UniProtKB - P0C2R0 (VEMP_CVMA5)
Protein
Envelope small membrane protein
Gene
E
Organism
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus)
Status
Functioni
Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis.2 Publications
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.UniRule annotation
GO - Biological processi
- disruption by virus of host cell membrane Source: CACAO
- pore formation by virus in membrane of host cell Source: InterPro
- viral budding from Golgi membrane Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Protein family/group databases
TCDBi | 1.A.65.1.1, the coronavirus viroporin e protein (viroporin e) family |
Names & Taxonomyi
Protein namesi | Recommended name: Envelope small membrane proteinUniRule annotationShort name: E proteinUniRule annotation Short name: sM proteinUniRule annotation |
Gene namesi | Name:EUniRule annotation Synonyms:sM ORF Names:5b |
Organismi | Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) |
Taxonomic identifieri | 11142 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus › |
Virus hosti | Mus musculus (Mouse) [TaxID: 10090] |
Proteomesi |
|
Subcellular locationi
- Host Golgi apparatus membrane UniRule annotation; Single-pass type III membrane protein UniRule annotation Note: The cytoplasmic tail functions as a Golgi complex-targeting signal.UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | Virion surfaceUniRule annotationAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 38 – 79 | IntravirionUniRule annotationAdd BLAST | 42 |
GO - Cellular componenti
- host cell Golgi membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Host Golgi apparatus, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284092 | 1 – 83 | Envelope small membrane proteinAdd BLAST | 83 |
Interactioni
Subunit structurei
Homopentamer.
Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex.
Interacts with Nucleoprotein.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the betacoronaviruses E protein family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
HAMAPi | MF_04204, BETA_CORONA_E, 1 hit |
InterProi | View protein in InterPro IPR043506, E_protein_bCoV IPR003873, E_protein_CoV |
Pfami | View protein in Pfam PF02723, CoV_E, 1 hit |
PROSITEi | View protein in PROSITE PS51926, COV_E, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C2R0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFNLFLTDTV WYVGQIIFIF AVCLMVTIIV VAFLASIKLC IQLCGLCNTL
60 70 80
VLSPSIYLYD RSKQLYKYYN EEMRLPLLEV DDI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029248 Genomic RNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029248 Genomic RNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
TCDBi | 1.A.65.1.1, the coronavirus viroporin e protein (viroporin e) family |
Family and domain databases
HAMAPi | MF_04204, BETA_CORONA_E, 1 hit |
InterProi | View protein in InterPro IPR043506, E_protein_bCoV IPR003873, E_protein_CoV |
Pfami | View protein in Pfam PF02723, CoV_E, 1 hit |
PROSITEi | View protein in PROSITE PS51926, COV_E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VEMP_CVMA5 | |
Accessioni | P0C2R0Primary (citable) accession number: P0C2R0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families