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Entry version 66 (02 Jun 2021)
Sequence version 1 (10 Jun 2008)
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Protein

Replicase polyprotein 1a

Gene

1a

Organism
Berne virus (BEV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 3C-like serine proteinase is responsible for the majority of cleavages.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3304Charge relay system; for 3C-like serine proteinase activitySequence analysis1
Active sitei3347Charge relay system; for 3C-like serine proteinase activitySequence analysis1
Active sitei3416Charge relay system; for 3C-like serine proteinase activitySequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandMetal-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S65.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1a
Short name:
pp1a
Alternative name(s):
ORF1a polyprotein
Cleaved into the following 9 chains:
Non-structural protein 1
Short name:
nsp1
Non-structural protein 2
Short name:
nsp2
3C-like serine proteinase (EC:3.4.21.-)
Short name:
3CLSP
Alternative name(s):
M-PRO
nsp3
p27
Non-structural protein 4
Short name:
nsp4
Non-structural protein 5
Short name:
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBerne virus (BEV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11156 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesTornidovirineaeTobaniviridaeTorovirinaeTorovirusRenitovirusEquine torovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiEquus caballus (Horse) [TaxID: 9796]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006571 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2303 – 2323HelicalSequence analysisAdd BLAST21
Transmembranei2330 – 2350HelicalSequence analysisAdd BLAST21
Transmembranei2385 – 2405HelicalSequence analysisAdd BLAST21
Transmembranei2535 – 2555HelicalSequence analysisAdd BLAST21
Transmembranei2639 – 2659HelicalSequence analysisAdd BLAST21
Transmembranei2664 – 2684HelicalSequence analysisAdd BLAST21
Transmembranei2889 – 2909HelicalSequence analysisAdd BLAST21
Transmembranei3057 – 3077HelicalSequence analysisAdd BLAST21
Transmembranei3106 – 3126HelicalSequence analysisAdd BLAST21
Transmembranei3142 – 3162HelicalSequence analysisAdd BLAST21
Transmembranei3556 – 3575HelicalSequence analysisAdd BLAST20
Transmembranei3580 – 3602HelicalSequence analysisAdd BLAST23
Transmembranei3611 – 3631HelicalSequence analysisAdd BLAST21
Transmembranei3640 – 3660HelicalSequence analysisAdd BLAST21
Transmembranei3663 – 3683HelicalSequence analysisAdd BLAST21
Transmembranei3698 – 3718HelicalSequence analysisAdd BLAST21
Transmembranei3723 – 3738HelicalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003380161 – 4569Replicase polyprotein 1aAdd BLAST4569
ChainiPRO_00003380171 – 2873Non-structural protein 1Sequence analysisAdd BLAST2873
ChainiPRO_00003380182874 – 3251Non-structural protein 2Sequence analysisAdd BLAST378
ChainiPRO_00003380203252 – 35433C-like serine proteinaseSequence analysisAdd BLAST292
ChainiPRO_00003380213544 – 3802Non-structural protein 4Sequence analysisAdd BLAST259
ChainiPRO_00003380223803 – 3979Non-structural protein 5Sequence analysisAdd BLAST177
ChainiPRO_00003380233980 – 4161Non-structural protein 6Sequence analysisAdd BLAST182
ChainiPRO_00003380244162 – 4246Non-structural protein 7Sequence analysisAdd BLAST85
ChainiPRO_00003380254247 – 4399Non-structural protein 8Sequence analysisAdd BLAST153
ChainiPRO_00003380264400 – 4569Non-structural protein 9Sequence analysisAdd BLAST170

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own protease yield mature proteins. 3CL-PRO is autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2873 – 2874Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei3251 – 3252Cleavage; by 3C-like serine proteinase2
Sitei3543 – 3544Cleavage; by 3C-like serine proteinase2
Sitei3802 – 3803Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei3979 – 3980Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4161 – 4162Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4246 – 4247Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4399 – 4400Cleavage; by 3C-like serine proteinaseSequence analysis2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0C6F3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C6F3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1679 – 1860MacroPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2158 – 2191DisorderedSequence analysisAdd BLAST34
Regioni2303 – 2683HD1Add BLAST381
Regioni2889 – 3162HD2Add BLAST274
Regioni3555 – 3738HD3Add BLAST184

