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Entry version 61 (02 Jun 2021)
Sequence version 1 (10 Jun 2008)
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Protein

Replicase polyprotein 1a

Gene

1a

Organism
Breda virus 1 (BRV-1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 3C-like serine proteinase is responsible for the majority of cleavages.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3184Charge relay system; for 3C-like serine proteinase activitySequence analysis1
Active sitei3222Charge relay system; for 3C-like serine proteinase activitySequence analysis1
Active sitei3291Charge relay system; for 3C-like serine proteinase activitySequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandMetal-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S65.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1a
Short name:
pp1a
Alternative name(s):
ORF1a polyprotein
Cleaved into the following 9 chains:
Non-structural protein 1
Short name:
nsp1
Non-structural protein 2
Short name:
nsp2
3C-like serine proteinase (EC:3.4.21.-)
Short name:
3CLSP
Alternative name(s):
M-PRO
nsp3
p27
Non-structural protein 4
Short name:
nsp4
Non-structural protein 5
Short name:
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBreda virus 1 (BRV-1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri360393 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesTornidovirineaeTobaniviridaeTorovirinaeTorovirusRenitovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBos taurus (Bovine) [TaxID: 9913]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000355 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2191 – 2211HelicalSequence analysisAdd BLAST21
Transmembranei2219 – 2239HelicalSequence analysisAdd BLAST21
Transmembranei2266 – 2286HelicalSequence analysisAdd BLAST21
Transmembranei2411 – 2431HelicalSequence analysisAdd BLAST21
Transmembranei2521 – 2541HelicalSequence analysisAdd BLAST21
Transmembranei2546 – 2566HelicalSequence analysisAdd BLAST21
Transmembranei2769 – 2789HelicalSequence analysisAdd BLAST21
Transmembranei2937 – 2957HelicalSequence analysisAdd BLAST21
Transmembranei2986 – 3006HelicalSequence analysisAdd BLAST21
Transmembranei3022 – 3042HelicalSequence analysisAdd BLAST21
Transmembranei3422 – 3442HelicalSequence analysisAdd BLAST21
Transmembranei3456 – 3478HelicalSequence analysisAdd BLAST23
Transmembranei3486 – 3506HelicalSequence analysisAdd BLAST21
Transmembranei3514 – 3534HelicalSequence analysisAdd BLAST21
Transmembranei3538 – 3558HelicalSequence analysisAdd BLAST21
Transmembranei3573 – 3593HelicalSequence analysisAdd BLAST21
Transmembranei3598 – 3613HelicalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003380271 – 4445Replicase polyprotein 1aAdd BLAST4445
ChainiPRO_00003380281 – 2753Non-structural protein 1Sequence analysisAdd BLAST2753
ChainiPRO_00003380292754 – 3131Non-structural protein 2Sequence analysisAdd BLAST378
ChainiPRO_00003380313132 – 34183C-like serine proteinaseBy similarityAdd BLAST287
ChainiPRO_00003380323419 – 3677Non-structural protein 4Sequence analysisAdd BLAST259
ChainiPRO_00003380333678 – 3854Non-structural protein 5Sequence analysisAdd BLAST177
ChainiPRO_00003380343855 – 4036Non-structural protein 6Sequence analysisAdd BLAST182
ChainiPRO_00003380354037 – 4121Non-structural protein 7Sequence analysisAdd BLAST85
ChainiPRO_00003380364122 – 4274Non-structural protein 8Sequence analysisAdd BLAST153
ChainiPRO_00003380374275 – 4445Non-structural protein 9Sequence analysisAdd BLAST171

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own protease yield mature proteins. 3CL-PRO is autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2753 – 2754Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei3131 – 3132Cleavage; by 3C-like serine proteinaseBy similarity2
Sitei3418 – 3419Cleavage; by 3C-like serine proteinaseBy similarity2
Sitei3677 – 3678Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei3854 – 3855Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4036 – 4037Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4121 – 4122Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4274 – 4275Cleavage; by 3C-like serine proteinaseSequence analysis2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1633 – 1814MacroPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2183 – 2565HD1By similarityAdd BLAST383
Regioni2769 – 3042HD2By similarityAdd BLAST274
Regioni3430 – 3613HD3By similarityAdd BLAST184

