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Protein

Alpha-conotoxin OIVB

Gene
N/A
Organism
Conus obscurus (Obscure cone) (Conus halitropus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (alpha-1/beta-1/gamma/delta subunits) (IC50=66 nM) with 1500/2000-fold greater affinity than the adult (alpha-1/beta-1/epsilon/delta) subtype (IC50=96000 nM). It blocks the currents completely and dissociates rapidly from the fetal muscle receptor. Has no inhibitory activity on various neuronal nAChRs. This toxin causes a reversible paralysis upon injection into gold fish.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin OIVB
Short name:
Alpha-A-O4b
Short name:
Alpha-A-OIVB
OrganismiConus obscurus (Obscure cone) (Conus halitropus)
Taxonomic identifieri89447 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusGastridium

Organism-specific databases

ConoServeri1688 OIVB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002497971 – 19Alpha-conotoxin OIVBAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 91 Publication
Disulfide bondi2 ↔ 141 Publication
Modified residuei54-hydroxyproline1 Publication1
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi12 ↔ 181 Publication
Modified residuei19Glycine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Sequencei

Sequence statusi: Complete.

P0C1W8-1 [UniParc]FASTAAdd to basket
« Hide
        10 
CCGVPNAACP PCVCNKTCG
Length:19
Mass (Da):1,840
Last modified:September 19, 2006 - v1
Checksum:i21A3765DF117119C
GO

Mass spectrometryi

Molecular mass is 1866.5 Da from positions 1 - 19. Determined by FAB. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1688 OIVB

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCA4B_CONOB
AccessioniPrimary (citable) accession number: P0C1W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 12, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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