Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-galactosidase

Gene

lacZ

Organism
Lactobacillus delbrueckii subsp. bulgaricus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei465Proton donorBy similarity1
Active sitei532NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKiP0C1Y0

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
OrganismiLactobacillus delbrueckii subsp. bulgaricus
Taxonomic identifieri1585 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000576642 – 1007Beta-galactosidaseAdd BLAST1006

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP0C1Y0
SMRiP0C1Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105CNT Bacteria
COG3250 LUCA

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR004199 B-gal_small/dom_5
IPR036156 Beta-gal/glucu_dom_sf
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR032312 LacZ_4
PfamiView protein in Pfam
PF02929 Bgal_small_N, 1 hit
PF16353 DUF4981, 1 hit
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SMARTiView protein in SMART
SM01038 Bgal_small_N, 1 hit
SUPFAMiSSF49303 SSF49303, 2 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1Y0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNKLVKEKR VDQADLAWLT DPEVYEVNTI PPHSDHESFQ SQEELEEGKS
60 70 80 90 100
SLVQSLDGDW LIDYAENGQG PVNFYAEDFD DSNFKSVKVP GNLELQGFGQ
110 120 130 140 150
PQYVNVQYPW DGSEEIFPPQ IPSKNPLASY VRYFDLDEAF WDKEVSLKFD
160 170 180 190 200
GAATAIYVWL NGHFVGYGED SFTPSEFMVT KFLKKENNRL AVALYKYSSA
210 220 230 240 250
SWLEDQDFWR MSGLFRSVTL QAKPRLHLED LKLTASLTDN YQKGKLEVEA
260 270 280 290 300
NIAYRLPNAS FKLEVRDSEG DLVAEKLGPI RSEQLEFTLA DLPVAAWSAE
310 320 330 340 350
KPNLYQVRLY LYQAGSLLEV SRQEVGFRNF ELKDGIMYLN GQRIVFKGAN
360 370 380 390 400
RHEFDSKLGR AITEEDMIWD IKTMKRSNIN AVRCSHYPNQ SLFYRLCDKY
410 420 430 440 450
GLYVIDEANL ESHGTWEKVG GHEDPSFNVP GDDQHWLGAS LSRVKNMMAR
460 470 480 490 500
DKNHASILIW SLGNESYAGT VFAQMADYVR KADPTRVQHY EGVTHNRKFD
510 520 530 540 550
DATQIESRMY APAKVIEEYL TNKPAKPFIS VEYAHAMGNS VGDLAAYTAL
560 570 580 590 600
EKYPHYQGGF IWDWIDQGLE KDGHLLYGGD FDDRPTDYEF CGNGLVFADR
610 620 630 640 650
TESPKLANVK ALYANLKLEV KDGQLFLKND NLFTNSSSYY FLTSLLVDGK
660 670 680 690 700
LTYQSRPLTF GLEPGESGTF ALPWPEVADE KGEVVYRVTA HLKEDLPWAD
710 720 730 740 750
EGFTVAEAEE VAQKLPEFKP EGRPDLVDSD YNLGLKGNNF QILFSKVKGW
760 770 780 790 800
PVSLKYAGRE YLKRLPEFTF WRALTDNDRG AGYGYDLARW ENAGKYARLK
810 820 830 840 850
DISCEVKEDS VLVKTAFTLP VALKGDLTVT YEVDGRGKIA VTADFPGAEE
860 870 880 890 900
AGLLPAFGLN LALPKELTDY RYYGLGPNES YPDRLEGNYL GIYQGAVKKN
910 920 930 940 950
FSPYRPQETG NRSKVRWYQL FDEKGGLEFT ANGADLNLSA LPYSAAQIEA
960 970 980 990 1000
ADHAFELTNN YTWVRALSAQ MGVGGDDSWG QKVHPEFCLD AQKARQLRLV

IQPLLLK
Length:1,007
Mass (Da):114,047
Last modified:January 23, 2007 - v2
Checksum:iD8E306D2A24071AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23530 Genomic DNA Translation: AAA25240.1
PIRiA30093

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23530 Genomic DNA Translation: AAA25240.1
PIRiA30093

3D structure databases

ProteinModelPortaliP0C1Y0
SMRiP0C1Y0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CNT Bacteria
COG3250 LUCA

Enzyme and pathway databases

SABIO-RKiP0C1Y0

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR004199 B-gal_small/dom_5
IPR036156 Beta-gal/glucu_dom_sf
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR032312 LacZ_4
PfamiView protein in Pfam
PF02929 Bgal_small_N, 1 hit
PF16353 DUF4981, 1 hit
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SMARTiView protein in SMART
SM01038 Bgal_small_N, 1 hit
SUPFAMiSSF49303 SSF49303, 2 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBGAL_LACDE
AccessioniPrimary (citable) accession number: P0C1Y0
Secondary accession number(s): P20043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again