570 2580 2590 2600
VSERINVVPG VPTNVYLVGK TLVFTLQAAF GNTGVCYDFD GVTTSDKCIF
2610 2620 2630 2640 2650
NSACTRLEGL GGDNVYCYNT DLIEGSKPYS TLQPNAYYKY DAKNYVRFPE
2660 2670 2680 2690 2700
ILARGFGLRT IRTLATRYCR VGECRDSHKG VCFGFDKWYV NDGRVDDGYI
2710 2720 2730 2740 2750
CGDGLIDLLV NVLSIFSSSF SVVAMSGHML FNFLFAAFIT FLCFLVTKFK
2760 2770 2780 2790 2800
RVFGDLSYGV FTVVCATLIN NISYVVTQNL FFMLLYAILY FVFTRTVRYA
2810 2820 2830 2840 2850
WIWHIAYIVA YFLLIPWWLL TWFSFAAFLE LLPNVFKLKI STQLFEGDKF
2860 2870 2880 2890 2900
IGTFESAAAG TFVLDMRSYE RLINTISPEK LKNYAASYNK YKYYSGSASE
2910 2920 2930 2940 2950
ADYRCACYAH LAKAMLDYAK DHNDMLYSPP TISYNSTLQS GLKKMAQPSG
2960 2970 2980 2990 3000
CVERCVVRVC YGSTVLNGVW LGDTVTCPRH VIAPSTTVLI DYDHAYSTMR
3010 3020 3030 3040 3050
LHNFSVSHNG VFLGVVGVTM HGSVLRIKVS QSNVHTPKHV FKTLKPGDSF
3060 3070 3080 3090 3100
NILACYEGIA SGVFGVNLRT NFTIKGSFIN GACGSPGYNV RNDGTVEFCY
3110 3120 3130 3140 3150
LHQIELGSGA HVGSDFTGSV YGNFDDQPSL QVESANLMLS DNVVAFLYAA
3160 3170 3180 3190 3200
LLNGCRWWLC STRVNVDGFN EWAMANGYTS VSSVECYSIL AAKTGVSVEQ
3210 3220 3230 3240 3250
LLASIQHLHE GFGGKNILGY SSLCDEFTLA EVVKQMYGVN LQSGKVIFGL
3260 3270 3280 3290 3300
KTMFLFSVFF TMFWAELFIY TNTIWINPVI LTPIFCLLLF LSLVLTMFLK
3310 3320 3330 3340 3350
HKFLFLQVFL LPTVIATALY NCVLDYYIVK FLADHFNYNV SVLQMDVQGL
3360 3370 3380 3390 3400
VNVLVCLFVV FLHTWRFSKE RFTHWFTYVC SLIAVAYTYF YSGDFLSLLV
3410 3420 3430 3440 3450
MFLCAISSDW YIGAIVFRLS RLIVFFSPES VFSVFGDVKL TLVVYLICGY
3460 3470 3480 3490 3500
LVCTYWGILY WFNRFFKCTM GVYDFKVSAA EFKYMVANGL HAPHGPFDAL
3510 3520 3530 3540 3550
WLSFKLLGIG GDRCIKISTV QSKLTDLKCT NVVLLGCLSS MNIAANSSEW
3560 3570 3580 3590 3600
AYCVDLHNKI NLCDDPEKAQ SMLLALLAFF LSKHSDFGLD GLIDSYFDNS
3610 3620 3630 3640 3650
STLQSVASSF VSMPSYIAYE NARQAYEDAI ANGSSSQLIK QLKRAMNIAK
3660 3670 3680 3690 3700
SEFDHEISVQ KKINRMAEQA ATQMYKEARS VNRKSKVISA MHSLLFGMLR
3710 3720 3730 3740 3750
RLDMSSVETV LNLARDGVVP LSVIPATSAS KLTIVSPDLE SYSKIVCDGS
3760 3770 3780 3790 3800
VHYAGVVWTL NDVKDNDGRP VHVKEITKEN VETLTWPLIL NCERVVKLQN
3810 3820 3830 3840 3850
NEIMPGKLKQ KPMKAEGDGG VLGDGNALYN TEGGKTFMYA YISNKADLKF
3860 3870 3880 3890 3900
VKWEYEGGCN TIELDSPCRF MVETPNGPQV KYLYFVKNLN TLRRGAVLGF
3910 3920 3930 3940 3950
IGATIRLQAG KQTELAVNSG LLTACAFSVD PATTYLEAVK HGAKPVSNCI
3960 3970 3980 3990 4000
KMLSNGAGNG QAITTSVDAN TNQDSYGGAS ICLYCRAHVP HPSMDGYCKF
4010 4020 4030 4040 4050
KGKCVQVPIG CLDPIRFCLE NNVCNVCGCW LGHGCACDRT TIQSVDISYL
4060
NEQGVLVQLD
Note: Produced by conventional translation.
Isoform Replicase polyprotein 1ab (identifier: P0C6X5-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
The sequence of this isoform can be found in the external entry P0C6X5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY567487 Genomic RNA No translation available. |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY567487 Genomic RNA No translation available. |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VRI | X-ray | 1.80 | A | 1258-1421 | [»] | |
3TLO | X-ray | 1.60 | A/B | 2940-3242 | [»] | |
5GWY | X-ray | 2.85 | A/B | 2940-3242 | [»] | |
SMRi | P0C6U6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | P0C6U6 |
ChEMBLi | CHEMBL3232683 |
Proteomic databases
PRIDEi | P0C6U6 |
Miscellaneous databases
EvolutionaryTracei | P0C6U6 |
Family and domain databases
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.370, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.40.220.10, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR011050, Pectin_lyase_fold/virulence IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043503, PLpro_palm_finger_dom_CoV IPR018995, RNA_synth_NSP10_CoV |
Pfami | View protein in Pfam PF09401, CoV_NSP10, 1 hit PF19212, CoV_NSP2_C, 2 hits PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 2 hits PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF50494, SSF50494, 1 hit SSF51126, SSF51126, 1 hit SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1A_CVHNL | |
Accessioni | P0C6U6Primary (citable) accession number: P0C6U6 Secondary accession number(s): Q6Q1S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | December 2, 2020 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families