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UniProtKB - P0C2W7 (CT47B_HUMAN)

Entry version 81 (12 Aug 2020)
Sequence version 1 (01 May 2007)
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Protein

Cancer/testis antigen 47B

Gene

CT47B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P0C2W7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cancer/testis antigen 47B
Alternative name(s):
Cancer/testis antigen 47.13
Short name:
CT47.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CT47B1
Synonyms:CT47.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000236446.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:33293, CT47B1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300790, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P0C2W7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000236446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164718327

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P0C2W7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CT47B1

Domain mapping of disease mutations (DMDM)

More...DMDMi		146286097

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002864331 – 299Cancer/testis antigen 47BAdd BLAST299

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P0C2W7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0C2W7

PeptideAtlas

More...PeptideAtlasi		P0C2W7

PRoteomics IDEntifications database

More...PRIDEi		P0C2W7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52306

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000236446, Expressed in testis and 6 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P0C2W7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000236446, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360360

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P0C2W7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili270 – 298Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 99Poly-Glu8
Compositional biasi168 – 171Poly-Leu4

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TF73, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_083200_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0C2W7

Identification of Orthologs from Complete Genome Data

More...OMAi		FLYLVHS

Database of Orthologous Groups

More...OrthoDBi		1561192at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0C2W7

TreeFam database of animal gene trees

More...TreeFami		TF342556

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028930, CT47

The PANTHER Classification System

More...PANTHERi		PTHR32157, PTHR32157, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15623, CT47, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0C2W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATGDRHPT QGDQEAPVSQ EGAQAEAAGA GNQEGGDSGP DSSDMVPAAE 
        60         70         80         90        100
VVGVAGPVEG LGEEEGEQAA GLAAVPQGGS AEEDSDIGPA TEEEEEEEEG 
       110        120        130        140        150
NEAANFDLAV ATRRYPAAGI GFVFLYLVHS LLRRLYHNDH IQIANRHLSR 
       160        170        180        190        200
LMVGPHAAVP NLWDNPPLLL LSQRLGAGAA APEGEGLGLI QEAASVQEAA 
       210        220        230        240        250
SVPEPAVPAD LAEMAREPAE EAADEKPPEE AAEEKLTEEA TEEPAAEEPT 
       260        270        280        290 
SEEAVAPEEV TKSQPEKWDE EAQDAAGEEE KEQEKEKDVE NKVKNSKGT
Length:299
Mass (Da):31,319
Last modified:May 1, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2FD8473EE062757
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07626799Missing 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC008162 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48161.1

NCBI Reference Sequences

More...RefSeqi		NP_001139190.1, NM_001145718.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371311; ENSP00000360360; ENSG00000236446
ENST00000672355; ENSP00000500741; ENSG00000288466

Database of genes from NCBI RefSeq genomes

More...GeneIDi		643311

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:643311

UCSC genome browser

More...UCSCi		uc011muc.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008162 Genomic DNA No translation available.
CCDSiCCDS48161.1
RefSeqiNP_001139190.1, NM_001145718.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000360360

Polymorphism and mutation databases

BioMutaiCT47B1
DMDMi146286097

Proteomic databases

MassIVEiP0C2W7
PaxDbiP0C2W7
PeptideAtlasiP0C2W7
PRIDEiP0C2W7
ProteomicsDBi52306

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		70794, 18 antibodies

Genome annotation databases

EnsembliENST00000371311; ENSP00000360360; ENSG00000236446
ENST00000672355; ENSP00000500741; ENSG00000288466
GeneIDi643311
KEGGihsa:643311
UCSCiuc011muc.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		643311
EuPathDBiHostDB:ENSG00000236446.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		CT47B1
HGNCiHGNC:33293, CT47B1
HPAiENSG00000236446, Tissue enriched (testis)
MIMi300790, gene
neXtProtiNX_P0C2W7
OpenTargetsiENSG00000236446
PharmGKBiPA164718327

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TF73, Eukaryota
GeneTreeiENSGT00390000002253
HOGENOMiCLU_083200_0_0_1
InParanoidiP0C2W7
OMAiFLYLVHS
OrthoDBi1561192at2759
PhylomeDBiP0C2W7
TreeFamiTF342556

Enzyme and pathway databases

PathwayCommonsiP0C2W7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		643311, 2 hits in 499 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		643311
PharosiP0C2W7, Tdark

Protein Ontology

More...PROi		PR:P0C2W7
RNActiP0C2W7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000236446, Expressed in testis and 6 other tissues
GenevisibleiP0C2W7, HS

Family and domain databases

InterProiView protein in InterPro
IPR028930, CT47
PANTHERiPTHR32157, PTHR32157, 1 hit
PfamiView protein in Pfam
PF15623, CT47, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCT47B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C2W7
Secondary accession number(s): A6NM97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: August 12, 2020
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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