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Protein

G-protein coupled receptor 52

Gene

Gpr52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).By similarity3 Publications

Miscellaneous

GPR52 is located within an intron of RABGAP1L gene, which exhibits epistatic effects on GPR52-mediated modulation of HTT levels by blocking this modulation.1 Publication

GO - Molecular functioni

  • G protein-coupled photoreceptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: UniProtKB

GO - Biological processi

  • cellular response to light stimulus Source: GO_Central
  • G protein-coupled receptor signaling pathway Source: GO_Central
  • locomotory behavior Source: UniProtKB
  • phototransduction Source: GO_Central
  • response to drug Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 52By similarity
Gene namesi
Name:Gpr52Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3643278 Gpr52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 81CytoplasmicSequence analysisAdd BLAST16
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 115ExtracellularSequence analysisAdd BLAST13
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 159CytoplasmicSequence analysisAdd BLAST23
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 205ExtracellularSequence analysisAdd BLAST25
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 265CytoplasmicSequence analysisAdd BLAST39
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini287 – 296ExtracellularSequence analysis10
Transmembranei297 – 317Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini318 – 361CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Gpr52 knockout mice are normal in body and brain weight. In the open field test, mice stay and move around the central zone significantly longer. The total distance traveled and brain morphology are normal. Mice are much more sensitive to the startle response following dizocilpine administration. Thus mice displayed psychosis-related behaviors (PubMed:24587241). Mice exhibit a significantly higher istradefylline-induced locomotor activity (PubMed:28583861).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076801 – 361G-protein coupled receptor 52Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0C5J4

PTM databases

PhosphoSitePlusiP0C5J4
SwissPalmiP0C5J4

Expressioni

Tissue specificityi

Expressed in brain, especially in striatum (PubMed:24587241). Expressed in the striatum, nucleus accumbens, and lateral globus pallidus (PubMed:28583861).2 Publications

Structurei

3D structure databases

ProteinModelPortaliP0C5J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051801
InParanoidiP0C5J4
KOiK08407
PhylomeDBiP0C5J4

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C5J4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNESRWTEWR ILNMSSSIVN VSEHHSCPLG FGHYSVEDVC IFETVVIVLL
60 70 80 90 100
TFLIISGNLT VIFVFHCAPL LHHYTTSYFI QTMAYADLLV GVTCLVPTLS
110 120 130 140 150
LLHYSTGVHE SLTCQVFGYI ISVLKSVSMA CLACISVDRY LAITKPLSYN
160 170 180 190 200
QLVTPCRLRI CIIMIWIYSC LIFLPSFFGW GKPGYHGDIF EWCATSWLTS
210 220 230 240 250
AYFTCFIVCL LYAPAALVVC FTYFHIFKIC RQHTKEINDR RARFPSHEVE
260 270 280 290 300
ASREAGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF
310 320 330 340 350
LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCV CAKDQEAQDP
360
KPRRRANSCS I
Length:361
Mass (Da):41,343
Last modified:October 23, 2007 - v1
Checksum:i150F8A395B63290B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117787 Genomic DNA No translation available.
RefSeqiNP_001139802.1, NM_001146330.1
XP_017177375.1, XM_017321886.1
XP_017177377.1, XM_017321888.1
UniGeneiMm.478780

Genome annotation databases

GeneIDi620246
KEGGimmu:620246
UCSCiuc011wum.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117787 Genomic DNA No translation available.
RefSeqiNP_001139802.1, NM_001146330.1
XP_017177375.1, XM_017321886.1
XP_017177377.1, XM_017321888.1
UniGeneiMm.478780

3D structure databases

ProteinModelPortaliP0C5J4
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP0C5J4
SwissPalmiP0C5J4

Proteomic databases

PRIDEiP0C5J4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi620246
KEGGimmu:620246
UCSCiuc011wum.1 mouse

Organism-specific databases

CTDi9293
MGIiMGI:3643278 Gpr52

Phylogenomic databases

HOVERGENiHBG051801
InParanoidiP0C5J4
KOiK08407
PhylomeDBiP0C5J4

Miscellaneous databases

PROiPR:P0C5J4
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR52_MOUSE
AccessioniPrimary (citable) accession number: P0C5J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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