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Protein

Olfactory receptor 10J4

Gene

OR10J4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10J4
Gene namesi
Name:OR10J4
Synonyms:OR10J4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15408 OR10J4
neXtProtiNX_P0C629

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 57CytoplasmicSequence analysis7
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 98ExtracellularSequence analysisAdd BLAST20
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 149CytoplasmicSequence analysisAdd BLAST30
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 202ExtracellularSequence analysisAdd BLAST32
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 237CytoplasmicSequence analysisAdd BLAST14
Transmembranei238 – 254Helical; Name=6Sequence analysisAdd BLAST17
Topological domaini255 – 272ExtracellularSequence analysisAdd BLAST18
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152791 – 311Olfactory receptor 10J4Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi98 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP0C629
ProteomicsDBi52320

Structurei

3D structure databases

ProteinModelPortaliP0C629
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiP0C629
PhylomeDBiP0C629

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C629-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRPNFMAVT EFTFEGFSIF EWHHRLILFV IFLVLYVLTL ASNAIILIVI
60 70 80 90 100
RLNHQLHTPM YFFLSVLSIS ETYYTVAINP QMLSGLLSPQ QTISIPGCAA
110 120 130 140 150
QLFFYLTFGV NKCFLLTAMG YDHYVAICNP LQYSVIMGKK ACIQLVSGSW
160 170 180 190 200
NIGLSTAIIQ VSSVFSLPFC DANLISHFFC DIRPIMKLAC ADTTIKEIIT
210 220 230 240 250
LLISLCVLVL PMVLIFISYV LIVTTILKIA SAEGRRKAFA TCASHLTVVI
260 270 280 290 300
VHYGRTSFIY LKPKSQNSLQ DRLISVTYTV ITPLLNPVVY SLRNKEVKDA
310
LLRALGRKPL S
Length:311
Mass (Da):34,891
Last modified:January 15, 2008 - v1
Checksum:iC3EE48AC8025530F
GO

Polymorphismi

A single nucleotide deletion at position Ile-198 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663023 Genomic DNA No translation available.
AF399454 Genomic DNA No translation available.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663023 Genomic DNA No translation available.
AF399454 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliP0C629
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi166215743

Proteomic databases

PRIDEiP0C629
ProteomicsDBi52320

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR10J4
HGNCiHGNC:15408 OR10J4
neXtProtiNX_P0C629
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiP0C629
PhylomeDBiP0C629

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:P0C629

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10J4_HUMAN
AccessioniPrimary (citable) accession number: P0C629
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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