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Protein

Alpha-conotoxin-like Bn1.3

Gene
N/A
Organism
Conus bandanus (Banded marbled cone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Does not show activity on the acetylcholine receptors tested.1 Publication

Miscellaneous

The synthetic peptide does not detectably affect any of the nAChR subtypes tested (alpha-2-beta-2, alpha-2-beta-4, alpha-3-beta-2, alpha-3-beta-3, alpha-3-beta-4, alpha-4-beta-2, alpha-4-beta-4, alpha-6-beta-2 and alpha-6-beta-3).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Bn1.31 Publication
OrganismiConus bandanus (Banded marbled cone)
Taxonomic identifieri72279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusConus

Organism-specific databases

ConoServeri20 Bn1.3 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000025123419 – 48By similarityAdd BLAST30
PeptideiPRO_000025123549 – 61Alpha-conotoxin-like Bn1.3Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 57By similarity
Disulfide bondi52 ↔ 61By similarity
Modified residuei61Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

3D structure databases

ProteinModelPortaliP0C1Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/3 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
IPR018072 Conotoxin_a-typ_CS
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1Y2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMRMMFTVF LLVVLATAVL PVTLDRASDG RNAAANAKTP RLIAPFIRDY
60
CCHRGPCMVW CG
Length:62
Mass (Da):6,830
Last modified:October 3, 2006 - v1
Checksum:iBF0D811758C3047D
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C1Y2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri20 Bn1.3 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
IPR018072 Conotoxin_a-typ_CS
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA13_CONBN
AccessioniPrimary (citable) accession number: P0C1Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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