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Protein

Alpha-conotoxin VxXXB

Gene
N/A
Organism
Conus vexillum (Flag cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7 (IC50=0.4 nM), alpha-3-beta-2/CHRNA3-CHRNB2 (IC50=8.4 nM) and alpha-4-beta-2/CHRNA4-CHRNB2 (IC50=228 nM) subtypes. VxXXB inhibits alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR subtypes more efficiently than VxXXA and VxXXC.1 Publication

Miscellaneous

[desGly-95]VxXXB is a minor form.

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin VxXXB1 Publication
Alternative name(s):
Vx20.2Imported
VxXIIB1 Publication
Cleaved into the following chain:
OrganismiConus vexillum (Flag cone)
Taxonomic identifieri89431 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusRhizoconus

Organism-specific databases

ConoServeri1685 VxXXB
3631 VxXXB precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000039178325 – 451 PublicationAdd BLAST21
ChainiPRO_000024979446 – 95Alpha-conotoxin VxXXB1 PublicationAdd BLAST50
ChainiPRO_000024979546 – 94Alpha-conotoxin [des-Gly95]VxXXB1 PublicationAdd BLAST49

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei484-carboxyglutamate1 Publication1
Modified residuei504-carboxyglutamate1 Publication1
Modified residuei594-hydroxyproline; partial1 Publication1
Modified residuei754-hydroxyproline; partial1 Publication1
Modified residuei944-hydroxyproline; partial1 Publication1
Modified residuei94Proline amide; in form [desGly-95]VxXXB1 Publication1

Post-translational modificationi

Contains 4 disulfide bonds.Curated

Keywords - PTMi

Amidation, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C1W6
SMRiP0C1W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is C-CC-C-CC-C-C-C.Curated

Sequence similaritiesi

Belongs to the conotoxin D superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKLAVVLLV LLILPLSYFD AAGGQAVQGD WRGNRLARDL QRGGRDDESE
60 70 80 90
CIINTRDSPW GRCCRTRMCG SMCCPRNGCT CVYHWRRGHG RSCPG
Length:95
Mass (Da):10,598
Last modified:March 2, 2010 - v2
Checksum:i7BFDFFF546136322
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91R → C AA sequence (PubMed:16790424).Curated1

Mass spectrometryi

Molecular mass is 5741.4 Da from positions 46 - 95. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN178634 mRNA Translation: CAX51120.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN178634 mRNA Translation: CAX51120.1

3D structure databases

ProteinModelPortaliP0C1W6
SMRiP0C1W6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1685 VxXXB
3631 VxXXB precursor

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCDKB_CONVX
AccessioniPrimary (citable) accession number: P0C1W6
Secondary accession number(s): C4PWC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 2, 2010
Last modified: September 12, 2018
This is version 32 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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