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Protein

Conotoxin ar11a

Gene
N/A
Organism
Conus arenatus (Sand-dusted cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Both natural (L-Leu form) and synthetic (D-Leu from) peptides equally cause sensitivity to touch and body tremor. Neither L-Leu form nor D-Leu form is active on nerve-muscle preparation.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin ar11a
Alternative name(s):
Ar11.1
OrganismiConus arenatus (Sand-dusted cone)
Taxonomic identifieri89451 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri2801 ArXIA precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000031408220 – 361 PublicationAdd BLAST17
ChainiPRO_000031408337 – 75Conotoxin ar11aAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 53By similarity
Disulfide bondi46 ↔ 58By similarity
Disulfide bondi52 ↔ 63By similarity
Disulfide bondi57 ↔ 70By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLCATFLLV LVTLPLVTGE KSSERSLSGA ILRGVRRTCS RRGHRCIRDS
60 70
QCCGGMCCQG NRCFVAIRRC FHLPF
Length:75
Mass (Da):8,377
Last modified:January 15, 2008 - v1
Checksum:i93AD875E576F8EB4
GO

Mass spectrometryi

Molecular mass is 4533 Da from positions 37 - 75. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCI1BA_CONAE
AccessioniPrimary (citable) accession number: P0C607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 22, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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