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UniProtKB - P0C6T7 (R1A_BCRP3)

Entry version 77 (02 Dec 2020)
Sequence version 1 (10 Jun 2008)
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Protein

Replicase polyprotein 1a

Gene

1a

Organism
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity).By similarity
Responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).PROSITE-ProRule annotation
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (By similarity).By similarity

Miscellaneous

Bat coronavirus rp3 is highly similar to SARS-CoV (SARS-like).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1649For PL-PRO activityPROSITE-ProRule annotation1
Active sitei1810For PL-PRO activityPROSITE-ProRule annotation1
Active sitei3279For 3CL-PRO activityPROSITE-ProRule annotation1
Active sitei3383For 3CL-PRO activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1727 – 1764C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4302 – 4318By similarityAdd BLAST17
Zinc fingeri4345 – 4358By similarityAdd BLAST14

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, RNA-binding, Thiol protease
Biological processActivation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host IRF3 by virus, Inhibition of host ISG15 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...MEROPSi		C16.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1a
Short name:
pp1a
Alternative name(s):
ORF1a polyprotein
Cleaved into the following 11 chains:
Non-structural protein 1
Short name:
nsp1
Alternative name(s):
Leader protein
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p65 homolog
Non-structural protein 3 (EC:3.4.19.12, EC:3.4.22.69)
Short name:
nsp3
Alternative name(s):
PL2-PRO
Papain-like proteinase
Short name:
PL-PRO
Non-structural protein 4
Short name:
nsp4
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
Non-structural protein 11
Short name:
nsp11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri349344 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiRhinolophus ferrumequinum (Greater horseshoe bat) [TaxID: 59479]
Rhinolophus macrotis (Big-eared horseshoe bat) [TaxID: 196889]
Rhinolophus pearsonii [TaxID: 188571]
Rhinolophus sinicus (Chinese rufous horseshoe bat) [TaxID: 89399]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2201 – 2221HelicalSequence analysisAdd BLAST21
Transmembranei2312 – 2334HelicalSequence analysisAdd BLAST23
Transmembranei2349 – 2369HelicalSequence analysisAdd BLAST21
Transmembranei2753 – 2773HelicalSequence analysisAdd BLAST21
Transmembranei3020 – 3040HelicalSequence analysisAdd BLAST21
Transmembranei3059 – 3079HelicalSequence analysisAdd BLAST21
Transmembranei3081 – 3101HelicalSequence analysisAdd BLAST21
Transmembranei3103 – 3123HelicalSequence analysisAdd BLAST21
Transmembranei3140 – 3160HelicalSequence analysisAdd BLAST21
Transmembranei3562 – 3582HelicalSequence analysisAdd BLAST21
Transmembranei3584 – 3604HelicalSequence analysisAdd BLAST21
Transmembranei3610 – 3630HelicalSequence analysisAdd BLAST21
Transmembranei3657 – 3676HelicalSequence analysisAdd BLAST20
Transmembranei3683 – 3702HelicalSequence analysisAdd BLAST20
Transmembranei3726 – 3746HelicalSequence analysisAdd BLAST21
Transmembranei3754 – 3774HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003381221 – 4380Replicase polyprotein 1aAdd BLAST4380
ChainiPRO_00003381231 – 179Non-structural protein 1By similarityAdd BLAST179
ChainiPRO_0000338124180 – 818Non-structural protein 2By similarityAdd BLAST639
ChainiPRO_0000338125819 – 2738Non-structural protein 3By similarityAdd BLAST1920
ChainiPRO_00003381262739 – 3238Non-structural protein 4By similarityAdd BLAST500
ChainiPRO_00003381273239 – 35443C-like proteinaseBy similarityAdd BLAST306
ChainiPRO_00003381283545 – 3834Non-structural protein 6By similarityAdd BLAST290
ChainiPRO_00003381293835 – 3917Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_00003381303918 – 4115Non-structural protein 8By similarityAdd BLAST198
ChainiPRO_00003381314116 – 4228Non-structural protein 9By similarityAdd BLAST113
ChainiPRO_00003381324229 – 4367Non-structural protein 10By similarityAdd BLAST139
ChainiPRO_00003381334368 – 4380Non-structural protein 11Sequence analysisAdd BLAST13

