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Protein

Homeobox protein Hox-B2

Gene

Hoxb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi141 – 200HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2
Alternative name(s):
Homeobox protein Hox-2.8
Gene namesi
Name:Hoxb2
Synonyms:Hox-2.8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96183 Hoxb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488411 – 354Homeobox protein Hox-B2Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0C1T1
PRIDEiP0C1T1

PTM databases

PhosphoSitePlusiP0C1T1

Expressioni

Gene expression databases

BgeeiENSMUSG00000075588 Expressed in 111 organ(s), highest expression level in head
CleanExiMM_HOXB2
GenevisibleiP0C1T1 MM

Interactioni

Subunit structurei

Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098092

Structurei

3D structure databases

ProteinModelPortaliP0C1T1
SMRiP0C1T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92 – 97Antp-type hexapeptide6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000063664
HOVERGENiHBG006088
InParanoidiP0C1T1
KOiK09302
OMAiHEFPWMK
OrthoDBiEOG091G0IJ4
PhylomeDBiP0C1T1
TreeFamiTF317730

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C1T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPLE
60 70 80 90 100
QTFPSLQLGA STLQRPGSQK QAGDGPALRS PPPLPVAPPA PEFPWMKEKK
110 120 130 140 150
STKKPSQSAA SPSPAASSVR ASEVGSPSDG PGLPECGGSG SRRLRTAYTN
160 170 180 190 200
TQLLELEKEF HFNKYLCRPR RVEIAALLDL TERQVKVWFQ NRRMKHKRQT
210 220 230 240 250
QHREPPEGEP GGPSAQDDAG EPAEEPTVSP GDVATHRLRE ACFHPAEAAQ
260 270 280 290 300
GPRGAPPSAL PATTLESVGA SSPGCTMLRA GGRQSEPLPE DACPERQDSP
310 320 330 340 350
FLPDLNFFAA DSCLQMSGGL SPSLQGSLDS PVPFSEEELD FFTSTLCAID

LQFP
Length:354
Mass (Da):38,096
Last modified:September 5, 2006 - v1
Checksum:iBA5EB460770DA045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606824 Genomic DNA No translation available.
BC138494 mRNA Translation: AAI38495.1
BC138495 mRNA Translation: AAI38496.1
CCDSiCCDS36290.1
RefSeqiNP_598793.2, NM_134032.2
UniGeneiMm.281153

Genome annotation databases

EnsembliENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588
GeneIDi103889
KEGGimmu:103889
UCSCiuc007lby.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606824 Genomic DNA No translation available.
BC138494 mRNA Translation: AAI38495.1
BC138495 mRNA Translation: AAI38496.1
CCDSiCCDS36290.1
RefSeqiNP_598793.2, NM_134032.2
UniGeneiMm.281153

3D structure databases

ProteinModelPortaliP0C1T1
SMRiP0C1T1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098092

PTM databases

PhosphoSitePlusiP0C1T1

Proteomic databases

PaxDbiP0C1T1
PRIDEiP0C1T1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588
GeneIDi103889
KEGGimmu:103889
UCSCiuc007lby.1 mouse

Organism-specific databases

CTDi3212
MGIiMGI:96183 Hoxb2

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000063664
HOVERGENiHBG006088
InParanoidiP0C1T1
KOiK09302
OMAiHEFPWMK
OrthoDBiEOG091G0IJ4
PhylomeDBiP0C1T1
TreeFamiTF317730

Miscellaneous databases

PROiPR:P0C1T1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075588 Expressed in 111 organ(s), highest expression level in head
CleanExiMM_HOXB2
GenevisibleiP0C1T1 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB2_MOUSE
AccessioniPrimary (citable) accession number: P0C1T1
Secondary accession number(s): A2A739, B9EHW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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