Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-crystallin S

Gene

Crygs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin S
Alternative name(s):
Beta-crystallin S
Gamma-S-crystallin
Gene namesi
Name:Crygs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1587483 Crygs

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003049732 – 178Gamma-crystallin SAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP0C5E9
PRIDEiP0C5E9

Expressioni

Gene expression databases

BgeeiENSRNOG00000038355 Expressed in 8 organ(s), highest expression level in liver
GenevisibleiP0C5E9 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055204

Structurei

3D structure databases

ProteinModelPortaliP0C5E9
SMRiP0C5E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 44Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini45 – 87Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini94 – 134Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini135 – 177Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 5N-terminal arm4
Regioni88 – 93Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEJ7 Eukaryota
ENOG4111EVU LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP0C5E9
OMAiHWMGLND
OrthoDBiEOG091G0L2P
PhylomeDBiP0C5E9

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5E9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKTGAKISF YEDRNFQGRR YDCDCDCVDF RSYLSRCNSI RVEGGTWAVY
60 70 80 90 100
ERPNFSGHMY ILPQGEYPEY QRWMGLNDRL GSCRAVHLSS GGQYKIQIFE
110 120 130 140 150
KGDFSGQMYE TTEDCPSTME RFHLREIHSC KVLEGTWIFY ELPSYHGRQY
160 170
LLDKKEYRKP VDWGAASPAV QSFRRIVE
Length:178
Mass (Da):20,942
Last modified:October 2, 2007 - v1
Checksum:i6D53173F98C25E00
GO

Sequence databases

RefSeqiNP_001103023.1, NM_001109553.1
UniGeneiRn.198271

Genome annotation databases

EnsembliENSRNOT00000058402; ENSRNOP00000055204; ENSRNOG00000038355
GeneIDi689897
KEGGirno:689897
UCSCiRGD:1587483 rat

Similar proteinsi

Entry informationi

Entry nameiCRYGS_RAT
AccessioniPrimary (citable) accession number: P0C5E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 12, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again