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21557, Macro_X_Nsp3-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009097, Cyclic_Pdiesterase
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR039573, NS2A-like
IPR038765, Papain-like_cys_pep_sf
IPR009003, Peptidase_S1_PA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05213, Corona_NS2A, 1 hit
PF01661, Macro, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
SSF54001, SSF54001, 1 hit
SSF55144, SSF55144, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51154, MACRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1a (identifier: P0C6F4-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTSRELTN ETELHLCSST LDLISKSQLL AQCLGTPQNL VSLSKMVPSI
60 70 80 90 100
LESPTLEPRY TSTHSSSLQS LQLLALNTSS TLYKWTTGSI SKLRGHLERE
110 120 130 140 150
LCRGLVPLND FIPKGNYVEL SLMIPSVLTG QGTSTTTTLQ EMCSDMVQSC
160 170 180 190 200
IKSMETDLLK GVLALKDQTS CQEYFLSANY QSLIPPQPLV NAMRMSSVVD
210 220 230 240 250
LSPLILENTR LLLKLSPFHG GTSVSYTSMI REFVDCSRRD EKCLKRRLTK
260 270 280 290 300
KQKRQEEGSF DANKVITLGG KMYRYRVVIL KCSDEVDDLI GFDGKVGEFD
310 320 330 340 350
YNFENVPHCW RDLVKRRCLI RAKATWNLAG GVDENLDHVY IDESQXDFRC
360 370 380 390 400
ADGSSDSPSA CVEDPHLEER IFSRVWLKQT SRFFGTKIQQ VSELFKSIGL
410 420 430 440 450
PELETTYCGV NPVKVGNKWL SFRDQGRSRV FFVYTDSNVY LATTRQKVCC
460 470 480 490 500
DYILTKFKSV KWIGNKPDQC RVVKVLAWLI SVNKVKNCTR VITPMLTVQG
510 520 530 540 550
KISHRRVDYL DISVLDSYVS DTAGLNCVQK VKKFLSMYYN CGADLGLLDN
560 570 580 590 600
FLTPIECGTK QLVFERCNCP NHQFYVAQFD NHVVLGLGRP TGVVYPEEIP
610 620 630 640 650
SCANIYAVGF ATQKRVVEVH YYSEMDRHQL PQDYYYFAYD QEFQHVGGDD
660 670 680 690 700
YVNHHLDDVE DQPFPPVLFD DVYDSGDSLD DGGSDLDCFD VGYDFFWPEA
710 720 730 740 750
PIPVPSPYGY YQGQRLRDLC VAGGDFGCDC PRCDGTFIYH PFRPRHYHSF
760 770 780 790 800
DEVGPFIQMC EFTLTYSGQN YNLFYGLEPK VCLQDLVEAS DKLLQLLVRG
810 820 830 840 850
QLENISLPND ILACLSSLKL GANIHPFLWP APFFNANGEW VDIFGGGDFT
860 870 880 890 900
VFGEDFCLKA KSMVESVYFL VENFFSVDCP IGNLYCNLHL DGDVKKMLWS
910 920 930 940 950
TIHMKYIYLA LIHSEKVFNI ILNSRQLSHQ ELVKLVIIGT FDVSIVAPCA
960 970 980 990 1000
CSGDCNHGKV YNWTNLLSSV YRFVTLDQLV GLSYCEKRSL VLRKVQQYLE
1010 1020 1030 1040 1050
VEEGYQRPVQ LLMAPFYGFN DNAEPDEQPL TGVFHQQVMQ MFDTCVMLDV
1060 1070 1080 1090 1100
ICGLKRPRAS VYNLFGVLAD YFRRPFTFRY YQVAEFSGSE STQVFTDVTS
1110 1120 1130 1140 1150
ALTSKDPCSN RPYIYHDYAV CRVVEPRTAA VTTRGAIYPP EVIEMIRSYL
