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UniProtKB - P0C6B8 (SVEP1_RAT)

Entry version 75 (07 Apr 2021)
Sequence version 1 (26 Feb 2008)
Previous versions | rss
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Protein

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Gene

Svep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the cell attachment process.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Svep1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		1588987, Svep1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032018018 – 3564Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1Add BLAST3547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi379 ↔ 421By similarity
Disulfide bondi407 ↔ 434By similarity
Disulfide bondi439 ↔ 481By similarity
Disulfide bondi467 ↔ 494By similarity
Disulfide bondi499 ↔ 544By similarity
Disulfide bondi530 ↔ 559By similarity
Disulfide bondi727 ↔ 769By similarity
Disulfide bondi753 ↔ 787By similarity
Disulfide bondi1192 ↔ 1203By similarity
Disulfide bondi1197 ↔ 1212By similarity
Disulfide bondi1214 ↔ 1223By similarity
Disulfide bondi1230 ↔ 1241By similarity
Disulfide bondi1235 ↔ 1250By similarity
Disulfide bondi1252 ↔ 1261By similarity
Disulfide bondi1268 ↔ 1279By similarity
Disulfide bondi1273 ↔ 1288By similarity
Disulfide bondi1290 ↔ 1299By similarity
Disulfide bondi1306 ↔ 1317By similarity
Disulfide bondi1311 ↔ 1326By similarity
Disulfide bondi1328 ↔ 1337By similarity
Disulfide bondi1344 ↔ 1355By similarity
Disulfide bondi1349 ↔ 1364By similarity
Disulfide bondi1366 ↔ 1375By similarity
Disulfide bondi1382 ↔ 1393By similarity
Disulfide bondi1387 ↔ 1402By similarity
Disulfide bondi1404 ↔ 1413By similarity
Disulfide bondi1626 ↔ 1667By similarity
Disulfide bondi1653 ↔ 1680By similarity
Disulfide bondi1685 ↔ 1725By similarity
Disulfide bondi1711 ↔ 1738By similarity
Disulfide bondi1744 ↔ 1756By similarity
Disulfide bondi1750 ↔ 1765By similarity
Glycosylationi1760N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1767 ↔ 1778By similarity
Disulfide bondi1784 ↔ 1824By similarity
Disulfide bondi1810 ↔ 1837By similarity
Disulfide bondi1842 ↔ 1882By similarity
Disulfide bondi1868 ↔ 1895By similarity
Disulfide bondi1900 ↔ 1940By similarity
Disulfide bondi1926 ↔ 1953By similarity
Disulfide bondi1958 ↔ 1998By similarity
Disulfide bondi1984 ↔ 2011By similarity
Disulfide bondi2016 ↔ 2056By similarity
Disulfide bondi2042 ↔ 2073By similarity
Disulfide bondi2078 ↔ 2121By similarity
Disulfide bondi2107 ↔ 2136By similarity
Disulfide bondi2141 ↔ 2181By similarity
Disulfide bondi2167 ↔ 2194By similarity
Disulfide bondi2199 ↔ 2240By similarity
Disulfide bondi2226 ↔ 2254By similarity
Disulfide bondi2259 ↔ 2299By similarity
Disulfide bondi2285 ↔ 2313By similarity
Disulfide bondi2318 ↔ 2358By similarity
Disulfide bondi2344 ↔ 2371By similarity
Disulfide bondi2376 ↔ 2417By similarity
Disulfide bondi2403 ↔ 2430By similarity
Disulfide bondi2435 ↔ 2475By similarity
Disulfide bondi2461 ↔ 2488By similarity
Disulfide bondi2493 ↔ 2533By similarity
Disulfide bondi2519 ↔ 2546By similarity
Disulfide bondi2551 ↔ 2591By similarity
Disulfide bondi2577 ↔ 2603By similarity
Disulfide bondi2679 ↔ 2706By similarity
Disulfide bondi2711 ↔ 2751By similarity
Disulfide bondi2737 ↔ 2764By similarity
Disulfide bondi2769 ↔ 2809By similarity
Disulfide bondi2795 ↔ 2822By similarity
Disulfide bondi2827 ↔ 2867By similarity
Disulfide bondi2853 ↔ 2880By similarity
Disulfide bondi2885 ↔ 2925By similarity
Disulfide bondi2911 ↔ 2938By similarity
Disulfide bondi2943 ↔ 2983By similarity
Disulfide bondi2969 ↔ 2996By similarity
Disulfide bondi3001 ↔ 3040By similarity
Disulfide bondi3026 ↔ 3052By similarity
Disulfide bondi3057 ↔ 3097By similarity
Disulfide bondi3083 ↔ 3110By similarity
Disulfide bondi3115 ↔ 3156By similarity
Disulfide bondi3141 ↔ 3169By similarity
Disulfide bondi3174 ↔ 3214By similarity
Disulfide bondi3200 ↔ 3229By similarity
Disulfide bondi3234 ↔ 3274By similarity
Disulfide bondi3260 ↔ 3287By similarity
Disulfide bondi3292 ↔ 3332By similarity
Disulfide bondi3318 ↔ 3345By similarity
Disulfide bondi3350 ↔ 3391By similarity
Disulfide bondi3377 ↔ 3404By similarity
Disulfide bondi3409 ↔ 3449By similarity
Disulfide bondi3435 ↔ 3461By similarity
Disulfide bondi3497 ↔ 3507By similarity
Disulfide bondi3501 ↔ 3513By similarity
Disulfide bondi3515 ↔ 3524By similarity
Disulfide bondi3529 ↔ 3539By similarity
Disulfide bondi3533 ↔ 3545By similarity
Disulfide bondi3547 ↔ 3556By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0C6B8

