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Protein

Kappa-conotoxin SrXIA

Gene
N/A
Organism
Conus spurius (Alphabet cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kappa-conotoxins bind and inhibit voltage-gated potassium channels. This toxin inhibits Kv1.2/KCNA2 and Kv1.6/KCNA6. Produces stiffening of body, limbs and tail when injected intracranially into mice.2 Publications

Miscellaneous

Has no effect on Kv1.3/KCNA3 channels.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17PharmacophoreCurated1
Sitei29PharmacophoreCurated1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin SrXIA
Short name:
Kappa-SrXIA
Alternative name(s):
I2-superfamily conotoxin sr11a
OrganismiConus spurius (Alphabet cone)
Taxonomic identifieri192919 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusLindaconus

Organism-specific databases

ConoServeri2802 SrXIA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140911 – 32Kappa-conotoxin SrXIAAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 15By similarity
Disulfide bondi8 ↔ 20By similarity
Modified residuei94-carboxyglutamate1 Publication1
Modified residuei104-carboxyglutamate1 Publication1
Disulfide bondi14 ↔ 24By similarity
Disulfide bondi19 ↔ 28By similarity
Modified residuei32Proline amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C615
SMRiP0C615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P0C615-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
CRTEGMSCEE NQQCCWRSCC RGECEAPCRF GP
Length:32
Mass (Da):3,660
Last modified:January 15, 2008 - v1
Checksum:i48D975B724F47F8F
GO

Mass spectrometryi

Molecular mass is 3651.78 Da from positions 1 - 32. Determined by MALDI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C615
SMRiP0C615
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri2802 SrXIA

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2BA_CONSP
AccessioniPrimary (citable) accession number: P0C615
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 10, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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