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei179 – 180CleavageBy similarity2
Sitei818 – 819Cleavage; by PL-PROBy similarity2
Sitei3238 – 3239Cleavage; by PL-PROBy similarity2
Sitei3544 – 3545Cleavage; by 3CL-PROBy similarity2
Sitei3834 – 3835Cleavage; by 3CL-PROBy similarity2
Sitei3917 – 3918Cleavage; by 3CL-PROBy similarity2
Sitei4115 – 4116Cleavage; by 3CL-PROBy similarity2
Sitei4228 – 4229Cleavage; by 3CL-PROBy similarity2
Sitei4367 – 4368Cleavage; by 3CL-PROBy similarity2

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P0C6T7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P0C6T7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C6T7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1001 – 1167MacroPROSITE-ProRule annotationAdd BLAST167
Domaini1609 – 1873Peptidase C16PROSITE-ProRule annotationAdd BLAST265
Domaini3239 – 3544Peptidase C30PROSITE-ProRule annotationAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2201 – 2369HD1By similarityAdd BLAST169
Regioni2753 – 3160HD2By similarityAdd BLAST408
Regioni3562 – 3774HD3By similarityAdd BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi930 – 999Glu-richAdd BLAST70
Compositional biasi2208 – 2211Poly-Leu4
Compositional biasi3764 – 3767Poly-Cys4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1727 – 1764C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4302 – 4318By similarityAdd BLAST17
Zinc fingeri4345 – 4358By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1a (identifier: P0C6T7-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESLVLGINE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKSGT 
        60         70         80         90        100
CGIVELEKGV LPQPEQPYVF IKRSDAQGTD HGHRVRELVA ELDGVQYGRS 
       110        120        130        140        150
GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSFGIDL KSYDLGDELG 
       160        170        180        190        200
TDPIEDYEQN WNTKHGSGVL RELTRELNGG ALTRYVDNNF CGPDGYPLEC 
       210        220        230        240        250
IKDLLARAGK SMCTLSEQLD YIESKRGVYC CRDHGHEIAW FTERSDKSYE 
       260        270        280        290        300
HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI 
       310        320        330        340        350
RSVYPVATPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEQCGTENLV 
       360        370        380        390        400
SEGPNTCGYL PTNAVVKMPC PACQDPEIGP EHSAADYHNH SNIETRLRKG 
       410        420        430        440        450
GRTRCFGGCV FAYVGCYNKR AYWVPRASAD IGSGHTGITG DNVETLNEDL 
       460        470        480        490        500
LEILSRERVN INIVGDFQLN EEVAIILASF SASTSAFIDT IKSLDYKSFK 
       510        520        530        540        550
TIVESCGNYK VTKGKPIKGA WNIGQHRSVL TPLCGFPSQA AGVIRSIFSR 
       560        570        580        590        600
TLDAANHSIP DLQRAAVTIL DSISEQSLRL VDAMVYTSNL LTNSVIIMAY 
       610        620        630        640        650
VTGGLVQQTS QWLSNLLDTT VEKLRPIFAW IEAKLSAGVE FLKDAWEILK 
       660        670        680        690        700
FLITGVFDIV KGQIQVASDN IKDCVKCFVD VVNKALEMCI DQVTIAGAKL 
