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Protein

Disintegrin VLO5A

Gene
N/A
Organism
Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1. Inhibition on alpha-IIb/beta-3 (ITGA2B/ITGB3) is low.1 Publication

Miscellaneous

Does not inhibit alpha-1/beta-1 (ITGA1/ITGB1), alpha-2/beta-1 (ITGA2/ITGB1) and alpha-6/beta-1 (ITGA6/ITGB1).1 Publication
The disintegrin belongs to the dimeric disintegrin subfamily.

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin VLO5A
OrganismiMacrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
Taxonomic identifieri209528 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeMacrovipera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190241 – 64Disintegrin VLO5AAdd BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 29PROSITE-ProRule annotation
Disulfide bondi7Interchain (with C-8 in VLO5B)PROSITE-ProRule annotation
Disulfide bondi12Interchain (with C-13 in VLO5B)PROSITE-ProRule annotation
Disulfide bondi20 ↔ 26PROSITE-ProRule annotation
Disulfide bondi25 ↔ 50PROSITE-ProRule annotation
Disulfide bondi38 ↔ 57PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP0C6A9

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with VLO5B; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C6A9
SMRiP0C6A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64DisintegrinPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 44Cell attachment site; atypical (VGD)3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C6A9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NSGNPCCDPV TCQPRRGEHC VSGKCCRNCK FLRAGTVCKR AVGDDMDDYC
60
TGISSDCPRN PYKD
Length:64
Mass (Da):7,005
Last modified:February 26, 2008 - v1
Checksum:i8640F0F3DA3368F3
GO

Similar proteinsi

Entry informationi

Entry nameiVM25A_MACLO
AccessioniPrimary (citable) accession number: P0C6A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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