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Protein

Delta-hemolysin

Gene

hld

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lyses erythrocytes and many other mammalian cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis

Protein family/group databases

TCDBi1.C.122.1.1 the pore-forming delta-hemolysin (hld) family

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-hemolysin
Short name:
Delta-lysin
Alternative name(s):
Delta-toxin
Gene namesi
Name:hld
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

Pathology & Biotechi

Chemistry databases

DrugBankiDB04464 N-Formylmethionine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000356481 – 26Delta-hemolysinAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Structurei

Secondary structure

126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0C1V1
SMRiP0C1V1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C1V1

Family & Domainsi

Sequence similaritiesi

Belongs to the delta-lysin family.Curated

Keywords - Domaini

Transmembrane

Family and domain databases

InterProiView protein in InterPro
IPR008034 Delta_lysin
PfamiView protein in Pfam
PF05372 Delta_lysin, 1 hit

Sequencei

Sequence statusi: Complete.

P0C1V1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
MAQDIISTIG DLVKWIIDTV NKFTKK
Length:26
Mass (Da):2,979
Last modified:March 18, 2008 - v2
Checksum:i854433C5EFE4DFD2
GO

Sequence cautioni

The sequence CAA36780 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti3Q → A in strain: canine. 1
Natural varianti10 – 12GDL → VEF in strain: canine. 3
Natural varianti15W → L in strain: canine. 1
Natural varianti17 – 18ID → AE in strain: canine. 2
Natural varianti21N → E in strain: canine. 1
Natural varianti24T → I in strain: canine. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52543 Genomic DNA Translation: CAA36780.1 Different initiation.
PIRiA01767 LESAD
RefSeqiWP_000046022.1, NZ_UHCG01000001.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52543 Genomic DNA Translation: CAA36780.1 Different initiation.
PIRiA01767 LESAD
RefSeqiWP_000046022.1, NZ_UHCG01000001.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DHLmodel-A/B1-26[»]
1DTCNMR-A1-26[»]
2DHLmodel-A/B1-26[»]
2DTBNMR-A1-26[»]
2KAMNMR-A1-26[»]
3DHLmodel-A/B1-26[»]
ProteinModelPortaliP0C1V1
SMRiP0C1V1
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB04464 N-Formylmethionine

Protein family/group databases

TCDBi1.C.122.1.1 the pore-forming delta-hemolysin (hld) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0C1V1
PROiPR:P0C1V1

Family and domain databases

InterProiView protein in InterPro
IPR008034 Delta_lysin
PfamiView protein in Pfam
PF05372 Delta_lysin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHLD_STAAU
AccessioniPrimary (citable) accession number: P0C1V1
Secondary accession number(s): P01506, P0A0M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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