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Protein

Disintegrin viperistatin

Gene
N/A
Organism
Daboia palaestinae (Palestine viper) (Vipera palaestinae)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent and highly selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin binding to collagen I and IV. Is about 25-fold more potent than obtustatin inhibiting the binding of this integrin to collagen IV.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin viperistatin
OrganismiDaboia palaestinae (Palestine viper) (Vipera palaestinae)
Taxonomic identifieri1170828 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeDaboia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24R → L: Decrease in inhibitory activity towards alpha-1/beta-1 integrin. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003218841 – 41Disintegrin viperistatinAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 10By similarity
Disulfide bondi6 ↔ 29By similarity
Disulfide bondi7 ↔ 34By similarity
Disulfide bondi19 ↔ 36By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C6E2
SMRiP0C6E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 41DisintegrinAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 23Cell attachment site; atypical (KTS)3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PRINTSiPR00289 DISINTEGRIN
SUPFAMiSSF57552 SSF57552, 1 hit

Sequencei

Sequence statusi: Complete.

P0C6E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
CTTGPCCRQC KLKPAGTTCW KTSRTSHYCT GKSCDCPVYQ G
Length:41
Mass (Da):4,461
Last modified:February 26, 2008 - v1
Checksum:iAC9720CBDE8DD536
GO

Mass spectrometryi

Molecular mass is 4454.5 Da from positions 1 - 41. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiDIS_DABPA
AccessioniPrimary (citable) accession number: P0C6E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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