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Entry version 94 (12 Aug 2020)
Sequence version 1 (20 Mar 2007)
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Protein

Protein FAM163B

Gene

FAM163B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P0C2L3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM163B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM163B
Synonyms:C9orf166
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196990.8

Human Gene Nomenclature Database

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HGNCi
HGNC:33277, FAM163B

neXtProt; the human protein knowledge platform

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neXtProti
NX_P0C2L3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
642968

Open Targets

More...
OpenTargetsi
ENSG00000196990

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162386945

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P0C2L3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM163B

Domain mapping of disease mutations (DMDM)

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DMDMi
134035404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002802581 – 166Protein FAM163BAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0C2L3

PeptideAtlas

More...
PeptideAtlasi
P0C2L3

PRoteomics IDEntifications database

More...
PRIDEi
P0C2L3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52303

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0C2L3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C2L3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196990, Expressed in anterior cingulate cortex and 87 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196990, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P0C2L3, 4 interactors

Molecular INTeraction database

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MINTi
P0C2L3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349336

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P0C2L3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RY59, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159387

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_138617_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C2L3

Identification of Orthologs from Complete Genome Data

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OMAi
YEPPAFF

Database of Orthologous Groups

More...
OrthoDBi
1417278at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0C2L3

TreeFam database of animal gene trees

More...
TreeFami
TF333084

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029379, FAM163
IPR040280, FAM163B

The PANTHER Classification System

More...
PANTHERi
PTHR31396, PTHR31396, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15069, FAM163, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0C2L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKDES EEDEEEPDFA
60 70 80 90 100
VHSHLPPLHS NRNLVLTNGP ALYPTASTSF SQKSPQARAL CRSCSHCEPP
110 120 130 140 150
TFFLQEPPEE EEDVLNGGER VLYKSVSQED VELPPGGFGG LQALNPNRLS
160
AMREAFARSR SISTDV
Length:166
Mass (Da):18,190
Last modified:March 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC048BBB4234EBC47
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX629352 Genomic DNA No translation available.
BC146946 mRNA Translation: AAI46947.1
BC146961 mRNA Translation: AAI46962.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35171.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073984.1, NM_001080515.2
XP_005272260.1, XM_005272203.4
XP_005272261.1, XM_005272204.4
XP_006717296.1, XM_006717233.3
XP_011517214.1, XM_011518912.2
XP_011517215.1, XM_011518913.2
XP_016870506.1, XM_017015017.1
XP_016870507.1, XM_017015018.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356873; ENSP00000349336; ENSG00000196990
ENST00000496132; ENSP00000419867; ENSG00000196990
ENST00000673969; ENSP00000501259; ENSG00000196990

Database of genes from NCBI RefSeq genomes

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GeneIDi
642968

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:642968

UCSC genome browser

More...
UCSCi
uc011mdm.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX629352 Genomic DNA No translation available.
BC146946 mRNA Translation: AAI46947.1
BC146961 mRNA Translation: AAI46962.1
CCDSiCCDS35171.1
RefSeqiNP_001073984.1, NM_001080515.2
XP_005272260.1, XM_005272203.4
XP_005272261.1, XM_005272204.4
XP_006717296.1, XM_006717233.3
XP_011517214.1, XM_011518912.2
XP_011517215.1, XM_011518913.2
XP_016870506.1, XM_017015017.1
XP_016870507.1, XM_017015018.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiP0C2L3, 4 interactors
MINTiP0C2L3
STRINGi9606.ENSP00000349336

PTM databases

iPTMnetiP0C2L3
PhosphoSitePlusiP0C2L3

Polymorphism and mutation databases

BioMutaiFAM163B
DMDMi134035404

Proteomic databases

PaxDbiP0C2L3
PeptideAtlasiP0C2L3
PRIDEiP0C2L3
ProteomicsDBi52303

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
78020, 5 antibodies

The DNASU plasmid repository

More...
DNASUi
642968

Genome annotation databases

EnsembliENST00000356873; ENSP00000349336; ENSG00000196990
ENST00000496132; ENSP00000419867; ENSG00000196990
ENST00000673969; ENSP00000501259; ENSG00000196990
GeneIDi642968
KEGGihsa:642968
UCSCiuc011mdm.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
642968
DisGeNETi642968
EuPathDBiHostDB:ENSG00000196990.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM163B
HGNCiHGNC:33277, FAM163B
HPAiENSG00000196990, Tissue enriched (brain)
neXtProtiNX_P0C2L3
OpenTargetsiENSG00000196990
PharmGKBiPA162386945

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RY59, Eukaryota
GeneTreeiENSGT00940000159387
HOGENOMiCLU_138617_0_0_1
InParanoidiP0C2L3
OMAiYEPPAFF
OrthoDBi1417278at2759
PhylomeDBiP0C2L3
TreeFamiTF333084

Enzyme and pathway databases

PathwayCommonsiP0C2L3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
642968, 14 hits in 867 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
642968
PharosiP0C2L3, Tdark

Protein Ontology

More...
PROi
PR:P0C2L3
RNActiP0C2L3, protein

Gene expression databases

BgeeiENSG00000196990, Expressed in anterior cingulate cortex and 87 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR029379, FAM163
IPR040280, FAM163B
PANTHERiPTHR31396, PTHR31396, 1 hit
PfamiView protein in Pfam
PF15069, FAM163, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF163B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C2L3
Secondary accession number(s): B2RUZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: August 12, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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