Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 70 (08 May 2019)
Sequence version 1 (26 Feb 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Gene

Svep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the cell attachment process.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Svep1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
1588987 Svep1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032018018 – 3564Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1Add BLAST3547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi379 ↔ 421By similarity
Disulfide bondi407 ↔ 434By similarity
Disulfide bondi439 ↔ 481By similarity
Disulfide bondi467 ↔ 494By similarity
Disulfide bondi499 ↔ 544By similarity
Disulfide bondi530 ↔ 559By similarity
Disulfide bondi727 ↔ 769By similarity
Disulfide bondi753 ↔ 787By similarity
Disulfide bondi1192 ↔ 1203By similarity
Disulfide bondi1197 ↔ 1212By similarity
Disulfide bondi1214 ↔ 1223By similarity
Disulfide bondi1230 ↔ 1241By similarity
Disulfide bondi1235 ↔ 1250By similarity
Disulfide bondi1252 ↔ 1261By similarity
Disulfide bondi1268 ↔ 1279By similarity
Disulfide bondi1273 ↔ 1288By similarity
Disulfide bondi1290 ↔ 1299By similarity
Disulfide bondi1306 ↔ 1317By similarity
Disulfide bondi1311 ↔ 1326By similarity
Disulfide bondi1328 ↔ 1337By similarity
Disulfide bondi1344 ↔ 1355By similarity
Disulfide bondi1349 ↔ 1364By similarity
Disulfide bondi1366 ↔ 1375By similarity
Disulfide bondi1382 ↔ 1393By similarity
Disulfide bondi1387 ↔ 1402By similarity
Disulfide bondi1404 ↔ 1413By similarity
Disulfide bondi1626 ↔ 1667By similarity
Disulfide bondi1653 ↔ 1680By similarity
Disulfide bondi1685 ↔ 1725By similarity
Disulfide bondi1711 ↔ 1738By similarity
Disulfide bondi1744 ↔ 1756By similarity
Disulfide bondi1750 ↔ 1765By similarity
Glycosylationi1760N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1767 ↔ 1778By similarity
Disulfide bondi1784 ↔ 1824By similarity
Disulfide bondi1810 ↔ 1837By similarity
Disulfide bondi1842 ↔ 1882By similarity
Disulfide bondi1868 ↔ 1895By similarity
Disulfide bondi1900 ↔ 1940By similarity
Disulfide bondi1926 ↔ 1953By similarity
Disulfide bondi1958 ↔ 1998By similarity
Disulfide bondi1984 ↔ 2011By similarity
Disulfide bondi2016 ↔ 2056By similarity
Disulfide bondi2042 ↔ 2073By similarity
Disulfide bondi2078 ↔ 2121By similarity
Disulfide bondi2107 ↔ 2136By similarity
Disulfide bondi2141 ↔ 2181By similarity
Disulfide bondi2167 ↔ 2194By similarity
Disulfide bondi2199 ↔ 2240By similarity
Disulfide bondi2226 ↔ 2254By similarity
Disulfide bondi2259 ↔ 2299By similarity
Disulfide bondi2285 ↔ 2313By similarity
Disulfide bondi2318 ↔ 2358By similarity
Disulfide bondi2344 ↔ 2371By similarity
Disulfide bondi2376 ↔ 2417By similarity
Disulfide bondi2403 ↔ 2430By similarity
Disulfide bondi2435 ↔ 2475By similarity
Disulfide bondi2461 ↔ 2488By similarity
Disulfide bondi2493 ↔ 2533By similarity
Disulfide bondi2519 ↔ 2546By similarity
Disulfide bondi2551 ↔ 2591By similarity
Disulfide bondi2577 ↔ 2603By similarity
Disulfide bondi2679 ↔ 2706By similarity
Disulfide bondi2711 ↔ 2751By similarity
Disulfide bondi2737 ↔ 2764By similarity
Disulfide bondi2769 ↔ 2809By similarity
Disulfide bondi2795 ↔ 2822By similarity
Disulfide bondi2827 ↔ 2867By similarity
Disulfide bondi2853 ↔ 2880By similarity
Disulfide bondi2885 ↔ 2925By similarity
Disulfide bondi2911 ↔ 2938By similarity
Disulfide bondi2943 ↔ 2983By similarity
Disulfide bondi2969 ↔ 2996By similarity
Disulfide bondi3001 ↔ 3040By similarity
Disulfide bondi3026 ↔ 3052By similarity
Disulfide bondi3057 ↔ 3097By similarity
Disulfide bondi3083 ↔ 3110By similarity
Disulfide bondi3115 ↔ 3156By similarity
Disulfide bondi3141 ↔ 3169By similarity
Disulfide bondi3174 ↔ 3214By similarity
Disulfide bondi3200 ↔ 3229By similarity
Disulfide bondi3234 ↔ 3274By similarity
Disulfide bondi3260 ↔ 3287By similarity
Disulfide bondi3292 ↔ 3332By similarity
Disulfide bondi3318 ↔ 3345By similarity
Disulfide bondi3350 ↔ 3391By similarity
Disulfide bondi3377 ↔ 3404By similarity
Disulfide bondi3409 ↔ 3449By similarity
Disulfide bondi3435 ↔ 3461By similarity
Disulfide bondi3497 ↔ 3507By similarity
Disulfide bondi3501 ↔ 3513By similarity
Disulfide bondi3515 ↔ 3524By similarity
Disulfide bondi3529 ↔ 3539By similarity
Disulfide bondi3533 ↔ 3545By similarity
Disulfide bondi3547 ↔ 3556By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0C6B8