PRoteomics IDEntifications database

More...PRIDEi		P0C6B8

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P0C6B8

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P0C6B8, 2 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Estrogen-dependent; induced upon 17betaE2 treatment in cultured osteoblasts (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000050549

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C6B8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 265VWFAPROSITE-ProRule annotationAdd BLAST182
Domaini377 – 436Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini437 – 496Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini497 – 561Sushi 3PROSITE-ProRule annotationAdd BLAST65
Domaini560 – 644HYR 1PROSITE-ProRule annotationAdd BLAST85
Domaini645 – 724HYR 2PROSITE-ProRule annotationAdd BLAST80
Domaini725 – 789Sushi 4PROSITE-ProRule annotationAdd BLAST65
Domaini1188 – 1224EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini1226 – 1262EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1264 – 1300EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1302 – 1338EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1340 – 1376EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1378 – 1414EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1419 – 1623Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST205
Domaini1624 – 1682Sushi 5PROSITE-ProRule annotationAdd BLAST59
Domaini1683 – 1740Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini1740 – 1779EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1776 – 1839Sushi 7PROSITE-ProRule annotationAdd BLAST64
Domaini1840 – 1897Sushi 8PROSITE-ProRule annotationAdd BLAST58
Domaini1898 – 1955Sushi 9PROSITE-ProRule annotationAdd BLAST58
Domaini1956 – 2013Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini2014 – 2075Sushi 11PROSITE-ProRule annotationAdd BLAST62
Domaini2076 – 2138Sushi 12PROSITE-ProRule annotationAdd BLAST63
Domaini2139 – 2196Sushi 13PROSITE-ProRule annotationAdd BLAST58
Domaini2197 – 2256Sushi 14PROSITE-ProRule annotationAdd BLAST60
Domaini2257 – 2315Sushi 15PROSITE-ProRule annotationAdd BLAST59
Domaini2316 – 2373Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini2374 – 2432Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini2433 – 2490Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2491 – 2548Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2549 – 2605Sushi 20PROSITE-ProRule annotationAdd BLAST57
Domaini2659 – 2708Sushi 21PROSITE-ProRule annotationAdd BLAST50
Domaini2709 – 2766Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2767 – 2824Sushi 23PROSITE-ProRule annotationAdd BLAST58
Domaini2825 – 2882Sushi 24PROSITE-ProRule annotationAdd BLAST58
Domaini2883 – 2940Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini2941 – 2998Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini2999 – 3054Sushi 27PROSITE-ProRule annotationAdd BLAST56
Domaini3055 – 3112Sushi 28PROSITE-ProRule annotationAdd BLAST58
Domaini3113 – 3171Sushi 29PROSITE-ProRule annotationAdd BLAST59
Domaini3172 – 3231Sushi 30PROSITE-ProRule annotationAdd BLAST60
Domaini3232 – 3289Sushi 31PROSITE-ProRule annotationAdd BLAST58
Domaini3290 – 3347Sushi 32PROSITE-ProRule annotationAdd BLAST58
Domaini3348 – 3406Sushi 33PROSITE-ProRule annotationAdd BLAST59
Domaini3407 – 3463Sushi 34PROSITE-ProRule annotationAdd BLAST57
Domaini3493 – 3525EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Domaini3526 – 3557EGF-like 9PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1217, Eukaryota
KOG4297, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0C6B8

