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Entry version 89 (08 May 2019)
Sequence version 1 (18 Mar 2008)
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Protein

Dynein heavy chain 2, axonemal

Gene

Dnah2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1832 – 1839ATPSequence analysis8
Nucleotide bindingi2113 – 2120ATPSequence analysis8
Nucleotide bindingi2445 – 2452ATPSequence analysis8
Nucleotide bindingi2791 – 2798ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 2, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnah2
Synonyms:Dnahc2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107731 Dnah2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225431 – 4456Dynein heavy chain 2, axonemalAdd BLAST4456

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0C6F1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0C6F1

PRoteomics IDEntifications database

More...
PRIDEi
P0C6F1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0C6F1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C6F1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005237 Expressed in 72 organ(s), highest expression level in small intestine

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P0C6F1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0C6F1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P0C6F1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104299

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C6F1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1439 – 1474TPR 1Add BLAST36
Repeati2750 – 2783TPR 2Add BLAST34
Repeati3101 – 3134TPR 3Add BLAST34
Repeati4101 – 4134TPR 4Add BLAST34
Repeati4135 – 4169TPR 5Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1795StemBy similarityAdd BLAST1795
Regioni1794 – 2015AAA 1By similarityAdd BLAST222
Regioni2075 – 2302AAA 2By similarityAdd BLAST228
Regioni2407 – 2654AAA 3By similarityAdd BLAST248
Regioni2751 – 3003AAA 4By similarityAdd BLAST253
Regioni3018 – 3301StalkBy similarityAdd BLAST284
Regioni3387 – 3617AAA 5By similarityAdd BLAST231
Regioni3833 – 4052AAA 6By similarityAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1218 – 1274Sequence analysisAdd BLAST57
Coiled coili3041 – 3078Sequence analysisAdd BLAST38
Coiled coili3245 – 3333Sequence analysisAdd BLAST89
Coiled coili3552 – 3596Sequence analysisAdd BLAST45

