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Protein

Transcription factor YY2

Gene

Yy2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation (By similarity).By similarity

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 282C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri287 – 309C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor YY2
Alternative name(s):
Yin and yang 2
Short name:
YY-2
Gene namesi
Name:Yy2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2324567 Yy2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241211 – 376Transcription factor YY2Add BLAST376

Proteomic databases

PRIDEiP0C6P6

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP0C6P6
SMRiP0C6P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 109Mediates transcriptional activationBy similarityAdd BLAST74
Regioni241 – 376Mediates transcriptional repressionBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the YY transcription factor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 282C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri287 – 309C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG006823
InParanoidiP0C6P6
KOiK09201
PhylomeDBiP0C6P6

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

P0C6P6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDTEKLMC LTTENAEIPA DFVELQPLDE IETVSLETNV SQTIEVYGDV
60 70 80 90 100
GVDWAHGGHY HSPLIALQPL AGSNLSNGDH DQEMIIVQTR EEVVDYQDSD
110 120 130 140 150
NLLLGTEFES QMVLPVNEDD YLQPTTATFS GFMAAENGQD ELSPYGGNLC
160 170 180 190 200
GLTTIIEAGA EEGVNPDLGD KQWEQKQIQI DGLDGEFPFA MWEDNNLKED
210 220 230 240 250
PVAEEEAGES TPDYSEYMTG KKFPPEGIPG IDLSDPKQLA EFTSMKPKKP
260 270 280 290 300
KGDFPRPVAC SHKGCGKMFK DNSAMRKHLH IHGPRVHVCA ECGKAFVESS
310 320 330 340 350
KLKRHQLVHT GEKPYQCTFE GCGRRFSLDF NLRTHVRIHT GDKPFVCPFD
360 370
ACNKKFAQST NLKSHILTHV KNKNDQ
Length:376
Mass (Da):41,805
Last modified:March 18, 2008 - v1
Checksum:iDF9B8A566B692012
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03122623 Genomic DNA No translation available.
RefSeqiXP_008756640.1, XM_008758418.1
XP_008771447.1, XM_008773225.1

Genome annotation databases

GeneIDi103690827
KEGGirno:103690827

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03122623 Genomic DNA No translation available.
RefSeqiXP_008756640.1, XM_008758418.1
XP_008771447.1, XM_008773225.1

3D structure databases

ProteinModelPortaliP0C6P6
SMRiP0C6P6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0C6P6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103690827
KEGGirno:103690827

Organism-specific databases

CTDi404281
RGDi2324567 Yy2

Phylogenomic databases

HOVERGENiHBG006823
InParanoidiP0C6P6
KOiK09201
PhylomeDBiP0C6P6

Miscellaneous databases

PROiPR:P0C6P6

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTYY2_RAT
AccessioniPrimary (citable) accession number: P0C6P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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