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Entry version 75 (08 May 2019)
Sequence version 1 (05 Feb 2008)
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Protein

Uncharacterized protein C6orf222

Gene

C6orf222

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C6orf222
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:33769 C6orf222

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0C671

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380399

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C6orf222

Domain mapping of disease mutations (DMDM)

More...
DMDMi
167008722

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003171871 – 652Uncharacterized protein C6orf222Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki302Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P0C671

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P0C671

PeptideAtlas

More...
PeptideAtlasi
P0C671

PRoteomics IDEntifications database

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PRIDEi
P0C671

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52323

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P0C671

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0C671

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C671

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189325 Expressed in 23 organ(s), highest expression level in mucosa of transverse colon

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038407
HPA058189

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
133119, 26 interactors

Protein interaction database and analysis system

More...
IntActi
P0C671, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418983

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0C671

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J23C Eukaryota
ENOG411169P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001176

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059254

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C671

Identification of Orthologs from Complete Genome Data

More...
OMAi
CVGGHRP

Database of Orthologous Groups

More...
OrthoDBi
475879at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0C671

TreeFam database of animal gene trees

More...
TreeFami
TF338223

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031362 C6orf222

The PANTHER Classification System

More...
PANTHERi
PTHR22435 PTHR22435, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15661 CF222, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0C671-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENPRCPRRP LAEKKARSLD RPQAPGKGSE SWDCHWLSLP TAPSRKALHW
60 70 80 90 100
TTSDWARHSD SPAPSAEAHC TTAAAPTPEE TGDFLPSEQR PSQDTKKGWL
110 120 130 140 150
KTMLNFFVRT GPEEPREKAS RRPRGKEGIS QHPEPLEAAG EPALRKKAHH
160 170 180 190 200
DKKPSRKKQG HKKHAAEVTK AAQDQEARGR EEGLSKAAAA LRSGEADLGP
210 220 230 240 250
ARRGGEDSDH QSFLIKVDGT GALDVSPHAT GHQQEEELKK PDQDAIIQMI
260 270 280 290 300
VELLKRVGDQ WEEEQSLASQ LGVALPNPAP AVRKKSQEKK TSLKRTSKTN
310 320 330 340 350
PKKHGSEEAK RGAADVSSPE AWPPKKSSFL PLCVSGHRPS ISSSYGLEEP
360 370 380 390 400
KVQEAPSTEA GAPGPSVLPT PSESQEPGEE LPLDRASEYK EFIQKIISML
410 420 430 440 450
QDAEEQQGEE QPQVQQEEVG VENPAPHCRR KSQEKRSSFR RAFYHKKHTS
460 470 480 490 500
KEPRRAGAAG AASPEARRPK RPSFLPLCVG GHRPSTSSSL DPEDLECREP
510 520 530 540 550
LPAEGEPVVI SEAPSQARGH TPEGAPQLSG ACESKEIIIQ KLVALLQEVD
560 570 580 590 600
GQLGQQIRRH PSFKRFFYEF SDSSLSKLVA TLRSQVAHSS KLDRNRARRL
610 620 630 640 650
YQFDVSLANK FAGSNSHAMC ILMGLRDHYN CTQFPYREDQ PNITSPKVES

PD
Length:652
Mass (Da):71,930
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC02ED8630E79D9A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118K → R in BX648558 (PubMed:17974005).Curated1
Sequence conflicti574S → P in BX648558 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056808582L → V. Corresponds to variant dbSNP:rs743852Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX648558 mRNA No translation available.
Z84484 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03884.1
BC140873 mRNA Translation: AAI40874.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34439.1

NCBI Reference Sequences

More...
RefSeqi
NP_001010903.3, NM_001010903.4
XP_011512898.1, XM_011514596.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000437635; ENSP00000418983; ENSG00000189325

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389384

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389384

UCSC genome browser

More...
UCSCi
uc003oly.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648558 mRNA No translation available.
Z84484 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03884.1
BC140873 mRNA Translation: AAI40874.1
CCDSiCCDS34439.1
RefSeqiNP_001010903.3, NM_001010903.4
XP_011512898.1, XM_011514596.2

3D structure databases

SMRiP0C671
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133119, 26 interactors
IntActiP0C671, 6 interactors
STRINGi9606.ENSP00000418983

PTM databases

iPTMnetiP0C671
PhosphoSitePlusiP0C671

Polymorphism and mutation databases

BioMutaiC6orf222
DMDMi167008722

Proteomic databases

jPOSTiP0C671
PaxDbiP0C671
PeptideAtlasiP0C671
PRIDEiP0C671
ProteomicsDBi52323
TopDownProteomicsiP0C671

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437635; ENSP00000418983; ENSG00000189325
GeneIDi389384
KEGGihsa:389384
UCSCiuc003oly.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389384

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C6orf222

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0025252
HGNCiHGNC:33769 C6orf222
HPAiHPA038407
HPA058189
neXtProtiNX_P0C671
PharmGKBiPA162380399

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J23C Eukaryota
ENOG411169P LUCA
GeneTreeiENSGT00390000001176
HOGENOMiHOG000059254
InParanoidiP0C671
OMAiCVGGHRP
OrthoDBi475879at2759
PhylomeDBiP0C671
TreeFamiTF338223

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389384

Protein Ontology

More...
PROi
PR:P0C671

Gene expression databases

BgeeiENSG00000189325 Expressed in 23 organ(s), highest expression level in mucosa of transverse colon

Family and domain databases

InterProiView protein in InterPro
IPR031362 C6orf222
PANTHERiPTHR22435 PTHR22435, 1 hit
PfamiView protein in Pfam
PF15661 CF222, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCF222_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C671
Secondary accession number(s): B2RTY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 8, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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