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Protein

GATA-type zinc finger protein 1

Gene

ZGLP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 230GATA-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-type zinc finger protein 1
Alternative name(s):
GATA-like protein 1
Short name:
GLP-1
Gene namesi
Name:ZGLP1
Synonyms:GLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000220201.7
HGNCiHGNC:37245 ZGLP1
MIMi611639 gene
neXtProtiNX_P0C6A0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100125288
OpenTargetsiENSG00000220201
PharmGKBiPA165394820

Polymorphism and mutation databases

BioMutaiZGLP1
DMDMi166990464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175571 – 271GATA-type zinc finger protein 1Add BLAST271

Proteomic databases

PaxDbiP0C6A0
PeptideAtlasiP0C6A0
PRIDEiP0C6A0
ProteomicsDBi52325

PTM databases

iPTMnetiP0C6A0
PhosphoSitePlusiP0C6A0

Expressioni

Gene expression databases

BgeeiENSG00000220201 Expressed in 87 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiP0C6A0 baseline and differential
GenevisibleiP0C6A0 HS

Organism-specific databases

HPAiHPA049855

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0C6A0, 1 interactor
STRINGi9606.ENSP00000384434

Structurei

3D structure databases

ProteinModelPortaliP0C6A0
SMRiP0C6A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 230GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00470000042444
HOGENOMiHOG000074114
HOVERGENiHBG107952
InParanoidiP0C6A0
KOiK21630
OMAiVQPKRLC
OrthoDBiEOG091G0O9L
PhylomeDBiP0C6A0

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR039355 Transcription_factor_GATA
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PANTHERiPTHR10071 PTHR10071, 1 hit
PfamiView protein in Pfam
PF00320 GATA, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 1 hit
PROSITEiView protein in PROSITE
PS50114 GATA_ZN_FINGER_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0C6A0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEPQVGCVA CPRVHKEPAQ VGTPWPAKPR SHPRKRDPTA LLPRSLWPAC
60 70 80 90 100
QESVTALCFL QETVERLGQS PAQDTPVLGP CWDPMALGTQ GRLLLDRDSK
110 120 130 140 150
DTQTRISQKG RRLQPPGTPS APPQRRPRKQ LNPCRGTERV DPGFEGVTLK
160 170 180 190 200
FQIKPDSSLQ IIPTYSLPCS SRSQESPADA VGGPAAHPGG TEAHSAGSEA
210 220 230 240 250
LEPRRCASCR TQRTPLWRDA EDGTPLCNAC GIRYKKYGTR CSSCWLVPRK
260 270
NVQPKRLCGR CGVSLDPIQE G
Length:271
Mass (Da):29,628
Last modified:February 5, 2008 - v1
Checksum:i7F15849AA6E74732
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCP8B5MCP8_HUMAN
GATA-type zinc finger protein 1
ZGLP1
187Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096830 mRNA No translation available.
AC011511 Genomic DNA No translation available.
BC044225 mRNA No translation available.
CCDSiCCDS45959.1
RefSeqiNP_001096637.1, NM_001103167.1
UniGeneiHs.709296

Genome annotation databases

EnsembliENST00000403903; ENSP00000384434; ENSG00000220201
GeneIDi100125288
KEGGihsa:100125288
UCSCiuc002mnw.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096830 mRNA No translation available.
AC011511 Genomic DNA No translation available.
BC044225 mRNA No translation available.
CCDSiCCDS45959.1
RefSeqiNP_001096637.1, NM_001103167.1
UniGeneiHs.709296

3D structure databases

ProteinModelPortaliP0C6A0
SMRiP0C6A0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0C6A0, 1 interactor
STRINGi9606.ENSP00000384434

PTM databases

iPTMnetiP0C6A0
PhosphoSitePlusiP0C6A0

Polymorphism and mutation databases

BioMutaiZGLP1
DMDMi166990464

Proteomic databases

PaxDbiP0C6A0
PeptideAtlasiP0C6A0
PRIDEiP0C6A0
ProteomicsDBi52325

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403903; ENSP00000384434; ENSG00000220201
GeneIDi100125288
KEGGihsa:100125288
UCSCiuc002mnw.5 human

Organism-specific databases

CTDi100125288
DisGeNETi100125288
EuPathDBiHostDB:ENSG00000220201.7
GeneCardsiZGLP1
HGNCiHGNC:37245 ZGLP1
HPAiHPA049855
MIMi611639 gene
neXtProtiNX_P0C6A0
OpenTargetsiENSG00000220201
PharmGKBiPA165394820
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00470000042444
HOGENOMiHOG000074114
HOVERGENiHBG107952
InParanoidiP0C6A0
KOiK21630
OMAiVQPKRLC
OrthoDBiEOG091G0O9L
PhylomeDBiP0C6A0

Miscellaneous databases

ChiTaRSiZGLP1 human
GenomeRNAii100125288
PROiPR:P0C6A0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000220201 Expressed in 87 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiP0C6A0 baseline and differential
GenevisibleiP0C6A0 HS

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR039355 Transcription_factor_GATA
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PANTHERiPTHR10071 PTHR10071, 1 hit
PfamiView protein in Pfam
PF00320 GATA, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 1 hit
PROSITEiView protein in PROSITE
PS50114 GATA_ZN_FINGER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZGLP1_HUMAN
AccessioniPrimary (citable) accession number: P0C6A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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