Yy2

Functionⁱ

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation (By similarity).By similarity

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	258 – 282	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	287 – 309	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	315 – 339	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	345 – 369	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor YY2 Alternative name(s): Yin and yang 2 Short name: YY-2
Gene namesⁱ	Name:Yy2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2324567 Yy2

RGDⁱ

2324567 Yy2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000324121	1 – 376	Transcription factor YY2Add BLAST		376

Proteomic databases

PRIDEⁱ	P0C6P6

PRIDEⁱ

P0C6P6

Interactionⁱ

GO - Molecular functionⁱ

RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0C6P6
SMRⁱ	P0C6P6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	36 – 109	Mediates transcriptional activationBy similarityAdd BLAST		74
Regionⁱ	241 – 376	Mediates transcriptional repressionBy similarityAdd BLAST		136

Sequence similaritiesⁱ

Belongs to the YY transcription factor family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	258 – 282	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	287 – 309	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	315 – 339	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	345 – 369	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENⁱ	HBG006823
InParanoidⁱ	P0C6P6
KEGG Orthology (KO) More...KOⁱ	K09201
PhylomeDBⁱ	P0C6P6

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P0C6P6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASDTEKLMC LTTENAEIPA DFVELQPLDE IETVSLETNV SQTIEVYGDV 
        60         70         80         90        100
GVDWAHGGHY HSPLIALQPL AGSNLSNGDH DQEMIIVQTR EEVVDYQDSD 
       110        120        130        140        150
NLLLGTEFES QMVLPVNEDD YLQPTTATFS GFMAAENGQD ELSPYGGNLC 
       160        170        180        190        200
GLTTIIEAGA EEGVNPDLGD KQWEQKQIQI DGLDGEFPFA MWEDNNLKED 
       210        220        230        240        250
PVAEEEAGES TPDYSEYMTG KKFPPEGIPG IDLSDPKQLA EFTSMKPKKP 
       260        270        280        290        300
KGDFPRPVAC SHKGCGKMFK DNSAMRKHLH IHGPRVHVCA ECGKAFVESS 
       310        320        330        340        350
KLKRHQLVHT GEKPYQCTFE GCGRRFSLDF NLRTHVRIHT GDKPFVCPFD 
       360        370 
ACNKKFAQST NLKSHILTHV KNKNDQ

Length:376

Mass (Da):41,805

Last modified:March 18, 2008 - v1

Checksum:ⁱDF9B8A566B692012

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR03122623 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_008756640.1, XM_008758418.1 XP_008771447.1, XM_008773225.1

Genome annotation databases

GeneIDⁱ	103690827
KEGGⁱ	rno:103690827

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0C6P6	Transcription factor YY2		RATRT		376	UniRef90_P0C6P6

Protein	Similar proteins		Species	Score	Length	Source
P0C6P6	Transcription factor YY2		HUMAN		372	UniRef50_O15391
Transcription factor YY2		RATRT		376
YY2 isoform 1		PANTR		372
Uncharacterized protein		PANPA		355
transcription factor YY2		LIPVE		366
+158

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR03122623 Genomic DNA No translation available.
RefSeqⁱ	XP_008756640.1, XM_008758418.1 XP_008771447.1, XM_008773225.1

3D structure databases

ProteinModelPortalⁱ	P0C6P6
SMRⁱ	P0C6P6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	P0C6P6

PRIDEⁱ

P0C6P6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	103690827
KEGGⁱ	rno:103690827

Organism-specific databases

CTDⁱ	404281
RGDⁱ	2324567 Yy2

Phylogenomic databases

HOVERGENⁱ	HBG006823
InParanoidⁱ	P0C6P6
KOⁱ	K09201
PhylomeDBⁱ	P0C6P6

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0C6P6

PROⁱ

PR:P0C6P6

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TYY2_RAT
Accessionⁱ	P0C6P6Primary (citable) accession number: P0C6P6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	March 18, 2008
	Last modified:	November 7, 2018
	This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - P0C6P6 (TYY2_RAT)

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Transcription factor YY2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