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UniProtKB - P0C6P5 (ARG28_RAT)

Entry version 84 (08 May 2019)
Sequence version 1 (18 Mar 2008)
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Protein

Rho guanine nucleotide exchange factor 28

Gene

Arhgef28

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri651 – 698Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, RNA-binding
Biological processDifferentiation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-3928662 EPHB-mediated forward signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 28
Alternative name(s):
190 kDa guanine nucleotide exchange factor
Short name:
p190-RhoGEF
Short name:
p190RhoGEF
Rho guanine nucleotide exchange factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgef28
Synonyms:Rgnef
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...RGDi		1307061 Arhgef28

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241201 – 1700Rho guanine nucleotide exchange factor 28Add BLAST1700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei312PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei623PhosphoserineBy similarity1
Modified residuei1535PhosphoserineBy similarity1
Modified residuei1604PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine upon stimulation of cells by laminin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P0C6P5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0C6P5

PRoteomics IDEntifications database

More...PRIDEi		P0C6P5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0C6P5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P0C6P5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000016544 Expressed in 10 organ(s), highest expression level in adult mammalian kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P0C6P5 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL. Interacts with CTNND2; prevents interaction with RHOA (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000059196

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C6P5

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini848 – 1043DHPROSITE-ProRule annotationAdd BLAST196
Domaini1085 – 1187PHPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1294 – 1303Interaction with PTK2/FAK1; required for regulation of axonal branching and synapse formationBy similarity10
Regioni1369 – 1380Mediates cytoplasmic retention and interaction with YWHAHBy similarityAdd BLAST12
Regioni1421 – 1700Interaction with microtubulesBy similarityAdd BLAST280
Regioni1493 – 1524RNA-bindingAdd BLAST32
Regioni1563 – 1576Mediates cytoplasmic retention and interaction with MAPK8IP1By similarityAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1473 – 1522Sequence analysisAdd BLAST50

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri651 – 698Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3519 Eukaryota
KOG3520 Eukaryota
ENOG410XT68 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000154109

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0C6P5

Identification of Orthologs from Complete Genome Data

More...OMAi		EIYANCM

Database of Orthologous Groups

More...OrthoDBi		69816at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0C6P5