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157623

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237308

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C6F1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR10676 PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 2 hits
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P0C6F1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKAEKKRK VAGRGGARAG RVVRAPQSTA GPGATEASLL PDGQEPEPES
60 70 80 90 100
GKEDSVLGLQ AFASWRLTPA LHGEANTPPT LLHPQPLFHR RLTTLNLILS
110 120 130 140 150
CSRAGTRDLA LKPFFLSRTM LTGLADATWT GEHDMVLEHF VQDPAVPALT
160 170 180 190 200
IFIDPVFGLK LELGMPVQTQ NQIVYFIRQA PVPITPENFE ETVQYGTVRG
210 220 230 240 250
AYIPALLRLL SGVYVPQIFM NKSWPESIRN HFVSHLHRFL ASLTDTRYKL
260 270 280 290 300
EGHTVLYIPA EAVQMDPEVV VKDKELVQRL ETSMIHWTRQ IKEVLSAQES
310 320 330 340 350
VETGENLGPL EEIEFWHNRC MDLSSISKQL VKKGVKHIES ILFLAKSSYL
360 370 380 390 400
TPFRKLAQQI QDGSRQAQSN LTFLSILREP YQELAFMKPK DISEKLPKLI
410 420 430 440 450
SLIRIIWVNS PHYNTRERLT ALFRKVCECQ YHFARWEDGK QGPLPCFFGA
460 470 480 490 500
QGPQITRNLL EIEDIFHKNL QTLRAVRGGI LDVKNTSWHE DYNKFRGGIK
510 520 530 540 550
DLEVMTQNLI TSAFELVRDV EHGVLLLDTF HRLATREAIM RTYEKKAVDL
560 570 580 590 600
YMLFNSELAL VNRELNKKWP YLEPYMTQYS GQAHWVRILR RRIDRVMNCL
610 620 630 640 650
SGAHFLPHIG TGEESIHTYQ QMAQAIDEMV RKTFQEWTAT LDKDCIRRLD
660 670 680 690 700
MSLLRISQEK VGMLDVNFDK TLLILFAEID YWERLLFETP HYVMNVAERA
710 720 730 740 750
EDLRILRENL LLVARDYNRI IAMLSPDEQA LFKERIRFLD KKIHPGLKKL
760 770 780 790 800
NWALKGASAF FITECRMHAS KVQMIVNDFK ASTLTIGWKA QEMSELLLVH
810 820 830 840 850
ITGKQVYRDL EFEEAQREHR MAAQQKLVKL HQDVVNIMTN SYEVFKNDGP
860 870 880 890 900
EIQQQWLLYT IRLDHMMEDA LRLNVKWSLL ELSKAINGDG KTTPNPLFRV
910 920 930 940 950
LVILQNDVRG GGSQVEFSPT LQTLASVVND IGSHLFATIS VFRHLPDILT
960 970 980 990 1000
KRKMNREPIY VLVERDEDIR KIQAQISSGM TNNASLLQNY LKTWDMYREI
1010 1020 1030 1040 1050
WEINKDSFIR RYQRLNPPVS SFDADIARYT EVANNVQKEE TVLNIQFVML
1060 1070 1080 1090 1100
DCSHLKFSLV QHCNEWQNKF TTLLKEMAAG RLADLHSYLK DNAEKISHPP
1110 1120 1130 1140 1150
QTLEELGVSL QLMDTLQHDL PNLETQIPPI HEQFTILEKY EVPVPDTVLE
1160 1170 1180 1190 1200
MLESLNGEWL TFQQILLDSE QMLKKHKEKF KTGLIHAADD FKKKAHNLLE
1210 1220 1230 1240 1250
DFEFKGPFTS TVGHTAALDQ IAQMRAMLMA MRDEENNLRS NLGIFKIEQP
1260 1270 1280 1290 1300
VSKDLQILEK ELDALQQVWE ITRDWEESWN QWKMGCFQTL QTEAMESMAH
1310 1320 1330 1340 1350
GLFRRLTRLA KEYKDRNWEI IETTRSKIEQ FKRTMPLISD LRNPALRERH
1360 1370 1380 1390 1400
WDQVKEEVQR EFDQESESFT LEQIVKLGMD QHVEKIAEIS ASATKELAIE
1410 1420 1430 1440 1450
VGLQNIAKTW DSTQLDIVPY KDKGHHRLRG TEEVFQALED NQVALSTMKA
1460 1470 1480 1490 1500
SRFVKAFEKD VDHWERCLSL ILEVIEMVLT VQRQWMYLEN IFLGEDIRKQ
1510 1520 1530 1540 1550
LPNESALFDQ VNNNWKAIMD RMNKDNNALR STHYPGLLET LIEMNAILED
1560 1570 1580 1590 1600
IQKSLDMYLE TKRHIFPRFY FLSNDDLLEI LGQSRNPEAV QPHLKKCFDN
1610 1620 1630 1640 1650
IKLLKIQKVG GSSSKWEAVG MFSGDGEYID FLHPVLLEGP VESWLGDVER
1660 1670 1680 1690 1700
AMRMTLRDLL RNCRVALKKF LNKRDKWVKD WAGQVVITAS QIQWTADVTK
1710 1720 1730 1740 1750
CLMTAKERSD KKILKVSILN KYSEAIRGNL TKIMRLKIVA LVTIEIHARD
1760 1770 1780 1790 1800
VLEKLYKSGL MDVSSFDWLS QLRFYWEKDV DDCIIRQTNT QFQYGYEYLG
1810 1820 1830 1840 1850
NSGRLVITPL TDRCYMTLTT ALHLHRGGSP KGPAGTGKTE TVKDLGKALG
1860 1870 1880 1890 1900
IYVIVVNCSE GLDYKSMGRM YSGLAQSGAW GCFDEFNRIN IEVLSVVAQQ
1910 1920 1930 1940 1950
ILSILSALTA NLTRFYFEGF EINLVWSCGI FITMNPGYAG RTELPENLKS
1960 1970 1980 1990 2000
MFRPIAMVVP DSTLIAEIIL FGEGFGNCKI LAKKVYTLYS LAVQQLSRQD
2010 2020 2030 2040 2050
HYDFGLRALT SLLRYAGKKR RLQPDLSDEE VLLLSMRDMN IAKLTSVDVP
2060 2070 2080 2090 2100
LFNAIVQDLF PNIELPVIDY GKLRDTIEQE IREMGLQITP FTLTKVLQLY
2110 2120 2130 2140 2150
ETKNSRHSTM IVGGTGSSKT TSWKILQASL TSLCRAGEPN YNIVREFPLN