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0C6B8

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 32 hits
cd00152, PTX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003410, HYR_dom
IPR001759, Pentraxin-related
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 6 hits
PF07645, EGF_CA, 2 hits
PF07699, Ephrin_rec_like, 4 hits
PF02494, HYR, 2 hits
PF00354, Pentaxin, 1 hit
PF00084, Sushi, 32 hits
PF00092, VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00895, PENTAXIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 34 hits
SM00181, EGF, 11 hits
SM00179, EGF_CA, 8 hits
SM00159, PTX, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 1 hit
SSF57184, SSF57184, 3 hits
SSF57535, SSF57535, 33 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 6 hits
PS50825, HYR, 2 hits
PS51828, PTX_2, 1 hit
PS50923, SUSHI, 34 hits
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P0C6B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTRLAFCCW ALALVSGWTN FQPMAPSLNF SFRLFPEASP GALGRLAVPP 
        60         70         80         90        100
RSGEEEAVGS KVERLGRTFR SRVRRLRELS DRLELVFLVD ESSSVGQTNF 
       110        120        130        140        150
LNELKFVRKL LSDFPVVSTA TRVAIVTFSS KNNVVARVDY ISTSRAHQHK 
       160        170        180        190        200
CALLSREIPA ITYRGGGTYT MGAFQQAAQI LRHSRENSTK VIFLITDGYS 
       210        220        230        240        250
NGGDPRPIAA SLRDFGVEIF TFGIWQGNIR ELNDMASTPK EEHCYLLHSF 
       260        270        280        290        300
EEFEALARRA LHEDLPSGSF IQEDMAHCSY LCEAGRDCCD RMASCKCGTH 
       310        320        330        340        350
TGQFECICEK GYYGKGLQYE CTACPPGTYK PEASPGGIST CIPCPDENHT 
       360        370        380        390        400
SPPGSTAPED CVCREGYQRS GQTCEVVHCP ALKPPENGFF IQNTCKNHFN 
       410        420        430        440        450
AACGVRCRPG FDLVGSSIHL CQPNGLWSGT ESFCRVRTCP HLRQPKHGHI 
       460        470        480        490        500
SCSTVEMSYN TVCLVTCNEG YRLEGHAKLT CQGNAQWDGT EPRCVERHCA 
       510        520        530        540        550
TFQKPKGVII SPPSCGKQPA KPGMICQLGC RQGYILSGIR EVRCATSGKW 
       560        570        580        590        600
SARVQTAVCK DVEAPQISCP NDIKAKTEGQ QDSANVTWQV PTAKDNSGEK 
       610        620        630        640        650
VSVHVHPAFS PPYLFPIGEV AITYTATDSS GNQASCTFYI KVIDVEPPVI 
       660        670        680        690        700
DWCRSPPPIQ VVEKEHPASW DEPQFSDNSG AELVITSSHT QGDLFPHGET 
       710        720        730        740        750
VVWYTATDPS GNNRTCDIHI VIKGSPCEVP FTPVNGDFIC AQDSAGVNCS 
       760        770        780        790        800
LTCREGYDFT EGSTEKYYCA FEDGIWRPPY STEWPDCAIK RFANHGFKSF 
       810        820        830        840        850
EMLYKTTRCD DMDLFKKFSA AFETTLGKMV PSFCSDADDI DCRLEDLTKK 
       860        870        880        890        900
YCIEYNYNYE NGFAIGPGGW GAGNRLDYSY DHFLDVVQET PADVGKTRSS 
       910        920        930        940        950
RIKRTVPLSD PQIQLIFNIT ASVPLPEERN DTVELENQQR LIRTLETITN 
       960        970        980        990       1000
RLKSTLNKGP MYSFQLASET VVADSNSLET EKAFLFCRPG SVLRGRMCVN 
      1010       1020       1030       1040       1050
