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Protein

Alpha-conotoxin-like S1.1

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like S1.1
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri12 S1.1 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000024979122 – 48By similarityAdd BLAST27
PeptideiPRO_000024979249 – 61Alpha-conotoxin-like S1.1Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 56By similarity
Disulfide bondi51 ↔ 61By similarity
Modified residuei61Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP0C1W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/4 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C1W4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMRMMFTVF LLVVLAITVV SFPLDRESDG ANAEARTHDH EKHALDRNGC
60
CRNPACESHR CG
Length:62
Mass (Da):6,918
Last modified:September 19, 2006 - v1
Checksum:iAEB1A801009C93D5
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C1W4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri12 S1.1 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA11_CONST
AccessioniPrimary (citable) accession number: P0C1W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 12, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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