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21557, Macro_X_Nsp3-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR039573, NS2A-like
IPR038765, Papain-like_cys_pep_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05213, Corona_NS2A, 1 hit
PF01661, Macro, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51154, MACRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1a (identifier: P0C6F3-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTSSSILDI PSKMFRILKN NTRETEQHLS SSTLDLISKS QLLAQCFDTQ
60 70 80 90 100
EIMASLSKTV RSILESQNLE HKSTLTPYNS SQSLQLLVMN TSCTQFKWTT
110 120 130 140 150
GSTSSVKALL EKELCRGLVP LNDITPKSNY VELSLLTPSI LIGNETSTTT
160 170 180 190 200
TLPEIPLDME QSIISCVENT LLKEVQALSG QESCQEYFLS ANYQSLIPPQ
210 220 230 240 250
VLLNLMKMSS VVDLSPLTLP NTRLWLKLSP FHGGTSVSYA TQIKGYANCA
260 270 280 290 300
RREEKCLKNR LTKKQKNQEK GSFDARSVIT LGGKMYRYKV VVLRCEDQSD
310 320 330 340 350
NLSELQFEPQ VEYTMDMVPH CWKELVKKRL IRAKGTWDLS CVEDLDLDHV
360 370 380 390 400
EVRGDSLLHR SSVVHDLTSI VDDTLQEKLF SRTWLRQSLK YSGNILQRLS
410 420 430 440 450
SLFATEGLKK ITLVNSDITP VQVGDKWLNF VDFGKSTVFF VKTLNNIHLA
460 470 480 490 500
MTRQRESCNY IHEKFGRVRW LGAKPEQGAI VKVFAWCLNK KEFKFRDNQL
510 520 530 540 550
KQYVCRQGVI KHEPCEYLNV EVLDEFVALN NDLNCVQKIK TYLAAYFGLK
560 570 580 590 600
KVKLTQKNFM TPLITKKQEL VFQPCNCPNH QFYVAQFDKH VTLGLGRKDG
610 620 630 640 650
ILFAEQVPSY AIILAVGFGT VETQLVTHYY SEMRRVYHPL DFQSNTFVFD
660 670 680 690 700
HQGVMLEDIS PADYNDVGEE DYQLEYSGGF DQPFQNYHSD DEDQAFPDFE
710 720 730 740 750
DERHPDEENW ARPIISSGES SVVSSRPSSP LVYSSLVPVA SPFGYMNGIR
760 770 780 790 800
VFDICLADDL DFLQIHGQCP CARCKGLYFY QPIRPRGFTI FENVVEFFSF
810 820 830 840 850
VEKCEVFEEI GPFFKMIEYS MLYNEYNIFY GLGKKIYQSD LVLPVKHLDQ
860 870 880 890 900
LWKRAQLDID VVSEFENFKN SLQNINNVVY IAPYFNDQGE WNDIFDGYEF
910 920 930 940 950
NLNDNQFWFQ AKPVYDLVCY IYQGFFSDSR PLEKLYQKLC LDYHTSAMLH
960 970 980 990 1000
TQTHLKYCYV ALLHSERAFQ MSINLDSLDN EQLHFLATMG MGDASLVGPT
1010 1020 1030 1040 1050
YLSEYHSNFN WYSIMSKACH YVKLEQLVGL TYQEKRLMIL SRVQEFYEQQ
1060 1070 1080 1090 1100
HRGPIQLILS PLKVVNLPPI TCTEGYCYQP VTRLFDTCVM PDIMKKLSRK
1110 1120 1130 1140 1150
RTSVSDVFGI LADYFKRTLS YRCFKVHEFC GIERQQEFSD MTTLKLVTDW
1160 1170 1180 1190 1200
CQDTYYFYNE YATMTDVEPK VQVSSDYYLK IPSEVVEHIR QFLPHNVNVG
1210 1220 1230 1240 1250
LMNYVSSNCD FDQCKFEFCL SGKGYVLGNM FFNRCAIQYV KTNLFIVLFK
1260 1270 1280 1290 1300
SRPLLYITQE SIYLSDFNVL QAQCLTGEFC LDFEPVQGKT LFGVYFTNGQ
1310 1320 1330 1340 1350
RYGQQWETLP RFSLKPLNSP RKRVPTQPFE ELAEVCIFKQ KLKLTQLHND
1360 1370 1380 1390 1400
CSVTPRVCSI PQTITATFQP YYCLENFYGV KAPKVIVSGH LATHYVKLTH
1410 1420 1430 1440 1450
KISKCVLVTK LAVARAFYFT PTSMGSHYHL DPMEGISFGK RATVQFEPVG
1460 1470 1480 1490 1500
LIKDVNLLVY QFGSHVSIQF FPEAPCIVAD GHYPSKYSGV WLGYLPSVEE
1510 1520 1530 1540 1550
CKIAQVNHRV YVPTILRTSK SAPFHIIQNG DMGRGPITVT YHYAKNFDNK
1560 1570 1580 1590 1600
SLTPMFKMFQ QVFEKSKDDI FKAFNTMSLE QKKVLSHFCG EFDEAYTLQT
1610 1620 1630 1640 1650
MSDEISFESS AYPDVVACSL AYILGYEMCL TVKVNAKNEK LDIGSQCERV
1660 1670 1680 1690 1700
FVDYDVKKNE WTLSPEEGED SDDNLDLPFE QYYEFKIGQT NVVLVQDDFK
1710 1720 1730 1740 1750
SVFEFLKSEQ GVDYVVNPAN SQLKHGGGIA KVISCMCGPK LQAWSNNYIT
1760 1770 1780 1790 1800
KNKTVPVTKA IKSPGFQLGK KVNIIHAVGP RVSDGDVFQK LDQAWRSVFD
1810 1820 1830 1840 1850
LCEDQHTILT SMLSTGIFGC TVNDSFNTFL SNVARLDKSL VVFVVTNMVE
1860 1870 1880 1890 1900
QYNQAFAVIK MYQQYHGLPN FGNTCWFNAL YQLLKSFSEK EQCVNDLLNC
1910 1920 1930 1940 1950
FDDFYDCPTS QCVEWVCEQL GVQFGQQQDA VEMLMKVFDV FKCDVRVGFD
1960 1970 1980 1990 2000
CLSRLQQVNC GFCVEVPAQA VLMFSGKDQC GHWTAARKIV DKWYTFDDNH
2010 2020 2030 2040 2050
VVQKDPVWQN VVLVLRDRGI FRSADFERKP ARRRRVSHRV PRDTLSQDAI
2060 2070 2080 2090 2100
TYIEDLRFSS GTCLSRYFVE SVESFVSGDN VSEVSDEQTC VEVAIEESDG
2110 2120 2130 2140 2150
HVEQICQSSV DCVGMPESFQ FTFSMPLQTF VQECDQKCED DFSQEHVECD
2160 2170 2180 2190 2200
QQFEPVEQVG QGGQQDGQVD QQIKESEQVV EPSAPSGQES PQALLQQVVD
2210 2220 2230 2240 2250
EVVYQIEQVK CDQKQDQDSV QCDEIEEINS RGEQTVQQQL QPILGHDLNE
2260 2270 2280 2290 2300
NEGPTLSVGA GKLVRCRSLA VTESNLSTSN TIFVWSEVLT HQYIGFKTDL
2310 2320 2330 2340 2350
MGLTYNIKFK LICYVLFLWF GVLCCTSHNT PFYMRLCIYL VLLWLSLMIW
2360 2370 2380 2390 2400
NASQINVKTG WNELYVLKLL TSIKLPNIVK FRCELVQWFV LKCLFVSFYV
2410 2420 2430 2440 2450
YDYVVKVCVS IFQMPQLRPF TWPFIKLGFV DTFLSHHILA FPEKVANQST
2460 2470 2480 2490 2500
LPTCGDKRYY VYVPSWCRAS FTSLVMRARE LTSTGRSKTL DNWHYQCCSK
2510 2520 2530 2540 2550
TAKPLSCFNV REFVFDQDCK HEAYGFLSSL CVYLLFYSGF LTFWLPLFCY
2560 2570 2580 2590 2600
YYVLFMCTFK NLPVDITKPI KWTVLQQVVN DVLSLVTKPL FGRPVCPPLT
2610 2620 2630 2640 2650
TYLTSTTADE AVKVSRSLLG RFCTPLGFQQ PVMNVENGVT VSNFGFFNPL
2660 2670 2680 2690 2700
MWPLFVVVLL DNRFIWFFNV LSYVMMPVFV IILFYFYLKK ICGCINFKGL
2710 2720 2730 2740 2750
SKCCTKHFNQ FSKPLVAAGV HGNRTNFTYQ PMQEHWCDRH SWYCPKEEHY