CPLGTSYSLE HSTCESCLMG SYQDEEGQLE CKLCPPRTHT EYLHSRSISE 
      1060       1070       1080       1090       1100
CKAQCKQGTY SSSGLETCES CPLGTYQPDF GSRSCLPCPE TTTTVKRGAV 
      1110       1120       1130       1140       1150
DISACGVPCP VGEFSRSGLT PCYPCPRDYY QPNAGKSFCL ACPFYGTTTI 
      1160       1170       1180       1190       1200
TGATSITDCS SFSSTFSAAE ESIVPLAAPG PTQNKYEVFH ECFLNPCHNS 
      1210       1220       1230       1240       1250
GTCQQLGRGY VCLCPPGYTG LKCETDIDEC SSLPCLNGGI CRDKVGGFTC 
      1260       1270       1280       1290       1300
ECSSGYTGQI CEENINECSS SPCLNKGTCT DGLASYRCTC VSGYVGVHCE 
      1310       1320       1330       1340       1350
TDVNECQSSP CLNNAVCKDQ VGGFSCKCPP GFLGTRCEKN VDECLSQPCQ 
      1360       1370       1380       1390       1400
NGATCKDGAN SFRCQCPAGF TGPHCELNIN ECQSNPCRNQ ATCVDELNSY 
      1410       1420       1430       1440       1450
SCKCRPGFSG RRCETEQPSG FNLDFEVSGI YGYVLLDGVL PTLHAITCAF 
      1460       1470       1480       1490       1500
WMKSSDVINY GTPISYALEG NKDNTFLLTD YNGWVLYVNG KEKITNCPSV 
      1510       1520       1530       1540       1550
NDGIWHHIAI TWTSTGGAWR VYIDGELSDS GTGLSVGKAI PGGGALVLGQ 
      1560       1570       1580       1590       1600
EQDKKGEGFN PAESFVGSIS QLNLWDYVLS PQQVKSLASS CPEELSRGNV 
      1610       1620       1630       1640       1650
LAWPDFVSGI TGKVKVDSSS IFCSDCPSLE GSVPHLRPAS GDRKPGSKVS 
      1660       1670       1680       1690       1700
LFCDPGFQMV GNPVQYCLNQ GQWSQPLPHC ERIRCGLPPT LENGFYSAED 
      1710       1720       1730       1740       1750
LHAGSTVTYQ CTSGYYLLGD SRMFCTDNGS WNGISPSCLD VDECAVGSDC 
      1760       1770       1780       1790       1800
SEHASCLNTN GSYICSCKPP YTGDGKNCAE PVKCKAPENP ENGHSLGKIY 
      1810       1820       1830       1840       1850
SVGAEVTFSC EEGHQLVGVR KITCLESGEW DHLRPSCEAI SCGAPPVPEN 
      1860       1870       1880       1890       1900
GGVDGSAFTY GSKVRYRCDK GYTLAGDEES ACLASGSWSH SSPVCELVKC 
      1910       1920       1930       1940       1950
SQPENINNGK YILSGLTYLS IASYSCEDGY SLQGPSLIEC TASGSWDRAP 
      1960       1970       1980       1990       2000
PSCQLVSCGE PPMVKDALTT GSNFTFGNMV TYTCKEGYTL AGPDTIICQA 
      2010       2020       2030       2040       2050
NGKWNSSNHQ CLAVSCDEPP NVDHASPETA HRLFGDTAFY YCADGYSLAD 
      2060       2070       2080       2090       2100
NSQLICNAQG NWVPPEGQAV PRCIAHFCEK PPSVSYSILE SVSKAKFAAG 
      2110       2120       2130       2140       2150
SVVSFKCMEG FVLNTSAKIE CLRGGQWSPS PLSVQCIPVR CGEPPSITNG 
      2160       2170       2180       2190       2200
YPSGTNYSFG AVVAYSCHKG FYIKGEKKST CEATGQWSRP LPTCHPVSCN 
      2210       2220       2230       2240       2250
EPPKVENGFL EHTTGRTFES EARFQCNPGY KAVGSPVFVC QANRHWHSDA 
      2260       2270       2280       2290       2300
PLSCTPLNCG KPPPIQNGFL RGESFEVGSK VQFVCNEGYE LVGDNSWTCQ 
      2310       2320       2330       2340       2350
KSGKWSKKPS PKCVPTKCAE PPLLENQLVL KELTSEVGVM TISCKEGHAL 
      2360       2370       2380       2390       2400
QGPSVLKCLP SGQWNGSFPV CKLVLCQSPP LIPFGVPASS GALHFGSTVK 
      2410       2420       2430       2440       2450
YLCVDGFFLR GNPIILCQVD GTWSSPLPEC VPVECPQPEE ILNGIIHVQG 
      2460       2470       2480       2490       2500
