UniProtKB - P0C1Z6 (TFPT_HUMAN)
TCF3 fusion partner
TFPT
Functioni
Appears to promote apoptosis in a p53/TP53-independent manner.
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
GO - Molecular functioni
- DNA binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein kinase binding Source: Ensembl
GO - Biological processi
- apoptotic signaling pathway Source: UniProtKB
- chromatin remodeling Source: ComplexPortal
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- male gonad development Source: Ensembl
- nucleosome mobilization Source: ComplexPortal
- positive regulation of apoptotic process Source: GO_Central
- positive regulation of DNA repair Source: Ensembl
- positive regulation of telomere maintenance in response to DNA damage Source: Ensembl
- positive regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of cell cycle Source: ComplexPortal
- regulation of chromosome organization Source: ComplexPortal
- regulation of DNA replication Source: ComplexPortal
- regulation of DNA strand elongation Source: ComplexPortal
- regulation of embryonic development Source: Ensembl
- telomere maintenance Source: Ensembl
Keywordsi
Biological process | Apoptosis, DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P0C1Z6 |
Reactomei | R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER |
SignaLinki | P0C1Z6 |
Names & Taxonomyi
Protein namesi | Recommended name: TCF3 fusion partnerAlternative name(s): INO80 complex subunit F Protein FB1 |
Gene namesi | Name:TFPT Synonyms:INO80F |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13630, TFPT |
MIMi | 609519, gene |
neXtProti | NX_P0C1Z6 |
VEuPathDBi | HostDB:ENSG00000105619 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- actin filament Source: Ensembl
Nucleus
- Ino80 complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 29844 |
OpenTargetsi | ENSG00000105619 |
PharmGKBi | PA37802 |
Miscellaneous databases
Pharosi | P0C1Z6, Tbio |
Genetic variation databases
BioMutai | TFPT |
DMDMi | 126352246 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254581 | 1 – 253 | TCF3 fusion partnerAdd BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 172 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 180 | PhosphoserineCombined sources | 1 | |
Modified residuei | 188 | PhosphoserineCombined sources | 1 | |
Modified residuei | 207 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 216 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 249 | PhosphoserineCombined sources | 1 | |
Modified residuei | 252 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P0C1Z6 |
jPOSTi | P0C1Z6 |
MassIVEi | P0C1Z6 |
MaxQBi | P0C1Z6 |
PaxDbi | P0C1Z6 |
PeptideAtlasi | P0C1Z6 |
PRIDEi | P0C1Z6 |
ProteomicsDBi | 33890 52299 |
PTM databases
iPTMneti | P0C1Z6 |
PhosphoSitePlusi | P0C1Z6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105619, Expressed in prefrontal cortex and 210 other tissues |
ExpressionAtlasi | P0C1Z6, baseline and differential |
Genevisiblei | P0C1Z6, HS |
Organism-specific databases
HPAi | ENSG00000105619, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death (By similarity).
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.
By similarity3 PublicationsBinary interactionsi
P0C1Z6
Isoform 2 [P0C1Z6-2]
GO - Molecular functioni
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 118931, 162 interactors |
ComplexPortali | CPX-846, INO80 chromatin remodeling complex |
IntActi | P0C1Z6, 44 interactors |
MINTi | P0C1Z6 |
STRINGi | 9606.ENSP00000375639 |
Miscellaneous databases
RNActi | P0C1Z6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 49 – 72 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 142 – 211 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 234 – 253 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 56 – 72 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 167 – 183 | Pro residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | ENOG502RHUP, Eukaryota |
