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Protein

Alpha-conotoxin VxXXC

Gene
N/A
Organism
Conus vexillum (Flag cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin VxXXC1 Publication
Alternative name(s):
VxXIIC1 Publication
OrganismiConus vexillum (Flag cone)
Taxonomic identifieri89431 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusRhizoconus

Organism-specific databases

ConoServeri1684 VxXXC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002497961 – 47Alpha-conotoxin VxXXCAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Hydroxyproline; partial1 Publication1
Modified residuei21Hydroxyproline; partial1 Publication1
Modified residuei29Hydroxyproline; partial1 Publication1

Post-translational modificationi

Contains 5 disulfide bonds.Curated
HydroxyPro-10 is only found in a minor form.

Keywords - PTMi

Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C1W7
SMRiP0C1W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XX (C-CC-C-CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin D superfamily.Curated

Sequencei

Sequence statusi: Complete.

P0C1W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
DLRQCTRNAP GSTWGRCCLN PMCGNFCCPR SGCTCAYNWR RGIYCSC
Length:47
Mass (Da):5,286
Last modified:September 19, 2006 - v1
Checksum:iA4AF94883E74571C
GO

Mass spectrometryi

Molecular mass is 5282.4 Da from positions 1 - 47. Determined by ESI. 1 Publication

Entry informationi

Entry nameiCDKC_CONVX
AccessioniPrimary (citable) accession number: P0C1W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 12, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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