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Protein

Iota-conotoxin-like Fi11.6

Gene
N/A
Organism
Conus figulinus (Fig cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like Fi11.6
OrganismiConus figulinus (Fig cone)
Taxonomic identifieri101301 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusDendroconus

Organism-specific databases

ConoServeri2809 Fi11.6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140861 – 43Iota-conotoxin-like Fi11.6Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 16By similarity
Modified residuei84-hydroxyprolineBy similarity1
Disulfide bondi9 ↔ 19By similarity
Disulfide bondi15 ↔ 24By similarity
Disulfide bondi18 ↔ 35By similarity
Modified residuei264-hydroxyprolineBy similarity1
Modified residuei306'-bromotryptophanBy similarity1
Modified residuei41D-phenylalanineBy similarity1

Keywords - PTMi

Bromination, D-amino acid, Disulfide bond, Hydroxylation

Proteomic databases

PRIDEiP0C610

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP0C610
SMRiP0C610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P0C610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
GCKKDRKPCS YHADCCNCCL SGICAPSTNW ILPGCSTSSF FKI
Length:43
Mass (Da):4,646
Last modified:January 15, 2008 - v1
Checksum:i182F49CD361F1A1B
GO

Similar proteinsi

Entry informationi

Entry nameiCI1B6_CONFI
AccessioniPrimary (citable) accession number: P0C610
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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