       710        720        730        740        750
RSLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV 
       760        770        780        790        800
LTSEEVVLKN GELEALETPV DSFTNGAVVG TPVCINGLML LEIKANEQYC 
       810        820        830        840        850
ALSPGLLATN NVFRLKGGAP TKGVTFGEDT VVEVQGYKNV RITFELDERV 
       860        870        880        890        900
DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE 
       910        920        930        940        950
WSVATFYLFD DSGEEKLSSR MYCSFYPPDE EEDCEEYEEE EEVSERTCEH 
       960        970        980        990       1000
EYGTEEDYKG LPLEFGASTD IIQVEEQEEE DWLDDAVEAE PEPEPLHEEP 
      1010       1020       1030       1040       1050
VNQLTGYLKL TDNVAIKCVD IVEEAQNANP MVIVNAANIH LKHGGGVAGA 
      1060       1070       1080       1090       1100
LNKATNGAMQ KESDHYIKLN GPLTVGGSCL LSGHNLAKKC LHVVGPNLNA 
      1110       1120       1130       1140       1150
GEDIQLLKAA YENFNSQDIL LAPLLSAGIF GAKPLQSLQM CVQTVRTQVY 
      1160       1170       1180       1190       1200
IVVNDKVLYE QVVMDYLDSL KPKVEAPKQE VLPKAEYPKV DEKSVVQKTI 
      1210       1220       1230       1240       1250
DVKPKIKACI DEVTTTLEET KFLTNKLLLF TDINGKLYQD SKNMLRGEDM 
      1260       1270       1280       1290       1300
SFLEKDAPYM VGDVITSGDI TCVVIPSKKA GGTTEMLSRA LKKVPINEYI 
      1310       1320       1330       1340       1350
TTYPGQGCAG YTLEEAKTAL KKCKSAFYVL PSETPNAKEE ILGTVSWNLR 
      1360       1370       1380       1390       1400
EMLAHAEETR KLMPVCMDVR AIMATIQRKY KGIKIQEGIV DYGVRFFFYT 
      1410       1420       1430       1440       1450
SKEPVASIIT KLNSLNEPLV TMPIGYVTHG FNLEEAARCM RSLKAPAIVS 
      1460       1470       1480       1490       1500
VSSPDAVTTY NGYLTSSSKT SEDHFVETVS LAGSYRDWSY SGQRTELGVE 
      1510       1520       1530       1540       1550
FLKRGEKIVY HTLESPVKFH LDGEVLPLDK LKSLLSLREV KTIKVFTTVD 
      1560       1570       1580       1590       1600
NTNLHTQLVD MSMTYGQQLG PTYLEGADVT KIKPHVNHEG KTFFVLPSDD 
      1610       1620       1630       1640       1650
TLRSEAFEYY HTLDESFLGR YMSALNHTKK WKFPQVGGLT SIKWADNNCY 
      1660       1670       1680       1690       1700
LSSVLLALQQ IEVKFNAPAL QEAYYRARAG DAANFCALIL AYSNKTVGEL 
      1710       1720       1730       1740       1750
GDVRETMTHL LQHANLESAK RVLNVVCKHC GQKTTTLTGV EAVMYMGTLS 
      1760       1770       1780       1790       1800
YDNLKMGVSI PCVCGRDATQ YLVQQESSFV MMSAPPAEYK LQQGTFLCAN 
      1810       1820       1830       1840       1850
EYTGNYQCGH YTHITAKETL YRIDGAHLTK MSEYKGPVTD VFYKETSYTT 
      1860       1870       1880       1890       1900
TIKPVSYKLD GVTYTEIEPK LDGYYKKDNA YYTEQPIDLI PTQPLPNASF 
      1910       1920       1930       1940       1950
DNFKLTCSNT KFADDLNQMT GFTKPASREL SVTFFPDLNG DVVAIDYRHY 
      1960       1970       1980       1990       2000
SASFKKGAKL LHKPIVWHIN QATTKTTFKP NTWCLRCLWS TKPVDTSNSF 
      2010       2020       2030       2040       2050
EVLAVEDTQG MDNLACESQQ PTPEEVVENP TIQKEVIECD VKTTEVVGNV 
      2060       2070       2080       2090       2100