1160 1170 1180 1190 1200
PIEFDVGVMN YVDGNCDFKY CNLEFCLSGR GLVKLDTGEL LDYKTNLFVV
1210 1220 1230 1240 1250
RYKTLPLLYV TSNPIYLSDF SLDNAVCLTG DFKLSFDVEP GSTLFGLYFT
1260 1270 1280 1290 1300
NGRCYRDVWE TLPRFGLGTL SPPKCHSKCE PFENLAEVFF FKRRVQLVPL
1310 1320 1330 1340 1350
VNNYTPVFRH RPDIPKVLTV ELMPYYSSIG YQGFVAPKCV LPGCVATQYC
1360 1370 1380 1390 1400
KLRHQLDRCV QVTKLAVAYA FYFKPLNIGS LYHLDPMRGT SYGKPAVVQF
1410 1420 1430 1440 1450
EPVGLIKEVN ILVYQFGKHV AIHYFPECPT YVAYGHYPSH SVGVWLGYLP
1460 1470 1480 1490 1500
SVEECVIAQR NYRVYVPTCF RLSRTGCYHI QQDEDFERTH ITVSYHYARD
1510 1520 1530 1540 1550
FDTKSLTPMF QMFSKIFGKS KQDLICALNS LSEESQSVLT LFCEEFDSAY
1560 1570 1580 1590 1600
TLQTISDEVS FETSTSPELV ACVLAYAIGY ELCLTVKTDG ECESLDVGSS
1610 1620 1630 1640 1650
LEQVYVDYDV SKNVWDLSTH LQDDSSDDLE LPFNQYYEFK VGRASVVLVQ
1660 1670 1680 1690 1700
DDFKSVYDFL KSEQGVDYVV NPANNQLKHG GGIAKVISCM CGPKLTSWSN
1710 1720 1730 1740 1750
NYIKQYKKLG VTCAIRSPGF QLGKGVQIIH VVGPKSADSD VVNKLEASWR
1760 1770 1780 1790 1800
SVFQNVKPDT TVLTSMLSTG IFGCSVTDSA TTLLSNLVDL DKDVVVFVVT
1810 1820 1830 1840 1850
NVSDQYIEAL GVVESFQSAH GLPNFGNTCW FNALYQLLKS FAVKEQIVQD
1860 1870 1880 1890 1900
LVNCFDDFYE CPTRQCVEWV CDQLGVVFGE QYDAVEMLVK IFDVFKCNVR
1910 1920 1930 1940 1950
VGYDCLARLQ QVALGSCREV PADAVLMFFG QDKSGHWVAA RKVCGVWYTF
1960 1970 1980 1990 2000
DDKVVVKKDP DWSKVVLVLR ERGLFKATDF ETPRPRRRRV AYRVPRDTIS
2010 2020 2030 2040 2050
QDAIMFLEER QFSSGTMLAH SCVESVESFH VEGVQPSPLQ SVDGLDDVAD
2060 2070 2080 2090 2100
LSCDNHVCDN SDLQEPQVVV SQPSEVLTTS MSIECPVLEN SECSVETDLN
2110 2120 2130 2140 2150
PVCEENEQVG ESGIKEQDGV TTSDSQQVFS KSLDPIIKQH EVESVEPQDL
2160 2170 2180 2190 2200
PVFSQQPQVM LSMTWRDVLF QQYLGFKSDL LSLTHVNKFK IVVYLMVLWF
2210 2220 2230 2240 2250
VLLYCFSDFS LLSRFCLYVF LLWLSHVVLV VKKLDLGLVN SGGESYVLRI
2260 2270 2280 2290 2300
LSSVKVPNCI AFNCDGVHWL ILKLLFYSFH FYDFFVKTLV VVFQMPQLRC
2310 2320 2330 2340 2350
FTWPLLKLGF ADTFLSHHIL AFPTKQVSQS CLPVFGDERK YIYVPYWCKE
2360 2370 2380 2390 2400
SFRTLVARAK QLTATGRTKT LDNWHYQCCS KTVKPSSCFN VRDFVFDDAC
2410 2420 2430 2440 2450
NNHKHYGFFS ALWFYVVFYS GFVSFWLPLM FCYCALFMCT FKNLPVNITR
2460 2470 2480 2490 2500
PIRWTVLQQV VDDLLSIITK PLFGRPACPP LSAYLTATTA DEAVRASRSL
2510 2520 2530 2540 2550
LGRFCTPVGF QQPIMNVENG VAVSSLGFIN PLMWPLFIVV LLDNRFVWFF
2560 2570 2580 2590 2600
NVLSYIMLPV FVIILFYFYL RKICGCVNVK GVVKNCTRHF QNFSKPLVAA
2610 2620 2630 2640 2650
