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Protein

Probable G-protein coupled receptor 25

Gene

Gpr25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 25
Gene namesi
Name:Gpr25
Synonyms:Gm1300
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2686146 Gpr25

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 76CytoplasmicSequence analysisAdd BLAST12
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 113ExtracellularSequence analysisAdd BLAST16
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 155CytoplasmicSequence analysisAdd BLAST21
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 200ExtracellularSequence analysisAdd BLAST24
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 239CytoplasmicSequence analysisAdd BLAST18
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 284ExtracellularSequence analysisAdd BLAST24
Transmembranei285 – 307Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini308 – 358CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003070931 – 358Probable G-protein coupled receptor 25Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0C5I1
PRIDEiP0C5I1

PTM databases

PhosphoSitePlusiP0C5I1

Expressioni

Gene expression databases

BgeeiENSMUSG00000052759 Expressed in 48 organ(s), highest expression level in brain
GenevisibleiP0C5I1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083583

Structurei

3D structure databases

ProteinModelPortaliP0C5I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJV0 Eukaryota
ENOG4111HMZ LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000112789
HOVERGENiHBG051803
InParanoidiP0C5I1
KOiK08405
OMAiMDSRYLR
OrthoDBiEOG091G0MQK
PhylomeDBiP0C5I1
TreeFamiTF330024

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C5I1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSTEPWSPS WGTLSWDYSG SGSLDQVELC PAWNLPYGHA IIPALYLAAF
60 70 80 90 100
AVGLPGNAFV VWLLSRQRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAEA
110 120 130 140 150
RGGLWPFGDG LCKVSSFALA VTRCAGALLL AGMSVDRYLA VGRPLSARPL
160 170 180 190 200
RSARCVRAVC GAAWAAAFLA GLPALLYRGL QPSLDGVGSQ CAEEPWEALQ
210 220 230 240 250
GVGLLLLLLT FALPLAVTLI CYWRVSRRLP RVGRARSNSL RIIFTVESVF
260 270 280 290 300
VGCWLPFGVL RSLFHLARLQ ALPLPCSLLL ALRWGLTVTT CLAFVNSSAN
310 320 330 340 350
PVIYLLLDRS FRARARFGLC ARAGRQVRRI SSASSLSRDD SSVFRGRSPK

VNSASATW
Length:358
Mass (Da):38,754
Last modified:October 2, 2007 - v1
Checksum:i2A7F7D925F4A3E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124550 Genomic DNA No translation available.
CCDSiCCDS48381.1
RefSeqiNP_001094986.1, NM_001101516.1
UniGeneiMm.40367

Genome annotation databases

EnsembliENSMUST00000086395; ENSMUSP00000083583; ENSMUSG00000052759
GeneIDi383563
KEGGimmu:383563
UCSCiuc011wsy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124550 Genomic DNA No translation available.
CCDSiCCDS48381.1
RefSeqiNP_001094986.1, NM_001101516.1
UniGeneiMm.40367

3D structure databases

ProteinModelPortaliP0C5I1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083583

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP0C5I1

Proteomic databases

PaxDbiP0C5I1
PRIDEiP0C5I1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086395; ENSMUSP00000083583; ENSMUSG00000052759
GeneIDi383563
KEGGimmu:383563
UCSCiuc011wsy.1 mouse

Organism-specific databases

CTDi2848
MGIiMGI:2686146 Gpr25

Phylogenomic databases

eggNOGiENOG410IJV0 Eukaryota
ENOG4111HMZ LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000112789
HOVERGENiHBG051803
InParanoidiP0C5I1
KOiK08405
OMAiMDSRYLR
OrthoDBiEOG091G0MQK
PhylomeDBiP0C5I1
TreeFamiTF330024

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:P0C5I1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052759 Expressed in 48 organ(s), highest expression level in brain
GenevisibleiP0C5I1 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR25_MOUSE
AccessioniPrimary (citable) accession number: P0C5I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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