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Protein

Olfactory receptor 4E1

Gene

OR4E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4E1
Alternative name(s):
Olfactory receptor OR14-43
Gene namesi
Name:OR4E1
Synonyms:OR4E1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:8296 OR4E1
neXtProtiNX_P0C645

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 61CytoplasmicSequence analysis7
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 101ExtracellularSequence analysisAdd BLAST19
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 143CytoplasmicSequence analysisAdd BLAST21
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 208ExtracellularSequence analysisAdd BLAST44
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 240CytoplasmicSequence analysisAdd BLAST11
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 272ExtracellularSequence analysisAdd BLAST11
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 315CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000276240

Polymorphism and mutation databases

DMDMi166215771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158241 – 315Olfactory receptor 4E1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0C645
ProteomicsDBi52321

Structurei

3D structure databases

ProteinModelPortaliP0C645
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000148993
HOVERGENiHBG017625
InParanoidiP0C645
KOiK04257
PhylomeDBiP0C645

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAILLNQT SLVTYFRLRG LSVNHKARIA MFSMFLIFYV LTLIGNVLIV
60 70 80 90 100
ITIIYDHRLH TPMYFFLSNL SFIDVCHSTV TVPKMLRDVW SEEKLISFDA
110 120 130 140 150
CVTQMFFLHL FACTEIFLLT VMAYDRYVAI CKPLQYMIVM NWKVCVLLAV
160 170 180 190 200
ALWTGGTIHS IALTSLTIKL PYCGPDEIDN FFCDVPQVIK LACIDTHVIE
210 220 230 240 250
ILIVSNSGLI SVVCFVVLVV SYAVILVSLR QQISKGKRKA LSTCAAHLTV
260 270 280 290 300
VTLFLGHCIF IYSRPSTSLP EDKVVSVFFT AVTPLLNPII YTLRNEEMKS
310
ALNKLVGRKE RKEEK
Length:315
Mass (Da):35,737
Last modified:March 28, 2018 - v2
Checksum:iE5068A662A804A21
GO

Polymorphismi

There at least 2 alleles for OR4E1. A non-functional allele results from a polymorphism at position 197 (dbSNP rs199890040), which leads to a frameshift, premature truncation of the coding region and hence pseudogenization. The presence of various combinations of functional (olfactory receptors) and non-functional (olfactory receptor segregating pseudogenes) alleles may underlie differences in olfactory sensitivity between individuals (hyperosmia, hyposmia or even anosmia).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080171199I → L1 PublicationCorresponds to variant dbSNP:rs10143044Ensembl.1
Natural variantiVAR_080172238R → W1 PublicationCorresponds to variant dbSNP:rs970025Ensembl.1
Natural variantiVAR_080173274V → A1 PublicationCorresponds to variant dbSNP:rs7144135Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065562 Genomic DNA No translation available.
KP290730 Genomic DNA Translation: ALI87888.1
AC243972 Genomic DNA No translation available.
AF399450 Genomic DNA No translation available.
BK004671 Genomic DNA No translation available.
RefSeqiNP_001304036.1, NM_001317107.1

Genome annotation databases

EnsembliENST00000641792; ENSP00000493111; ENSG00000276240
GeneIDi26687
KEGGihsa:26687

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4E1_HUMAN
AccessioniPrimary (citable) accession number: P0C645
Secondary accession number(s): A0A126GWU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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