UniProtKB - P0C5I8 (SIX3F_LEIHE)
Protein
Beta-insect depressant toxin Lqh-dprIT3f
Gene
N/A
Organism
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Status
Functioni
Depressant insect beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and block action potentials, primarily by depolarizing the axonal membrane and suppressing the sodium current. This depressant toxin is active only on insects. It is found in a relatively small amount in the venom.1 Publication
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-insect depressant toxin Lqh-dprIT3f |
Organismi | Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus) |
Taxonomic identifieri | 6884 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Leiurus › |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
PD50 is 19 ng/100 mg of body weight of Sarcophaga larvae for contraction paralysis, and 85 ng/100 mg for flaccid paralysis.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000307616 | 22 – 82 | Beta-insect depressant toxin Lqh-dprIT3fAdd BLAST | 61 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 81 | PROSITE-ProRule annotation | ||
Disulfide bondi | 35 ↔ 56 | PROSITE-ProRule annotation | ||
Disulfide bondi | 42 ↔ 63 | PROSITE-ProRule annotation | ||
Disulfide bondi | 46 ↔ 65 | PROSITE-ProRule annotation | ||
Modified residuei | 82 | Glycine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Disulfide bondProteomic databases
PRIDEi | P0C5I8 |
Expressioni
Tissue specificityi
Expressed by the venom gland.
Structurei
3D structure databases
ProteinModelPortali | P0C5I8 |
SMRi | P0C5I8 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 82 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00107 Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR003614 Scorpion_toxin-like IPR036574 Scorpion_toxin-like_sf IPR018218 Scorpion_toxinL IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
PRINTSi | PR00285 SCORPNTOXIN |
SMARTi | View protein in SMART SM00505 Knot1, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0C5I8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLLLLLTIS ASMLIEGLVN ADGYIRGGDG CKVSCVINHV FCDNECKAAG
60 70 80
GSYGYCWGWG LACWCEGLPA DREWDYETDT CGGKK
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P0C5I8 |
SMRi | P0C5I8 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | P0C5I8 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
CDDi | cd00107 Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR003614 Scorpion_toxin-like IPR036574 Scorpion_toxin-like_sf IPR018218 Scorpion_toxinL IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
PRINTSi | PR00285 SCORPNTOXIN |
SMARTi | View protein in SMART SM00505 Knot1, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | SIX3F_LEIHE | |
Accessioni | P0C5I8Primary (citable) accession number: P0C5I8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 5, 2018 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families