ILKPSDEGVK VTQELDHEDL MAAYVENTSI TIKKPNELSL ALGLKTIATH 
      2110       2120       2130       2140       2150
GIAAINSVPW GKILAYVKPF LGQAAVTTSN CAKRLVQRMF NNYMPYVLTL 
      2160       2170       2180       2190       2200
LFQLCTFTKS TNSRIRASLP TTIAKNSVRG IVRLCLDAGI NYVKSPKFSK 
      2210       2220       2230       2240       2250
LFTIAMWLLL LSICLGSLIY VTAALGVLLS NFGAPSYCSG VRESYLNSSN 
      2260       2270       2280       2290       2300
VTTMDFCEGS FPCSVCLSGL DSLDSYPALE TIQVTISSYK LDLTILGLAA 
      2310       2320       2330       2340       2350
EWFFAYMLFT KFFYLLGLSA IMQVFFGYFA SHFISNSWLM WFIISIVQMA 
      2360       2370       2380       2390       2400
PVSAMVRMYI FFASFYYIWK SYVHIMDGCT SSTCMMCYKR NRATRVECTT 
      2410       2420       2430       2440       2450
IVNGMKRSFY VYANGGRGFC KTHNWNCLNC DTFCAGSTFI SDEVARDLSL 
      2460       2470       2480       2490       2500
QFKRPINPTD QSSYVVDSVA VKNGALHLYF DKAGQKTYER HPLSHFVNLD 
      2510       2520       2530       2540       2550
NLRANNTKGS LPINVIVFDG KSKCDESAAK SASVYYSQLM CQPILLLDQA 
      2560       2570       2580       2590       2600
LVSDVGDSTE VSVKMFDAYV DTFSATFSVP MEKLKALVAT AHSELAKGVA 
      2610       2620       2630       2640       2650
LDGVLSTFVS ASRQGVVDTD VDTKDVIECL KLSHHSDLEV TGDSCNNFML 
      2660       2670       2680       2690       2700
TYNKVENMTP RDLGACIDCN ARHINAQVAR SHNVSLIWNV KDYMSLSEQL 
      2710       2720       2730       2740       2750
RKQIRSAAKK NNIPFRLTCA TTRQVVNVIT TKISLKGGKI VSTWFKIMLK 
      2760       2770       2780       2790       2800
ATLLCVLAAL VCYIVMPVHI LSVHGGYTNE IIGYKAIQDG VTRDIVSTDD 
      2810       2820       2830       2840       2850
CFANKHAGFD SWFSQRGGSY KNDKSCPVVA AIITREIGFI VPGLPGTVLR 
      2860       2870       2880       2890       2900
AINGDFLHFL PRVFSAVGNI CYTPSKLIEY SDFSTSACVL AAECTIFKDA 
      2910       2920       2930       2940       2950
MGKPVPYCYD TNLLEGSISY SELRPDTRYV LMDGSIIQFP NAYLEGSVRV 
      2960       2970       2980       2990       3000
VTTFDAEYCR HGTCERSEAG ICLSTSGRWV LNNEHYRALP GVFCGVDAMN 
      3010       3020       3030       3040       3050
LIANIFTPLV QPVGALDVSA SVVAGGIIAI LVTCAAYYFM KFRRAFGEYN 
      3060       3070       3080       3090       3100
HVVAANAPLF LMSFTILCLA PAYSFLPGVY SVFYLYLTFY FTNDVSFLAH 
      3110       3120       3130       3140       3150
LQWFAMFSPI VPFWITAIYV FCISLKHFHW FFNNYLRKRV VFNGVTFSTF 
      3160       3170       3180       3190       3200
EEAALCTFLL NKEMYLKLRS ETLLPLTQYN RYLALYNKYK YFSGALDTTS 
      3210       3220       3230       3240       3250
YREAACCHLA KALNDFSNSG ADVLYQPPQT SITSAVLQSG FRKMAFPSGK 
      3260       3270       3280       3290       3300
VEGCMVQVTC GTTTLNGLWL DDTVYCPRHV ICTAEDMLNP NYEDLLIRKS 
      3310       3320       3330       3340       3350
NHSFLVQAGN VQLRVIGHSM QNCLLRLKVD TSNPKTPKYK FVRIQPGQTF 
      3360       3370       3380       3390       3400
SVLACYNGSP SGVYQCAMRP NHTIKGSFLN GSCGSVGFNI DYDCVSFCYM 
      3410       3420       3430       3440       3450
HHMELPTEVH AGTDLEGKFY GPFVDRQTAQ AAGTDTTITL NVLAWLYAAV 
      3460       3470       3480       3490       3500