2160 2170 2180 2190 2200
PKALSLGELY GEYDLNTNEW TDGILSSVMR VACADEKPDE KWILFDGPVD
2210 2220 2230 2240 2250
TLWIESMNSV MDDNKVLTLI NGERIAMPEQ VSLLFEVENL AVASPATVSR
2260 2270 2280 2290 2300
CGMVYTDYVD LGWKPYVQSW LEKRPKTEVE PLQRMFEKFI NKILSFKKDN
2310 2320 2330 2340 2350
CNELVPVPEY SGIISLCKLY TVLATPENGV NPADAENYSF MVEMTFVFSM
2360 2370 2380 2390 2400
IWSVCASVDE DGRKKIDSYL REIEGSFPNK DTVYEYYVNP KMRTWTSFEE
2410 2420 2430 2440 2450
KLPKSWRYPP NAPFYKIMVP TVDTVRYNYL VSTLVANQNP VLLVGPVGTG
2460 2470 2480 2490 2500
KTSIAQSVLQ SLPSSQWSVL VVNMSAQTTS NNVQSIIESR VEKRTKGVYV
2510 2520 2530 2540 2550
PFGGKSMITF MDDLNMPAKD MFGSQPPLEL IRLWIDYGFW YDRVKQSIKH
2560 2570 2580 2590 2600
IRDMFLMAAM GPPGGGRTVI SPRLQSRFNI INMTFPTESQ IIRIFGTMIN
2610 2620 2630 2640 2650
QKLQDFEEEV KPIGNVVTEA TLDVYNTVVQ RFLPTPAKIH YLFNLRDISK
2660 2670 2680 2690 2700
VFQGMLRANK DFHDTKASIT RLWIHECFRV FSDRLVDTAD MEAFMGILSD
2710 2720 2730 2740 2750
KLGTFFDLTF HHLCPNKRPP IFGDFLKEPK VYEDLVDLTV LKTAMETALN
2760 2770 2780 2790 2800
EYNLSPSVVP MQLVLFREAI EHITRIVRVI GQPRGNMLLV GIGGSGRQSL
2810 2820 2830 2840 2850
ARLASSICDY NTFQIEVTKH YRKQEFRDDI KRLYRQAGVE LQTTSFLFVD
2860 2870 2880 2890 2900
TQIADESFLE DINNILSSGE VPNLYKSDEF EEIQNHIIDQ ARAEQIPESS
2910 2920 2930 2940 2950
DSLFAYLIER VRNNLHIVLC LSPVGDPFRN WIRQYPALVN CTTINWFSEW
2960 2970 2980 2990 3000
PREALLEVAE KYIIGVDLGT QENIHRKVAQ IFVTMHWSVA QYSQKMLLEL
3010 3020 3030 3040 3050
RRYNYVTPTN YLELVSGYKK LLGEKRQELL DQANKLRTGL FKIDETREKV
3060 3070 3080 3090 3100
EVMSLELEDA KKKVAEFQKQ CEEYLVIIVQ QKREADEQQK AVTANSEKIA
3110 3120 3130 3140 3150
IEEVKCQALA DNAQKDLEEA LPALEEAMRA LESLNKKDIG EIKSYGRPPA
3160 3170 3180 3190 3200
QVEIVMQAVM ILRGNEPTWA EAKRQLGEQN FIKSLINFDK DNISDKVLKK
3210 3220 3230 3240 3250
IGAYCAQPDF QPDIIGRVSL AAKSLCMWVR AMELYGRLYR VVEPKRIRMN
3260 3270 3280 3290 3300
AAMAQLQEKQ AALAEAQEKL REVAEKLEML KKQYDEKLAQ KEELRKKSEE
3310 3320 3330 3340 3350
MELKLERAGM LVSGLAGEKA RWEETVQGLE EDLGYLVGDC LIAAAFLSYM
3360 3370 3380 3390 3400
GPFLTNYRDE IINQIWIRKI RELQVPCSPR FAIDNFLTNP TKVRDWNIQG
3410 3420 3430 3440 3450
LPSDAFSTEN GIIVTRGNRW ALMIDPQGQA LKWIKNMEGN QGLKIIDLQM
3460 3470 3480 3490 3500
HDYLRVLEHA IQFGFPVLLQ NVQEYLDPTL NPVLNKSVAR IGGRMLIRIG
3510 3520 3530 3540 3550
DKEVEYNPNF RFYLTTKLSN PHYNPETSAK TTIVNFAVKE QGLEAQLLGI
3560 3570 3580 3590 3600
VVRKERPELE EQKDSLVINI AAGKRKLKEL EDEILRLLNE ATGSLLDDVQ
3610 3620 3630 3640 3650
LVNTLQTSKI TATEVTEQLE TSETTEINID LAREAYRPCA QRASVLFFVL
3660 3670 3680 3690 3700
NDMGRIDPMY QFSLDAYIGL FILSIDKSHR SNKLEDRIEY LNDYHTYAVY
3710 3720 3730 3740 3750
RYTCRTLFER HKLLFSFHMC AKILETSGKL NMDEYNFFLR GGVVLDREGQ
3760 3770 3780 3790 3800
MDNPCTSWLA DAYWDNITEL DKLTNFHGLM NSFEQYPRDW HLWYTNSSPE
3810 3820 3830 3840 3850
KAMLPGEWEN ACNEMQRMLI VRSLRQDRVA FCVTSFIVSN LGSRFIEPPV
3860 3870 3880 3890 3900
LNMKSVMEDS TPRSPLVFIL SPGVDPTSAL LQLAEHTGMA HRFHALSLGQ
3910 3920 3930 3940 3950
GQAPIAARLL REGVNQGHWV FLANCHLSLS WMPNLDKLVE QLQVEDPHPS
3960 3970 3980 3990 4000
FRLWLSSSPH PDFPISILQA SIKMTTEPPK GLKANMTRLY QLMTEAQFTH
4010 4020 4030 4040 4050
CSKPAKYKKL LFALCFFHSI LLERKKFLQL GWNIIYGFND SDFEVSENLL
4060 4070 4080 4090 4100
SLYLDEYEET PWDALKYLIA GVNYGGHVTD DWDRRLLTTY INDYFCDLSL
4110 4120 4130 4140 4150
TTPFYRLSVL DTYYIPKDGS LASYKEYISM LPSMDPPEAF GQHPNADVAS
4160 4170 4180 4190 4200
QITEARTLFE TLLSLQPQIT PTRVGGQSRE EKVLELAADV KQKIPEMIDY
4210 4220 4230 4240 4250
EGTRKLLALD PSPLNVVLLQ EIQRYNKLMK TILFSLTDLE KGIQGLIVMS
4260 4270 4280 4290 4300
TSLEEIFNCI FDAHVPPLWG KVYPSQKPLA SWTRDLAVRV EQFETWASRA
4310 4320 4330 4340 4350
RPPVLFWLSG FTFPTGFLTA VLQSAARQNN ISVDSLSWEF IVSTVDDSNL
4360 4370 4380 4390 4400
VYPPKDGVWV RGLYLEGAGW DRKNSCLVEA EPMQLVCLMP TIHFRPAESR
4410 4420 4430 4440 4450
KKSAKGMYSC PCYYYPNRAG STDRASFVIG IDLRSGSMTS DHWIKRGTAL

