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Entry version 91 (13 Feb 2019)
Sequence version 1 (11 Sep 2007)
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Protein

Phosphatidylinositol phosphatase PTPRQ

Gene

Ptprq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2201Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
Alternative name(s):
Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
Short name:
PTP-RQ
Short name:
R-PTP-Q
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptprq
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1096349 Ptprq

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 1906ExtracellularSequence analysisAdd BLAST1889
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1907 – 1927HelicalSequence analysisAdd BLAST21
Topological domaini1928 – 2300CytoplasmicSequence analysisAdd BLAST373

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show rapid postnatal deterioration in cochlear hair-bundle structure, associated with smaller than normal transducer currents with otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.1 Publication

Keywords - Diseasei

Deafness

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030285118 – 2300Phosphatidylinositol phosphatase PTPRQAdd BLAST2283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi718N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi744N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi996N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1008N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1038N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1059N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1803N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0C5E4

PeptideAtlas

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PeptideAtlasi
P0C5E4

PRoteomics IDEntifications database

More...
PRIDEi
P0C5E4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P0C5E4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C5E4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the inner ear of the early postnatal mouse, it is present in hair bundles in the cochlea and in the vestibule. Restricted to the hair bundles and not detected in any other cell type within the inner ear. Restricted to the basal region of the hair bundle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035916 Expressed in 9 organ(s), highest expression level in female gonad

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
231884, 9 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058572

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0C5E4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0C5E4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 154Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini158 – 253Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini309 – 397Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST89
Domaini400 – 495Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini497 – 564Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST68
Domaini568 – 663Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST96
Domaini668 – 757Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini762 – 852Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST91
Domaini857 – 946Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST90
Domaini951 – 1051Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST101
Domaini1056 – 1149Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST94
Domaini1154 – 1241Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST88
Domaini1246 – 1339Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST94
Domaini1343 – 1429Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST87
Domaini1433 – 1537Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST105
Domaini1542 – 1640Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST99
Domaini1645 – 1746Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST102
Domaini2004 – 2260Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST257

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3510 Eukaryota
KOG4228 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159215

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115793

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108308

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P0C5E4

KEGG Orthology (KO)

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KOi
K16910

Identification of Orthologs from Complete Genome Data

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OMAi
WMQTAYT

Database of Orthologous Groups

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OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P0C5E4

