UniProtKB - P0C6S2 (CLEA_CONCF)
Protein
Kappa-conotoxin-like as14a
Gene
N/A
Organism
Conus cancellatus (Cancellate cone) (Conus austini)
Status
Functioni
Blocks potassium channels (By similarity). When intracranially injected, elicits scratching and grooming activity in mice.By similarity1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Kappa-conotoxin-like as14a |
Organismi | Conus cancellatus (Cancellate cone) (Conus austini) |
Taxonomic identifieri | 289020 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Dauciconus |
Organism-specific databases
ConoServeri | 2828 AsXIVA |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000326393 | 1 – 27 | Kappa-conotoxin-like as14aAdd BLAST | 27 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 6 ↔ 26 | By similarity | ||
Disulfide bondi | 10 ↔ 22 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Family & Domainsi
Domaini
The cysteine framework is XIV (C-C-C-C).
Sequence similaritiesi
Belongs to the conotoxin L superfamily.Curated
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Molecular mass is 2883.92 Da from positions 1 - 27. Determined by MALDI. Monoisotopic mass.1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ConoServeri | 2828 AsXIVA |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | CLEA_CONCF | |
Accessioni | P0C6S2Primary (citable) accession number: P0C6S2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | September 12, 2018 | |
This is version 26 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families