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Protein

Iota-conotoxin-like M11.1

Gene
N/A
Organism
Conus magus (Magus cone) (Magician's cone snail)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like M11.1
OrganismiConus magus (Magus cone) (Magician's cone snail)
Taxonomic identifieri6492 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri1420 M11.1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000262685‹1 – 45Iota-conotoxin-like M11.1Add BLAST›45
PropeptideiPRO_000026268646Removed by a carboxypeptidaseBy similarity1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 19By similarity
Disulfide bondi12 ↔ 22By similarity
Disulfide bondi18 ↔ 27By similarity
Disulfide bondi21 ↔ 38By similarity
Modified residuei44D-methionineBy similarity1

Keywords - PTMi

D-amino acid, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0C257
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C257-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
GAVPCGKDGR QCRNHADCCN CCPIGTCAPS TNWILPGCST GQFMTR
Length:46
Mass (Da):4,832
Last modified:November 28, 2006 - v1
Checksum:i3ECFBC8E501E11F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0C257
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1420 M11.1a

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI1B1_CONMA
AccessioniPrimary (citable) accession number: P0C257
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 10, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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