GVHGNRTNFT YQPMQENWCD RHSWYCPKEE HYMTPEMAMF IKNYYNLATS
2660 2670 2680 2690 2700
PMADTIWCDY VKSVPNMTWA NFKFSLFKSN ETVMCGPSSH ADSMLLSWYA
2710 2720 2730 2740 2750
FLHGIRFAVN PSVIDIPSQT QPIYVSSDSD DSLDKGCDVS LRPTKNKGKF
2760 2770 2780 2790 2800
KKQSVAYFSA GPVDLWYYVM LIIALGAIFV FMYSCFMVGQ YVVMPRDKFF
2810 2820 2830 2840 2850
GVNPTGYSYV NAQPYLHASP PVLRNSDGMV LATPLKVPSI SYSVYRLLSG
2860 2870 2880 2890 2900
HLYFTKLIVA ENECTPPFGA XRLSHEFTCN DFTYILPAHL RIFGRYIMLI
2910 2920 2930 2940 2950
HPDQLHMLPF EVEHSTHTRL CYVTGTNIVE CLPTFEIISP YVFVVLVAIF
2960 2970 2980 2990 3000
TIVFLFLLRM YIVMYSYFKV FTYVVFKLLF VNTVMVLFVV CLPPLVPGVV
3010 3020 3030 3040 3050
FVLALWLCDS VVFLLYLAVL SLFILPWFYV MLFVLIVGGF VFWWMMKSSD
3060 3070 3080 3090 3100
VVHLTPDGLT FNGTFEQVSK CVFPLNPLIV NRLLLDCRMS HSDLVEKSKL
3110 3120 3130 3140 3150
KTTEGKLATE MMKVFMTGET AYYQPSNFSF QSVFSKVVSP FTLHARPPMP
3160 3170 3180 3190 3200
MFRLYVYFNG QCVGTTCTGT GFAIDDSTIV TAKHLFECDD LKPTHLSVEL
3210 3220 3230 3240 3250
SCRSYWCTWK EPNVLSWKFE GENAYISVEN LRDFYGIDFK YLPFQQIECE
3260 3270 3280 3290 3300
FYKRMEAVTI YSIKYGSEFA TQAWQTVNGH FVCCNTEGGD SGAPLVWRDS
3310 3320 3330 3340 3350
VIGVHQGLCD SFKTTLASDS KGVMMTEVKG YHVDPPVYYK PIIMSAAYNK
3360 3370 3380 3390 3400
FVADSDVSVG ECTNYHNFVN EDFFSMHDEL EKVSFGDKMF RYCQSLPRYL
3410 3420 3430 3440 3450
EPLHYFHVPS FWQPFKKQSV SSNVSWVVEN LHFIFSVYFL VCDFVAYWWL
3460 3470 3480 3490 3500
DDPFSVVLPL FFVVQLLSTV VLKNVLFWNT SYLVTLAVTF YVHSEVAESM
3510 3520 3530 3540 3550
YLLGLFSDQI VNRVGLILVV SVMCLFVVVR VVVNVKRAIF VVVVSVLLIV
3560 3570 3580 3590 3600
VNVVLGVVQF NSLVAVCMFD IYAVFAALLT PQPVVAIMML ILFDTKCLMS
3610 3620 3630 3640 3650
FAFVVIVLSF RVFKNYKFVR VLHNLCNFDF VLTQLSLFRY RHHNQGNNPS
3660 3670 3680 3690 3700
HYEALWLFLK ELYYGVQDVK YEVFSPQAGT YNVRFLTDMT EQDQLEAVEQ
3710 3720 3730 3740 3750
VQRRLQRFSI VQDKNSQRLV LYSKNVDFLR SQIQHQRVLG ANPFIITTLT
3760 3770 3780 3790 3800
PKDIAIDNVE VHNPSQFKPE DLQAHMWFYS KSPIFVGQVP IPTNVQTAAV
3810 3820 3830 3840 3850
LDTTYNCQDL TADEKNNVAA NLQIQNAALT LSLFEECNRF LESELGDVPT
3860 3870 3880 3890 3900
LMWQSEDVVD VKQLEVQIEK LRVVLDGMQL GTSEYKATRK QINILQSQLD
3910 3920 3930 3940 3950
KALAFERKLA KFLEKVDQQQ AITNETAKQL SAFKNLVKQV YESYMSSLKV
3960 3970 3980 3990 4000
RVVESNDASC LLTSTDLPRK LVLMRPITGL DNIKIVEKAN GCEITAFGDT
4010 4020 4030 4040 4050
FTTGLGSNLA GLAYSSTQPL SAYPFIFNLE GIFKQQANIG YKTVECNMSS
4060 4070 4080 4090 4100
DNGSVLYKGK IVAVPSEDNP DFVVCGKGYK LDCGINVLMI PSIVRYITLN
