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UniProtKB - P0C1T1 (HXB2_MOUSE)
Protein
Homeobox protein Hox-B2
Gene
Hoxb2
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 141 – 200 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anterior/posterior pattern specification Source: MGI
- dorsal/ventral pattern formation Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- facial nerve structural organization Source: MGI
- morphogenesis of an epithelial sheet Source: MGI
- neural nucleus development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- rhombomere 3 development Source: MGI
- rhombomere 4 development Source: MGI
- skeletal system morphogenesis Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-B2Alternative name(s): Homeobox protein Hox-2.8 |
Gene namesi | Name:Hoxb2 Synonyms:Hox-2.8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96183, Hoxb2 |
VEuPathDBi | HostDB:ENSMUSG00000075588 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248841 | 1 – 354 | Homeobox protein Hox-B2Add BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 272 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P0C1T1 |
PRIDEi | P0C1T1 |
PTM databases
PhosphoSitePlusi | P0C1T1 |
Expressioni
Developmental stagei
At 8 dpc, expressed in the developing hindbrain in regions that give rise to rhombomeric segmentations r3, r4 and r5.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000075588, Expressed in head and 136 other tissues |
Genevisiblei | P0C1T1, MM |
Interactioni
Subunit structurei
Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.
By similarityProtein-protein interaction databases
BioGRIDi | 222192, 1 interactor |
STRINGi | 10090.ENSMUSP00000098092 |
Miscellaneous databases
RNActi | P0C1T1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 39 – 143 | DisorderedSequence analysisAdd BLAST | 105 | |
Regioni | 193 – 231 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 246 – 295 | DisorderedSequence analysisAdd BLAST | 50 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 92 – 97 | Antp-type hexapeptide | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 54 – 69 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 78 – 92 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 105 – 124 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000155029 |
HOGENOMi | CLU_048378_0_0_1 |
InParanoidi | P0C1T1 |
OMAi | EDICDPA |
OrthoDBi | 835724at2759 |
PhylomeDBi | P0C1T1 |
TreeFami | TF317730 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C1T1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPLE
60 70 80 90 100
QTFPSLQLGA STLQRPGSQK QAGDGPALRS PPPLPVAPPA PEFPWMKEKK
110 120 130 140 150
STKKPSQSAA SPSPAASSVR ASEVGSPSDG PGLPECGGSG SRRLRTAYTN
160 170 180 190 200
TQLLELEKEF HFNKYLCRPR RVEIAALLDL TERQVKVWFQ NRRMKHKRQT
210 220 230 240 250
QHREPPEGEP GGPSAQDDAG EPAEEPTVSP GDVATHRLRE ACFHPAEAAQ
260 270 280 290 300
GPRGAPPSAL PATTLESVGA SSPGCTMLRA GGRQSEPLPE DACPERQDSP
310 320 330 340 350
FLPDLNFFAA DSCLQMSGGL SPSLQGSLDS PVPFSEEELD FFTSTLCAID
LQFP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL606824 Genomic DNA No translation available. BC138494 mRNA Translation: AAI38495.1 BC138495 mRNA Translation: AAI38496.1 |
CCDSi | CCDS36290.1 |
RefSeqi | NP_598793.2, NM_134032.2 |
Genome annotation databases
Ensembli | ENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588 |
GeneIDi | 103889 |
KEGGi | mmu:103889 |
UCSCi | uc007lby.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL606824 Genomic DNA No translation available. BC138494 mRNA Translation: AAI38495.1 BC138495 mRNA Translation: AAI38496.1 |
CCDSi | CCDS36290.1 |
RefSeqi | NP_598793.2, NM_134032.2 |
3D structure databases
SMRi | P0C1T1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 222192, 1 interactor |
STRINGi | 10090.ENSMUSP00000098092 |
PTM databases
PhosphoSitePlusi | P0C1T1 |
Proteomic databases
PaxDbi | P0C1T1 |
PRIDEi | P0C1T1 |
Protocols and materials databases
Antibodypediai | 30263, 170 antibodies from 27 providers |
DNASUi | 103889 |
Genome annotation databases
Ensembli | ENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588 |
GeneIDi | 103889 |
KEGGi | mmu:103889 |
UCSCi | uc007lby.1, mouse |
Organism-specific databases
CTDi | 3212 |
MGIi | MGI:96183, Hoxb2 |
VEuPathDBi | HostDB:ENSMUSG00000075588 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000155029 |
HOGENOMi | CLU_048378_0_0_1 |
InParanoidi | P0C1T1 |
OMAi | EDICDPA |
OrthoDBi | 835724at2759 |
PhylomeDBi | P0C1T1 |
TreeFami | TF317730 |
Miscellaneous databases
BioGRID-ORCSi | 103889, 5 hits in 64 CRISPR screens |
ChiTaRSi | Hoxb2, mouse |
PROi | PR:P0C1T1 |
RNActi | P0C1T1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075588, Expressed in head and 136 other tissues |
Genevisiblei | P0C1T1, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXB2_MOUSE | |
Accessioni | P0C1T1Primary (citable) accession number: P0C1T1 Secondary accession number(s): A2A739, B9EHW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families