TreeFam database of animal gene trees

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TreeFami
TF351926

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 15 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 14 hits
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 12 hits
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 16 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 9 hits
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 16 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0C5E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFLFFFLFS LIGTSESQVD VSGSFDDTVY DITLSSISAT TYSSPVSRTL
60 70 80 90 100
ATNVSKPGPP VFLAGERVGS AGILLSWNTP PNPNGRIISY VVKYKEVCPW
110 120 130 140 150
MQTAYTRVRA KPDSLEVLLT NLNPGTTYEI KVAAENSAGI GVFSDPFLFQ
160 170 180 190 200
TAESAPGKVV NLTVEALNYS AVNLIWYLPR QPNGKITSFK ISVKHARSGI
210 220 230 240 250
VVKDVSIKVE DLLSGKLPEC NENSDSFLWS TTSPSPTLSR ATPPLRTTHL
260 270 280 290 300
SNTLARNKIS SVWKEPISFV VTHLRPYTTY LFEVSAVTTE AGYIDSTIVR
310 320 330 340 350
TPESVPEGPP QNCITGNVTG KAFSISWDPP AIVTGKFSYR VELYGPTGRI
360 370 380 390 400
LDNSTKDLRF VFTHLTPFTM YDVYVAAETS AGVGPKSNLS VFTPPDVPGA
410 420 430 440 450
VFDLQIVEVE ATEIRVSWRK PRQPNGIISQ YRVKVSVLES GVILENTLLT
460 470 480 490 500
GQDEYINNPM TPEIMNLVDP MIGFYEGSGE MSSDLHSLAS FIYNSHPHDF
510 520 530 540 550
PARTRVEDQR SPVVATRNQY MTDIAAEHLS YVIRRLVPFT EHTISVSAFT
560 570 580 590 600
VMGEGPPTVL TVRTREQVPS SIQIINYKNI SSSSILLYWD PPEYPNGKIT
610 620 630 640 650
HYTIYAMELD TNRAFQMTTV DNSFLITGLK KYTRYKMRVA ASTHVGESSL
660 670 680 690 700
SEENDLFVRT PEDEPESSPQ DVKVTDVSPS ELSLTWSPPE KPNGIIIAYE
710 720 730 740 750
VFYQNADALF VKNTSTTNIT LSDLKPYTLY NISIQSYTRL GHGNQSSSLL
760 770 780 790 800
SVRTSETVPD SAPENITYKN ISSEEIEIFF LPPRSPNGII QKYTIYLKRS
810 820 830 840 850
NSHEARTIET TSLTLTIGGL KKYTHYVIEV SASTLKGEGV RSMPISILTE
860 870 880 890 900
EDAPDSPPQN FSVKQLSGVT VMLSWQPPLE PNGIILYYTV YVWDKVSLKT
910 920 930 940 950
INATEVSLEL SDLDYHADYS AYVTASTRFG DGKTRSSVIN FRTPEGEPSD
960 970 980 990 1000
PPKDVHYVNL SSSSIILFWT PPVKPNGIIQ YYSVYYQNTS STFVQNFTLL
1010 1020 1030 1040 1050
EVTQEPGNVT VSARIYKLAV FSYYTFWLTA STLVGNGNKS SDVIHVYTDQ
1060 1070 1080 1090 1100
DIPEGGVGNL TYESLSSTAI NVSWTPPSQP NGLVFYYVSL NLQQSPPRHR
1110 1120 1130 1140 1150
RPPLTTYENS IYFDNLEKYT DYIFKITPST EKGFSETYTA QLHIKTEEDV
1160 1170 1180 1190 1200
PDTPPIINTF KNLSSTSILL SWDPPLKPNG AILSYHLTLQ GTHANRTFVT
1210 1220 1230 1240 1250
SGNHIVLEEL SPFTLYSFLA AARTMKGLGP SSILFFYTDE SAPLAPPQNL
1260 1270 1280 1290 1300
TLINYTSDFV WLTWSPSPLP GGIVKVYSFK IHEHETDTVF YKNISGFQTD
1310 1320 1330 1340 1350
AKLAGLEPVS TYSISVSAFT KVGNGNQFSN VVKFTTQESV PDAVQNIACV
1360 1370 1380 1390 1400
ARDWQSVSVM WDPPRKANGI IIHYMITVEG NSTKVSPRDP MYTFTKLLAN
1410 1420 1430 1440 1450
TSYIFEVRAS TSAGEGNESQ CNVSTLPETV PSVPTNTAFS NVQSTSVTLR
1460 1470 1480 1490 1500
WIKPDTILGY FQNYKITTQL RAQKCREWEP EECVEHQEVQ YLYEANQTED
1510 1520 1530 1540 1550
TVRGLKKFQW YRFQVAASTN AGYGNASSWI STQTLPGPPD GPPENVRVVA
1560 1570 1580 1590 1600
TSPFGINISW NEPAIITGPT FYLIDVKSVD NDNFNISFVK SNEENKTTEI
1610 1620 1630 1640 1650
NDLEVFTRYS VVITAFVGNV SGAYTDGKSS AEVIITTLES VPKDPPNNMT
1660 1670 1680 1690 1700
FQKIPDEVTK FQLSFLPPSQ PNGNIQVYQA LVYREDDPTA VQIHNLSIIQ
1710 1720 1730 1740 1750
KTDTSVIAML EGLKGGHTYN ISVYAINSAG AGPKVQMRIT MDIKAPARPK
1760 1770 1780 1790 1800
TKPIPIHDAT GKLLVTSTTI TIRMPICYYN DDHGPIRNVQ VLVAEAGAQQ
1810 1820 1830 1840 1850
DGNVTKWYDA YFNKARPYFT NEGFPNPPCI EGKTKFSGNE EIYVIGADNA
1860 1870 1880 1890 1900
CMIPGNEEKI CNGPLKPKKQ YLFKFRATNV MGQFTDSEYS DPIKTLGEGL
1910 1920 1930 1940 1950
SERTVEIILS VTLCILSIIL LGTAIFAFAR IRQKQKEGGT YSPRDAEIID
1960 1970 1980 1990 2000
TKFKLDQLIT VADLELKDER LTRLLSYRKS IKPVSKKSFL QHVEELCTNN
2010 2020 2030 2040 2050
NLKFQEEFSE LPKFLQDLSS TDADLPWNRA KNRFPNIKPY NNNRVKLIAD
2060 2070 2080 2090 2100
VSIPGSDYIN ASYVSGYLCP NEFIATQGPL PGTVGDFWRM VWETRAKTLV
2110 2120 2130 2140 2150
MLTQCFEKGR IRCHQYWPED NKPVTVFGDI LITKLMEDIQ IDWTIRDLKI
2160 2170 2180 2190 2200
ERHGDCMTVR QCNFTGWPEH GVPENTTPLI HFVKLVRTSR AHDATPMVVH
2210 2220 2230 2240 2250
CSAGVGRTGV FIALDHLTQH IHDHDFVDIY GLVAELRSER MCMVQNLAQY
2260 2270 2280 2290 2300
IFLHQCILDL LSNKGGHQPV CFVNYSTLQK MDSLDAMEGD VELEWEETTM
Length:2,300
Mass (Da):256,785
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1866AE48D19FAB09
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC021642 Genomic DNA No translation available.
AC123948 Genomic DNA No translation available.
AC155168 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS36051.1

