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Protein

Kappa-conotoxin-like as14a

Gene
N/A
Organism
Conus cancellatus (Cancellate cone) (Conus austini)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks potassium channels (By similarity). When intracranially injected, elicits scratching and grooming activity in mice.By similarity1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like as14a
OrganismiConus cancellatus (Cancellate cone) (Conus austini)
Taxonomic identifieri289020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusDauciconus

Organism-specific databases

ConoServeri2828 AsXIVA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003263931 – 27Kappa-conotoxin-like as14aAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 26By similarity
Disulfide bondi10 ↔ 22By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is XIV (C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin L superfamily.Curated

Sequencei

Sequence statusi: Complete.

P0C6S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
GGVGRCIYNC MNSGGGLNFI QCKTMCY
Length:27
Mass (Da):2,890
Last modified:March 18, 2008 - v1
Checksum:i97A8E2C1EAAA526D
GO

Mass spectrometryi

Molecular mass is 2883.92 Da from positions 1 - 27. Determined by MALDI. Monoisotopic mass.1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri2828 AsXIVA

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCLEA_CONCF
AccessioniPrimary (citable) accession number: P0C6S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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