UniProtKB - P0C5G5 (NA11_HETCR)
Protein
Delta-stichotoxin-Hcr3a
Gene
N/A
Organism
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Status
Functioni
Inhibits voltage-gated sodium channels (Nav).By similarity
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of signal transduction Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Delta-stichotoxin-Hcr3a1 PublicationShort name: Delta-SHTX-Hcr3a1 Publication Alternative name(s): Rc-I Short name: Rc I1 Publication Short name: Rc-1 |
Organismi | Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus) |
Taxonomic identifieri | 175771 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Stichodactylidae › Heteractis |
Subcellular locationi
Extracellular region or secreted
Other locations
- Nematocyst Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- nematocyst Source: UniProtKB-SubCell
Keywords - Cellular componenti
Nematocyst, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305119 | 1 – 47 | Delta-stichotoxin-Hcr3a1 PublicationAdd BLAST | 47 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | Hydroxyproline1 Publication | 1 | |
Disulfide bondi | 4 ↔ 44 | By similarity | ||
Disulfide bondi | 6 ↔ 34 | By similarity | ||
Disulfide bondi | 27 ↔ 45 | By similarity |
Keywords - PTMi
Disulfide bond, HydroxylationStructurei
3D structure databases
ProteinModelPortali | P0C5G5 |
SMRi | P0C5G5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR000693 Anenome_toxin IPR023355 Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF00706 Toxin_4, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C5G5-1 [UniParc]FASTAAdd to basket
10 20 30 40
GVPCRCDSDG PSVHGNTLSG TIWVGSCETG WHKCNTEHNL FHECCKQ
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P0C5G5 |
SMRi | P0C5G5 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR000693 Anenome_toxin IPR023355 Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF00706 Toxin_4, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | NA11_HETCR | |
Accessioni | P0C5G5Primary (citable) accession number: P0C5G5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | November 22, 2017 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families