Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kappa-conotoxin-like as14b

Gene
N/A
Organism
Conus cancellatus (Cancellate cone) (Conus austini)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks potassium channels (By similarity). When intracranially injected, elicits scratching and grooming activity in mice, and causes body and rear limb extension and tail curling immediately upon injection.By similarity1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like as14b
OrganismiConus cancellatus (Cancellate cone) (Conus austini)
Taxonomic identifieri289020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusDauciconus

Organism-specific databases

ConoServeri2829 AsXIVB precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003263941 – 28Kappa-conotoxin-like as14bAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 27By similarity
Disulfide bondi11 ↔ 23By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is XIV (C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin L superfamily.Curated

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C6S3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
RWDVDQCIYY CLNGVVGYSY TECQTMCT
Length:28
Mass (Da):3,315
Last modified:March 18, 2008 - v1
Checksum:i8E0A92128F384997
GO

Mass spectrometryi

Molecular mass is 3308.63 Da from positions 1 - 28. Determined by MALDI. Monoisotopic mass.1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri2829 AsXIVB precursor

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCLEB_CONCF
AccessioniPrimary (citable) accession number: P0C6S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again