INGDRWFLNR FTTTLNDFNL VAMKYNYEPL TQDHVDILGP LSAQTGIAVL 
      3510       3520       3530       3540       3550
DMCAALKELL QNGMNGRTIL GSTILEDEFT PFDVVRQCSG VTFQGKFKRI 
      3560       3570       3580       3590       3600
VKGTHHWMLL TFLTSLLILV QSTQWSLFFF VYENAFLPFT LGIMAVAACA 
      3610       3620       3630       3640       3650
MLLVKHKHAF LCLFLLPSLA TVAYFNMVYM PASWVMRIMT WLELADTSLS 
      3660       3670       3680       3690       3700
GYRLKDCVMY ASALVLLVLM TARTVYDDAA RRVWTLMNVI TLVYKVYYGN 
      3710       3720       3730       3740       3750
ALDQAISMWA LVISVTSNYS GVVTTIMFLA RAIVFVCVEY YPLLFITGNT 
      3760       3770       3780       3790       3800
LQCIMLVYCF LGYCCCCYFG LFCLLNRYFR LTLGVYDYLV STQEFRYMNS 
      3810       3820       3830       3840       3850
QGLLPPKSSI DAFKLNIKLL GIGGKPCIKV ATVQSKMSDV KCTSVVLLSV 
      3860       3870       3880       3890       3900
LQQLRVESSS KLWAQCVQLH NDILLAKDTT EAFEKMVSLL SVLLSMQGAV 
      3910       3920       3930       3940       3950
DINKLCEEML DNRATLQAIA SEFSSLPSYA AYATAQEAYE QAVANGDSEV 
      3960       3970       3980       3990       4000
VLKKLKKSLN VAKSEFDRNA AMQRKLEKMA DQAMTQMYKQ ARSEDKRAKV 
      4010       4020       4030       4040       4050
TSAMQTMLFT MLRKLDNDAL NNIINNARDG CVPLNIIPLT TAAKLMVVVP 
      4060       4070       4080       4090       4100
DYGTYKNTCD GNTFTYASAL WEIQQVVDAD SKIVQLSEIN MENSSNLAWP 
      4110       4120       4130       4140       4150
LIVTALRANS AVKLQNNELS PVALRQMSCA AGTTQTACTD DNALAYYNNS 
      4160       4170       4180       4190       4200
KGGRFVLALL SDHQDLKWAR FPKSDGTGTI YTELEPPCRF VTDTPKGPKV 
      4210       4220       4230       4240       4250
KYLHFIKGLN NLNRGMVLGS LAATVRLQAG NATEVPANST VLSFCAFAVD 
      4260       4270       4280       4290       4300
PAKAYKDYLA SGGQPITNCV KMLCTHTGTG QAITVTPEAN MDQESFGGAS 
      4310       4320       4330       4340       4350
CCLYCRCHID HPNPKGFCDL KGKYVQIPTT CANDPVGFTL RNTVCTVCGM 
      4360       4370       4380
WKGYGCSCDQ LREPMMQSAD ASTFLNGFAV
Note: Produced by conventional translation.
Length:4,380
Mass (Da):486,337
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DDA57CD3DF1535B
GO
Isoform Replicase polyprotein 1ab (identifier: P0C6W6-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
The sequence of this isoform can be found in the external entry P0C6W6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:7,071
Mass (Da):790,103
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ071615 Genomic RNA Translation: AAZ67050.1

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ071615 Genomic RNA Translation: AAZ67050.1

3D structure databases

BMRBiP0C6T7
SMRiP0C6T7
ModBaseiSearch...

Protein family/group databases

MEROPSiC16.009

Proteomic databases

PRIDEiP0C6T7

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1A_BCRP3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6T7
Secondary accession number(s): Q3I5J6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 2, 2020
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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