PRoteomics IDEntifications database

More...
PRIDEi
P0C6B8

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P0C6B8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Estrogen-dependent; induced upon 17betaE2 treatment in cultured osteoblasts (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000050549

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C6B8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 265VWFAPROSITE-ProRule annotationAdd BLAST182
Domaini377 – 436Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini437 – 496Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini497 – 561Sushi 3PROSITE-ProRule annotationAdd BLAST65
Domaini560 – 644HYR 1PROSITE-ProRule annotationAdd BLAST85
Domaini645 – 724HYR 2PROSITE-ProRule annotationAdd BLAST80
Domaini725 – 789Sushi 4PROSITE-ProRule annotationAdd BLAST65
Domaini1188 – 1224EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini1226 – 1262EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1264 – 1300EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1302 – 1338EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1340 – 1376EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1378 – 1414EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1419 – 1623Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST205
Domaini1624 – 1682Sushi 5PROSITE-ProRule annotationAdd BLAST59
Domaini1683 – 1740Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini1740 – 1779EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1776 – 1839Sushi 7PROSITE-ProRule annotationAdd BLAST64
Domaini1840 – 1897Sushi 8PROSITE-ProRule annotationAdd BLAST58
Domaini1898 – 1955Sushi 9PROSITE-ProRule annotationAdd BLAST58
Domaini1956 – 2013Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini2014 – 2075Sushi 11PROSITE-ProRule annotationAdd BLAST62
Domaini2076 – 2138Sushi 12PROSITE-ProRule annotationAdd BLAST63
Domaini2139 – 2196Sushi 13PROSITE-ProRule annotationAdd BLAST58
Domaini2197 – 2256Sushi 14PROSITE-ProRule annotationAdd BLAST60
Domaini2257 – 2315Sushi 15PROSITE-ProRule annotationAdd BLAST59
Domaini2316 – 2373Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini2374 – 2432Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini2433 – 2490Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2491 – 2548Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2549 – 2605Sushi 20PROSITE-ProRule annotationAdd BLAST57
Domaini2659 – 2708Sushi 21PROSITE-ProRule annotationAdd BLAST50
Domaini2709 – 2766Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2767 – 2824Sushi 23PROSITE-ProRule annotationAdd BLAST58
Domaini2825 – 2882Sushi 24PROSITE-ProRule annotationAdd BLAST58
Domaini2883 – 2940Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini2941 – 2998Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini2999 – 3054Sushi 27PROSITE-ProRule annotationAdd BLAST56
Domaini3055 – 3112Sushi 28PROSITE-ProRule annotationAdd BLAST58
Domaini3113 – 3171Sushi 29PROSITE-ProRule annotationAdd BLAST59
Domaini3172 – 3231Sushi 30PROSITE-ProRule annotationAdd BLAST60
Domaini3232 – 3289Sushi 31PROSITE-ProRule annotationAdd BLAST58
Domaini3290 – 3347Sushi 32PROSITE-ProRule annotationAdd BLAST58
Domaini3348 – 3406Sushi 33PROSITE-ProRule annotationAdd BLAST59
Domaini3407 – 3463Sushi 34PROSITE-ProRule annotationAdd BLAST57
Domaini3493 – 3525EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Domaini3526 – 3557EGF-like 9PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154457

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C6B8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0C6B8