NCBI Reference Sequences

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RefSeqi
NP_001074901.1, NM_001081432.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.391418

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000050702; ENSMUSP00000058572; ENSMUSG00000035916

Database of genes from NCBI RefSeq genomes

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GeneIDi
237523

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:237523

UCSC genome browser

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UCSCi
uc007gzb.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021642 Genomic DNA No translation available.
AC123948 Genomic DNA No translation available.
AC155168 Genomic DNA No translation available.
CCDSiCCDS36051.1
RefSeqiNP_001074901.1, NM_001081432.1
UniGeneiMm.391418

3D structure databases

ProteinModelPortaliP0C5E4
SMRiP0C5E4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231884, 9 interactors
STRINGi10090.ENSMUSP00000058572

PTM databases

iPTMnetiP0C5E4
PhosphoSitePlusiP0C5E4

Proteomic databases

PaxDbiP0C5E4
PeptideAtlasiP0C5E4
PRIDEiP0C5E4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050702; ENSMUSP00000058572; ENSMUSG00000035916
GeneIDi237523
KEGGimmu:237523
UCSCiuc007gzb.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
374462
MGIiMGI:1096349 Ptprq

Phylogenomic databases

eggNOGiKOG3510 Eukaryota
KOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000159215
HOGENOMiHOG000115793
HOVERGENiHBG108308
InParanoidiP0C5E4
KOiK16910
OMAiWMQTAYT
OrthoDBi411281at2759
PhylomeDBiP0C5E4
TreeFamiTF351926

Miscellaneous databases

Protein Ontology

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PROi
PR:P0C5E4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035916 Expressed in 9 organ(s), highest expression level in female gonad

Family and domain databases

CDDicd00063 FN3, 15 hits
Gene3Di2.60.40.10, 14 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 12 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 16 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 9 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 16 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRQ_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C5E4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: February 13, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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