UniProtKB - P0C603 (3NBA_BOIDE)
Protein
Boigatoxin-A
Gene
N/A
Organism
Boiga dendrophila (Mangrove snake) (Gold-ringed cat snake)
Status
Functioni
This toxin may inhibit nicotinic acetylcholine receptor (nAChR). It has poorly reversible postsynaptic blocking activity in a chick muscle preparation and readily reversible inhibitory activity at a presynaptic site in the rat vas deferens prostatic segment most likely to prevent the release of neurotransmitters.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Presynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Boigatoxin-A |
Organismi | Boiga dendrophila (Mangrove snake) (Gold-ringed cat snake) |
Taxonomic identifieri | 46286 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Colubridae › Colubrinae › Boiga |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- other organism postsynaptic membrane Source: UniProtKB-KW
- other organism presynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313787 | 1 – ›47 | Boigatoxin-AAdd BLAST | ›47 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | Pyrrolidone carboxylic acidBy similarity | 1 | |
Disulfide bondi | 10 ↔ 34 | By similarity | ||
Disulfide bondi | 13 ↔ 21 | By similarity |
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acidExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Interactioni
Subunit structurei
Monomer.By similarity
Structurei
3D structure databases
ProteinModelPortali | P0C603 |
SMRi | P0C603 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the snake three-finger toxin family. Non-conventional subfamily. Boigatoxin sub-subfamily.Curated
i Sequence
Sequence statusi: Fragment.
P0C603-1 [UniParc]FASTAAdd to basket
10 20 30 40
QAIGLPHTAC IQCNRKTSSK CLSGQICLPY HMTCYTLYKP DENGELK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 47 | 1 |
Mass spectrometryi
Cross-referencesi
3D structure databases
ProteinModelPortali | P0C603 |
SMRi | P0C603 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | 3NBA_BOIDE | |
Accessioni | P0C603Primary (citable) accession number: P0C603 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | November 22, 2017 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families