LAYLSTTLYT CKPGFELVGN TTTLCGENGQ WLGGKPMCRP IECPEPKEIL 
      2510       2520       2530       2540       2550
NGQFSSVSFQ YGQTITYSCD RGFRLEGPKS LTCLETGNWD MDAPSCNAIH 
      2560       2570       2580       2590       2600
CSDPQPIENG FVEGADYRYG AMIIYSCFPG FQVVGHAMQT CEETGWSSSS 
      2610       2620       2630       2640       2650
PTCVPIDCGL PPHIDFGDCT RVSDGQGYFV QEDDMMEVPY LTPHPQHLEA 
      2660       2670       2680       2690       2700
TAKASEITEE SLVPHASQFL YGTTVSYRCE PGYELLGIPV LVCQEDGTWN 
      2710       2720       2730       2740       2750
GTAPSCISIE CDLPVAPENG FLHFTQTTMG SAAQYSCKPG HVLEGSHLRL 
      2760       2770       2780       2790       2800
CLQNKQWSGT VPRCEVISCS EPNPLGNGSI KGNDYSYLGV LHYECDSGYV 
      2810       2820       2830       2840       2850
LNGTEKRTCQ ENKQWDGHEP VCLPVDCGSP PVPTNGQVTG EEYTFQKEIA 
      2860       2870       2880       2890       2900
YSCGEGFILE GARSRVCLTN GSWSGTTPSC VPVRCPAPPQ VANGVTDGLD 
      2910       2920       2930       2940       2950
YGFKKEVTFH CLEGYVLQGT PKLTCQSNGT WDAEVPICKP ATCGPPADLP 
      2960       2970       2980       2990       3000
QGFPNGFSFF HGGHIQYQCF TGYKLHGNPS RRCLPDGSWS GSTPSCLPCT 
      3010       3020       3030       3040       3050
CSTPIIQQGT VNATDLGCGK TVQIECFKGF KLLGLPEITC DANGQWSDFP 
      3060       3070       3080       3090       3100
LCEHADCGPL PTVPNGIVIK GSPSEDNVVT YSCRPGYIIQ GSSDLICTEK 
      3110       3120       3130       3140       3150
GIWSEPYPTC EPVSCGPPPT VANAVATGEA HTYESKVKLR CLEGYVVDTD 
      3160       3170       3180       3190       3200
TDTFTCQQDG RWFPERINCS PKTCPVPSNR TRIRVHGDDF QVNRQVSVSC 
      3210       3220       3230       3240       3250
TEGFTYDGAD RSTCQPDGTW EPPLSEESCI PVVCGQPESP EHGFVVGSEY 
      3260       3270       3280       3290       3300
SFGSTVVYQC DPGYELEGNR ERVCQENRQW SGRVAVCRES RCEAPAEFPN 
      3310       3320       3330       3340       3350
GKAVLENTTS GPSLLFSCHR GYTLEGPPEA HCTANGTWSH LAPLCKPNPC 
      3360       3370       3380       3390       3400
PVPFVIPENA LLSEREFYVN QNVSIKCREG FLLKGNGIIT CNPDETWTQT 
      3410       3420       3430       3440       3450
NARCEKISCG PPTHVENAIA RGVHYQYGDM VTFSCYSGYM LEGSLRSVCL 
      3460       3470       3480       3490       3500
ENGTWTPPPI CRAVCRFPCQ NGGVCQRPNA CSCPDGWMGR LCEEPICILP 
      3510       3520       3530       3540       3550
CLNGGRCVAP YRCDCPAGWT GSRCHTATCQ SPCLNGGKCV RPNRCHCLSS 
      3560 
WTGHDCSRKR RSGL
Length:3,564
Mass (Da):387,355
Last modified:February 26, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA1A3F013BEE2A31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JUE3A0A0G2JUE3_RAT
Sushi, von Willebrand factor type A...
Svep1
3,681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LPU2F1LPU2_RAT
Sushi, von Willebrand factor type A...
Svep1
3,565Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR03040659 Genomic DNA No translation available.
AABR03041327 Genomic DNA No translation available.
AABR03041522 Genomic DNA No translation available.
AABR03042206 Genomic DNA No translation available.
AABR03044351 Genomic DNA No translation available.
AABR03044745 Genomic DNA No translation available.
AABR03045322 Genomic DNA No translation available.

