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Protein

Uncharacterized serine/threonine-protein kinase SBK3

Gene

SBK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72ATPPROSITE-ProRule annotation1
Active sitei163Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 57ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP0C264

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized serine/threonine-protein kinase SBK3 (EC:2.7.11.1)
Alternative name(s):
SH3-binding domain kinase family member 3
Sugen kinase 110
Gene namesi
Name:SBK3
Synonyms:SGK110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000231274.5
HGNCiHGNC:44121 SBK3
neXtProtiNX_P0C264

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231274

Chemistry databases

ChEMBLiCHEMBL5116
GuidetoPHARMACOLOGYi2290

Polymorphism and mutation databases

DMDMi161783904

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629951 – 359Uncharacterized serine/threonine-protein kinase SBK3Add BLAST359

Proteomic databases

PaxDbiP0C264
PeptideAtlasiP0C264
PRIDEiP0C264
ProteomicsDBi52302

PTM databases

PhosphoSitePlusiP0C264

Expressioni

Gene expression databases

BgeeiENSG00000231274
ExpressionAtlasiP0C264 baseline and differential

Organism-specific databases

HPAiHPA078322

Interactioni

Protein-protein interaction databases

IntActiP0C264, 11 interactors

Chemistry databases

BindingDBiP0C264

Structurei

3D structure databases

ProteinModelPortaliP0C264
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 309Protein kinasePROSITE-ProRule annotationAdd BLAST267

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi189 – 278Pro-richAdd BLAST90

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
HOVERGENiHBG108481
InParanoidiP0C264
KOiK08858
OMAiGRCVSAH
OrthoDBiEOG091G0QNH
PhylomeDBiP0C264

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P0C264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRASETPE DGDPEEDTAT ALQRLVELTT SRVTPVRSLR DQYHLIRKLG
60 70 80 90 100
SGSYGRVLLA QPHQGGPAVA LKLLRRDLVL RSTFLREFCV GRCVSAHPGL
110 120 130 140 150
LQTLAGPLQT PRYFAFAQEY APCGDLSGML QERGLPELLV KRVVAQLAGA
160 170 180 190 200
LDFLHSRGLV HADVKPDNVL VFDPVCSRVA LGDLGLTRPE GSPTPAPPVP
210 220 230 240 250
LPTAPPELCL LLPPDTLPLR PAVDSWGLGV LLFCAATACF PWDVALAPNP
260 270 280 290 300
EFEAFAGWVT TKPQPPQPPP PWDQFAPPAL ALLQGLLDLD PETRSPPLAV
310 320 330 340 350
LDFLGDDWGL QGNREGPGVL GSAVSYEDRE EGGSSLEEWT DEGDDSKSGG

RTGTDGGAP
Length:359
Mass (Da):38,488
Last modified:October 23, 2007 - v2
Checksum:i3E6AFF74412256C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA No translation available.
CCDSiCCDS74457.1
RefSeqiNP_001186753.1, NM_001199824.2
UniGeneiHs.712129

Genome annotation databases

EnsembliENST00000612221; ENSP00000483467; ENSG00000231274
GeneIDi100130827
KEGGihsa:100130827
UCSCiuc032ifx.1 human

Similar proteinsi

Entry informationi

Entry nameiSBK3_HUMAN
AccessioniPrimary (citable) accession number: P0C264
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 23, 2007
Last modified: July 18, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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