LMSLDS
Length:4,456
Mass (Da):511,565
Last modified:March 18, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC57E71F45BDC3C58
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z667D3Z667_MOUSE
Dynein heavy chain 2, axonemal
Dnah2 Dnahc2
4,462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHI3A0A140LHI3_MOUSE
Dynein heavy chain 2, axonemal
Dnah2
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC26619 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1893V → L in CAB06067 (PubMed:9373155).Curated1
Sequence conflicti1895S → P in CAB06067 (PubMed:9373155).Curated1
Sequence conflicti1898A → P in CAB06067 (PubMed:9373155).Curated1
Sequence conflicti1900Q → K in CAB06067 (PubMed:9373155).Curated1
Sequence conflicti1909T → S in CAB06067 (PubMed:9373155).Curated1
Sequence conflicti2004F → Y in CAB06067 (PubMed:9373155).Curated1
Sequence conflicti2006L → M in CAB06067 (PubMed:9373155).Curated1
Sequence conflicti2007R → S in CAB06067 (PubMed:9373155).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL596125 Genomic DNA No translation available.
AL731687 Genomic DNA No translation available.
Z83813 mRNA Translation: CAB06067.1
AK029791 mRNA Translation: BAC26619.1 Different initiation.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035539; ENSMUSP00000047329; ENSMUSG00000005237

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596125 Genomic DNA No translation available.
AL731687 Genomic DNA No translation available.
Z83813 mRNA Translation: CAB06067.1
AK029791 mRNA Translation: BAC26619.1 Different initiation.

3D structure databases

SMRiP0C6F1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0C6F1, 1 interactor
STRINGi10090.ENSMUSP00000104299

PTM databases

iPTMnetiP0C6F1
PhosphoSitePlusiP0C6F1

Proteomic databases

EPDiP0C6F1
PaxDbiP0C6F1
PRIDEiP0C6F1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035539; ENSMUSP00000047329; ENSMUSG00000005237

Organism-specific databases

MGIiMGI:107731 Dnah2

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000157623
HOGENOMiHOG000237308
InParanoidiP0C6F1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0C6F1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005237 Expressed in 72 organ(s), highest expression level in small intestine
ExpressionAtlasiP0C6F1 baseline and differential
GenevisibleiP0C6F1 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 2 hits
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6F1
Secondary accession number(s): B1AR18, O08826, Q8C0U5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 8, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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