2760 2770 2780 2790 2800
MTPDMAVYIK NYYNLACAPT ADLVWCDYTK SAPTMTWSNF KYSSYKAKET
2810 2820 2830 2840 2850
VLCAPSSHAD SMLMAWYALL HNVRFTVNPN VVDLPPAVNT IYVSSDSEDS
2860 2870 2880 2890 2900
VQDKSQPDVK LRPKKPKGNF KKQSVAYFSR EPVDIWYYTT LVIVMGVLFM
2910 2920 2930 2940 2950
FMYSCLMVGQ YVVMPRDKFF GVNPTGYSYV NAPPYLHAAP PVLQNSDGMI
2960 2970 2980 2990 3000
LATQLKVPSI TYSVYRLLSG HLYFTKLIVS DNECTPPFGA ARLSNEFSCN
3010 3020 3030 3040 3050
GFTYVLPAHL RFFNRYVMLI HPDQLHMLPF EVEYGSHTRV CYTTGSNSVE
3060 3070 3080 3090 3100
CLPTFEIISP YVFVFIVVIF TVIFLILIRL YIVMYSYFKV FTYVVFKLLF
3110 3120 3130 3140 3150
VNIIMVLFVV CLPPLVPGVV FVLALWLCDS VMFLLYLAFL SLFILPWFYV
3160 3170 3180 3190 3200
LFFLFMVGGF VFWWMMRSAD VVHLTTDGLT FNGTFEQISK CVFPLNPLIV
3210 3220 3230 3240 3250
NRMLLDCQMS HSDLVEKSKL KTTEGKLANE MMKVFMTGET SYYQPSNFSF
3260 3270 3280 3290 3300
QSVFSKATSP FTLHARPPMP MFKLYVHFTG SCVGSTSTGT GFAIDDNTIV
3310 3320 3330 3340 3350
TAKHLFEYDD LKPTHVSVEI VTRSHSARSA SIIWKEPDVK GWTFKGENAY
3360 3370 3380 3390 3400
IQVENLKDFY IEDFKYLPFQ QIEKDFYKRM EPVTIYSVKY GSEFATQAWQ
3410 3420 3430 3440 3450
TVNGHFVCYN TEGGDSGAPL VCNGRIVGVH QGLCDNFKTT LASDFEGKMM
3460 3470 3480 3490 3500
TEVKGHHVDP PVYYKPIIIS AAYNKFVAGE DSSVGDGKNY HKFENEDFAC
3510 3520 3530 3540 3550
MCKELESVTF GDQLRRYCYN LPQFLEPLQY FHVPSFWQPF KKQSVSNNVS
3560 3570 3580 3590 3600
WVVEHLHFIF SIYFLICDFV AYWWLDDPFS VVLPLFFIVQ LLSTVFLKNV
3610 3620 3630 3640 3650
LFWTTSYLIT LAVTFYIHSE VAESMFLLGF LSDRVVNRMS LIIVVAIMCL
3660 3670 3680 3690 3700
FVVVRVVVNV KRAIFVFVVS VVLIFVHICL GIVQFNSFVN VVLFDVYAVF
3710 3720 3730 3740 3750
TALLTPQPVV AIIMLLLFDT KMLMSFAFIV IVLSFRVFKD YKFVKVLHNF
3760 3770 3780 3790 3800
CNFDFVLSQV SLFRYRHRNQ GNDPTHYEAL WLFLKELYYG IQDAKYEVFS
3810 3820 3830 3840 3850
PQAGSYNVKF LTDMTEQDQL EAVEQVQRRL QRFNIVQDKA SPRLVLYSKT
3860 3870 3880 3890 3900
IEFIKDQIQQ QRAVGANPFI ITTLTSNDIG LDNVEVHNPA NFKPEDLQAH
3910 3920 3930 3940 3950
MWFFSKSPVF IGQVPIPTNV QTAAVLDTTY NCQDLTADEK NNVAATLQIQ
3960 3970 3980 3990 4000
NAAITLSLFE KCTQFLESEL GEVPTLMWQA EDVADIKHLE SQIENLRKVL
4010 4020 4030 4040 4050
DGMQFGTTEY KATRKQLNIC QSQLDQAKAF ERKLAKFLEK VDQQQAITNE
4060 4070 4080 4090 4100
TAKQLSAFKN LVKQVYESYM SSLKVKVLEA NDASCLLTST DLPRKLVLMR
4110 4120 4130 4140 4150
PITGVDGIKI VEKANGCEIT AFGTTFNTGH GSNLAGLAYS TTQPLSAYPF
4160 4170 4180 4190 4200
IFNLEGIFKQ QANIGYKTVE CNMSSHNGSV LYKGKVVAVP SDDNPDFVVC
4210 4220 4230 4240 4250