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 32 hits
cd00152 PTX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR003410 HYR_dom
IPR001759 Pentraxin-related
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 6 hits
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 4 hits
PF02494 HYR, 2 hits
PF00354 Pentaxin, 1 hit
PF00084 Sushi, 32 hits
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00895 PENTAXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 34 hits
SM00181 EGF, 11 hits
SM00179 EGF_CA, 8 hits
SM01411 Ephrin_rec_like, 4 hits
SM00159 PTX, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
SSF57184 SSF57184, 3 hits
SSF57535 SSF57535, 33 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 6 hits
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 6 hits
PS50825 HYR, 2 hits
PS51828 PTX_2, 1 hit
PS50923 SUSHI, 34 hits
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P0C6B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTRLAFCCW ALALVSGWTN FQPMAPSLNF SFRLFPEASP GALGRLAVPP
60 70 80 90 100
RSGEEEAVGS KVERLGRTFR SRVRRLRELS DRLELVFLVD ESSSVGQTNF
110 120 130 140 150
LNELKFVRKL LSDFPVVSTA TRVAIVTFSS KNNVVARVDY ISTSRAHQHK
160 170 180 190 200
CALLSREIPA ITYRGGGTYT MGAFQQAAQI LRHSRENSTK VIFLITDGYS
210 220 230 240 250
NGGDPRPIAA SLRDFGVEIF TFGIWQGNIR ELNDMASTPK EEHCYLLHSF
260 270 280 290 300
EEFEALARRA LHEDLPSGSF IQEDMAHCSY LCEAGRDCCD RMASCKCGTH
310 320 330 340 350
TGQFECICEK GYYGKGLQYE CTACPPGTYK PEASPGGIST CIPCPDENHT
360 370 380 390 400
SPPGSTAPED CVCREGYQRS GQTCEVVHCP ALKPPENGFF IQNTCKNHFN
410 420 430 440 450
AACGVRCRPG FDLVGSSIHL CQPNGLWSGT ESFCRVRTCP HLRQPKHGHI
460 470 480 490 500
SCSTVEMSYN TVCLVTCNEG YRLEGHAKLT CQGNAQWDGT EPRCVERHCA
510 520 530 540 550
TFQKPKGVII SPPSCGKQPA KPGMICQLGC RQGYILSGIR EVRCATSGKW
560 570 580 590 600
SARVQTAVCK DVEAPQISCP NDIKAKTEGQ QDSANVTWQV PTAKDNSGEK
610 620 630 640 650
VSVHVHPAFS PPYLFPIGEV AITYTATDSS GNQASCTFYI KVIDVEPPVI
660 670 680 690 700
DWCRSPPPIQ VVEKEHPASW DEPQFSDNSG AELVITSSHT QGDLFPHGET
710 720 730 740 750
VVWYTATDPS GNNRTCDIHI VIKGSPCEVP FTPVNGDFIC AQDSAGVNCS
760 770 780 790 800
LTCREGYDFT EGSTEKYYCA FEDGIWRPPY STEWPDCAIK RFANHGFKSF
810 820 830 840 850
EMLYKTTRCD DMDLFKKFSA AFETTLGKMV PSFCSDADDI DCRLEDLTKK
860 870 880 890 900
YCIEYNYNYE NGFAIGPGGW GAGNRLDYSY DHFLDVVQET PADVGKTRSS
910 920 930 940 950
RIKRTVPLSD PQIQLIFNIT ASVPLPEERN DTVELENQQR LIRTLETITN
960 970 980 990 1000
RLKSTLNKGP MYSFQLASET VVADSNSLET EKAFLFCRPG SVLRGRMCVN
1010 1020 1030 1040 1050
CPLGTSYSLE HSTCESCLMG SYQDEEGQLE CKLCPPRTHT EYLHSRSISE
1060 1070 1080 1090 1100
CKAQCKQGTY SSSGLETCES CPLGTYQPDF GSRSCLPCPE TTTTVKRGAV
1110 1120 1130 1140 1150
DISACGVPCP VGEFSRSGLT PCYPCPRDYY QPNAGKSFCL ACPFYGTTTI
1160 1170 1180 1190 1200
TGATSITDCS SFSSTFSAAE ESIVPLAAPG PTQNKYEVFH ECFLNPCHNS
1210 1220 1230 1240 1250
GTCQQLGRGY VCLCPPGYTG LKCETDIDEC SSLPCLNGGI CRDKVGGFTC
1260 1270 1280 1290 1300
ECSSGYTGQI CEENINECSS SPCLNKGTCT DGLASYRCTC VSGYVGVHCE
1310 1320 1330 1340 1350
TDVNECQSSP CLNNAVCKDQ VGGFSCKCPP GFLGTRCEKN VDECLSQPCQ
1360 1370 1380 1390 1400
NGATCKDGAN SFRCQCPAGF TGPHCELNIN ECQSNPCRNQ ATCVDELNSY
1410 1420 1430 1440 1450
SCKCRPGFSG RRCETEQPSG FNLDFEVSGI YGYVLLDGVL PTLHAITCAF
1460 1470 1480 1490 1500
WMKSSDVINY GTPISYALEG NKDNTFLLTD YNGWVLYVNG KEKITNCPSV
1510 1520 1530 1540 1550
NDGIWHHIAI TWTSTGGAWR VYIDGELSDS GTGLSVGKAI PGGGALVLGQ
1560 1570 1580 1590 1600
EQDKKGEGFN PAESFVGSIS QLNLWDYVLS PQQVKSLASS CPEELSRGNV
1610 1620 1630 1640 1650
LAWPDFVSGI TGKVKVDSSS IFCSDCPSLE GSVPHLRPAS GDRKPGSKVS
1660 1670 1680 1690 1700
LFCDPGFQMV GNPVQYCLNQ GQWSQPLPHC ERIRCGLPPT LENGFYSAED
1710 1720 1730 1740 1750
LHAGSTVTYQ CTSGYYLLGD SRMFCTDNGS WNGISPSCLD VDECAVGSDC
1760 1770 1780 1790 1800