4110 4120 4130 4140 4150
LTDHLQRQSL KPRRRLQYKQ QGVRLGGVNL GEHQAFSNEL ISSVGYTTWV
4160 4170 4180 4190 4200
SSTVCTDKSH KHPWFVQIPS SEKDPEWFMH NTQVKNNQWV VDAKPTHWLV
4210 4220 4230 4240 4250
DADTNEQLFA LALTDEEYLK AESILAKWSP ITQDVECWFK DLRGYYTVSG
4260 4270 4280 4290 4300
LQPLWPVCPK KICSLKIVPI FQSQSVAYAD EPTHFLSLPV VNKNFLEAFY
4310 4320 4330 4340 4350
ELQEGFPGEK QVAPHISLTM LKLTEEDVAK VEDILDEMVL PNTYATITNP
4360 4370 4380 4390 4400
HMMGQYYVFE VEGLQALHDE VVSVLRQHGI ACDQTRMWKP HLTIGEIKDG
4410 4420 4430 4440
SVFNKFKDFG ITCKLEDCDF VKLGAPKANA RYEFIATLPV GDLNC
Note: Produced by conventional translation.
Length:4,445
Mass (Da):505,933
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4F915B6BBF9F9D9
GO
Isoform Replicase polyprotein 1ab (identifier: P0C6V8-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
The sequence of this isoform can be found in the external entry P0C6V8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:6,733
Mass (Da):765,975
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY427798 Genomic RNA Translation: AAS17958.1

NCBI Reference Sequences

More...
RefSeqi
YP_337906.1, NC_007447.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
3707765

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3707765

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY427798 Genomic RNA Translation: AAS17958.1
RefSeqiYP_337906.1, NC_007447.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein family/group databases

MEROPSiS65.001

Genome annotation databases

GeneIDi3707765
KEGGivg:3707765

Family and domain databases

CDDicd21557, Macro_X_Nsp3-like, 1 hit
Gene3Di3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR009097, Cyclic_Pdiesterase
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR039573, NS2A-like
IPR038765, Papain-like_cys_pep_sf
IPR009003, Peptidase_S1_PA
PfamiView protein in Pfam
PF05213, Corona_NS2A, 1 hit
PF01661, Macro, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
SSF54001, SSF54001, 1 hit
SSF55144, SSF55144, 1 hit
PROSITEiView protein in PROSITE
PS51154, MACRO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1A_BRV1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6F4
Secondary accession number(s): Q3T8J2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 2, 2021
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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