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Protein

Disintegrin VLO4

Gene
N/A
Organism
Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low.1 Publication

Miscellaneous

Does no inhibit alpha-1/beta-1 (ITGA1/ITGB1), alpha-2/beta-1 (ITGA2/ITGB1) and alpha-6/beta-1 (ITGA6/ITGB1).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin VLO4
OrganismiMacrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
Taxonomic identifieri209528 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeMacrovipera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190231 – 65Disintegrin VLO4Add BLAST65

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 30PROSITE-ProRule annotation
Disulfide bondi8Interchain (with C-8)PROSITE-ProRule annotation
Disulfide bondi13Interchain (with C-13)PROSITE-ProRule annotation
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation
Disulfide bondi26 ↔ 51PROSITE-ProRule annotation
Disulfide bondi39 ↔ 58PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C6A8
SMRiP0C6A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 65DisintegrinPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 45Cell attachment site3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C6A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGNPCCDP VTCKPRRGEH CVSGPCCRNC KFLNAGTICK RARGDDMNDY
60
CTGISPDCPR NPWKG
Length:65
Mass (Da):7,108
Last modified:February 26, 2008 - v1
Checksum:iFF715C1D6BF713E3
GO

Mass spectrometryi

Molecular mass is 14196 Da from positions 1 - 65. Determined by MALDI. Homodimer.1 Publication

Similar proteinsi

Entry informationi

Entry nameiDID4_MACLO
AccessioniPrimary (citable) accession number: P0C6A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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