TreeFam database of animal gene trees

More...TreeFami		TF334740

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029 C1, 1 hit
cd14680 PH_p190RhoGEF, 1 hit
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037819 ARHGEF28_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130 C1_1, 1 hit
PF17838 PH_16, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0C6P5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSCSEVPL YGQRTVYAKF GKNVYLPEDA EFYFIYDGSH QRHVVIADRV 
        60         70         80         90        100
EDNVLQSIIP GHWLQETVMV SVCLCSEGYS PVTMGSGSVT YVDNMACRLA 
       110        120        130        140        150
RLLVTQADRL TPCSHQTLLT PFALTAEALP ALDEELVLAL TQLELPLGWT 
       160        170        180        190        200
VLGNSSLEVC LHRESLLHLA VRWALPKLFH FLLCLPGGVK ALELPNEEAT 
       210        220        230        240        250
TPLDLALHGG HSMLVEDISN FQGRRSPGFS RLRLNEDATL QFDRSSETLT 
       260        270        280        290        300
LTVNHTAEHL LEADIKLFRK YFWDRAFLVK ALDQEAKTER ATMPSGAAET 
       310        320        330        340        350
EEEVRNLESG RSPSEEEEDG QLVKSQADGP SEQEDQDRLV LDHSFDGLKK 
       360        370        380        390        400
SKHAPASLAA GQLSDVPNGG DEVYANCMVI DQVGDLDINY INIEGLSTHT 
       410        420        430        440        450
SPESMRSTLG PQACKHILPP DTSPCGHLLC EDSDRTLDAA ASQSCMSPPS 
       460        470        480        490        500
SHTSNLNLSF GLHGFVKEQS HLKKRSSSLD ALVADSEEEG RSEPPICYAV 
       510        520        530        540        550
GSQSSPRTGL PGGDELDSFD ANTEPDCNIS RTESLSLSST LHSKESLLSG 
       560        570        580        590        600
IRSRSYSCSS PKISSGKSRL VRDFTVCSSS EEQRSYSFQE PPGEKRIQEE 
       610        620        630        640        650
EWDDYIIPAK AESEKHKVSR TFSFLMNRMT SPRNKSKMKN KDTKDKEKLN 
       660        670        680        690        700
RHQFVPGTFS GVLQCSGCDK TLLGKESLQC ANCKANTHKG CKDTVPPCTK 
       710        720        730        740        750
KFQDKYNKNK PQTILGSSSV RDVPPPGLSL HPSPSMPIGL PAGRKETAGQ 
       760        770        780        790        800
AHPLSRSVPG TTLESFRRAV TSLESEGDSN SWRSRSHSDE LFQSMGSSPS 
       810        820        830        840        850
TESFMMEDVV DSSLWSELSS DAQEFEAESW SLVVDPSFCS RQEKDVIKRQ 
       860        870        880        890        900
DVIFELMQTE VHHIQTLLIM SEVFRKGMKE ELQLDHSTVD RIFPCLDELL 
       910        920        930        940        950
ETHKHFFFSM KERRQESCTG NDRNFVINQI GDILVQQFSE ENASKMKRIY 
       960        970        980        990       1000
GDFCSHHKEA MSLFKELQQN KKFQNFIKIR NSNLLARRRG IPECILLVTQ 
      1010       1020       1030       1040       1050
RITKYPVLVE RILQYTKERT EEHRDLCRAL GLIKDMIAAV DLKVSEYEKN 
      1060       1070       1080       1090       1100
QKWLEILNKI ENKTYTKLKN GHVFRKQALM SQERALLHDG LVYWKTATGR 
      1110       1120       1130       1140       1150
FKDILALLLT DVLLFLQEKD QKYIFAAVDQ KPSVISLQKL IAREVANEER 
      1160       1170       1180       1190       1200
GMFLISASSA GPEMYEIHTS SKEERNNWMR RIQQAVESCP EEEGGRTSES 
      1210       1220       1230       1240       1250
DEERRKADAR VAKIQQCQEI LSNQDQQICT YLEEKLHIYA ELGELSGFED 
      1260       1270       1280       1290       1300
VHLEPHLLIK PDPGEPPQAA SLLAAALREA ESLQVAVKAS KLADVSQPSE 
      1310       1320       1330       1340       1350
EGPGGAVLAD TLSAQDAPAS PTAFTEGTEG RGCWDVDPRL QGVVTDLAVS 
      1360       1370       1380       1390       1400
DAGEKVEYRS FSGSSQSEII QAIQNLTRLL YSLQAALTIQ DSHIEIHKLV 
      1410       1420       1430       1440       1450
LQQQESLAPS HSFRGGPLQD QEKSRYLEKH REELANIHKL QYQFQQEQRR 
      1460       1470       1480       1490       1500
WHRTCDQQQR EQEAQESWLQ ARERECQSQE ELLLRHRSEL DHQLQEYQQN 
      1510       1520       1530       1540       1550
LERLREGQRM VERERQRMRD QQGLLGHCKH SRQRSLPAVF SPGSKEVTEL 
      1560       1570       1580       1590       1600
NRAESLCHEK SFFLNDAFTH MSLNTSNKPN PSGAPWDAHP PGGSHLDLAR 
      1610       1620       1630       1640       1650
TSDSQIEVKM DVSQPSDVNS ELWTTGLGPQ RPARQESIKD SCKNVADLNS 
      1660       1670       1680       1690       1700
FQTESPDPQD SNQRGPQPQT LITEAKLTPP MAAGHGGDAG DGAEENIVYL
Length:1,700
Mass (Da):190,757
Last modified:March 18, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D21C8E6600728F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR03012977 Genomic DNA No translation available.
AABR03013324 Genomic DNA No translation available.
AABR03013680 Genomic DNA No translation available.
AABR03015604 Genomic DNA No translation available.
AABR03016111 Genomic DNA No translation available.
AABR03017173 Genomic DNA No translation available.
AABR03017199 Genomic DNA No translation available.
AABR03018551 Genomic DNA No translation available.
AABR03019008 Genomic DNA No translation available.
AABR03021286 Genomic DNA No translation available.
AABR03022481 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_008758898.1, XM_008760676.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000065143; ENSRNOP00000059196; ENSRNOG00000016544

Database of genes from NCBI RefSeq genomes

More...GeneIDi		361882

UCSC genome browser

More...UCSCi		RGD:1307061 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012977 Genomic DNA No translation available.
AABR03013324 Genomic DNA No translation available.
AABR03013680 Genomic DNA No translation available.
AABR03015604 Genomic DNA No translation available.
AABR03016111 Genomic DNA No translation available.
AABR03017173 Genomic DNA No translation available.
AABR03017199 Genomic DNA No translation available.
AABR03018551 Genomic DNA No translation available.
AABR03019008 Genomic DNA No translation available.
AABR03021286 Genomic DNA No translation available.
AABR03022481 Genomic DNA No translation available.
RefSeqiXP_008758898.1, XM_008760676.1

3D structure databases

SMRiP0C6P5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059196

PTM databases

iPTMnetiP0C6P5
PhosphoSitePlusiP0C6P5

Proteomic databases

jPOSTiP0C6P5
PaxDbiP0C6P5
PRIDEiP0C6P5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065143; ENSRNOP00000059196; ENSRNOG00000016544
GeneIDi361882
UCSCiRGD:1307061 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64283
RGDi1307061 Arhgef28

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
KOG3520 Eukaryota
ENOG410XT68 LUCA
GeneTreeiENSGT00940000155831
HOGENOMiHOG000154109
InParanoidiP0C6P5
OMAiEIYANCM
OrthoDBi69816at2759
PhylomeDBiP0C6P5
TreeFamiTF334740

Enzyme and pathway databases

ReactomeiR-RNO-3928662 EPHB-mediated forward signaling

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0C6P5

Gene expression databases

BgeeiENSRNOG00000016544 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP0C6P5 RN

Family and domain databases

CDDicd00029 C1, 1 hit
cd14680 PH_p190RhoGEF, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037819 ARHGEF28_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF17838 PH_16, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARG28_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6P5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 8, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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