GKGYKLDCGI NVLMIPSIVR YITLNLTDHL QKQSLKPRRR LQYRQQGVRL
4260 4270 4280 4290 4300
GGVNLGEHQA FSNELISTVG YTTWVSSTVC RDNTHKHPWF VQIPVNEKDP
4310 4320 4330 4340 4350
EWFMHNTQLK DNQWVVDLKP THWLVNADTG EQLFALSLTD EQALKAEAIL
4360 4370 4380 4390 4400
QKWSPITQDV ECWFKDLKGY YTVSGFQPLW PVCPVNICNV RLDPVFKPQS
4410 4420 4430 4440 4450
IVYADDPTHF LSLPVVNKNF LAAFYDLQEG FPGKKQVAPH ISLTMLKLSD
4460 4470 4480 4490 4500
EDIEKVEDIL DEMVLPNSWV TITNPHMMGK HYVCDVEGLD SLHDEVVSVL
4510 4520 4530 4540 4550
REHGIACDQK RLWKPHLTIG ELNDVSFDKF KDFAISCKLE DCDFVKLGAP
4560
KANARYEFIT TLPLGDLNC
Note: Produced by conventional translation.
Length:4,569
Mass (Da):523,793
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i753D2EA1FEF31AEA
GO
Isoform Replicase polyprotein 1ab (identifier: P0C6V7-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
The sequence of this isoform can be found in the external entry P0C6V7.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:6,857
Mass (Da):784,289
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251 – 252RR → KK in CAA39493 (PubMed:1856694).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ310701 Genomic RNA Translation: ABC26008.1
X56016 Genomic RNA Translation: CAA39493.1
X52374 Genomic RNA Translation: CAA36600.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S11237
S11238

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ310701 Genomic RNA Translation: ABC26008.1
X56016 Genomic RNA Translation: CAA39493.1
X52374 Genomic RNA Translation: CAA36600.1
PIRiS11237
S11238

3D structure databases

SMRiP0C6F3
ModBaseiSearch...

Protein family/group databases

MEROPSiS65.001

Proteomic databases

PRIDEiP0C6F3

Family and domain databases

CDDicd21557, Macro_X_Nsp3-like, 1 hit
Gene3Di2.40.10.10, 2 hits
3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR039573, NS2A-like
IPR038765, Papain-like_cys_pep_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
PfamiView protein in Pfam
PF05213, Corona_NS2A, 1 hit
PF01661, Macro, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51154, MACRO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1A_BEV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6F3
Secondary accession number(s): P18458
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 2, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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