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Protein

Serine/threonine-protein kinase SBK2

Gene

SBK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91ATPPROSITE-ProRule annotation1
Active sitei183Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 76ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP0C263

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK2 (EC:2.7.11.1)
Alternative name(s):
SH3-binding domain kinase family member 2
Sugen kinase 69
Short name:
SgK069
Gene namesi
Name:SBK2
Synonyms:SGK069
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000187550.8
HGNCiHGNC:34416 SBK2
neXtProtiNX_P0C263

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187550

Polymorphism and mutation databases

BioMutaiSBK2
DMDMi254763329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629941 – 348Serine/threonine-protein kinase SBK2Add BLAST348

Proteomic databases

PaxDbiP0C263
PeptideAtlasiP0C263
PRIDEiP0C263
ProteomicsDBi52301

Expressioni

Gene expression databases

BgeeiENSG00000187550 Expressed in 32 organ(s), highest expression level in right atrium auricular region

Organism-specific databases

HPAiHPA030631

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345044

Structurei

3D structure databases

ProteinModelPortaliP0C263
SMRiP0C263
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 330Protein kinasePROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
InParanoidiP0C263
KOiK08858
OMAiRPWRQRE
OrthoDBiEOG091G0QNH
PhylomeDBiP0C263
TreeFamiTF326736

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P0C263-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGKQSEEGP AEAGASEDSE EEGLGGLTLE ELQQGQEAAR ALEDMMTLSA
60 70 80 90 100
QTLVRAEVDE LYEEVRPLGQ GCYGRVLLVT HRQKGTPLAL KQLPKPRTSL
110 120 130 140 150
RGFLYEFCVG LSLGAHSAIV TAYGIGIESA HSYSFLTEPV LHGDLMAFIQ
160 170 180 190 200
PKVGLPQPAV HRCAAQLASA LEYIHARGLV YRDLKPENVL VCDPACRRFK
210 220 230 240 250
LTDFGHTRPR GTLLRLAGPP IPYTAPELCA PPPLPEGLPI QPALDAWALG
260 270 280 290 300
VLLFCLLTGY FPWDRPLAEA DPFYEDFLIW QASGQPRDRP QPWFGLAAAA
310 320 330 340
DALLRGLLDP HPRRRSAVIA IREHLGRPWR QREGEAEAVG AVEEEAGQ
Length:348
Mass (Da):38,088
Last modified:July 28, 2009 - v2
Checksum:i2A7E12C4289AC2C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04107720E → K1 PublicationCorresponds to variant dbSNP:rs34316437Ensembl.1
Natural variantiVAR_04107841A → E1 Publication1
Natural variantiVAR_041079102G → D1 PublicationCorresponds to variant dbSNP:rs56158623Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA No translation available.
CCDSiCCDS42631.1
RefSeqiNP_001094871.2, NM_001101401.2
XP_006723390.1, XM_006723327.3
UniGeneiHs.532676

Genome annotation databases

EnsembliENST00000344158; ENSP00000345044; ENSG00000187550
ENST00000413299; ENSP00000389015; ENSG00000187550
GeneIDi646643
KEGGihsa:646643
UCSCiuc032ifw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA No translation available.
CCDSiCCDS42631.1
RefSeqiNP_001094871.2, NM_001101401.2
XP_006723390.1, XM_006723327.3
UniGeneiHs.532676

3D structure databases

ProteinModelPortaliP0C263
SMRiP0C263
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345044

Polymorphism and mutation databases

BioMutaiSBK2
DMDMi254763329

Proteomic databases

PaxDbiP0C263
PeptideAtlasiP0C263
PRIDEiP0C263
ProteomicsDBi52301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344158; ENSP00000345044; ENSG00000187550
ENST00000413299; ENSP00000389015; ENSG00000187550
GeneIDi646643
KEGGihsa:646643
UCSCiuc032ifw.2 human

Organism-specific databases

CTDi646643
EuPathDBiHostDB:ENSG00000187550.8
GeneCardsiSBK2
HGNCiHGNC:34416 SBK2
HPAiHPA030631
neXtProtiNX_P0C263
OpenTargetsiENSG00000187550
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
InParanoidiP0C263
KOiK08858
OMAiRPWRQRE
OrthoDBiEOG091G0QNH
PhylomeDBiP0C263
TreeFamiTF326736

Enzyme and pathway databases

SignaLinkiP0C263

Miscellaneous databases

GenomeRNAii646643
PROiPR:P0C263

Gene expression databases

BgeeiENSG00000187550 Expressed in 32 organ(s), highest expression level in right atrium auricular region

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSBK2_HUMAN
AccessioniPrimary (citable) accession number: P0C263
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 28, 2009
Last modified: September 12, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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