SEHASCLNTN GSYICSCKPP YTGDGKNCAE PVKCKAPENP ENGHSLGKIY
1810 1820 1830 1840 1850
SVGAEVTFSC EEGHQLVGVR KITCLESGEW DHLRPSCEAI SCGAPPVPEN
1860 1870 1880 1890 1900
GGVDGSAFTY GSKVRYRCDK GYTLAGDEES ACLASGSWSH SSPVCELVKC
1910 1920 1930 1940 1950
SQPENINNGK YILSGLTYLS IASYSCEDGY SLQGPSLIEC TASGSWDRAP
1960 1970 1980 1990 2000
PSCQLVSCGE PPMVKDALTT GSNFTFGNMV TYTCKEGYTL AGPDTIICQA
2010 2020 2030 2040 2050
NGKWNSSNHQ CLAVSCDEPP NVDHASPETA HRLFGDTAFY YCADGYSLAD
2060 2070 2080 2090 2100
NSQLICNAQG NWVPPEGQAV PRCIAHFCEK PPSVSYSILE SVSKAKFAAG
2110 2120 2130 2140 2150
SVVSFKCMEG FVLNTSAKIE CLRGGQWSPS PLSVQCIPVR CGEPPSITNG
2160 2170 2180 2190 2200
YPSGTNYSFG AVVAYSCHKG FYIKGEKKST CEATGQWSRP LPTCHPVSCN
2210 2220 2230 2240 2250
EPPKVENGFL EHTTGRTFES EARFQCNPGY KAVGSPVFVC QANRHWHSDA
2260 2270 2280 2290 2300
PLSCTPLNCG KPPPIQNGFL RGESFEVGSK VQFVCNEGYE LVGDNSWTCQ
2310 2320 2330 2340 2350
KSGKWSKKPS PKCVPTKCAE PPLLENQLVL KELTSEVGVM TISCKEGHAL
2360 2370 2380 2390 2400
QGPSVLKCLP SGQWNGSFPV CKLVLCQSPP LIPFGVPASS GALHFGSTVK
2410 2420 2430 2440 2450
YLCVDGFFLR GNPIILCQVD GTWSSPLPEC VPVECPQPEE ILNGIIHVQG
2460 2470 2480 2490 2500
LAYLSTTLYT CKPGFELVGN TTTLCGENGQ WLGGKPMCRP IECPEPKEIL
2510 2520 2530 2540 2550
NGQFSSVSFQ YGQTITYSCD RGFRLEGPKS LTCLETGNWD MDAPSCNAIH
2560 2570 2580 2590 2600
CSDPQPIENG FVEGADYRYG AMIIYSCFPG FQVVGHAMQT CEETGWSSSS
2610 2620 2630 2640 2650
PTCVPIDCGL PPHIDFGDCT RVSDGQGYFV QEDDMMEVPY LTPHPQHLEA
2660 2670 2680 2690 2700
TAKASEITEE SLVPHASQFL YGTTVSYRCE PGYELLGIPV LVCQEDGTWN
2710 2720 2730 2740 2750
GTAPSCISIE CDLPVAPENG FLHFTQTTMG SAAQYSCKPG HVLEGSHLRL
2760 2770 2780 2790 2800
CLQNKQWSGT VPRCEVISCS EPNPLGNGSI KGNDYSYLGV LHYECDSGYV
2810 2820 2830 2840 2850
LNGTEKRTCQ ENKQWDGHEP VCLPVDCGSP PVPTNGQVTG EEYTFQKEIA
2860 2870 2880 2890 2900
YSCGEGFILE GARSRVCLTN GSWSGTTPSC VPVRCPAPPQ VANGVTDGLD
2910 2920 2930 2940 2950
YGFKKEVTFH CLEGYVLQGT PKLTCQSNGT WDAEVPICKP ATCGPPADLP
2960 2970 2980 2990 3000
QGFPNGFSFF HGGHIQYQCF TGYKLHGNPS RRCLPDGSWS GSTPSCLPCT
3010 3020 3030 3040 3050
CSTPIIQQGT VNATDLGCGK TVQIECFKGF KLLGLPEITC DANGQWSDFP
3060 3070 3080 3090 3100
LCEHADCGPL PTVPNGIVIK GSPSEDNVVT YSCRPGYIIQ GSSDLICTEK
3110 3120 3130 3140 3150
GIWSEPYPTC EPVSCGPPPT VANAVATGEA HTYESKVKLR CLEGYVVDTD
3160 3170 3180 3190 3200
TDTFTCQQDG RWFPERINCS PKTCPVPSNR TRIRVHGDDF QVNRQVSVSC
3210 3220 3230 3240 3250
TEGFTYDGAD RSTCQPDGTW EPPLSEESCI PVVCGQPESP EHGFVVGSEY
3260 3270 3280 3290 3300
SFGSTVVYQC DPGYELEGNR ERVCQENRQW SGRVAVCRES RCEAPAEFPN
3310 3320 3330 3340 3350
GKAVLENTTS GPSLLFSCHR GYTLEGPPEA HCTANGTWSH LAPLCKPNPC
3360 3370 3380 3390 3400
PVPFVIPENA LLSEREFYVN QNVSIKCREG FLLKGNGIIT CNPDETWTQT
3410 3420 3430 3440 3450
NARCEKISCG PPTHVENAIA RGVHYQYGDM VTFSCYSGYM LEGSLRSVCL
3460 3470 3480 3490 3500
ENGTWTPPPI CRAVCRFPCQ NGGVCQRPNA CSCPDGWMGR LCEEPICILP
3510 3520 3530 3540 3550
CLNGGRCVAP YRCDCPAGWT GSRCHTATCQ SPCLNGGKCV RPNRCHCLSS
3560
WTGHDCSRKR RSGL
Length:3,564
Mass (Da):387,355
Last modified:February 26, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA1A3F013BEE2A31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JUE3A0A0G2JUE3_RAT
Sushi, von Willebrand factor type A...
Svep1
3,681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LPU2F1LPU2_RAT
Sushi, von Willebrand factor type A...
Svep1
3,565Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR03040659 Genomic DNA No translation available.
AABR03041327 Genomic DNA No translation available.
AABR03041522 Genomic DNA No translation available.
AABR03042206 Genomic DNA No translation available.
AABR03044351 Genomic DNA No translation available.
AABR03044745 Genomic DNA No translation available.
AABR03045322 Genomic DNA No translation available.

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:1588987 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040659 Genomic DNA No translation available.
AABR03041327 Genomic DNA No translation available.
AABR03041522 Genomic DNA No translation available.
AABR03042206 Genomic DNA No translation available.
AABR03044351 Genomic DNA No translation available.
AABR03044745 Genomic DNA No translation available.
AABR03045322 Genomic DNA No translation available.

3D structure databases

SMRiP0C6B8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050549

PTM databases

CarbonylDBiP0C6B8

Proteomic databases

PaxDbiP0C6B8
PRIDEiP0C6B8

Genome annotation databases

UCSCiRGD:1588987 rat

Organism-specific databases

RGDi1588987 Svep1

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000154457
InParanoidiP0C6B8
PhylomeDBiP0C6B8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0C6B8

Family and domain databases

CDDicd00033 CCP, 32 hits
cd00152 PTX, 1 hit
Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR003410 HYR_dom
IPR001759 Pentraxin-related
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 4 hits
PF02494 HYR, 2 hits
PF00354 Pentaxin, 1 hit
PF00084 Sushi, 32 hits
PF00092 VWA, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00032 CCP, 34 hits
SM00181 EGF, 11 hits
SM00179 EGF_CA, 8 hits
SM01411 Ephrin_rec_like, 4 hits
SM00159 PTX, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
SSF57184 SSF57184, 3 hits
SSF57535 SSF57535, 33 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 6 hits
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 6 hits
PS50825 HYR, 2 hits
PS51828 PTX_2, 1 hit
PS50923 SUSHI, 34 hits
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVEP1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6B8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 8, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again