UniProtKB - P0C6S6 (VMXJ4_BOTJA)
Protein
Snake venom metalloproteinase jararafibrase-4
Gene
N/A
Organism
Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Status
Functioni
The metalloproteinase is a probable venom zinc protease that induces local hemorrhage in the skin of rats. Degrades type-IV collagen, gelatin, laminin and fibronectin. Has fibrinolytic activities. Has high hemagglutinating activity on red blood cells. Cleaves insulin B chain at 29-His-|-Leu-30, and 38-Ala-|-Leu-39 bonds (PubMed:8087204).2 Publications
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Activity regulationi
Inhibited by 1,10-phenanthroline and EDTA.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 9 | CalciumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Fibrinolytic toxin, Hemorrhagic toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Protease, Toxin |
Ligand | Calcium, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Snake venom metalloproteinase jararafibrase-4 (EC:3.4.24.-)Short name: SVMP Alternative name(s): Jararafibrase IV |
Organismi | Bothrops jararaca (Jararaca) (Bothrops jajaraca) |
Taxonomic identifieri | 8724 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Bothrops |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326427 | 1 – ›47 | Snake venom metalloproteinase jararafibrase-4Add BLAST | ›47 |
Expressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Monomer.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – ›47 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | ›42 |
Sequence similaritiesi
Belongs to the venom metalloproteinase (M12B) family.Curated
Family and domain databases
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B |
Pfami | View protein in Pfam PF01421 Reprolysin, 1 hit |
PROSITEi | View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit |
i Sequence
Sequence statusi: Fragment.
P0C6S6-1 [UniParc]FASTAAdd to basket
10 20 30 40
TPEHQRYIEL FLVVDHGMFM KYNGNSDKIY YYIHQMVNIM KXAYXYL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | K → L AA sequence (PubMed:12165326).Curated | 1 | |
Non-terminal residuei | 47 | 1 |
Cross-referencesi
3D structure databases
ProteinModelPortali | P0C6S6 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B |
Pfami | View protein in Pfam PF01421 Reprolysin, 1 hit |
PROSITEi | View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | VMXJ4_BOTJA | |
Accessioni | P0C6S6Primary (citable) accession number: P0C6S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | September 12, 2018 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families