Genome annotation databases

UCSC genome browser

More...UCSCi		RGD:1588987, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040659 Genomic DNA No translation available.
AABR03041327 Genomic DNA No translation available.
AABR03041522 Genomic DNA No translation available.
AABR03042206 Genomic DNA No translation available.
AABR03044351 Genomic DNA No translation available.
AABR03044745 Genomic DNA No translation available.
AABR03045322 Genomic DNA No translation available.

3D structure databases

SMRiP0C6B8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050549

PTM databases

CarbonylDBiP0C6B8
GlyGeniP0C6B8, 2 sites

Proteomic databases

PaxDbiP0C6B8
PRIDEiP0C6B8

Genome annotation databases

UCSCiRGD:1588987, rat

Organism-specific databases

RGDi1588987, Svep1

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
KOG4297, Eukaryota
InParanoidiP0C6B8
PhylomeDBiP0C6B8

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0C6B8

Family and domain databases

CDDicd00033, CCP, 32 hits
cd00152, PTX, 1 hit
Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003410, HYR_dom
IPR001759, Pentraxin-related
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF00008, EGF, 6 hits
PF07645, EGF_CA, 2 hits
PF07699, Ephrin_rec_like, 4 hits
PF02494, HYR, 2 hits
PF00354, Pentaxin, 1 hit
PF00084, Sushi, 32 hits
PF00092, VWA, 1 hit
PRINTSiPR00895, PENTAXIN
SMARTiView protein in SMART
SM00032, CCP, 34 hits
SM00181, EGF, 11 hits
SM00179, EGF_CA, 8 hits
SM00159, PTX, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 1 hit
SSF57184, SSF57184, 3 hits
SSF57535, SSF57535, 33 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 6 hits
PS50825, HYR, 2 hits
PS51828, PTX_2, 1 hit
PS50923, SUSHI, 34 hits
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVEP1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6B8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 7, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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