GeneTreei | ENSGT00390000016605 |
InParanoidi | P0C1Z6 |
OMAi | NEPPDKE |
PhylomeDBi | P0C1Z6 |
TreeFami | TF338152 |
Family and domain databases
InterProi | View protein in InterPro IPR033555, TFPT |
PANTHERi | PTHR35084, PTHR35084, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG
60 70 80 90 100
GLGGSGLRER DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL
110 120 130 140 150
NRLHQVQRIT RRLQQERRFL MRVLDSYGDD YRASQFTIVL EDEGSQGTDA
160 170 180 190 200
PTPGNAENEP PEKETLSPPR RTPAPPEPGS PAPGEGPSGR KRRRVPRDGR
210 220 230 240 250
RAGNALTPEL APVQIKVEED FGFEADEALD SSWVSRGPDK LLPYPTLASP
ASD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MTQ3 | A8MTQ3_HUMAN | TCF3 fusion partner | TFPT | 193 | Annotation score: | ||
A0A0G2JP55 | A0A0G2JP55_HUMAN | TCF3 fusion partner | TFPT | 145 | Annotation score: | ||
F8WDC1 | F8WDC1_HUMAN | TCF3 fusion partner | TFPT | 105 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058937 | 1 – 9 | Missing in isoform 2. | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF052052 mRNA Translation: AAD45182.1 AC012314 Genomic DNA No translation available. AC245052 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72186.1 BC001728 mRNA No translation available. BC004281 mRNA Translation: AAH04281.1 BC007776 mRNA Translation: AAH07776.1 |
CCDSi | CCDS12878.1 [P0C1Z6-1] CCDS82396.1 [P0C1Z6-2] |
RefSeqi | NP_001308721.1, NM_001321792.1 [P0C1Z6-2] NP_037474.1, NM_013342.3 [P0C1Z6-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF052052 mRNA Translation: AAD45182.1 AC012314 Genomic DNA No translation available. AC245052 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72186.1 BC001728 mRNA No translation available. BC004281 mRNA Translation: AAH04281.1 BC007776 mRNA Translation: AAH07776.1 |
CCDSi | CCDS12878.1 [P0C1Z6-1] CCDS82396.1 [P0C1Z6-2] |
RefSeqi | NP_001308721.1, NM_001321792.1 [P0C1Z6-2] NP_037474.1, NM_013342.3 [P0C1Z6-1] |
3D structure databases
SMRi | P0C1Z6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118931, 162 interactors |
ComplexPortali | CPX-846, INO80 chromatin remodeling complex |
IntActi | P0C1Z6, 44 interactors |
MINTi | P0C1Z6 |
STRINGi | 9606.ENSP00000375639 |
PTM databases
iPTMneti | P0C1Z6 |
PhosphoSitePlusi | P0C1Z6 |
Genetic variation databases
BioMutai | TFPT |
DMDMi | 126352246 |
Proteomic databases
EPDi | P0C1Z6 |
jPOSTi | P0C1Z6 |
MassIVEi | P0C1Z6 |
MaxQBi | P0C1Z6 |
PaxDbi | P0C1Z6 |
PeptideAtlasi | P0C1Z6 |
PRIDEi | P0C1Z6 |
ProteomicsDBi | 33890 52299 |
Protocols and materials databases
Antibodypediai | 32793, 155 antibodies from 28 providers |
DNASUi | 29844 |
Genome annotation databases
Organism-specific databases
CTDi | 29844 |
DisGeNETi | 29844 |
GeneCardsi | TFPT |
HGNCi | HGNC:13630, TFPT |
HPAi | ENSG00000105619, Low tissue specificity |
MIMi | 609519, gene |
neXtProti | NX_P0C1Z6 |
OpenTargetsi | ENSG00000105619 |
PharmGKBi | PA37802 |
VEuPathDBi | HostDB:ENSG00000105619 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RHUP, Eukaryota |
GeneTreei | ENSGT00390000016605 |
InParanoidi | P0C1Z6 |
OMAi | NEPPDKE |
PhylomeDBi | P0C1Z6 |
TreeFami | TF338152 |
Enzyme and pathway databases
PathwayCommonsi | P0C1Z6 |
Reactomei | R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER |
SignaLinki | P0C1Z6 |
Miscellaneous databases
BioGRID-ORCSi | 29844, 73 hits in 1058 CRISPR screens |
ChiTaRSi | TFPT, human |
GeneWikii | TFPT |
GenomeRNAii | 29844 |
Pharosi | P0C1Z6, Tbio |
PROi | PR:P0C1Z6 |
RNActi | P0C1Z6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105619, Expressed in prefrontal cortex and 210 other tissues |
ExpressionAtlasi | P0C1Z6, baseline and differential |
Genevisiblei | P0C1Z6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033555, TFPT |
PANTHERi | PTHR35084, PTHR35084, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TFPT_HUMAN | |
Accessioni | P0C1Z6Primary (citable) accession number: P0C1Z6 Secondary accession number(s): G5E9B5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot