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Protein

Disintegrin schistatin-like subunit B

Gene
N/A
Organism
Echis carinatus (Saw-scaled viper)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind to both alpha-IIb/beta-3 (ITGA2B/ITGB3) and alpha-V/beta-3 (ITGAV/ITGB3) integrins, and may inhibit platelet aggregation.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin schistatin-like subunit B
OrganismiEchis carinatus (Saw-scaled viper)
Taxonomic identifieri40353 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEchis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003194701 – 63Disintegrin schistatin-like subunit BAdd BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 29PROSITE-ProRule annotation1 Publication
Disulfide bondi7Interchain (with C-11 in subunit A)PROSITE-ProRule annotation1 Publication
Disulfide bondi12Interchain (with C-6 in subunit A)PROSITE-ProRule annotation1 Publication
Disulfide bondi20 ↔ 26PROSITE-ProRule annotation1 Publication
Disulfide bondi25 ↔ 50PROSITE-ProRule annotation1 Publication
Disulfide bondi38 ↔ 57PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with subunit A; disulfide-linked.1 Publication

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 11Combined sources3
Beta strandi12 – 14Combined sources3
Beta strandi21 – 23Combined sources3
Beta strandi37 – 39Combined sources3
Beta strandi42 – 45Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TEJX-ray1.90B1-63[»]
ProteinModelPortaliP0C6B5
SMRiP0C6B5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C6B5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63DisintegrinPROSITE-ProRule annotationAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 44Cell attachment site3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C6B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NSVNPCCDPQ TCKPIEGKHC ISGPCCENCY FLRSGTICQR ARGDGNNDYC
60
TGITPDCPRN RYN
Length:63
Mass (Da):6,961
Last modified:February 26, 2008 - v1
Checksum:i15996A964A6A0CE0
GO

Similar proteinsi

Entry informationi

Entry nameiDIDLB_ECHCA
AccessioniPrimary (citable) accession number: P0C6B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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