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Protein

Keratin-associated protein 1-4

Gene

KRTAP1-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 1-4
Alternative name(s):
High sulfur keratin-associated protein 1.4
Keratin-associated protein 1.4
Gene namesi
Name:KRTAP1-4
Synonyms:KAP1.4, KRTAP1.4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000204887.4
HGNCiHGNC:18904 KRTAP1-4
MIMi608821 gene
neXtProtiNX_P0C5Y4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi162416160

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003125051 – 121Keratin-associated protein 1-4Add BLAST121

Proteomic databases

PaxDbiP0C5Y4
PeptideAtlasiP0C5Y4
PRIDEiP0C5Y4
ProteomicsDBi52312

Expressioni

Tissue specificityi

Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.1 Publication

Gene expression databases

BgeeiENSG00000204887

Interactioni

Subunit structurei

Interacts with hair keratins.

Structurei

3D structure databases

ProteinModelPortaliP0C5Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KRTAP type 1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00730000111060
HOGENOMiHOG000234033
HOVERGENiHBG008671
InParanoidiP0C5Y4
OMAiSSCCETS
OrthoDBiEOG091G16MK
PhylomeDBiP0C5Y4

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF01500 Keratin_B2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C5Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASCSTSGTC GSSCCQPSCC ETSCCQPSCC QTSSCGTGCG IGGGIGYGQE
60 70 80 90 100
GSGGSVSTRI RWCHPDCHVE GTCLPPCYLV SCTPPSCCQL HHAEASCCRP
110 120
SYCGQSCCRP ACCCHCCEPT C
Length:121
Mass (Da):12,324
Last modified:December 4, 2007 - v1
Checksum:i55FDE67F43900398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007455 Genomic DNA No translation available.
CCDSiCCDS58548.1
RefSeqiNP_001244234.1, NM_001257305.1
UniGeneiHs.744827

Genome annotation databases

EnsembliENST00000377747; ENSP00000366976; ENSG00000204887
ENST00000576814; ENSP00000458243; ENSG00000263242
GeneIDi728255
KEGGihsa:728255
UCSCiuc031raf.2 human

Similar proteinsi

Entry informationi

Entry nameiKRA14_HUMAN
AccessioniPrimary (citable) accession number: P0C5Y4
Secondary accession number(s): A6NJ92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 18, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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