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UniProtKB - P0C6P6 (TYY2_RAT)
Protein
Transcription factor YY2
Gene
Yy2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation (By similarity).
By similarityMiscellaneous
The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 258 – 282 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 287 – 309 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 315 – 339 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 345 – 369 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor YY2Alternative name(s): Yin and yang 2 Short name: YY-2 |
Gene namesi | Name:Yy2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2324567, Yy2 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: RGD
- PcG protein complex Source: GO_Central
Other locations
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324121 | 1 – 376 | Transcription factor YY2Add BLAST | 376 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 36 – 109 | Mediates transcriptional activationBy similarityAdd BLAST | 74 | |
Regioni | 201 – 220 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 241 – 376 | Mediates transcriptional repressionBy similarityAdd BLAST | 136 |
Sequence similaritiesi
Belongs to the YY transcription factor family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 258 – 282 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 287 – 309 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 315 – 339 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 345 – 369 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
InParanoidi | P0C6P6 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P0C6P6 |
Family and domain databases
InterProi | View protein in InterPro IPR017114, YY1-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
PIRSFi | PIRSF037113, TF_Yin_yang, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P0C6P6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASDTEKLMC LTTENAEIPA DFVELQPLDE IETVSLETNV SQTIEVYGDV
60 70 80 90 100
GVDWAHGGHY HSPLIALQPL AGSNLSNGDH DQEMIIVQTR EEVVDYQDSD
110 120 130 140 150
NLLLGTEFES QMVLPVNEDD YLQPTTATFS GFMAAENGQD ELSPYGGNLC
160 170 180 190 200
GLTTIIEAGA EEGVNPDLGD KQWEQKQIQI DGLDGEFPFA MWEDNNLKED
210 220 230 240 250
PVAEEEAGES TPDYSEYMTG KKFPPEGIPG IDLSDPKQLA EFTSMKPKKP
260 270 280 290 300
KGDFPRPVAC SHKGCGKMFK DNSAMRKHLH IHGPRVHVCA ECGKAFVESS
310 320 330 340 350
KLKRHQLVHT GEKPYQCTFE GCGRRFSLDF NLRTHVRIHT GDKPFVCPFD
360 370
ACNKKFAQST NLKSHILTHV KNKNDQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3ZDS6 | D3ZDS6_RAT | Membrane-bound transcription factor... | Mbtps2 | 533 | Annotation score: | ||
A0A0G2K1S2 | A0A0G2K1S2_RAT | Membrane-bound transcription factor... | Mbtps2 | 503 | Annotation score: | ||
A0A8I6A7T1 | A0A8I6A7T1_RAT | Membrane-bound transcription factor... | Mbtps2 | 224 | Annotation score: | ||
A0A8I6AN61 | A0A8I6AN61_RAT | Membrane-bound transcription factor... | Mbtps2 | 519 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03122623 Genomic DNA No translation available. |
RefSeqi | XP_008756640.1, XM_008758418.1 XP_008771447.1, XM_008773225.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03122623 Genomic DNA No translation available. |
RefSeqi | XP_008756640.1, XM_008758418.1 XP_008771447.1, XM_008773225.1 |
3D structure databases
AlphaFoldDBi | P0C6P6 |
SMRi | P0C6P6 |
ModBasei | Search... |
Genome annotation databases
Organism-specific databases
CTDi | 404281 |
RGDi | 2324567, Yy2 |
Phylogenomic databases
InParanoidi | P0C6P6 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P0C6P6 |
Miscellaneous databases
PROi | PR:P0C6P6 |
Family and domain databases
InterProi | View protein in InterPro IPR017114, YY1-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
PIRSFi | PIRSF037113, TF_Yin_yang, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TYY2_RAT | |
Accessioni | P0C6P6Primary (citable) accession number: P0C6P6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families